2a3e - Revision history

OCA at 08:16, 25 October 2023

2023-10-25T08:16:19Z

← Older revision		Revision as of 08:16, 25 October 2023
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	<StructureSection load='2a3e' size='340' side='right'caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2a3e' size='340' side='right'caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [https://pdbe.org/2a3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [https://www.ebi.ac.uk/pdbsum/2a3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [https://pdbe.org/2a3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [https://www.ebi.ac.uk/pdbsum/2a3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3e ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/CHIB1_ASPFM CHIB1_ASPFM] Major secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Plays a role in the morphogenesis and autolysis (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Chitinase~~]]		[[Category: Aspergillus fumigatus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Aalten, D M.F van]]~~		[[Category: Andersen OA]]
	[[Category: Andersen~~, O A~~]]		[[Category: DeMartino JA]]
	[[Category: DeMartino~~, J A~~]]		[[Category: Rao FV]]
	[[Category: Rao~~, F V~~]]		[[Category: Vora KA]]
	[[Category: Vora~~, K A~~]]		[[Category: Van Aalten DMF]]
	[[Category: ~~Chitinase-allosamidin complex]]~~
	~~[[Category: Hydrolase~~]]

OCA at 14:35, 17 November 2021

2021-11-17T14:35:51Z

← Older revision		Revision as of 14:35, 17 November 2021
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	<StructureSection load='2a3e' size='340' side='right'caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2a3e' size='340' side='right'caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2A3E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=~~NAA~~:~~N-ACETYL-D-ALLOSAMINE~~'>~~NAA~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [~~http~~://pdbe.org/2a3e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2a3e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [https://pdbe.org/2a3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [https://www.ebi.ac.uk/pdbsum/2a3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:23, 13 February 2020

2020-02-13T05:23:20Z

← Older revision		Revision as of 05:23, 13 February 2020
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	==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin==		==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin==
	<StructureSection load='2a3e' size='340' side='right' caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2a3e' size='340' side='right'caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Chitinase\|Chitinase]]		*[[Chitinase 3D structures\|Chitinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Chitinase]]		[[Category: Chitinase]]
			[[Category: Large Structures]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]
	[[Category: Andersen, O A]]		[[Category: Andersen, O A]]

OCA at 07:15, 9 May 2018

2018-05-09T07:15:45Z

OCA at 23:54, 8 February 2016

2016-02-08T23:54:36Z

← Older revision		Revision as of 23:54, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a3e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:35, 10 September 2015

2015-09-10T16:35:57Z

← Older revision		Revision as of 16:35, 10 September 2015
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	<StructureSection load='2a3e' size='340' side='right' caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2a3e' size='340' side='right' caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://pdbe.org/2a3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2a3e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Aspergillus fumigatus]]~~
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Aalten, D M.F van]]		[[Category: Aalten, D M.F van]]

OCA at 09:35, 8 January 2015

2015-01-08T09:35:42Z

← Older revision		Revision as of 09:35, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
	[[Category: Aalten, D M.F van.]]		[[Category: Aalten, D M.F van]]
	[[Category: Andersen, O A.]]		[[Category: Andersen, O A]]
	[[Category: DeMartino, J A.]]		[[Category: DeMartino, J A]]
	[[Category: Rao, F V.]]		[[Category: Rao, F V]]
	[[Category: Vora, K A.]]		[[Category: Vora, K A]]
	[[Category: Chitinase-allosamidin complex]]		[[Category: Chitinase-allosamidin complex]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 02:32, 29 September 2014

2014-09-29T02:32:36Z

← Older revision		Revision as of 02:32, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2a3e~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin==
			<StructureSection load='2a3e' size='340' side='right' caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/2a3e_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Family 18 chitinases play key roles in a range of pathogenic organisms and are overexpressed in the asthmatic lung. By screening a library of marketed drug molecules, we have identified methylxanthine derivatives as possible inhibitor leads. These derivatives, theophylline, caffeine, and pentoxifylline, are used therapeutically as antiinflammatory agents, with pleiotropic mechanisms of action. Here it is shown that they are also competitive inhibitors against a fungal family 18 chitinase, with pentoxifylline being the most potent (K(i) of 37 microM). Crystallographic analysis of chitinase-inhibitor complexes revealed specific interactions with the active site, mimicking the reaction intermediate analog, allosamidin. Mutagenesis identified the key active site residues, conserved in mammalian chitinases, which contribute to inhibitor affinity. Enzyme assays also revealed that these methylxanthines are active against human chitinases.

