2aba - Revision history

OCA at 08:16, 25 October 2023

2023-10-25T08:16:55Z

← Older revision		Revision as of 08:16, 25 October 2023
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	<StructureSection load='2aba' size='340' side='right'caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='2aba' size='340' side='right'caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter~~ cloacae~~" (jordan 1890) bergey et al. 1923~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.05Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [https://pdbe.org/2aba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [https://www.ebi.ac.uk/pdbsum/2aba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aba ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [https://pdbe.org/2aba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [https://www.ebi.ac.uk/pdbsum/2aba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aba ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/P71278_ENTCL P71278_ENTCL]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Enterobacter cloacae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Barna, T]]		[[Category: Barna T]]
	[[Category: Bruce~~, N C~~]]		[[Category: Bruce NC]]
	[[Category: Khan, H]]		[[Category: Khan H]]
	[[Category: Leys, D]]		[[Category: Leys D]]
	[[Category: Munro~~, A W~~]]		[[Category: Munro AW]]
	[[Category: Scrutton~~, N S]]~~		[[Category: Scrutton NS]]
	~~[[Category: Atomic resolution]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Petn]]~~
	~~[[Category: Progesterone]]~~
	~~[[Category: Reduced flavoprotein~~]]

OCA at 14:38, 17 November 2021

2021-11-17T14:38:47Z

← Older revision		Revision as of 14:38, 17 November 2021
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	<StructureSection load='2aba' size='340' side='right'caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='2aba' size='340' side='right'caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ABA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [~~http~~://pdbe.org/2aba PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aba PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aba ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [https://pdbe.org/2aba PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [https://www.ebi.ac.uk/pdbsum/2aba PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aba ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:24, 13 February 2020

2020-02-13T05:24:59Z

← Older revision		Revision as of 05:24, 13 February 2020
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	==Structure of reduced PETN reductase in complex with progesterone==		==Structure of reduced PETN reductase in complex with progesterone==
	<StructureSection load='2aba' size='340' side='right' caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='2aba' size='340' side='right'caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Barna, T]]		[[Category: Barna, T]]
	[[Category: Bruce, N C]]		[[Category: Bruce, N C]]

OCA at 07:17, 9 May 2018

2018-05-09T07:17:07Z

← Older revision		Revision as of 07:17, 9 May 2018
Line 1:		Line 1:

	==Structure of reduced PETN reductase in complex with progesterone==		==Structure of reduced PETN reductase in complex with progesterone==
	<StructureSection load='2aba' size='340' side='right' caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='2aba' size='340' side='right' caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://pdbe.org/2aba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://pdbe.org/2aba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aba ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2aba_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2aba_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:39, 8 February 2016

2016-02-08T13:39:13Z

← Older revision		Revision as of 13:39, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aba ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 12:06, 10 September 2015

2015-09-10T12:06:05Z

← Older revision		Revision as of 12:06, 10 September 2015
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	<StructureSection load='2aba' size='340' side='right' caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>		<StructureSection load='2aba' size='340' side='right' caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Enterobacter_cloacae Enterobacter~~ cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"aerobacter_cloacae"_(jordan_1890)_bergey_et_al._1923 "aerobacter cloacae" (jordan 1890) bergey et al. 1923]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://pdbe.org/2aba PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2aba" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Enterobacter cloacae]]~~
	[[Category: Barna, T]]		[[Category: Barna, T]]
	[[Category: Bruce, N C]]		[[Category: Bruce, N C]]

OCA at 09:37, 8 January 2015

2015-01-08T09:37:39Z

← Older revision		Revision as of 09:37, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Enterobacter cloacae]]		[[Category: Enterobacter cloacae]]
	[[Category: Barna, T.]]		[[Category: Barna, T]]
	[[Category: Bruce, N C.]]		[[Category: Bruce, N C]]
	[[Category: Khan, H.]]		[[Category: Khan, H]]
	[[Category: Leys, D.]]		[[Category: Leys, D]]
	[[Category: Munro, A W.]]		[[Category: Munro, A W]]
	[[Category: Scrutton, N S.]]		[[Category: Scrutton, N S]]
	[[Category: Atomic resolution]]		[[Category: Atomic resolution]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 02:04, 30 September 2014

