2abd - Revision history

OCA at 06:37, 1 May 2024

2024-05-01T06:37:30Z

← Older revision		Revision as of 06:37, 1 May 2024
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	==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==		==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==
	<StructureSection load='2abd' size='340' side='right'caption='[[2abd~~]], [[NMR_Ensembles_of_Models \| 29 NMR models~~]]' scene=''>		<StructureSection load='2abd' size='340' side='right'caption='[[2abd]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [https://pdbe.org/2abd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [https://www.ebi.ac.uk/pdbsum/2abd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abd ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [https://pdbe.org/2abd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [https://www.ebi.ac.uk/pdbsum/2abd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN]] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref>		[https://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 18:		Line 19:
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2abd ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2abd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	The 3D structure of bovine recombinant acyl-coenzyme A binding protein has been determined using multidimensional heteronuclear magnetic resonance spectroscopy in a study that combines investigations of 15N-labeled and unlabeled protein. The present structure determination is a refinement of the structure previously determined (Andersen, K.V. and Poulsen, F.M. (1992) J. Mol. Biol., 226, 1131-1141). It is based on 1096 distance restraints and 124 dihedral angle restraints of which 69 are for phi-angles and 8 for chiral centers and 47 for prochiral centers. The new experimental input for the structure determination has provided an increase of 263 distance restraints, 5 phi-angle restraints, and 32 chi-angle restraints in 2 chiral centers, and 31 prochiral centers restraining an additional 23 chi 1, 8 chi 2, and 1 chi 3 angles. The increase of 300 distance and dihedral angle restraints representing an additional 30% of input parameters for the structure determination has been shown to be in agreement with the first structure. A set of 29 structures has been calculated and each of the structures has been compared to a mean structure to give an atomic root mean square deviation of 0.44 +/- 0.12 A (1 A is 0.1 nm) for the backbone atoms C, C alpha, and N in the four alpha-helices A1, residues 4-15, A2, residues 21-36, A3, residues 51-62 and A4, residues 65-84. The loop-region of residues Gly45-Lys50 could not be defined by the restraints obtained by NMR. The program PRONTO has been used for the spectrum analysis, assignment of the individual nuclear Overhauser effects, the integration of the cross peaks, and the measurement of the coupling constants. The programs DIANA, X-PLOR and INSIGHT have been used in the structure calculations and evaluations.

	The three-dimensional structure of acyl-coenzyme A binding protein from bovine liver: structural refinement using heteronuclear multidimensional NMR spectroscopy.,Andersen KV, Poulsen FM J Biomol NMR. 1993 May;3(3):271-84. PMID:8358232<ref>PMID:8358232</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2abd" style="background-color:#fffaf0;"></div>~~
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bovin~~]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Andersen~~, K V~~]]		[[Category: Andersen KV]]
	[[Category: Poulsen~~, F M]]~~		[[Category: Poulsen FM]]
	~~[[Category: Acyl-coenzyme a binding protein~~]]

OCA at 06:36, 6 October 2021

2021-10-06T06:36:35Z

← Older revision		Revision as of 06:36, 6 October 2021
Line 3:		Line 3:
	<StructureSection load='2abd' size='340' side='right'caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>		<StructureSection load='2abd' size='340' side='right'caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ABD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [~~http~~://pdbe.org/2abd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2abd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2abd ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [https://pdbe.org/2abd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [https://www.ebi.ac.uk/pdbsum/2abd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2abd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN]] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref>		[[https://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN]] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:12, 11 December 2019

2019-12-11T19:12:35Z

← Older revision		Revision as of 19:12, 11 December 2019
Line 1:		Line 1:

	==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==		==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==
	<StructureSection load='2abd' size='340' side='right' caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>		<StructureSection load='2abd' size='340' side='right'caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abd_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abd_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
			[[Category: Large Structures]]
	[[Category: Andersen, K V]]		[[Category: Andersen, K V]]
	[[Category: Poulsen, F M]]		[[Category: Poulsen, F M]]
	[[Category: Acyl-coenzyme a binding protein]]		[[Category: Acyl-coenzyme a binding protein]]

OCA at 07:03, 29 November 2017

2017-11-29T07:03:44Z

← Older revision		Revision as of 07:03, 29 November 2017
Line 1:		Line 1:

	==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==		==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==
	<StructureSection load='2abd' size='340' side='right' caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>		<StructureSection load='2abd' size='340' side='right' caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://pdbe.org/2abd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://pdbe.org/2abd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2abd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 15:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2abd ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:19, 11 September 2015

2015-09-11T08:19:58Z

← Older revision		Revision as of 08:19, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2abd' size='340' side='right' caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>		<StructureSection load='2abd' size='340' side='right' caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://pdbe.org/2abd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2abd" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bos taurus~~]]		[[Category: Bovin]]
	[[Category: Andersen, K V]]		[[Category: Andersen, K V]]
	[[Category: Poulsen, F M]]		[[Category: Poulsen, F M]]
	[[Category: Acyl-coenzyme a binding protein]]		[[Category: Acyl-coenzyme a binding protein]]

OCA at 13:46, 25 December 2014

2014-12-25T13:46:49Z

← Older revision		Revision as of 13:46, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>		<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACBP_BOVIN ACBP_BOVIN]] Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.<ref>PMID:11491287</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Andersen, K V.]]		[[Category: Andersen, K V]]
	[[Category: Poulsen, F M.]]		[[Category: Poulsen, F M]]
	[[Category: Acyl-coenzyme a binding protein]]		[[Category: Acyl-coenzyme a binding protein]]

