2a2f - Revision history

OCA at 09:10, 14 February 2024

2024-02-14T09:10:54Z

← Older revision		Revision as of 09:10, 14 February 2024
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	<StructureSection load='2a2f' size='340' side='right'caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a2f' size='340' side='right'caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2F FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~sec15 (~~[~~https://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5&~~id=7227 DROME])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [https://pdbe.org/2a2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [https://www.ebi.ac.uk/pdbsum/2a2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [https://pdbe.org/2a2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [https://www.ebi.ac.uk/pdbsum/2a2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/EXOC6_DROME EXOC6_DROME]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.		[https://www.uniprot.org/uniprot/EXOC6_DROME EXOC6_DROME] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2f ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Sec15, a component of the exocyst, recognizes vesicle-associated Rab GTPases, helps target transport vesicles to the budding sites in yeast and is thought to recruit other exocyst proteins. Here we report the characterization of a 35-kDa fragment that comprises most of the C-terminal half of Drosophila melanogaster Sec15. This C-terminal domain was found to bind a subset of Rab GTPases, especially Rab11, in a GTP-dependent manner. We also provide evidence that in fly photoreceptors Sec15 colocalizes with Rab11 and that loss of Sec15 affects rhabdomere morphology. Determination of the 2.5-A crystal structure of the C-terminal domain revealed a novel fold consisting of ten alpha-helices equally distributed between two subdomains (N and C subdomains). We show that the C subdomain, mainly via a single helix, is sufficient for Rab binding.

	Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.,Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA Nat Struct Mol Biol. 2005 Oct;12(10):879-85. Epub 2005 Sep 11. PMID:16155582<ref>PMID:16155582</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2a2f" style="background-color:#fffaf0;"></div>~~
	~~== References ==~~
	~~<references/>~~
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Drome~~]]		[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bellen~~, H J~~]]		[[Category: Bellen HJ]]
	[[Category: Mehta~~, S Q~~]]		[[Category: Mehta SQ]]
	[[Category: Pichaud, F]]		[[Category: Pichaud F]]
	[[Category: Quiocho~~, F A~~]]		[[Category: Quiocho FA]]
	[[Category: Wu, S]]		[[Category: Wu S]]
	~~[[Category: All helical structure]]~~
	~~[[Category: Protein transport~~]]

OCA at 08:24, 27 January 2021

2021-01-27T08:24:27Z

← Older revision		Revision as of 08:24, 27 January 2021
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	==Crystal Structure of Sec15 C-terminal domain==		==Crystal Structure of Sec15 C-terminal domain==
	<StructureSection load='2a2f' size='340' side='right' caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a2f' size='340' side='right'caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2A2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [~~http~~://pdbe.org/2a2f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2a2f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [https://pdbe.org/2a2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [https://www.ebi.ac.uk/pdbsum/2a2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/EXOC6_DROME EXOC6_DROME]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.		[[https://www.uniprot.org/uniprot/EXOC6_DROME EXOC6_DROME]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Drome]]		[[Category: Drome]]
			[[Category: Large Structures]]
	[[Category: Bellen, H J]]		[[Category: Bellen, H J]]
	[[Category: Mehta, S Q]]		[[Category: Mehta, S Q]]

OCA at 07:20, 9 May 2018

2018-05-09T07:20:15Z

← Older revision		Revision as of 07:20, 9 May 2018
Line 1:		Line 1:

	==Crystal Structure of Sec15 C-terminal domain==		==Crystal Structure of Sec15 C-terminal domain==
	<StructureSection load='2a2f' size='340' side='right' caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a2f' size='340' side='right' caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://pdbe.org/2a2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://pdbe.org/2a2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a2f ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2f_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 17:48, 9 February 2016

2016-02-09T17:48:21Z

← Older revision		Revision as of 17:48, 9 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:34, 11 September 2015

2015-09-11T00:34:51Z

← Older revision		Revision as of 00:34, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2a2f' size='340' side='right' caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2a2f' size='340' side='right' caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Drosophila_melanogaster Drosophila melanogaster~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 ~~Drosophila melanogaster~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://pdbe.org/2a2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/EXOC6_DROME EXOC6_DROME]] Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2a2f" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Drosophila melanogaster~~]]		[[Category: Drome]]
	[[Category: Bellen, H J]]		[[Category: Bellen, H J]]
	[[Category: Mehta, S Q]]		[[Category: Mehta, S Q]]

