2aeb - Revision history

OCA at 07:22, 23 August 2023

2023-08-23T07:22:51Z

← Older revision		Revision as of 07:22, 23 August 2023
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	<StructureSection load='2aeb' size='340' side='right'caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='2aeb' size='340' side='right'caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ABH:2(S)-AMINO-6~~-~~BORONOHEXANOIC+ACID'>ABH</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.29Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Arginase Arginase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [https://pdbe.org/2aeb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [https://www.ebi.ac.uk/pdbsum/2aeb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [https://pdbe.org/2aeb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [https://www.ebi.ac.uk/pdbsum/2aeb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>		[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
			== Function ==
			[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arginase]]~~		[[Category: Homo sapiens]]
	~~[[Category: Human~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Centeno, F]]		[[Category: Centeno F]]
	[[Category: Christianson~~, D W~~]]		[[Category: Christianson DW]]
	[[Category: Costanzo, L Di]]		[[Category: Di Costanzo L]]
	[[Category: Mora, A]]		[[Category: Mora A]]
	[[Category: Ochoa~~, A C~~]]		[[Category: Ochoa AC]]
	[[Category: Rodriguez~~, P C~~]]		[[Category: Rodriguez PC]]
	[[Category: Sabio, G]]		[[Category: Sabio G]]
	~~[[Category: Binuclear manganese cluster]]~~
	~~[[Category: Boronic acid inhibitor]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Perfectly twinned crystal~~]]

OCA at 06:36, 6 October 2021

2021-10-06T06:36:44Z

← Older revision		Revision as of 06:36, 6 October 2021
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	<StructureSection load='2aeb' size='340' side='right'caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='2aeb' size='340' side='right'caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Arginase Arginase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arginase Arginase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [~~http~~://pdbe.org/2aeb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aeb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [https://pdbe.org/2aeb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [https://www.ebi.ac.uk/pdbsum/2aeb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[~~http~~://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>		[[https://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[https://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 19:33, 11 December 2019

2019-12-11T19:33:21Z

← Older revision		Revision as of 19:33, 11 December 2019
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	==Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.==		==Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.==
	<StructureSection load='2aeb' size='340' side='right' caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='2aeb' size='340' side='right'caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Arginase\|Arginase]]		*[[Arginase 3D structures\|Arginase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Centeno, F]]		[[Category: Centeno, F]]
	[[Category: Christianson, D W]]		[[Category: Christianson, D W]]

OCA at 05:32, 8 March 2018

2018-03-08T05:32:03Z

← Older revision		Revision as of 05:32, 8 March 2018
Line 1:		Line 1:

	==Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.==		==Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.==
	<StructureSection load='2aeb' size='340' side='right' caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='2aeb' size='340' side='right' caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://pdbe.org/2aeb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://pdbe.org/2aeb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeb ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aeb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aeb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aeb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 10:08, 11 September 2015

2015-09-11T10:08:15Z

← Older revision		Revision as of 10:08, 11 September 2015
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	<StructureSection load='2aeb' size='340' side='right' caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>		<StructureSection load='2aeb' size='340' side='right' caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://pdbe.org/2aeb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2aeb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Centeno, F]]		[[Category: Centeno, F]]
	[[Category: Christianson, D W]]		[[Category: Christianson, D W]]

OCA at 14:55, 25 December 2014

2014-12-25T14:55:38Z

← Older revision		Revision as of 14:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>		[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
	~~== Function ==~~

	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 39:		Line 37:
	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Centeno, F.]]		[[Category: Centeno, F]]
	[[Category: Christianson, D W.]]		[[Category: Christianson, D W]]
	[[Category: Costanzo, L Di.]]		[[Category: Costanzo, L Di]]
	[[Category: Mora, A.]]		[[Category: Mora, A]]
	[[Category: Ochoa, A C.]]		[[Category: Ochoa, A C]]
	[[Category: Rodriguez, P C.]]		[[Category: Rodriguez, P C]]
	[[Category: Sabio, G.]]		[[Category: Sabio, G]]
	[[Category: Binuclear manganese cluster]]		[[Category: Binuclear manganese cluster]]
	[[Category: Boronic acid inhibitor]]		[[Category: Boronic acid inhibitor]]

OCA at 04:20, 3 October 2014

2014-10-03T04:20:34Z

← Older revision		Revision as of 04:20, 3 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2aeb\| PDB=2aeb \| SCENE= }}~~		==Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.==
	===Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.===		<StructureSection load='2aeb' size='340' side='right' caption='[[2aeb]], [[Resolution\|resolution]] 1.29Å' scene=''>
	~~{{ABSTRACT_PUBMED_16141327}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2aeb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AEB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ABH:2(S)-AMINO-6-BORONOHEXANOIC+ACID'>ABH</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2zav\|2zav]], [[1d3v\|1d3v]], [[1wva\|1wva]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arginase Arginase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.3.1 3.5.3.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aeb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aeb RCSB], [http://www.ebi.ac.uk/pdbsum/2aeb PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>
			== Function ==

