2aps - Revision history

OCA at 05:05, 17 October 2024

2024-10-17T05:05:49Z

← Older revision		Revision as of 05:05, 17 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/2aps_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/2aps_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:27, 23 August 2023

2023-08-23T07:27:55Z

← Older revision		Revision as of 07:27, 23 August 2023
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	<StructureSection load='2aps' size='340' side='right'caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2aps' size='340' side='right'caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Actpl Actpl~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2APS FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>~~, ~~<scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~SODC~~ (~~[https:~~/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=715 ACTPL])~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [https://pdbe.org/2aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [https://www.ebi.ac.uk/pdbsum/2aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [https://pdbe.org/2aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [https://www.ebi.ac.uk/pdbsum/2aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SODC_ACTPL SODC_ACTPL]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.		[https://www.uniprot.org/uniprot/SODC_ACTPL SODC_ACTPL] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Actpl~~]]		[[Category: Actinobacillus pleuropneumoniae]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Forest~~, K T~~]]		[[Category: Forest KT]]
	[[Category: Getzoff~~, E D~~]]		[[Category: Getzoff ED]]
	[[Category: Kroll~~, J S~~]]		[[Category: Kroll JS]]
	[[Category: Langford~~, P R]]~~		[[Category: Langford PR]]
	~~[[Category: Beta barrel]]~~
	~~[[Category: Sod]]~~
	~~[[Category: Superoxide dismutase]]~~
	~~[[Category: Water-mediated dimer~~]]

OCA at 08:35, 27 January 2021

2021-01-27T08:35:45Z

← Older revision		Revision as of 08:35, 27 January 2021
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	==CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE==		==CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE==
	<StructureSection load='2aps' size='340' side='right' caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2aps' size='340' side='right'caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 ACTPL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 ACTPL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [~~http~~://pdbe.org/2aps PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aps PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aps ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [https://pdbe.org/2aps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [https://www.ebi.ac.uk/pdbsum/2aps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SODC_ACTPL SODC_ACTPL]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.		[[https://www.uniprot.org/uniprot/SODC_ACTPL SODC_ACTPL]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Superoxide ~~Dismutase~~\|Superoxide ~~Dismutase~~]]		*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Actpl]]		[[Category: Actpl]]
			[[Category: Large Structures]]
	[[Category: Forest, K T]]		[[Category: Forest, K T]]
	[[Category: Getzoff, E D]]		[[Category: Getzoff, E D]]

OCA at 07:21, 9 May 2018

2018-05-09T07:21:32Z

← Older revision		Revision as of 07:21, 9 May 2018
Line 1:		Line 1:

	==CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE==		==CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE==
	<StructureSection load='2aps' size='340' side='right' caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2aps' size='340' side='right' caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 ACTPL])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 ACTPL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://pdbe.org/2aps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://pdbe.org/2aps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aps ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/2aps_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/2aps_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aps ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:35, 11 September 2015

2015-09-11T15:35:05Z

← Older revision		Revision as of 15:35, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2aps' size='340' side='right' caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='2aps' size='340' side='right' caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Actpl Actpl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2APS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 ~~Actinobacillus pleuropneumoniae~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 ACTPL])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://pdbe.org/2aps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2aps" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Actinobacillus pleuropneumoniae~~]]		[[Category: Actpl]]
	[[Category: Forest, K T]]		[[Category: Forest, K T]]
	[[Category: Getzoff, E D]]		[[Category: Getzoff, E D]]

OCA at 18:27, 25 December 2014

2014-12-25T18:27:58Z

← Older revision		Revision as of 18:27, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2APS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2APS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 Actinobacillus pleuropneumoniae])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 Actinobacillus pleuropneumoniae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SODC_ACTPL SODC_ACTPL]] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Actinobacillus pleuropneumoniae]]		[[Category: Actinobacillus pleuropneumoniae]]
	[[Category: Forest, K T.]]		[[Category: Forest, K T]]
	[[Category: Getzoff, E D.]]		[[Category: Getzoff, E D]]
	[[Category: Kroll, J S.]]		[[Category: Kroll, J S]]
	[[Category: Langford, P R.]]		[[Category: Langford, P R]]
	[[Category: Beta barrel]]		[[Category: Beta barrel]]
	[[Category: Sod]]		[[Category: Sod]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Water-mediated dimer]]		[[Category: Water-mediated dimer]]

