2auc - Revision history

OCA at 22:20, 26 March 2025

2025-03-26T22:20:28Z

← Older revision		Revision as of 22:20, 26 March 2025
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:18, 22 May 2024

2024-05-22T11:18:04Z

← Older revision		Revision as of 11:18, 22 May 2024
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	<StructureSection load='2auc' size='340' side='right'caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2auc' size='340' side='right'caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plakn Plakn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi] and [https://en.wikipedia.org/wiki/Plasmodium_yoelii_yoelii Plasmodium yoelii yoelii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non~~-~~Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [https://pdbe.org/2auc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [https://www.ebi.ac.uk/pdbsum/2auc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [https://pdbe.org/2auc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [https://www.ebi.ac.uk/pdbsum/2auc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/D0VWV5_PLAKN D0VWV5_PLAKN]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Plakn~~]]		[[Category: Plasmodium knowlesi]]
	[[Category: ~~Bosch, J~~]]		[[Category: Plasmodium yoelii yoelii]]
	[[Category: ~~Hol, W G.~~J]]		[[Category: Bosch J]]
	[[Category: ~~Structural genomic~~]]		[[Category: Hol WGJ]]
	[[Category: Turley, S]]		[[Category: Turley S]]
	~~[[Category: Membrane protein]]~~
	~~[[Category: Myoa]]~~
	~~[[Category: Myoa tail interacting protein]]~~
	~~[[Category: Myosin a-tail]]~~
	~~[[Category: PSI, Protein structure initiative]]~~
	~~[[Category: Sgpp~~]]

OCA at 14:45, 17 November 2021

2021-11-17T14:45:17Z

← Older revision		Revision as of 14:45, 17 November 2021
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	<StructureSection load='2auc' size='340' side='right'caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2auc' size='340' side='right'caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [~~http~~://pdbe.org/2auc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2auc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2auc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [https://pdbe.org/2auc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [https://www.ebi.ac.uk/pdbsum/2auc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2auc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 04:56, 13 February 2020

2020-02-13T04:56:22Z

← Older revision		Revision as of 04:56, 13 February 2020
Line 1:		Line 1:

	==Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor==		==Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor==
	<StructureSection load='2auc' size='340' side='right' caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2auc' size='340' side='right'caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Plakn]]		[[Category: Plakn]]
	[[Category: Bosch, J]]		[[Category: Bosch, J]]

OCA at 06:44, 9 May 2018

2018-05-09T06:44:49Z

← Older revision		Revision as of 06:44, 9 May 2018
Line 1:		Line 1:

	==Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor==		==Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor==
	<StructureSection load='2auc' size='340' side='right' caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2auc' size='340' side='right' caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://pdbe.org/2auc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://pdbe.org/2auc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2auc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 22:00, 7 February 2016

2016-02-07T22:00:53Z

← Older revision		Revision as of 22:00, 7 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2auc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:19, 10 September 2015

2015-09-10T05:19:44Z

← Older revision		Revision as of 05:19, 10 September 2015
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	<StructureSection load='2auc' size='340' side='right' caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='2auc' size='340' side='right' caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_knowlesi Plasmodium knowlesi~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plakn Plakn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://pdbe.org/2auc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2auc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Plasmodium knowlesi~~]]		[[Category: Plakn]]
	[[Category: Bosch, J]]		[[Category: Bosch, J]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]

OCA at 08:51, 8 January 2015

2015-01-08T08:51:23Z

← Older revision		Revision as of 08:51, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Plasmodium knowlesi]]		[[Category: Plasmodium knowlesi]]
	[[Category: Bosch, J.]]		[[Category: Bosch, J]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J]]
	[[Category: ~~SGPP,~~ Structural ~~Genomics of Pathogenic Protozoa Consortium.~~]]		[[Category: Structural genomic]]
	[[Category: Turley, S.]]		[[Category: Turley, S]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]
	[[Category: Myoa]]		[[Category: Myoa]]
	[[Category: Myoa tail interacting protein]]		[[Category: Myoa tail interacting protein]]
	[[Category: Myosin a-tail]]		[[Category: Myosin a-tail]]
	[[Category: Protein structure initiative ~~mtip]]~~		[[Category: PSI, Protein structure initiative]]
	~~[[Category: Psi~~]]
	[[Category: Sgpp]]		[[Category: Sgpp]]
	~~[[Category: Structural genomic]]~~
	~~[[Category: Structural genomics of pathogenic protozoa consortium]]~~

OCA at 01:31, 30 September 2014

2014-09-30T01:31:23Z

← Older revision		Revision as of 01:31, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2auc~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of the Plasmodium MTIP-MyoA complex, a key component of the parasite invasion motor==
			<StructureSection load='2auc' size='340' side='right' caption='[[2auc]], [[Resolution\|resolution]] 2.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2auc]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SAC:N-ACETYL-SERINE'>SAC</scene></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2auc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2auc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2auc RCSB], [http://www.ebi.ac.uk/pdbsum/2auc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2auc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The causative agents of malaria have developed a sophisticated machinery for entering multiple cell types in the human and insect hosts. In this machinery, a critical interaction occurs between the unusual myosin motor MyoA and the MyoA-tail Interacting Protein (MTIP). Here we present one crystal structure that shows three different conformations of Plasmodium MTIP, one of these in complex with the MyoA-tail, which reveal major conformational changes in the C-terminal domain of MTIP upon binding the MyoA-tail helix, thereby creating several hydrophobic pockets in MTIP that are the recipients of key hydrophobic side chains of MyoA. Because we also show that the MyoA helix is able to block parasite growth, this provides avenues for designing antimalarials.

	~~{{STRUCTURE_2auc\| PDB=2auc \| SCENE= }}~~		Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor.,Bosch J, Turley S, Daly TM, Bogh SM, Villasmil ML, Roach C, Zhou N, Morrisey JM, Vaidya AB, Bergman LW, Hol WG Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):4852-7. Epub 2006 Mar 17. PMID:16547135<ref>PMID:16547135</ref>

	~~===Structure of the Plasmodium MTIP-MyoA complex~~, a ~~key component~~ of the ~~parasite invasion motor===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16547135}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2auc]] is a 4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_knowlesi Plasmodium knowlesi]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2AUC OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016547135<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Plasmodium knowlesi]]		[[Category: Plasmodium knowlesi]]
	[[Category: Bosch, J.]]		[[Category: Bosch, J.]]

OCA: Protected "2auc" [edit=sysop:move=sysop]

2013-01-06T10:46:02Z

Protected "2auc" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:46, 6 January 2013
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