2aug - Revision history

OCA at 07:29, 23 August 2023

2023-08-23T07:29:49Z

← Older revision		Revision as of 07:29, 23 August 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [https://pdbe.org/2aug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [https://www.ebi.ac.uk/pdbsum/2aug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aug ProSAT]</span></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [https://pdbe.org/2aug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [https://www.ebi.ac.uk/pdbsum/2aug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GRB14_HUMAN GRB14_HUMAN]] Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.<ref>PMID:15210700</ref> <ref>PMID:19648926</ref>		[https://www.uniprot.org/uniprot/GRB14_HUMAN GRB14_HUMAN] Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.<ref>PMID:15210700</ref> <ref>PMID:19648926</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 37:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Daly~~, R J~~]]		[[Category: Daly RJ]]
	[[Category: Depetris~~, R S~~]]		[[Category: Depetris RS]]
	[[Category: Gimpelevich, I]]		[[Category: Gimpelevich I]]
	[[Category: Holt~~, L J~~]]		[[Category: Holt LJ]]
	[[Category: Hu, J]]		[[Category: Hu J]]
	[[Category: Hubbard~~, S R]]~~		[[Category: Hubbard SR]]
	~~[[Category: Phosphorylation]]~~
	~~[[Category: Sh2 domain]]~~
	~~[[Category: Signaling protein~~]]

OCA at 14:45, 17 November 2021

2021-11-17T14:45:23Z

← Older revision		Revision as of 14:45, 17 November 2021
Line 3:		Line 3:
	<StructureSection load='2aug' size='340' side='right'caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2aug' size='340' side='right'caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2AUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [~~http~~://pdbe.org/2aug PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2aug PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2aug ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [https://pdbe.org/2aug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [https://www.ebi.ac.uk/pdbsum/2aug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GRB14_HUMAN GRB14_HUMAN]] Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.<ref>PMID:15210700</ref> <ref>PMID:19648926</ref>		[[https://www.uniprot.org/uniprot/GRB14_HUMAN GRB14_HUMAN]] Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.<ref>PMID:15210700</ref> <ref>PMID:19648926</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 05:24, 13 February 2020

2020-02-13T05:24:23Z

← Older revision		Revision as of 05:24, 13 February 2020
Line 1:		Line 1:

	==Crystal structure of the Grb14 SH2 domain==		==Crystal structure of the Grb14 SH2 domain==
	<StructureSection load='2aug' size='340' side='right' caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2aug' size='340' side='right'caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
	*[[Growth factor receptor-bound ~~protein~~\|Growth factor receptor-bound ~~protein~~]]		*[[Growth factor receptor-bound proteins 3D structures\|Growth factor receptor-bound proteins 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
			[[Category: Large Structures]]
	[[Category: Daly, R J]]		[[Category: Daly, R J]]
	[[Category: Depetris, R S]]		[[Category: Depetris, R S]]

OCA at 07:16, 9 May 2018

2018-05-09T07:16:31Z

← Older revision		Revision as of 07:16, 9 May 2018
Line 1:		Line 1:

	==Crystal structure of the Grb14 SH2 domain==		==Crystal structure of the Grb14 SH2 domain==
	<StructureSection load='2aug' size='340' side='right' caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2aug' size='340' side='right' caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://pdbe.org/2aug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://pdbe.org/2aug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2aug ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2aug_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2aug_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aug ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:36, 11 September 2015

2015-09-11T11:36:15Z

← Older revision		Revision as of 11:36, 11 September 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://pdbe.org/2aug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2aug" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 15:55, 25 December 2014

2014-12-25T15:55:57Z

← Older revision		Revision as of 15:55, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>		<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GRB14_HUMAN GRB14_HUMAN]] Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.<ref>PMID:15210700</ref> <ref>PMID:19648926</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Daly, R J.]]		[[Category: Daly, R J]]
	[[Category: Depetris, R S.]]		[[Category: Depetris, R S]]
	[[Category: Gimpelevich, I.]]		[[Category: Gimpelevich, I]]
	[[Category: Holt, L J.]]		[[Category: Holt, L J]]
	[[Category: Hu, J.]]		[[Category: Hu, J]]
	[[Category: Hubbard, S R.]]		[[Category: Hubbard, S R]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 01:15, 30 September 2014