	==~~Disease~~==		== Evolutionary Conservation ==
	[[http://~~www~~.~~uniprot~~.~~org~~/~~uniprot/ARGI1_HUMAN ARGI1_HUMAN~~]] ~~Defects in ARG1 are~~ the ~~cause of argininemia (ARGIN) [MIM:~~[http://~~omim~~.~~org~~/~~entry~~/~~207800 207800]~~]; also ~~known~~ as ~~hyperargininemia~~. ~~Argininemia~~ is a ~~rare autosomal recessive disorder~~ of the ~~urea cycle. Arginine is elevated~~ in the ~~blood~~ and ~~cerebrospinal fluid,~~ and ~~periodic hyperammonemia occurs~~. ~~Clinical manifestations include developmental delay~~, ~~seizures~~, ~~mental retardation~~, ~~hypotonia~~, ~~ataxia~~, ~~progressive spastic quadriplegia~~.~~<ref>~~PMID:~~1463019</ref>~~ <ref>PMID:~~7649538~~</ref>		[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aeb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human arginase I is a potential target for therapeutic intervention in diseases linked to compromised l-arginine homeostasis. Here, we report high-affinity binding of the reaction coordinate analogue inhibitors 2(S)-amino-6-boronohexanoic acid (ABH, Kd = 5 nM) and S-(2-boronoethyl)-l-cysteine (BEC, Kd = 270 nM) to human arginase I, and we report x-ray crystal structures of the respective enzyme-inhibitor complexes at 1.29- and 1.94-A resolution determined from crystals twinned by hemihedry. The ultrahigh-resolution structure of the human arginase I-ABH complex yields an unprecedented view of the binuclear manganese cluster and illuminates the structural basis for nanomolar affinity: bidentate inner-sphere boronate-manganese coordination interactions and fully saturated hydrogen bond networks with inhibitor alpha-amino and alpha-carboxylate groups. These interactions are therefore implicated in the stabilization of the transition state for l-arginine hydrolysis. Electron density maps also reveal that active-site residue H141 is protonated as the imidazolium cation. The location of H141 is such that it could function as a general acid to protonate the leaving amino group of l-ornithine during catalysis, and this is a revised mechanistic proposal for arginase. This work serves as a foundation for studying the structural and chemical biology of arginase I in the immune response, and we demonstrate the inhibition of arginase activity by ABH in human and murine myeloid cells.

			Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.,Di Costanzo L, Sabio G, Mora A, Rodriguez PC, Ochoa AC, Centeno F, Christianson DW Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13058-63. Epub 2005 Sep 2. PMID:16141327<ref>PMID:16141327</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2aeb]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2AEB OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:016141327</ref><ref group~~=~~"xtra">PMID:012859189</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Arginase\|Arginase]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 23:59, 3 April 2013

2013-04-03T23:59:34Z

← Older revision		Revision as of 23:59, 3 April 2013
Line 4:		Line 4:

	==Disease==		==Disease==
	[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref><ref>PMID:7649538</ref>		[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref> <ref>PMID:7649538</ref>

	==About this Structure==		==About this Structure==
Line 23:		Line 23:
	[[Category: Boronic acid inhibitor]]		[[Category: Boronic acid inhibitor]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
			[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Perfectly twinned crystal]]		[[Category: Perfectly twinned crystal]]

OCA at 07:01, 25 March 2013

2013-03-25T07:01:41Z

← Older revision		Revision as of 07:01, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2aeb.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2aeb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2aeb\| PDB=2aeb \| SCENE= }}		{{STRUCTURE_2aeb\| PDB=2aeb \| SCENE= }}

	===Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.===		===Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response.===
			{{ABSTRACT_PUBMED_16141327}}

			==Disease==
	~~<!--~~		[[http://www.uniprot.org/uniprot/ARGI1_HUMAN ARGI1_HUMAN]] Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:[http://omim.org/entry/207800 207800]]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia.<ref>PMID:1463019</ref><ref>PMID:7649538</ref>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16141327}}, adds~~ the ~~Publication Abstract to the page~~
	(~~as it appears on PubMed at~~ http://~~www~~.~~pubmed~~.~~gov), where 16141327~~ is the ~~PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_16141327}}~~

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
	<ref group="xtra">PMID:016141327</ref><ref group="xtra">PMID:012859189</ref><~~ref~~ group="xtra"~~>PMID:001052097<~~/~~ref~~><references ~~group="xtra"~~/>		<ref group="xtra">PMID:016141327</ref><ref group="xtra">PMID:012859189</ref><references group="xtra"/><references/>
	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]

OCA at 04:54, 27 July 2011

2011-07-27T04:54:40Z

← Older revision		Revision as of 04:54, 27 July 2011
Line 22:		Line 22:

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16141327~~</ref><ref group="xtra">PMID:~~12859189~~</ref><ref group="xtra">PMID:~~1052097~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016141327</ref><ref group="xtra">PMID:012859189</ref><ref group="xtra">PMID:001052097</ref><references group="xtra"/>
	[[Category: Arginase]]		[[Category: Arginase]]
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]