2b2a - Revision history

OCA at 09:15, 14 February 2024

2024-02-14T09:15:31Z

← Older revision		Revision as of 09:15, 14 February 2024
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>		[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>
	~~<div style="background-color:#fffaf0;">~~
	~~== Publication Abstract from PubMed ==~~
	Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear chromosomes. Here we report the first high-resolution structure of any portion of the telomerase reverse transcriptase, the telomerase essential N-terminal (TEN) domain from Tetrahymena thermophila. The structure, which seems to represent a novel protein fold, shows phylogenetically conserved amino acid residues in a groove on its surface. These residues are crucial for telomerase catalytic activity, and several of them are required for sequence-specific binding of a single-stranded telomeric DNA primer. The positively charged C terminus, which becomes ordered upon interaction with other macromolecules, is involved in binding RNA in a non-sequence-specific manner. The TEN domain's ability to bind both RNA and telomeric DNA, coupled with the notably strong effects on activity upon mutagenesis of single surface residues, suggest how this domain contributes to telomerase catalysis.

	Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.,Jacobs SA, Podell ER, Cech TR Nat Struct Mol Biol. 2006 Mar;13(3):218-25. Epub 2006 Feb 5. PMID:16462747<ref>PMID:16462747</ref>

	~~From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>~~
	~~</div>~~
	~~<div class="pdbe-citations 2b2a" style="background-color:#fffaf0;"></div>~~

	==See Also==		==See Also==

OCA at 13:04, 26 July 2023

2023-07-26T13:04:48Z

← Older revision		Revision as of 13:04, 26 July 2023
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	<StructureSection load='2b2a' size='340' side='right'caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2b2a' size='340' side='right'caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Tetth Tetth~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2A FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>TERT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=5911 TETTH])</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.22Å</td></tr>
	~~<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class~~="~~sblockDat~~">~~<span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA~~-~~directed DNA polymerase]~~, ~~with EC number~~ [~~https://www.brenda-enzymes.info/php/result_flat.php4?ecno=~~2.~~7.7.49 2.7.7.49] </span>~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [https://pdbe.org/2b2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [https://www.ebi.ac.uk/pdbsum/2b2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [https://pdbe.org/2b2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [https://www.ebi.ac.uk/pdbsum/2b2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~TERT_TETTH TERT_TETTH~~]~~] Telomerase is a~~ ribonucleoprotein enzyme ~~essential for~~ the ~~replication of chromosome termini in most eukaryotes. It elongates telomeres~~. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (~~By similarity~~).		[https://www.uniprot.org/uniprot/TERT_TETTS TERT_TETTS] Catalytic component of telomerase, an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747). TERT is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (PubMed:10944124, PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:16462747).<ref>PMID:10944124</ref> <ref>PMID:15696174</ref> <ref>PMID:16462747</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Telomerase\|Telomerase]]
	*[[Telomerase 3D structures\|Telomerase 3D structures]]		*[[Telomerase 3D structures\|Telomerase 3D structures]]
	*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]		*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~RNA-directed DNA polymerase]]~~		[[Category: Tetrahymena thermophila]]
	~~[[Category: Tetth~~]]		[[Category: Cech TR]]
	[[Category: Cech~~, T R~~]]		[[Category: Jacobs SA]]
	[[Category: Jacobs~~, S A~~]]		[[Category: Podell ER]]
	[[Category: Podell~~, E R]]~~
	~~[[Category: Reverse transcriptase]]~~
	~~[[Category: Rt]]~~
	~~[[Category: Telomerase]]~~
	~~[[Category: Tert]]~~
	~~[[Category: Transferase~~]]

OCA at 08:42, 27 January 2021

2021-01-27T08:42:16Z

← Older revision		Revision as of 08:42, 27 January 2021
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	==Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase==		==Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase==
	<StructureSection load='2b2a' size='340' side='right' caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2b2a' size='340' side='right'caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Tetth Tetth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B2A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetth Tetth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B2A FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [~~http~~://pdbe.org/2b2a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b2a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [https://pdbe.org/2b2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [https://www.ebi.ac.uk/pdbsum/2b2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TERT_TETTH TERT_TETTH]] Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).		[[https://www.uniprot.org/uniprot/TERT_TETTH TERT_TETTH]] Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Reverse transcriptase\|Reverse transcriptase]]
	*[[Telomerase\|Telomerase]]		*[[Telomerase\|Telomerase]]
	*[[Telomerase 3D structures\|Telomerase 3D structures]]		*[[Telomerase 3D structures\|Telomerase 3D structures]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: RNA-directed DNA polymerase]]		[[Category: RNA-directed DNA polymerase]]
	[[Category: Tetth]]		[[Category: Tetth]]

