2a4e - Revision history

OCA at 07:18, 23 August 2023

2023-08-23T07:18:58Z

← Older revision		Revision as of 07:18, 23 August 2023
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	<StructureSection load='2a4e' size='340' side='right'caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2a4e' size='340' side='right'caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~Cdh11, Cad-11 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [https://pdbe.org/2a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [https://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [https://pdbe.org/2a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [https://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		[https://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Lk3 transgenic mice~~]]		[[Category: Mus musculus]]
	[[Category: Arkus, N]]		[[Category: Arkus N]]
	[[Category: Bahna, F]]		[[Category: Bahna F]]
	[[Category: Chen~~, C P~~]]		[[Category: Chen CP]]
	[[Category: Ciatto, C]]		[[Category: Ciatto C]]
	[[Category: Honig, B]]		[[Category: Honig B]]
	[[Category: Jessell~~, T M~~]]		[[Category: Jessell TM]]
	[[Category: Patel~~, S D~~]]		[[Category: Patel SD]]
	[[Category: Price~~, S R~~]]		[[Category: Price SR]]
	[[Category: Rajebhosale, M]]		[[Category: Rajebhosale M]]
	[[Category: Shapiro, L]]		[[Category: Shapiro L]]
	~~[[Category: Cadherin]]~~
	~~[[Category: Calcium binding]]~~
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Dimer~~]]

OCA at 08:25, 27 January 2021

2021-01-27T08:25:28Z

← Older revision		Revision as of 08:25, 27 January 2021
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	==Crystal structure of mouse cadherin-11 EC1-2==		==Crystal structure of mouse cadherin-11 EC1-2==
	<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2a4e' size='340' side='right'caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [~~http~~://pdbe.org/2a4e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [https://pdbe.org/2a4e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [https://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.		[[https://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Cadherin\|Cadherin]]		*[[Cadherin 3D structures\|Cadherin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Arkus, N]]		[[Category: Arkus, N]]

OCA at 07:20, 9 May 2018

2018-05-09T07:20:17Z

← Older revision		Revision as of 07:20, 9 May 2018
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	==Crystal structure of mouse cadherin-11 EC1-2==		==Crystal structure of mouse cadherin-11 EC1-2==
	<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://pdbe.org/2a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://pdbe.org/2a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2a4e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4e_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 01:43, 9 February 2016

2016-02-09T01:43:25Z

← Older revision		Revision as of 01:43, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a4e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 17:23, 10 September 2015

2015-09-10T17:23:27Z

← Older revision		Revision as of 17:23, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mus_musculus Mus musculus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 ~~Mus musculus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://pdbe.org/2a4e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2a4e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Mus musculus~~]]		[[Category: Lk3 transgenic mice]]
	[[Category: Arkus, N]]		[[Category: Arkus, N]]
	[[Category: Bahna, F]]		[[Category: Bahna, F]]

OCA at 03:33, 25 December 2014

2014-12-25T03:33:56Z

← Older revision		Revision as of 03:33, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CAD11_MOUSE CAD11_MOUSE]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arkus, N.]]		[[Category: Arkus, N]]
	[[Category: Bahna, F.]]		[[Category: Bahna, F]]
	[[Category: Chen, C P.]]		[[Category: Chen, C P]]
	[[Category: Ciatto, C.]]		[[Category: Ciatto, C]]
	[[Category: Honig, B.]]		[[Category: Honig, B]]
	[[Category: Jessell, T M.]]		[[Category: Jessell, T M]]
	[[Category: Patel, S D.]]		[[Category: Patel, S D]]
	[[Category: Price, S R.]]		[[Category: Price, S R]]
	[[Category: Rajebhosale, M.]]		[[Category: Rajebhosale, M]]
	[[Category: Shapiro, L.]]		[[Category: Shapiro, L]]
	[[Category: Cadherin]]		[[Category: Cadherin]]
	[[Category: Calcium binding]]		[[Category: Calcium binding]]
	[[Category: Cell adhesion]]		[[Category: Cell adhesion]]
	[[Category: Dimer]]		[[Category: Dimer]]

OCA at 03:11, 29 September 2014

2014-09-29T03:11:30Z

← Older revision		Revision as of 03:11, 29 September 2014
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	[[Image:~~2a4e~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of mouse cadherin-11 EC1-2==
			<StructureSection load='2a4e' size='340' side='right' caption='[[2a4e]], [[Resolution\|resolution]] 3.20Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A4E FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1zvn\|1zvn]], [[1zxk\|1zxk]], [[2a4c\|2a4c]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cdh11, Cad-11 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a4e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a4e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2a4e RCSB], [http://www.ebi.ac.uk/pdbsum/2a4e PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/2a4e_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Type I and II classical cadherins help to determine the adhesive specificities of animal cells. Crystal-structure determination of ectodomain regions from three type II cadherins reveals adhesive dimers formed by exchange of N-terminal beta strands between partner extracellular cadherin-1 (EC1) domains. These interfaces have two conserved tryptophan side chains that anchor each swapped strand, compared with one in type I cadherins, and include large hydrophobic regions unique to type II interfaces. The EC1 domains of type I and type II cadherins appear to encode cell adhesive specificity in vitro. Moreover, perturbation of motor neuron segregation with chimeric cadherins depends on EC1 domain identity, suggesting that this region, which includes the structurally defined adhesive interface, encodes type II cadherin functional specificity in vivo.

	~~{{STRUCTURE_2a4e\| PDB=2a4e \| SCENE= }}~~		Type II cadherin ectodomain structures: implications for classical cadherin specificity.,Patel SD, Ciatto C, Chen CP, Bahna F, Rajebhosale M, Arkus N, Schieren I, Jessell TM, Honig B, Price SR, Shapiro L Cell. 2006 Mar 24;124(6):1255-68. PMID:16564015<ref>PMID:16564015</ref>

	~~===Crystal structure~~ of ~~mouse cadherin-11 EC1-2===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16564015}}~~

	~~==About this Structure==~~
	~~[[2a4e]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2A4E OCA].~~

	==See Also==		==See Also==
	*[[Cadherin\|Cadherin]]		*[[Cadherin\|Cadherin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016564015<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arkus, N.]]		[[Category: Arkus, N.]]

OCA at 12:12, 20 October 2012

2012-10-20T12:12:38Z

← Older revision		Revision as of 12:12, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2a4e]] is a 1 chain structure ~~of [[Cadherin]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA].		[[2a4e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A4E OCA].

	==See Also==		==See Also==

OCA at 07:57, 26 July 2012

2012-07-26T07:57:45Z

← Older revision		Revision as of 07:57, 26 July 2012
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	[[Image:2a4e.png\|left\|200px]]		[[Image:2a4e.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2a4e", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2a4e\| PDB=2a4e \| SCENE= }}		{{STRUCTURE_2a4e\| PDB=2a4e \| SCENE= }}

	===Crystal structure of mouse cadherin-11 EC1-2===		===Crystal structure of mouse cadherin-11 EC1-2===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16564015}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16564015 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16564015}}		{{ABSTRACT_PUBMED_16564015}}

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	==See Also==		==See Also==
	*[[Cadherin]]		*[[Cadherin\|Cadherin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16564015~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016564015</ref><references group="xtra"/>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Arkus, N.]]		[[Category: Arkus, N.]]

OCA: Protected "2a4e" [edit=sysop:move=sysop]

2010-12-26T20:34:23Z

Protected "2a4e" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:34, 26 December 2010
(No difference)