OCA at 09:40, 8 January 2015

2015-01-08T09:40:43Z

← Older revision		Revision as of 09:40, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Bellen, H J.]]		[[Category: Bellen, H J]]
	[[Category: Mehta, S Q.]]		[[Category: Mehta, S Q]]
	[[Category: Pichaud, F.]]		[[Category: Pichaud, F]]
	[[Category: Quiocho, F A.]]		[[Category: Quiocho, F A]]
	[[Category: Wu, S.]]		[[Category: Wu, S]]
	[[Category: All helical structure]]		[[Category: All helical structure]]
	[[Category: Protein transport]]		[[Category: Protein transport]]

OCA at 02:07, 30 September 2014

2014-09-30T02:07:50Z

← Older revision		Revision as of 02:07, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2a2f~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of Sec15 C-terminal domain==
			<StructureSection load='2a2f' size='340' side='right' caption='[[2a2f]], [[Resolution\|resolution]] 2.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2F FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">sec15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a2f RCSB], [http://www.ebi.ac.uk/pdbsum/2a2f PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2f_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Sec15, a component of the exocyst, recognizes vesicle-associated Rab GTPases, helps target transport vesicles to the budding sites in yeast and is thought to recruit other exocyst proteins. Here we report the characterization of a 35-kDa fragment that comprises most of the C-terminal half of Drosophila melanogaster Sec15. This C-terminal domain was found to bind a subset of Rab GTPases, especially Rab11, in a GTP-dependent manner. We also provide evidence that in fly photoreceptors Sec15 colocalizes with Rab11 and that loss of Sec15 affects rhabdomere morphology. Determination of the 2.5-A crystal structure of the C-terminal domain revealed a novel fold consisting of ten alpha-helices equally distributed between two subdomains (N and C subdomains). We show that the C subdomain, mainly via a single helix, is sufficient for Rab binding.

	~~{{STRUCTURE_2a2f\| PDB=2a2f \| SCENE= }}~~		Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.,Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA Nat Struct Mol Biol. 2005 Oct;12(10):879-85. Epub 2005 Sep 11. PMID:16155582<ref>PMID:16155582</ref>

	~~===Crystal Structure~~ of ~~Sec15 C-terminal domain===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16155582}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2a2f]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Drosophila_melanogaster Drosophila melanogaster]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016155582<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Bellen, H J.]]		[[Category: Bellen, H J.]]

OCA: Protected "2a2f" [edit=sysop:move=sysop]

2013-01-06T11:20:40Z

Protected "2a2f" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:20, 6 January 2013
(No difference)

OCA at 11:20, 6 January 2013

2013-01-06T11:20:35Z

← Older revision		Revision as of 11:20, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2a2f.png\|left\|200px]]		[[Image:2a2f.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2a2f", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2a2f\| PDB=2a2f \| SCENE= }}		{{STRUCTURE_2a2f\| PDB=2a2f \| SCENE= }}

	===Crystal Structure of Sec15 C-terminal domain===		===Crystal Structure of Sec15 C-terminal domain===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16155582}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16155582 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_16155582}}		{{ABSTRACT_PUBMED_16155582}}

	==About this Structure==		==About this Structure==
	~~2A2F~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA].		[[2a2f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16155582~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016155582</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	[[Category: Bellen, H J.]]		[[Category: Bellen, H J.]]
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	[[Category: Wu, S.]]		[[Category: Wu, S.]]
	[[Category: All helical structure]]		[[Category: All helical structure]]
			[[Category: Protein transport]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 11:34:46 2009''~~

OCA at 09:34, 17 February 2009

2009-02-17T09:34:47Z

← Older revision		Revision as of 09:34, 17 February 2009
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	==About this Structure==		==About this Structure==
	2A2F is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA].		2A2F is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2F OCA].

	==Reference==		==Reference==
	~~Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo., Wu S, Mehta SQ, Pichaud F, Bellen HJ, Quiocho FA, Nat Struct Mol Biol. 2005 Oct;12(10):879-85. Epub 2005 Sep 11.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16155582 16155582]~~		<ref group="xtra">PMID:16155582</ref><references group="xtra"/>
	[[Category: Drosophila melanogaster]]		[[Category: Drosophila melanogaster]]
	~~[[Category: Single protein]]~~
	[[Category: Bellen, H J.]]		[[Category: Bellen, H J.]]
	[[Category: Mehta, S Q.]]		[[Category: Mehta, S Q.]]
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	[[Category: All helical structure]]		[[Category: All helical structure]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Mon Jul 28 15~~:42:~~11 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:34:46 2009''