2ask - Revision history

OCA at 07:50, 30 October 2024

2024-10-30T07:50:34Z

← Older revision		Revision as of 07:50, 30 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2ask_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2ask_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:17, 22 May 2024

2024-05-22T11:17:39Z

← Older revision		Revision as of 11:17, 22 May 2024
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	<StructureSection load='2ask' size='340' side='right'caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ask' size='340' side='right'caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.55Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [https://pdbe.org/2ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [https://www.ebi.ac.uk/pdbsum/2ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ask ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [https://pdbe.org/2ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [https://www.ebi.ac.uk/pdbsum/2ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ask ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/ARTN_HUMAN ARTN_HUMAN] Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.<ref>PMID:9883723</ref> <ref>PMID:10583383</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Boriack-Sjodin~~, P A~~]]		[[Category: Boriack-Sjodin PA]]
	[[Category: Carmillo, P]]		[[Category: Carmillo P]]
	[[Category: Gong~~, B J~~]]		[[Category: Gong BJ]]
	[[Category: Jin, P]]		[[Category: Jin P]]
	[[Category: Pelletier, C]]		[[Category: Pelletier C]]
	[[Category: Pepinsky, B]]		[[Category: Pepinsky B]]
	[[Category: Rossomando, A]]		[[Category: Rossomando A]]
	[[Category: Rushe, M]]		[[Category: Rushe M]]
	[[Category: Sah, D]]		[[Category: Sah D]]
	[[Category: Silvian, L]]		[[Category: Silvian L]]
	~~[[Category: Glial cell derived family ligand]]~~
	~~[[Category: Hormone-growth factor complex]]~~
	~~[[Category: Neurotrphoic growth factor]]~~
	~~[[Category: Sulfate~~]]

OCA at 14:44, 17 November 2021

2021-11-17T14:44:23Z

← Older revision		Revision as of 14:44, 17 November 2021
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	<StructureSection load='2ask' size='340' side='right'caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ask' size='340' side='right'caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [~~http~~://pdbe.org/2ask PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ask PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ask ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [https://pdbe.org/2ask PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [https://www.ebi.ac.uk/pdbsum/2ask PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ask ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 05:34, 13 February 2020

2020-02-13T05:34:57Z

← Older revision		Revision as of 05:34, 13 February 2020
Line 1:		Line 1:

	==Structure of human Artemin==		==Structure of human Artemin==
	<StructureSection load='2ask' size='340' side='right' caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ask' size='340' side='right'caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Boriack-Sjodin, P A]]		[[Category: Boriack-Sjodin, P A]]
	[[Category: Carmillo, P]]		[[Category: Carmillo, P]]

OCA at 07:29, 9 May 2018

2018-05-09T07:29:21Z

← Older revision		Revision as of 07:29, 9 May 2018
Line 1:		Line 1:

	==Structure of human Artemin==		==Structure of human Artemin==
	<StructureSection load='2ask' size='340' side='right' caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ask' size='340' side='right' caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://pdbe.org/2ask PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://pdbe.org/2ask PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ask ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2ask_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2ask_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 06:57, 8 February 2016

2016-02-08T06:57:40Z

← Older revision		Revision as of 06:57, 8 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ask ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 09:02, 10 September 2015

2015-09-10T09:02:34Z

← Older revision		Revision as of 09:02, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2ask' size='340' side='right' caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>		<StructureSection load='2ask' size='340' side='right' caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://pdbe.org/2ask PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ask" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Boriack-Sjodin, P A]]		[[Category: Boriack-Sjodin, P A]]
	[[Category: Carmillo, P]]		[[Category: Carmillo, P]]

OCA at 09:51, 8 January 2015

2015-01-08T09:51:52Z

← Older revision		Revision as of 09:51, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boriack-Sjodin, P A.]]		[[Category: Boriack-Sjodin, P A]]
	[[Category: Carmillo, P.]]		[[Category: Carmillo, P]]
	[[Category: Gong, B J.]]		[[Category: Gong, B J]]
	[[Category: Jin, P.]]		[[Category: Jin, P]]
	[[Category: Pelletier, C.]]		[[Category: Pelletier, C]]
	[[Category: Pepinsky, B.]]		[[Category: Pepinsky, B]]
	[[Category: Rossomando, A.]]		[[Category: Rossomando, A]]
	[[Category: Rushe, M.]]		[[Category: Rushe, M]]
	[[Category: Sah, D.]]		[[Category: Sah, D]]
	[[Category: Silvian, L.]]		[[Category: Silvian, L]]
	[[Category: Glial cell derived family ligand]]		[[Category: Glial cell derived family ligand]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]
	[[Category: Neurotrphoic growth factor]]		[[Category: Neurotrphoic growth factor]]
	[[Category: Sulfate]]		[[Category: Sulfate]]

OCA at 02:17, 30 September 2014

2014-09-30T02:17:29Z

← Older revision		Revision as of 02:17, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2ask~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of human Artemin==
			<StructureSection load='2ask' size='340' side='right' caption='[[2ask]], [[Resolution\|resolution]] 1.55Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ask]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASK FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ask FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ask OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ask RCSB], [http://www.ebi.ac.uk/pdbsum/2ask PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2ask_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Artemin (ART) promotes the growth of developing peripheral neurons by signaling through a multicomponent receptor complex comprised of a transmembrane tyrosine kinase receptor (cRET) and a specific glycosylphosphatidylinositol-linked co-receptor (GFRalpha3). Glial cell line-derived neurotrophic factor (GDNF) signals through a similar ternary complex but requires heparan sulfate proteoglycans (HSPGs) for full activity. HSPG has not been demonstrated as a requirement for ART signaling. We crystallized ART in the presence of sulfate and solved its structure by isomorphous replacement. The structure reveals ordered sulfate anions bound to arginine residues in the pre-helix and amino-terminal regions that were organized in a triad arrangement characteristic of heparan sulfate. Three residues in the pre-helix were singly or triply substituted with glutamic acid, and the resulting proteins were shown to have reduced heparin-binding affinity that is partly reflected in their ability to activate cRET. This study suggests that ART binds HSPGs and identifies residues that may be involved in HSPG binding.

	~~{{STRUCTURE_2ask\| PDB=2ask \| SCENE= }}~~		Artemin crystal structure reveals insights into heparan sulfate binding.,Silvian L, Jin P, Carmillo P, Boriack-Sjodin PA, Pelletier C, Rushe M, Gong B, Sah D, Pepinsky B, Rossomando A Biochemistry. 2006 Jun 6;45(22):6801-12. PMID:16734417<ref>PMID:16734417</ref>

	~~===Structure~~ of ~~human Artemin===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16734417}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ask]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ASK OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016734417<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Boriack-Sjodin, P A.]]		[[Category: Boriack-Sjodin, P A.]]

OCA: Protected "2ask" [edit=sysop:move=sysop]

2013-01-06T11:30:17Z

Protected "2ask" [edit=sysop:move=sysop]

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