2asu - Revision history

OCA at 09:00, 6 November 2024

2024-11-06T09:00:16Z

← Older revision		Revision as of 09:00, 6 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2asu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2asu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:29, 23 August 2023

2023-08-23T07:29:23Z

← Older revision		Revision as of 07:29, 23 August 2023
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	<StructureSection load='2asu' size='340' side='right'caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2asu' size='340' side='right'caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASU FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1bui\|1bui]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.85Å</td></tr>
	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">MST1, HGFL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax~~.~~cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [https://pdbe.org/2asu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [https://www.ebi.ac.uk/pdbsum/2asu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [https://pdbe.org/2asu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [https://www.ebi.ac.uk/pdbsum/2asu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asu ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/HGFL_HUMAN HGFL_HUMAN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blundell~~, T L~~]]		[[Category: Blundell TL]]
	[[Category: Carafoli, F]]		[[Category: Carafoli F]]
	[[Category: Chirgadze~~, D Y~~]]		[[Category: Chirgadze DY]]
	[[Category: Gherardi, E]]		[[Category: Gherardi E]]
	~~[[Category: Beta-chain]]~~
	~~[[Category: Hgfl]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Msp]]~~
	~~[[Category: Serine proteinase~~]]

OCA at 08:37, 27 January 2021

2021-01-27T08:37:47Z

← Older revision		Revision as of 08:37, 27 January 2021
Line 1:		Line 1:

	==Crystal Structure of the beta-chain of HGFl/MSP==		==Crystal Structure of the beta-chain of HGFl/MSP==
	<StructureSection load='2asu' size='340' side='right' caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2asu' size='340' side='right'caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ASU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ASU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bui\|1bui]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [~~http~~://pdbe.org/2asu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2asu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2asu ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [https://pdbe.org/2asu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [https://www.ebi.ac.uk/pdbsum/2asu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2asu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2asu_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2asu_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]

OCA at 14:37, 12 October 2017

2017-10-12T14:37:44Z

← Older revision		Revision as of 14:37, 12 October 2017
Line 1:		Line 1:

	==Crystal Structure of the beta-chain of HGFl/MSP==		==Crystal Structure of the beta-chain of HGFl/MSP==
	<StructureSection load='2asu' size='340' side='right' caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2asu' size='340' side='right' caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>
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	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://pdbe.org/2asu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://pdbe.org/2asu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2asu ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 23:51, 7 February 2016

2016-02-07T23:51:19Z

← Older revision		Revision as of 23:51, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2asu ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:59, 10 September 2015

2015-09-10T05:59:24Z

← Older revision		Revision as of 05:59, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2asu' size='340' side='right' caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>		<StructureSection load='2asu' size='340' side='right' caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASU FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://pdbe.org/2asu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2asu" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Blundell, T L]]		[[Category: Blundell, T L]]
	[[Category: Carafoli, F]]		[[Category: Carafoli, F]]

OCA at 19:04, 24 December 2014

2014-12-24T19:04:44Z

← Older revision		Revision as of 19:04, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASU FirstGlance]. <br>		<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASU FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L]]
	[[Category: Carafoli, F.]]		[[Category: Carafoli, F]]
	[[Category: Chirgadze, D Y.]]		[[Category: Chirgadze, D Y]]
	[[Category: Gherardi, E.]]		[[Category: Gherardi, E]]
	[[Category: Beta-chain]]		[[Category: Beta-chain]]
	[[Category: Hgfl]]		[[Category: Hgfl]]

OCA at 02:14, 30 September 2014

2014-09-30T02:14:52Z

← Older revision		Revision as of 02:14, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2asu~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal Structure of the beta-chain of HGFl/MSP==
			<StructureSection load='2asu' size='340' side='right' caption='[[2asu]], [[Resolution\|resolution]] 1.85Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2asu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ASU FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bui\|1bui]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MST1, HGFL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2asu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2asu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2asu RCSB], [http://www.ebi.ac.uk/pdbsum/2asu PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/as/2asu_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hepatocyte growth factor like/macrophage stimulating protein (HGFl/MSP) and hepatocyte growth factor/scatter factor (HGF/SF) define a distinct family of vertebrate-specific growth factors structurally related to the blood proteinase precursor plasminogen and with important roles in development and cancer. Although the two proteins share a similar domain structure and mechanism of activation, there are differences between HGFl/MSP and HGF/SF in terms of the contribution of individual domains to receptor binding. Here we present a crystal structure of the 30 kDa beta-chain of human HGFl/MSP, a serine proteinase homology domain containing the high-affinity binding site for the RON receptor. The structure describes at 1.85 Angstrom resolution the region of the domain corresponding to the receptor binding site recently defined in the HGF/SF beta-chain, namely the central cleft harboring the three residues corresponding to the catalytic ones of active proteinases (numbers in brackets define the sequence position according to the standard chymotrypsinogen numbering system) [Gln522 (c57), Gln568 (c102) and Tyr661 (c195)] and an adjacent loop flanking the S1 specificity pocket and containing residues Asn682 (c217) and Arg683 (c218) previously shown to be essential for binding of HGFl/MSP to the RON receptor. The study confirms the concept that the serine proteinase homology domains of HGFl/MSP and HGF/SF bind their receptors in an 'enzyme-substrate' mode, reflecting the common evolutionary origin of the plasminogen-related growth factors and the proteinases of the clotting and fibrinolytic pathways. However, analysis of the intermolecular interactions in the crystal lattice of beta-chain HGFl/MSP fails to show the same contacts seen in the HGF/SF structures and does not support a conserved mode of dimerization of the serine proteinase homology domains of HGFl/MSP and HGF/SF responsible for receptor activation.

	~~{{STRUCTURE_2asu\| PDB=2asu \| SCENE= }}~~		Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein.,Carafoli F, Chirgadze DY, Blundell TL, Gherardi E FEBS J. 2005 Nov;272(22):5799-807. PMID:16279944<ref>PMID:16279944</ref>

	~~===Crystal Structure~~ of the ~~beta-chain of HGFl/MSP===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16279944}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2asu]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016279944<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L.]]

OCA: Protected "2asu" [edit=sysop:move=sysop]

2013-01-06T11:27:38Z

Protected "2asu" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:27, 6 January 2013
(No difference)

OCA at 11:27, 6 January 2013

2013-01-06T11:27:36Z

← Older revision		Revision as of 11:27, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2asu.png\|left\|200px]]		[[Image:2asu.png\|left\|200px]]

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	{{STRUCTURE_2asu\| PDB=2asu \| SCENE= }}		{{STRUCTURE_2asu\| PDB=2asu \| SCENE= }}

	===Crystal Structure of the beta-chain of HGFl/MSP===		===Crystal Structure of the beta-chain of HGFl/MSP===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16279944}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_16279944}}		{{ABSTRACT_PUBMED_16279944}}

	==About this Structure==		==About this Structure==
	~~2ASU~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA].		[[2asu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ASU OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16279944~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016279944</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Blundell, T L.]]		[[Category: Blundell, T L.]]
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	[[Category: Beta-chain]]		[[Category: Beta-chain]]
	[[Category: Hgfl]]		[[Category: Hgfl]]
			[[Category: Hydrolase]]
	[[Category: Msp]]		[[Category: Msp]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:18:46 2009''~~