OCA at 00:49, 30 September 2014

2014-09-30T00:49:33Z

← Older revision		Revision as of 00:49, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2abd~~.~~png~~\|~~left~~\|~~200px~~]]		==THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY==
			<StructureSection load='2abd' size='340' side='right' caption='[[2abd]], [[NMR_Ensembles_of_Models \| 29 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ABD FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2abd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2abd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2abd RCSB], [http://www.ebi.ac.uk/pdbsum/2abd PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ab/2abd_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The 3D structure of bovine recombinant acyl-coenzyme A binding protein has been determined using multidimensional heteronuclear magnetic resonance spectroscopy in a study that combines investigations of 15N-labeled and unlabeled protein. The present structure determination is a refinement of the structure previously determined (Andersen, K.V. and Poulsen, F.M. (1992) J. Mol. Biol., 226, 1131-1141). It is based on 1096 distance restraints and 124 dihedral angle restraints of which 69 are for phi-angles and 8 for chiral centers and 47 for prochiral centers. The new experimental input for the structure determination has provided an increase of 263 distance restraints, 5 phi-angle restraints, and 32 chi-angle restraints in 2 chiral centers, and 31 prochiral centers restraining an additional 23 chi 1, 8 chi 2, and 1 chi 3 angles. The increase of 300 distance and dihedral angle restraints representing an additional 30% of input parameters for the structure determination has been shown to be in agreement with the first structure. A set of 29 structures has been calculated and each of the structures has been compared to a mean structure to give an atomic root mean square deviation of 0.44 +/- 0.12 A (1 A is 0.1 nm) for the backbone atoms C, C alpha, and N in the four alpha-helices A1, residues 4-15, A2, residues 21-36, A3, residues 51-62 and A4, residues 65-84. The loop-region of residues Gly45-Lys50 could not be defined by the restraints obtained by NMR. The program PRONTO has been used for the spectrum analysis, assignment of the individual nuclear Overhauser effects, the integration of the cross peaks, and the measurement of the coupling constants. The programs DIANA, X-PLOR and INSIGHT have been used in the structure calculations and evaluations.

	~~{{STRUCTURE_2abd\| PDB=2abd \| SCENE= }}~~		The three-dimensional structure of acyl-coenzyme A binding protein from bovine liver: structural refinement using heteronuclear multidimensional NMR spectroscopy.,Andersen KV, Poulsen FM J Biomol NMR. 1993 May;3(3):271-84. PMID:8358232<ref>PMID:8358232</ref>

	~~===THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_8358232}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2abd]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:008358232<~~/~~ref><ref group="xtra">PMID:017154716</ref~~><~~references group="xtra"~~/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Andersen, K V.]]		[[Category: Andersen, K V.]]
	[[Category: Poulsen, F M.]]		[[Category: Poulsen, F M.]]
	[[Category: Acyl-coenzyme a binding protein]]		[[Category: Acyl-coenzyme a binding protein]]

OCA: Protected "2abd" [edit=sysop:move=sysop]

2013-01-06T10:09:22Z

Protected "2abd" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:09, 6 January 2013
(No difference)

OCA at 10:09, 6 January 2013

2013-01-06T10:09:20Z

← Older revision		Revision as of 10:09, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2abd.png\|left\|200px]]		[[Image:2abd.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2abd", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2abd\| PDB=2abd \| SCENE= }}		{{STRUCTURE_2abd\| PDB=2abd \| SCENE= }}

	===THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY===		===THE THREE-DIMENSIONAL STRUCTURE OF ACYL-COENZYME A BINDING PROTEIN FROM BOVINE LIVER. STRUCTURAL REFINEMENT USING HETERONUCLEAR MULTIDIMENSIONAL NMR SPECTROSCOPY===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_8358232}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 8358232 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_8358232}}		{{ABSTRACT_PUBMED_8358232}}

	==About this Structure==		==About this Structure==
	~~2ABD~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA].		[[2abd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~8358232~~</ref><references group="xtra"/>		<ref group="xtra">PMID:008358232</ref><ref group="xtra">PMID:017154716</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Andersen, K V.]]		[[Category: Andersen, K V.]]
	[[Category: Poulsen, F M.]]		[[Category: Poulsen, F M.]]
	[[Category: Acyl-coenzyme a binding protein]]		[[Category: Acyl-coenzyme a binding protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:49:27 2009''~~

OCA at 15:49, 17 February 2009

2009-02-17T15:49:29Z

← Older revision		Revision as of 15:49, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2ABD is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA].		2ABD is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ABD OCA].

	==Reference==		==Reference==
	The three-dimensional structure of acyl-coenzyme A binding protein from bovine liver: structural refinement using heteronuclear multidimensional NMR spectroscopy., Andersen KV, Poulsen FM, J Biomol NMR. 1993 May;3(3):271-84. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~8358232 8358232]~~		<ref group="xtra">PMID:8358232</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	~~[[Category: Single protein]]~~
	[[Category: Andersen, K V.]]		[[Category: Andersen, K V.]]
	[[Category: Poulsen, F M.]]		[[Category: Poulsen, F M.]]
	[[Category: Acyl-coenzyme a binding protein]]		[[Category: Acyl-coenzyme a binding protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 00~~:53:~~41 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:49:27 2009''