2asm - Revision history

OCA at 08:00, 23 August 2023

2023-08-23T08:00:21Z

← Older revision		Revision as of 08:00, 23 August 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [https://pdbe.org/2asm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [https://www.ebi.ac.uk/pdbsum/2asm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [https://pdbe.org/2asm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [https://www.ebi.ac.uk/pdbsum/2asm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.		[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Allingham~~, J S~~]]		[[Category: Allingham JS]]
	[[Category: Auria~~, M V.D~~]]		[[Category: D'Auria MV]]
	[[Category: Rayment, I]]		[[Category: Rayment I]]
	[[Category: Zampella, A]]		[[Category: Zampella A]]
	~~[[Category: Actin]]~~
	~~[[Category: Filament capping]]~~
	~~[[Category: Filament severing]]~~
	~~[[Category: Marine macrolide]]~~
	~~[[Category: Reidispongiolide some]]~~
	~~[[Category: Structural protein]]~~
	~~[[Category: Toxin~~]]

OCA at 14:44, 17 November 2021

2021-11-17T14:44:26Z

← Older revision		Revision as of 14:44, 17 November 2021
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	<StructureSection load='2asm' size='340' side='right'caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2asm' size='340' side='right'caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ASM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASM FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [~~http~~://pdbe.org/2asm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2asm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2asm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [https://pdbe.org/2asm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [https://www.ebi.ac.uk/pdbsum/2asm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.		[[https://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 05:02, 13 February 2020

2020-02-13T05:02:15Z

← Older revision		Revision as of 05:02, 13 February 2020
Line 1:		Line 1:

	==Structure of Rabbit Actin In Complex With Reidispongiolide A==		==Structure of Rabbit Actin In Complex With Reidispongiolide A==
	<StructureSection load='2asm' size='340' side='right' caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2asm' size='340' side='right'caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASM FirstGlance]. <br>
Line 21:		Line 21:

	==See Also==		==See Also==
	*[[Actin\|Actin]]		*[[Actin 3D structures\|Actin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Allingham, J S]]		[[Category: Allingham, J S]]

OCA at 06:51, 9 May 2018

2018-05-09T06:51:19Z

← Older revision		Revision as of 06:51, 9 May 2018
Line 1:		Line 1:

	==Structure of Rabbit Actin In Complex With Reidispongiolide A==		==Structure of Rabbit Actin In Complex With Reidispongiolide A==
	<StructureSection load='2asm' size='340' side='right' caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2asm' size='340' side='right' caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://pdbe.org/2asm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://pdbe.org/2asm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2asm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 11:14, 11 September 2015

2015-09-11T11:14:58Z

← Older revision		Revision as of 11:14, 11 September 2015
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://pdbe.org/2asm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2asm" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:42, 25 December 2014

2014-12-25T15:42:00Z

← Older revision		Revision as of 15:42, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASM FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASM FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ACTS_RABIT ACTS_RABIT]] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Allingham, J S.]]		[[Category: Allingham, J S]]
	[[Category: Auria, M V.D.]]		[[Category: Auria, M V.D]]
	[[Category: Rayment, I.]]		[[Category: Rayment, I]]
	[[Category: Zampella, A.]]		[[Category: Zampella, A]]
	[[Category: Actin]]		[[Category: Actin]]
	[[Category: Filament capping]]		[[Category: Filament capping]]

OCA at 02:49, 29 September 2014

2014-09-29T02:49:58Z

← Older revision		Revision as of 02:49, 29 September 2014
Line 1:		Line 1:
	[[~~Image~~:~~2asm~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of Rabbit Actin In Complex With Reidispongiolide A==
			<StructureSection load='2asm' size='340' side='right' caption='[[2asm]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2asm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASM FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=RGA:REIDISPONGIOLIDE+A'>RGA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1qz5\|1qz5]], [[1qz6\|1qz6]], [[1s22\|1s22]], [[2aso\|2aso]], [[2asp\|2asp]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asm RCSB], [http://www.ebi.ac.uk/pdbsum/2asm PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Marine macrolides that disrupt the actin cytoskeleton are promising candidates for cancer treatment. Here, we present the actin-bound x-ray crystal structures of reidispongiolide A and C and sphinxolide B, three marine macrolides found among a recently discovered family of cytotoxic compounds. Their structures allow unequivocal assignment of the absolute configuration for each compound. A comparison of their actin-binding site to macrolides found in the trisoxazole family, as well as the divalent macrolide, swinholide A, reveals the existence of a common binding surface for a defined segment of their macrocyclic ring. This surface is located on a hydrophobic patch adjacent to the cleft separating domains 1 and 3 at the barbed-end of actin. The large area surrounding this surface accommodates a wide variety of conformations and designs observed in the macrocyclic component of barbed-end-targeting macrolides. Conversely, the binding pocket for the macrolide tail, located within the cleft itself, shows very limited variation. Functional characterization of these macrolides by using in vitro actin filament severing and polymerization assays demonstrate the necessity of the N-methyl-vinylformamide moiety at the terminus of the macrolide tail for toxin potency. These analyses also show the importance of stable interactions between the macrocyclic ring and the hydrophobic patch on actin for modifying filament structure and how this stability can be compromised by subtle changes in macrolactone ring composition. By identifying the essential components of these complex natural products that underlie their high actin affinity, we have established a framework for designing new therapeutic agents.

	~~{{STRUCTURE_2asm\| PDB=2asm \| SCENE= }}~~		Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity.,Allingham JS, Zampella A, D'Auria MV, Rayment I Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14527-32. Epub 2005 Sep 28. PMID:16192358<ref>PMID:16192358</ref>

	~~===Structure~~ of ~~Rabbit Actin In Complex With Reidispongiolide A===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16192358}}~~

	~~==About this Structure==~~
	~~[[2asm]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2ASM OCA].~~

	==See Also==		==See Also==
	*[[Actin\|Actin]]		*[[Actin\|Actin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016192358<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Allingham, J S.]]		[[Category: Allingham, J S.]]

OCA at 18:28, 20 October 2012

2012-10-20T18:28:32Z

← Older revision		Revision as of 18:28, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2asm]] is a 1 chain structure ~~of [[Actin]]~~ with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA].		[[2asm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASM OCA].

	==See Also==		==See Also==

OCA at 04:11, 27 July 2012

2012-07-27T04:11:56Z

← Older revision		Revision as of 04:11, 27 July 2012
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	[[Image:2asm.png\|left\|200px]]		[[Image:2asm.png\|left\|200px]]

	~~<!--~~
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	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2asm\| PDB=2asm \| SCENE= }}		{{STRUCTURE_2asm\| PDB=2asm \| SCENE= }}

	===Structure of Rabbit Actin In Complex With Reidispongiolide A===		===Structure of Rabbit Actin In Complex With Reidispongiolide A===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16192358}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16192358 is the PubMed ID number.~~
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	{{ABSTRACT_PUBMED_16192358}}		{{ABSTRACT_PUBMED_16192358}}

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	==See Also==		==See Also==
	*[[Actin]]		*[[Actin\|Actin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16192358~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016192358</ref><references group="xtra"/>
	[[Category: Oryctolagus cuniculus]]		[[Category: Oryctolagus cuniculus]]
	[[Category: Allingham, J S.]]		[[Category: Allingham, J S.]]

OCA: Protected "2asm" [edit=sysop:move=sysop]

2010-12-26T19:38:24Z

Protected "2asm" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:38, 26 December 2010
(No difference)