2014-09-30T02:04:54Z

← Older revision		Revision as of 02:04, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2aba~~\| ~~PDB~~=2aba \| ~~SCENE~~= }}		==Structure of reduced PETN reductase in complex with progesterone==
	===~~Structure~~ of reduced PETN reductase in complex with ~~progesterone===~~		<StructureSection load='2aba' size='340' side='right' caption='[[2aba]], [[Resolution\|resolution]] 1.05Å' scene=''>
	~~{{ABSTRACT_PUBMED_16156787}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2aba]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacter_cloacae Enterobacter cloacae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABA FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=STR:PROGESTERONE'>STR</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1h60\|1h60]], [[1vyr\|1vyr]], [[2abb\|2abb]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aba FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aba OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aba RCSB], [http://www.ebi.ac.uk/pdbsum/2aba PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2aba_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The roles of His181, His184 and Tyr186 in PETN reductase have been examined by mutagenesis, spectroscopic and stopped-flow kinetics, and by determination of crystallographic structures for the Y186F PETN reductase and reduced wild-type enzyme-progesterone complex. Residues His181 and His184 are important in the binding of coenzyme, steroids, nitroaromatic ligands and the substrate 2-cyclohexen-1-one. The H181A and H184A enzymes retain activity in reductive and oxidative half-reactions, and thus do not play an essential role in catalysis. Ligand binding and catalysis is not substantially impaired in Y186F PETN reductase, which contrasts with data for the equivalent mutation (Y196F) in Old Yellow Enzyme. The structure of Y186F PETN reductase is identical to wild-type enzyme, with the obvious exception of the mutation. We show in PETN reductase that Tyr186 is not a key proton donor in the reduction of alpha/beta unsaturated carbonyl compounds. The structure of two electron-reduced PETN reductase bound to the inhibitor progesterone mimics the catalytic enzyme-steroid substrate complex and is similar to the structure of the oxidized enzyme-inhibitor complex. The reactive C1-C2 unsaturated bond of the steroid is inappropriately orientated with the flavin N5 atom for hydride transfer. With steroid substrates, the productive conformation is achieved by orientating the steroid through flipping by 180 degrees , consistent with known geometries for hydride transfer in flavoenzymes. Our data highlight mechanistic differences between Old Yellow Enzyme and PETN reductase and indicate that catalysis requires a metastable enzyme-steroid complex and not the most stable complex observed in crystallographic studies.

	~~==About this~~ Structure==		Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase. Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181, His184.,Khan H, Barna T, Bruce NC, Munro AW, Leys D, Scrutton NS FEBS J. 2005 Sep;272(18):4660-71. PMID:16156787<ref>PMID:16156787</ref>
	~~[[2aba]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Enterobacter_cloacae Enterobacter cloacae]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.il/~~oca-bin/ocashort?id=2ABA OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
	*[[Pentaerythritol tetranitrate reductase\|Pentaerythritol tetranitrate reductase]]		*[[Pentaerythritol tetranitrate reductase\|Pentaerythritol tetranitrate reductase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016156787<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Enterobacter cloacae]]		[[Category: Enterobacter cloacae]]
	[[Category: Barna, T.]]		[[Category: Barna, T.]]

OCA at 10:35, 11 March 2013

2013-03-11T10:35:12Z

← Older revision		Revision as of 10:35, 11 March 2013
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	~~[[Image:2aba.png\|left\|200px]]~~

	{{STRUCTURE_2aba\| PDB=2aba \| SCENE= }}		{{STRUCTURE_2aba\| PDB=2aba \| SCENE= }}

	===Structure of reduced PETN reductase in complex with progesterone===		===Structure of reduced PETN reductase in complex with progesterone===

	{{ABSTRACT_PUBMED_16156787}}		{{ABSTRACT_PUBMED_16156787}}

OCA: Protected "2aba" [edit=sysop:move=sysop]

2013-01-06T11:18:03Z

Protected "2aba" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:18, 6 January 2013
(No difference)