2aco - Revision history

OCA at 07:22, 23 August 2023

2023-08-23T07:22:23Z

← Older revision		Revision as of 07:22, 23 August 2023
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	<StructureSection load='2aco' size='340' side='right'caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2aco' size='340' side='right'caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACO FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[1qwd\|1qwd]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">blc ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [https://pdbe.org/2aco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [https://www.ebi.ac.uk/pdbsum/2aco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [https://pdbe.org/2aco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [https://www.ebi.ac.uk/pdbsum/2aco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aco ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BLC_ECOLI BLC_ECOLI]] Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.<ref>PMID:15044022</ref>		[https://www.uniprot.org/uniprot/BLC_ECOLI BLC_ECOLI] Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.<ref>PMID:15044022</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bishop~~, R E~~]]		[[Category: Bishop RE]]
	[[Category: Blangy, S]]		[[Category: Blangy S]]
	[[Category: Cambillau, C]]		[[Category: Cambillau C]]
	[[Category: Campanacci, V]]		[[Category: Campanacci V]]
	[[Category: Reese, L]]		[[Category: Reese L]]
	[[Category: Tegoni, M]]		[[Category: Tegoni M]]
	~~[[Category: E coli]]~~
	~~[[Category: Fatty acid]]~~
	~~[[Category: Lipid transport]]~~
	~~[[Category: Lipocalin]]~~
	~~[[Category: Membrane protein~~]]

OCA at 08:29, 27 January 2021

2021-01-27T08:29:42Z

← Older revision		Revision as of 08:29, 27 January 2021
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	==Xray structure of Blc dimer in complex with vaccenic acid==		==Xray structure of Blc dimer in complex with vaccenic acid==
	<StructureSection load='2aco' size='340' side='right' caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2aco' size='340' side='right'caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ACO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ACO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qwd\|1qwd]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [~~http~~://pdbe.org/2aco PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aco PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aco ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [https://pdbe.org/2aco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [https://www.ebi.ac.uk/pdbsum/2aco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aco ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BLC_ECOLI BLC_ECOLI]] Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.<ref>PMID:15044022</ref>		[[https://www.uniprot.org/uniprot/BLC_ECOLI BLC_ECOLI]] Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.<ref>PMID:15044022</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Bishop, R E]]		[[Category: Bishop, R E]]
	[[Category: Blangy, S]]		[[Category: Blangy, S]]

OCA at 06:50, 9 May 2018

2018-05-09T06:50:15Z

← Older revision		Revision as of 06:50, 9 May 2018
Line 1:		Line 1:

	==Xray structure of Blc dimer in complex with vaccenic acid==		==Xray structure of Blc dimer in complex with vaccenic acid==
	<StructureSection load='2aco' size='340' side='right' caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2aco' size='340' side='right' caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://pdbe.org/2aco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://pdbe.org/2aco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aco ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2aco_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2aco_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aco ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 14:21, 11 September 2015

2015-09-11T14:21:36Z

← Older revision		Revision as of 14:21, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2aco' size='340' side='right' caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='2aco' size='340' side='right' caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACO FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 ~~Escherichia~~ coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://pdbe.org/2aco PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2aco" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Bishop, R E]]		[[Category: Bishop, R E]]
	[[Category: Blangy, S]]		[[Category: Blangy, S]]

OCA at 17:38, 25 December 2014

2014-12-25T17:38:32Z

← Older revision		Revision as of 17:38, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACO FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACO FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BLC_ECOLI BLC_ECOLI]] Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.<ref>PMID:15044022</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bishop, R E.]]		[[Category: Bishop, R E]]
	[[Category: Blangy, S.]]		[[Category: Blangy, S]]
	[[Category: Cambillau, C.]]		[[Category: Cambillau, C]]
	[[Category: Campanacci, V.]]		[[Category: Campanacci, V]]
	[[Category: Reese, L.]]		[[Category: Reese, L]]
	[[Category: Tegoni, M.]]		[[Category: Tegoni, M]]
	[[Category: E coli]]		[[Category: E coli]]
	[[Category: Fatty acid]]		[[Category: Fatty acid]]

OCA at 00:45, 30 September 2014

2014-09-30T00:45:40Z

← Older revision		Revision as of 00:45, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2aco~~.~~png~~\|~~left~~\|~~200px~~]]		==Xray structure of Blc dimer in complex with vaccenic acid==
			<StructureSection load='2aco' size='340' side='right' caption='[[2aco]], [[Resolution\|resolution]] 1.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2aco]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ACO FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VCA:VACCENIC+ACID'>VCA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qwd\|1qwd]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">blc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aco OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aco RCSB], [http://www.ebi.ac.uk/pdbsum/2aco PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ac/2aco_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Lipocalins, a widespread multifunctional family of small proteins (15-25kDa) have been first described in eukaryotes and more recently in Gram-negative bacteria. Bacterial lipocalins belonging to class I are outer membrane lipoproteins, among which Blc from E. coli is the better studied. Blc is expressed under conditions of starvation and high osmolarity, conditions known to exert stress on the cell envelope. The structure of Blc that we have previously solved (V. Campanacci, D. Nurizzo, S. Spinelli, C. Valencia, M. Tegoni, C. Cambillau, FEBS Lett. 562 (2004) 183-188.) suggested its possible role in binding fatty acids or phospholipids. Both physiological and structural data on Blc, therefore, point to a role in storage or transport of lipids necessary for membrane maintenance. In order to further document this hypothesis for Blc function, we have performed binding studies using fluorescence quenching experiments. Our results indicate that dimeric Blc binds fatty acids and phospholipids in a micromolar K(d) range. The crystal structure of Blc with vaccenic acid, an unsaturated C18 fatty acid, reveals that the binding site spans across the Blc dimer, opposite to its membrane anchored face. An exposed unfilled pocket seemingly suited to bind a polar group attached to the fatty acid prompted us to investigate lyso-phospholipids, which were found to bind in a nanomolar K(d) range. We discuss these findings in terms of a potential role for Blc in the metabolism of lysophospholipids generated in the bacterial outer membrane.