2014-09-30T01:15:46Z

← Older revision		Revision as of 01:15, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2aug~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of the Grb14 SH2 domain==
			<StructureSection load='2aug' size='340' side='right' caption='[[2aug]], [[Resolution\|resolution]] 2.30Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AUG FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2aug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aug OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2aug RCSB], [http://www.ebi.ac.uk/pdbsum/2aug PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/au/2aug_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Grb14, a member of the Grb7 adaptor protein family, possesses a pleckstrin homology (PH) domain, a C-terminal Src homology-2 (SH2) domain, and an intervening stretch of approximately 45 residues known as the BPS region, which is unique to this adaptor family. Previous studies have demonstrated that Grb14 is a tissue-specific negative regulator of insulin receptor signaling and that inhibition is mediated by the BPS region. We have determined the crystal structure of the Grb14 BPS region in complex with the tyrosine kinase domain of the insulin receptor. The structure reveals that the N-terminal portion of the BPS region binds as a pseudosubstrate inhibitor in the substrate peptide binding groove of the kinase. Together with the crystal structure of the SH2 domain, we present a model for the interaction of Grb14 with the insulin receptor, which indicates how Grb14 functions as a selective protein inhibitor of insulin signaling.

	~~{{STRUCTURE_2aug\| PDB=2aug \| SCENE= }}~~		Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.,Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR Mol Cell. 2005 Oct 28;20(2):325-33. PMID:16246733<ref>PMID:16246733</ref>

	~~===Crystal structure~~ of the ~~Grb14 SH2 domain===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_16246733}}~~		==See Also==
			*[[Growth factor receptor-bound protein\|Growth factor receptor-bound protein]]
	==~~About this Structure~~==		== References ==
	[[~~2aug~~]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:016246733<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Daly, R J.]]		[[Category: Daly, R J.]]

OCA: Protected "2aug" [edit=sysop:move=sysop]

2013-01-06T10:30:31Z

Protected "2aug" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:30, 6 January 2013
(No difference)

OCA at 10:30, 6 January 2013

2013-01-06T10:30:28Z

← Older revision		Revision as of 10:30, 6 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2aug.png\|left\|200px]]		[[Image:2aug.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2aug", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2aug\| PDB=2aug \| SCENE= }}		{{STRUCTURE_2aug\| PDB=2aug \| SCENE= }}

	===Crystal structure of the Grb14 SH2 domain===		===Crystal structure of the Grb14 SH2 domain===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16246733}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16246733 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16246733}}		{{ABSTRACT_PUBMED_16246733}}

	==About this Structure==		==About this Structure==
	~~2AUG~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA].		[[2aug]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16246733~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016246733</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Daly, R J.]]		[[Category: Daly, R J.]]
Line 33:		Line 21:
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]
			[[Category: Signaling protein]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Tue Feb 17 21:03:05 2009''~~

OCA at 19:03, 17 February 2009

2009-02-17T19:03:05Z

← Older revision		Revision as of 19:03, 17 February 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2AUG is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA].		2AUG is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AUG OCA].

	==Reference==		==Reference==
	~~Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14., Depetris RS, Hu J, Gimpelevich I, Holt LJ, Daly RJ, Hubbard SR, Mol Cell. 2005 Oct 28;20(2):325-33.~~ PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16246733 16246733]~~		<ref group="xtra">PMID:16246733</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	~~[[Category: Single protein]]~~
	[[Category: Daly, R J.]]		[[Category: Daly, R J.]]
	[[Category: Depetris, R S.]]		[[Category: Depetris, R S.]]
Line 35:		Line 34:
	[[Category: Sh2 domain]]		[[Category: Sh2 domain]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 05~~:04:~~32 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 21:03:05 2009''