2ack - Revision history

OCA at 06:41, 9 August 2023

2023-08-09T06:41:10Z

← Older revision		Revision as of 06:41, 9 August 2023
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	<StructureSection load='2ack' size='340' side='right'caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ack' size='340' side='right'caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Torpedo_californica Torpedo~~ californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [https://pdbe.org/2ack PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [https://www.ebi.ac.uk/pdbsum/2ack PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ack ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [https://pdbe.org/2ack PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [https://www.ebi.ac.uk/pdbsum/2ack PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ack ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~ACES_TORCA ACES_TORCA]~~] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.		[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Acetylcholinesterase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Torpedo~~ californica]]		[[Category: Tetronarce californica]]
	[[Category: Harel, M]]		[[Category: Harel M]]
	[[Category: Raves~~, M L~~]]		[[Category: Raves ML]]
	[[Category: Silman, I]]		[[Category: Silman I]]
	[[Category: Sussman~~, J L]]~~		[[Category: Sussman JL]]
	~~[[Category: Carboxylic esterase]]~~
	~~[[Category: Hydrolase~~]]

OCA at 14:39, 17 November 2021

2021-11-17T14:39:09Z

← Older revision		Revision as of 14:39, 17 November 2021
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	<StructureSection load='2ack' size='340' side='right'caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ack' size='340' side='right'caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ACK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [~~http~~://pdbe.org/2ack PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ack PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ack ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [https://pdbe.org/2ack PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [https://www.ebi.ac.uk/pdbsum/2ack PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ack ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.		[[https://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:

	==See Also==		==See Also==
	*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]
	*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]		*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
	*[[Acetylcholinesterase: Treatment of Alzheimer's disease\|Acetylcholinesterase: Treatment of Alzheimer's disease]]
	*[[Journal:Protein Science:1\|Journal:Protein Science:1]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 05:24, 13 February 2020

2020-02-13T05:24:37Z

← Older revision		Revision as of 05:24, 13 February 2020
Line 1:		Line 1:

	==ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA==		==ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA==
	<StructureSection load='2ack' size='340' side='right' caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ack' size='340' side='right'caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
Line 40:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
			[[Category: Large Structures]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]
	[[Category: Harel, M]]		[[Category: Harel, M]]

OCA at 07:16, 9 May 2018

2018-05-09T07:16:41Z

← Older revision		Revision as of 07:16, 9 May 2018
Line 3:		Line 3:
	<StructureSection load='2ack' size='340' side='right' caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ack' size='340' side='right' caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Tetronarce_californica Tetronarce~~ californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
Line 14:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2ack_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2ack_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	==See Also==		==See Also==
	*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]		*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase 3D structures\|Acetylcholinesterase 3D structures]]
			*[[Acetylcholinesterase: Treatment of Alzheimer's disease\|Acetylcholinesterase: Treatment of Alzheimer's disease]]
	*[[Journal:Protein Science:1\|Journal:Protein Science:1]]		*[[Journal:Protein Science:1\|Journal:Protein Science:1]]
	== References ==		== References ==
Line 39:		Line 40:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: ~~Tetronarce~~ californica]]		[[Category: Torpedo californica]]
	[[Category: Harel, M]]		[[Category: Harel, M]]
	[[Category: Raves, M L]]		[[Category: Raves, M L]]

OCA at 17:57, 12 July 2016

2016-07-12T17:57:09Z

← Older revision		Revision as of 17:57, 12 July 2016
Line 1:		Line 1:

	==ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA==		==ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA==
	<StructureSection load='2ack' size='340' side='right' caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2ack' size='340' side='right' caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Torpedo_californica Torpedo~~ californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://pdbe.org/2ack PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://pdbe.org/2ack PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ack ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 38:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: ~~Torpedo~~ californica]]		[[Category: Tetronarce californica]]
	[[Category: Harel, M]]		[[Category: Harel, M]]
	[[Category: Raves, M L]]		[[Category: Raves, M L]]

OCA at 23:56, 8 February 2016

2016-02-08T23:56:57Z

← Older revision		Revision as of 23:56, 8 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ack ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:36, 10 September 2015