OCA at 05:55, 29 September 2014

2014-09-29T05:55:50Z

← Older revision		Revision as of 05:55, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2aps~~.~~png~~\|~~left~~\|~~200px~~]]		==CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE==
			<StructureSection load='2aps' size='340' side='right' caption='[[2aps]], [[Resolution\|resolution]] 1.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2APS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">SODC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=715 Actinobacillus pleuropneumoniae])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aps OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aps RCSB], [http://www.ebi.ac.uk/pdbsum/2aps PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/2aps_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Macrophages and neutrophils protect animals from microbial infection in part by issuing a burst of toxic superoxide radicals when challenged. To counteract this onslaught, many Gram-negative bacterial pathogens possess periplasmic Cu,Zn superoxide dismutases (SODs), which act on superoxide to yield molecular oxygen and hydrogen peroxide. We have solved the X-ray crystal structure of the Cu,Zn SOD from Actinobacillus pleuropneumoniae, a major porcine pathogen, by molecular replacement at 1.9 A resolution. The structure reveals that the dimeric bacterial enzymes form a structurally homologous class defined by a water-mediated dimer interface, and share with all Cu,Zn SODs the Greek-key beta-barrel subunit fold with copper and zinc ions located at the base of a deep loop-enclosed active-site channel. Our structure-based sequence alignment of the bacterial enzymes explains the monomeric nature of at least two of these, and suggests that there may be at least one additional structural class for the bacterial SODs. Two metal-mediated crystal contacts yielded our C222(1) crystals, and the geometry of these sites could be engineered into proteins recalcitrant to crystallization in their native form. This work highlights structural differences between eukaryotic and prokaryotic Cu,Zn SODs, as well as similarities and differences among prokaryotic SODs, and lays the groundwork for development of antimicrobial drugs that specifically target periplasmic Cu,Zn SODs of bacterial pathogens.

	~~{{STRUCTURE_2aps\| PDB=2aps \| SCENE= }}~~		Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface.,Forest KT, Langford PR, Kroll JS, Getzoff ED J Mol Biol. 2000 Feb 11;296(1):145-53. PMID:10656823<ref>PMID:10656823</ref>

	~~===CU~~/~~ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_10656823}}~~

	~~==About this Structure==~~
	~~[[2aps]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin~~/~~ocashort?id=2APS OCA].~~

	==See Also==		==See Also==
	*[[Superoxide Dismutase\|Superoxide Dismutase]]		*[[Superoxide Dismutase\|Superoxide Dismutase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:010656823<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Actinobacillus pleuropneumoniae]]		[[Category: Actinobacillus pleuropneumoniae]]
	[[Category: Forest, K T.]]		[[Category: Forest, K T.]]

OCA at 19:59, 20 October 2012

2012-10-20T19:59:17Z

← Older revision		Revision as of 19:59, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2aps]] is a 2 chain structure ~~of [[Superoxide Dismutase]]~~ with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA].		[[2aps]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA].

	==See Also==		==See Also==

OCA: Protected "2aps" [edit=sysop:move=sysop]

2012-07-27T09:05:17Z

Protected "2aps" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:05, 27 July 2012
(No difference)

OCA at 09:05, 27 July 2012

2012-07-27T09:05:16Z

← Older revision		Revision as of 09:05, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2aps.png\|left\|200px]]		[[Image:2aps.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2aps", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2aps\| PDB=2aps \| SCENE= }}		{{STRUCTURE_2aps\| PDB=2aps \| SCENE= }}

	===CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE===		===CU/ZN SUPEROXIDE DISMUTASE FROM ACTINOBACILLUS PLEUROPNEUMONIAE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_10656823}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 10656823 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_10656823}}		{{ABSTRACT_PUBMED_10656823}}

	==About this Structure==		==About this Structure==
	~~2APS~~ is a 2 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA].		[[2aps]] is a 2 chain structure of [[Superoxide Dismutase]] with sequence from [http://en.wikipedia.org/wiki/Actinobacillus_pleuropneumoniae Actinobacillus pleuropneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2APS OCA].

			==See Also==
			*[[Superoxide Dismutase\|Superoxide Dismutase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~10656823~~</ref><references group="xtra"/>		<ref group="xtra">PMID:010656823</ref><references group="xtra"/>
	[[Category: Actinobacillus pleuropneumoniae]]		[[Category: Actinobacillus pleuropneumoniae]]
	[[Category: Forest, K T.]]		[[Category: Forest, K T.]]
Line 33:		Line 24:
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Water-mediated dimer]]		[[Category: Water-mediated dimer]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:26:56 2009''~~