	~~{{STRUCTURE_2a3e\| PDB=2a3e \| SCENE= }}~~		Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.,Rao FV, Andersen OA, Vora KA, Demartino JA, van Aalten DM Chem Biol. 2005 Sep;12(9):973-80. PMID:16183021<ref>PMID:16183021</ref>

	~~===Crystal structure~~ of ~~Aspergillus fumigatus chitinase B1 in complex with allosamidin===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16183021}}~~

	~~==About this Structure==~~
	~~[[2a3e]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2A3E OCA].~~

	==See Also==		==See Also==
	*[[Chitinase\|Chitinase]]		*[[Chitinase\|Chitinase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016183021<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]

OCA at 11:54, 20 October 2012

2012-10-20T11:54:31Z

← Older revision		Revision as of 11:54, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2a3e]] is a 2 chain structure ~~of [[Chitinase]]~~ with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA].		[[2a3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA].

	==See Also==		==See Also==

OCA at 06:59, 26 July 2012

2012-07-26T06:59:34Z

← Older revision		Revision as of 06:59, 26 July 2012
Line 1:		Line 1:
	[[Image:2a3e.png\|left\|200px]]		[[Image:2a3e.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2a3e", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2a3e\| PDB=2a3e \| SCENE= }}		{{STRUCTURE_2a3e\| PDB=2a3e \| SCENE= }}

	===Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin===		===Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16183021}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16183021 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16183021}}		{{ABSTRACT_PUBMED_16183021}}

	==About this Structure==		==About this Structure==
	[[2a3e]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA].		[[2a3e]] is a 2 chain structure of [[Chitinase]] with sequence from [http://en.wikipedia.org/wiki/Aspergillus_fumigatus Aspergillus fumigatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA].

			==See Also==
			*[[Chitinase\|Chitinase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16183021~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016183021</ref><references group="xtra"/>
	[[Category: Aspergillus fumigatus]]		[[Category: Aspergillus fumigatus]]
	[[Category: Chitinase]]		[[Category: Chitinase]]
Line 30:		Line 22:
	[[Category: Rao, F V.]]		[[Category: Rao, F V.]]
	[[Category: Vora, K A.]]		[[Category: Vora, K A.]]
			[[Category: Chitinase-allosamidin complex]]
			[[Category: Hydrolase]]

← Older revision		Revision as of 07:15, 9 May 2018
Line 1:		Line 1:

	==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin==		==Crystal structure of Aspergillus fumigatus chitinase B1 in complex with allosamidin==
	<StructureSection load='2a3e' size='340' side='right' caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='2a3e' size='340' side='right' caption='[[2a3e]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a3e]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A3E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene>, <scene name='pdbligand=~~NAA~~:~~N-ACETYL-D-ALLOSAMINE~~'>~~NAA~~</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMI:ALLOSAMIZOLINE'>AMI</scene>, <scene name='pdbligand=NAA:N-ACETYL-D-ALLOSAMINE'>NAA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1w9p\|1w9p]], [[1w9v\|1w9v]], [[1w9u\|1w9u]], [[1hkk\|1hkk]], [[2a3a\|2a3a]], [[2a3b\|2a3b]], [[2a3c\|2a3c]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Chitinase Chitinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.14 3.2.1.14] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://pdbe.org/2a3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a3e OCA], [http://pdbe.org/2a3e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a3e RCSB], [http://www.ebi.ac.uk/pdbsum/2a3e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a3e ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/2a3e_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a3/2a3e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>