2015-09-10T16:36:58Z

← Older revision		Revision as of 16:36, 10 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://pdbe.org/2ack PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ack" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]		*[[AChE inhibitors and substrates\|AChE inhibitors and substrates]]
	*[[AChE inhibitors and substrates (Part II)\|AChE inhibitors and substrates (Part II)]]
	*[[AChE inhibitors and substrates (Part III)\|AChE inhibitors and substrates (Part III)]]
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
	*[[Journal:Protein Science:1\|Journal:Protein Science:1]]		*[[Journal:Protein Science:1\|Journal:Protein Science:1]]

OCA at 03:02, 25 December 2014

2014-12-25T03:02:29Z

← Older revision		Revision as of 03:02, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACES_TORCA ACES_TORCA]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 40:
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]
	[[Category: Harel, M.]]		[[Category: Harel, M]]
	[[Category: Raves, M L.]]		[[Category: Raves, M L]]
	[[Category: Silman, I.]]		[[Category: Silman, I]]
	[[Category: Sussman, J L.]]		[[Category: Sussman, J L]]
	[[Category: Carboxylic esterase]]		[[Category: Carboxylic esterase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 00:24, 30 September 2014

2014-09-30T00:24:42Z

← Older revision		Revision as of 00:24, 30 September 2014
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	~~{{STRUCTURE_2ack~~\| PDB=2ack \| ~~SCENE~~= }}		==ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA==
	===~~ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA~~===		<StructureSection load='2ack' size='340' side='right' caption='[[2ack]], [[Resolution\|resolution]] 2.40Å' scene=''>
	~~{{ABSTRACT_PUBMED_10089512}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ack]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ack 1ack]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDR:EDROPHONIUM+ION'>EDR</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ack FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ack OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ack RCSB], [http://www.ebi.ac.uk/pdbsum/2ack PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2ack_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Acetylcholinesterase (AChE) is one of nature's fastest enzymes, despite the fact that its three-dimensional structure reveals its active site to be deeply sequestered within the molecule. This raises questions with respect to traffic of substrate to, and products from, the active site, which may be investigated by time-resolved crystallography. In order to address one aspect of the feasibility of performing time-resolved studies on AChE, a data set has been collected using the Laue technique on a trigonal crystal of Torpedo californica AChE soaked with the reversible inhibitor edrophonium, using a total X-ray exposure time of 24 ms. Electron-density maps obtained from the Laue data, which are of surprisingly good quality compared with similar maps from monochromatic data, show essentially the same features. They clearly reveal the bound ligand, as well as a structural change in the conformation of the active-site Ser200 induced upon binding.

	~~==About this Structure==~~		Static Laue diffraction studies on acetylcholinesterase.,Ravelli RB, Raves ML, Ren Z, Bourgeois D, Roth M, Kroon J, Silman I, Sussman JL Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1359-66. PMID:10089512<ref>PMID:10089512</ref>
	~~[[2ack]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Torpedo_californica Torpedo californica]. This structure supersedes the now removed PDB entry [http~~:~~//oca.weizmann.ac.il/oca-bin/send~~-~~pdb?obs=1&id=1ack 1ack]~~. ~~Full crystallographic information is available from [http~~://~~oca~~.~~weizmann~~.ac.~~il/oca-bin~~/~~ocashort?id=2ACK OCA].~~
			From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	==See Also==		==See Also==
Line 12:		Line 32:
	*[[Acetylcholinesterase\|Acetylcholinesterase]]		*[[Acetylcholinesterase\|Acetylcholinesterase]]
	*[[Journal:Protein Science:1\|Journal:Protein Science:1]]		*[[Journal:Protein Science:1\|Journal:Protein Science:1]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:010089512<~~/~~ref><ref group="xtra">doi 10.1002/pro.2101</ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Acetylcholinesterase]]		[[Category: Acetylcholinesterase]]
	[[Category: Torpedo californica]]		[[Category: Torpedo californica]]

OCA at 09:29, 11 March 2013

2013-03-11T09:29:15Z

← Older revision		Revision as of 09:29, 11 March 2013
Line 1:		Line 1:
	~~[[Image:2ack.png\|left\|200px]]~~

	{{STRUCTURE_2ack\| PDB=2ack \| SCENE= }}		{{STRUCTURE_2ack\| PDB=2ack \| SCENE= }}

	===ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA===		===ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA===

	{{ABSTRACT_PUBMED_10089512}}		{{ABSTRACT_PUBMED_10089512}}