2adj - Revision history

OCA at 07:22, 23 August 2023

2023-08-23T07:22:44Z

← Older revision		Revision as of 07:22, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2adg\|2adg]], [[2adi\|2adi]]~~</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [https://pdbe.org/2adj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [https://www.ebi.ac.uk/pdbsum/2adj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [https://pdbe.org/2adj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [https://www.ebi.ac.uk/pdbsum/2adj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adj ProSAT]</span></td></tr>
	</table>		</table>
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hamer~~, D H~~]]		[[Category: Hamer DH]]
	[[Category: Hendrickson~~, W A~~]]		[[Category: Hendrickson WA]]
	[[Category: Kwong~~, P D~~]]		[[Category: Kwong PD]]
	[[Category: Sattentau~~, Q J~~]]		[[Category: Sattentau QJ]]
	[[Category: Zhou, T]]		[[Category: Zhou T]]
	~~[[Category: Anti-cd4]]~~
	~~[[Category: Antibody recognition]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Interfacial metal~~]]

OCA at 14:39, 17 November 2021

2021-11-17T14:39:43Z

← Older revision		Revision as of 14:39, 17 November 2021
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	<StructureSection load='2adj' size='340' side='right'caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2adj' size='340' side='right'caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2adg\|2adg]], [[2adi\|2adi]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [~~http~~://pdbe.org/2adj PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2adj PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2adj ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [https://pdbe.org/2adj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [https://www.ebi.ac.uk/pdbsum/2adj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2adj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:30, 13 February 2020

2020-02-13T05:30:06Z

← Older revision		Revision as of 05:30, 13 February 2020
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	==Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium==		==Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium==
	<StructureSection load='2adj' size='340' side='right' caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2adj' size='340' side='right'caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hamer, D H]]		[[Category: Hamer, D H]]

OCA at 07:24, 9 May 2018

2018-05-09T07:24:38Z

← Older revision		Revision as of 07:24, 9 May 2018
Line 1:		Line 1:

	==Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium==		==Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium==
	<StructureSection load='2adj' size='340' side='right' caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2adj' size='340' side='right' caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://pdbe.org/2adj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://pdbe.org/2adj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2adj ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adj_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adj_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 28:		Line 29:

	==See Also==		==See Also==
	*[[Monoclonal ~~Antibody~~\|Monoclonal ~~Antibody~~]]		*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:34, 7 February 2016

2016-02-07T03:34:37Z

← Older revision		Revision as of 03:34, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2adj ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:20, 9 September 2015

2015-09-09T21:20:58Z

← Older revision		Revision as of 21:20, 9 September 2015
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://pdbe.org/2adj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2adj" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 09:44, 8 January 2015

2015-01-08T09:44:18Z

← Older revision		Revision as of 09:44, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hamer, D H.]]		[[Category: Hamer, D H]]
	[[Category: Hendrickson, W A.]]		[[Category: Hendrickson, W A]]
	[[Category: Kwong, P D.]]		[[Category: Kwong, P D]]
	[[Category: Sattentau, Q J.]]		[[Category: Sattentau, Q J]]
	[[Category: Zhou, T.]]		[[Category: Zhou, T]]
	[[Category: Anti-cd4]]		[[Category: Anti-cd4]]
	[[Category: Antibody recognition]]		[[Category: Antibody recognition]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Interfacial metal]]		[[Category: Interfacial metal]]

OCA at 02:39, 29 September 2014

2014-09-29T02:39:14Z

← Older revision		Revision as of 02:39, 29 September 2014
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	[[Image:~~2adj~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of monoclonal anti-CD4 antibody Q425 in complex with Calcium==
			<StructureSection load='2adj' size='340' side='right' caption='[[2adj]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2adj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ADJ FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2adg\|2adg]], [[2adi\|2adi]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2adj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2adj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2adj RCSB], [http://www.ebi.ac.uk/pdbsum/2adj PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ad/2adj_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The unique ligation properties of metal ions are widely exploited by proteins, with approximately one-third of all proteins estimated to be metalloproteins. Although antibodies use various mechanisms for recognition, to our knowledge, none has ever been characterized that uses an interfacial metal. We previously described a family of CD4-reactive antibodies, the archetype being Q425. CD4:Q425 engagement does not interfere with CD4:HIV-1 gp120 envelope glycoprotein binding, but it blocks subsequent steps required for viral entry. Here, we use surface-plasmon resonance to show that Q425 requires calcium for recognition of CD4. Specifically, Q425 binding of calcium resulted in a 55,000-fold enhancement in affinity for CD4. X-ray crystallographic analyses of Q425 in the presence of Ca(2+), Ba(2+), or EDTA revealed an exposed metal-binding site, partially coordinated by five atoms contributed from four antibody complementarity-determining regions. The results suggest that Q425 recognition of CD4 involves direct ligation of antigen by the Q425-held calcium, with calcium binding each ligating atom of CD4 with approximately 1.5 kcal/mol of binding energy. This energetic contribution, which is greater than that from a typical protein atom, demonstrates how interfacial metal ligation can play a unique role in antigen recognition.

	~~{{STRUCTURE_2adj\| PDB=2adj \| SCENE= }}~~		Interfacial metal and antibody recognition.,Zhou T, Hamer DH, Hendrickson WA, Sattentau QJ, Kwong PD Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14575-80. Epub 2005 Sep 29. PMID:16195378<ref>PMID:16195378</ref>

	~~===Crystal structure~~ of ~~monoclonal anti-CD4 antibody Q425 in complex with Calcium===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16195378}}~~

	~~==About this Structure==~~
	~~[[2adj]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mus_musculus Mus musculus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2ADJ OCA].~~

	==See Also==		==See Also==
	*[[Monoclonal Antibody\|Monoclonal Antibody]]		*[[Monoclonal Antibody\|Monoclonal Antibody]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016195378<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Mus musculus]]		[[Category: Mus musculus]]
	[[Category: Hamer, D H.]]		[[Category: Hamer, D H.]]

OCA at 05:29, 20 October 2012

2012-10-20T05:29:05Z

← Older revision		Revision as of 05:29, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2adj]] is a 2 chain structure ~~of [[Monoclonal Antibody]]~~ with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA].		[[2adj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADJ OCA].

	==See Also==		==See Also==

OCA: Protected "2adj" [edit=sysop:move=sysop]

2012-07-25T10:12:20Z

Protected "2adj" [edit=sysop:move=sysop]

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