	~~{{STRUCTURE_2aco\| PDB=2aco \| SCENE= }}~~		The membrane bound bacterial lipocalin Blc is a functional dimer with binding preference for lysophospholipids.,Campanacci V, Bishop RE, Blangy S, Tegoni M, Cambillau C FEBS Lett. 2006 Sep 4;580(20):4877-83. Epub 2006 Aug 10. PMID:16920109<ref>PMID:16920109</ref>

	~~===Xray structure~~ of ~~Blc dimer in complex with vaccenic acid===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16920109}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2aco]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016920109<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bishop, R E.]]		[[Category: Bishop, R E.]]

OCA: Protected "2aco" [edit=sysop:move=sysop]

2013-01-06T10:06:13Z

Protected "2aco" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:06, 6 January 2013
(No difference)

OCA at 10:06, 6 January 2013

2013-01-06T10:06:09Z

← Older revision		Revision as of 10:06, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2aco.png\|left\|200px]]		[[Image:2aco.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2aco", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2aco\| PDB=2aco \| SCENE= }}		{{STRUCTURE_2aco\| PDB=2aco \| SCENE= }}

	===Xray structure of Blc dimer in complex with vaccenic acid===		===Xray structure of Blc dimer in complex with vaccenic acid===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16920109}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16920109 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16920109}}		{{ABSTRACT_PUBMED_16920109}}

	==About this Structure==		==About this Structure==
	~~2ACO~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA].		[[2aco]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16920109~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016920109</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Bishop, R E.]]		[[Category: Bishop, R E.]]
Line 33:		Line 21:
	[[Category: E coli]]		[[Category: E coli]]
	[[Category: Fatty acid]]		[[Category: Fatty acid]]
			[[Category: Lipid transport]]
	[[Category: Lipocalin]]		[[Category: Lipocalin]]
			[[Category: Membrane protein]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Feb 18 00:26:51 2009''~~

OCA at 22:26, 17 February 2009

2009-02-17T22:26:52Z

← Older revision		Revision as of 22:26, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2ACO is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA].		2ACO is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ACO OCA].

	==Reference==		==Reference==
	The membrane bound bacterial lipocalin Blc is a functional dimer with binding preference for lysophospholipids., Campanacci V, Bishop RE, Blangy S, Tegoni M, Cambillau C, FEBS Lett. 2006 Sep 4;580(20):4877-83. Epub 2006 Aug 10. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16920109 16920109]~~		<ref group="xtra">PMID:16920109</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	~~[[Category: Single protein]]~~
	[[Category: Bishop, R E.]]		[[Category: Bishop, R E.]]
	[[Category: Blangy, S.]]		[[Category: Blangy, S.]]
Line 36:		Line 35:
	[[Category: Lipocalin]]		[[Category: Lipocalin]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue Jul 29 07~~:49:~~40 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 00:26:51 2009''

OCA at 04:49, 29 July 2008

2008-07-29T04:49:42Z

← Older revision		Revision as of 04:49, 29 July 2008
Line 1:		Line 1:
	[[Image:2aco.~~gif~~\|left\|200px]]		{{Seed}}
			[[Image:2aco.png\|left\|200px]]

	<!--		<!--
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	{{STRUCTURE_2aco\| PDB=2aco \| SCENE= }}		{{STRUCTURE_2aco\| PDB=2aco \| SCENE= }}

	~~'''~~Xray structure of Blc dimer in complex with vaccenic acid~~'''~~		===Xray structure of Blc dimer in complex with vaccenic acid===


	~~==Overview==~~		<!--
	~~Lipocalins~~, a widespread multifunctional family of small proteins (15-25kDa) have been first described in eukaryotes and more recently in Gram-negative bacteria. Bacterial lipocalins belonging to class I are outer membrane lipoproteins, ~~among which Blc from E. coli is~~ the ~~better studied. Blc is expressed under conditions of starvation and high osmolarity, conditions known~~ to ~~exert stress on~~ the ~~cell envelope. The structure of Blc that we have previously solved~~ (V. Campanacci, D. Nurizzo, S. Spinelli, C. Valencia, M. Tegoni, C. Cambillau, FEBS Lett. 562 (2004) 183-188.) suggested its possible role in binding fatty acids or phospholipids. Both physiological and structural data on ~~Blc, therefore, point to a role in storage or transport of lipids necessary for membrane maintenance~~. ~~In order to further document this hypothesis for Blc function, we have performed binding studies using fluorescence quenching experiments~~. ~~Our results indicate that dimeric Blc binds fatty acids and phospholipids in a micromolar K(d~~) ~~range. The crystal structure of Blc with vaccenic acid~~, ~~an unsaturated C18 fatty acid, reveals that the binding site spans across~~ the ~~Blc dimer, opposite to its membrane anchored face~~. ~~An exposed unfilled pocket seemingly suited to bind a polar group attached to the fatty acid prompted us to investigate lyso~~-phospholipids, which were found to bind in a nanomolar K(d) range. We discuss these findings in terms of a potential role for Blc in the metabolism of lysophospholipids generated in the bacterial outer membrane.		The line below this paragraph, {{ABSTRACT_PUBMED_16920109}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16920109 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16920109}}

	==About this Structure==		==About this Structure==
Line 31:		Line 35:
	[[Category: Fatty acid]]		[[Category: Fatty acid]]
	[[Category: Lipocalin]]		[[Category: Lipocalin]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:53:03 2008''
			''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:49:40 2008''