OCA at 06:21, 16 May 2018

2018-05-16T06:21:19Z

← Older revision		Revision as of 06:21, 16 May 2018
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	==Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase==		==Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase==
	<StructureSection load='2b2a' size='340' side='right' caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2b2a' size='340' side='right' caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>
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	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://pdbe.org/2b2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://pdbe.org/2b2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b2a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	==See Also==		==See Also==
	*[[Reverse transcriptase\|Reverse transcriptase]]		*[[Reverse transcriptase\|Reverse transcriptase]]
			*[[Telomerase\|Telomerase]]
	*[[Telomerase 3D structures\|Telomerase 3D structures]]		*[[Telomerase 3D structures\|Telomerase 3D structures]]
	*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]		*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]

OCA at 03:07, 11 September 2015

2015-09-11T03:07:48Z

← Older revision		Revision as of 03:07, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2b2a' size='340' side='right' caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>		<StructureSection load='2b2a' size='340' side='right' caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Tetrahymena_thermophila Tetrahymena thermophila~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetth Tetth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2A FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 ~~Tetrahymena thermophila~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 TETTH])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://pdbe.org/2b2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2b2a" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 27:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: RNA-directed DNA polymerase]]		[[Category: RNA-directed DNA polymerase]]
	[[Category: ~~Tetrahymena thermophila~~]]		[[Category: Tetth]]
	[[Category: Cech, T R]]		[[Category: Cech, T R]]
	[[Category: Jacobs, S A]]		[[Category: Jacobs, S A]]

OCA at 10:15, 25 December 2014

2014-12-25T10:15:23Z

← Older revision		Revision as of 10:15, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2A FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 Tetrahymena thermophila])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 Tetrahymena thermophila])</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TERT_TETTH TERT_TETTH]] Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
	*[[Reverse transcriptase\|Reverse transcriptase]]		*[[Reverse transcriptase\|Reverse transcriptase]]
	*[[Telomerase\|Telomerase]]		*[[Telomerase 3D structures\|Telomerase 3D structures]]
	*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]		*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]
	== References ==		== References ==
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	[[Category: RNA-directed DNA polymerase]]		[[Category: RNA-directed DNA polymerase]]
	[[Category: Tetrahymena thermophila]]		[[Category: Tetrahymena thermophila]]
	[[Category: Cech, T R.]]		[[Category: Cech, T R]]
	[[Category: Jacobs, S A.]]		[[Category: Jacobs, S A]]
	[[Category: Podell, E R.]]		[[Category: Podell, E R]]
	[[Category: Reverse transcriptase]]		[[Category: Reverse transcriptase]]
	[[Category: Rt]]		[[Category: Rt]]

OCA at 05:36, 29 September 2014

2014-09-29T05:36:17Z

← Older revision		Revision as of 05:36, 29 September 2014
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	[[~~Image~~:2b2a.~~png\|left\|200px~~]]		==Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase==
			<StructureSection load='2b2a' size='340' side='right' caption='[[2b2a]], [[Resolution\|resolution]] 2.22Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2b2a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B2A FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TERT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5911 Tetrahymena thermophila])</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_DNA_polymerase RNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.49 2.7.7.49] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b2a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b2a RCSB], [http://www.ebi.ac.uk/pdbsum/2b2a PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Telomerase, a ribonucleoprotein enzyme, adds telomeric DNA repeats to the ends of linear chromosomes. Here we report the first high-resolution structure of any portion of the telomerase reverse transcriptase, the telomerase essential N-terminal (TEN) domain from Tetrahymena thermophila. The structure, which seems to represent a novel protein fold, shows phylogenetically conserved amino acid residues in a groove on its surface. These residues are crucial for telomerase catalytic activity, and several of them are required for sequence-specific binding of a single-stranded telomeric DNA primer. The positively charged C terminus, which becomes ordered upon interaction with other macromolecules, is involved in binding RNA in a non-sequence-specific manner. The TEN domain's ability to bind both RNA and telomeric DNA, coupled with the notably strong effects on activity upon mutagenesis of single surface residues, suggest how this domain contributes to telomerase catalysis.

	~~{{STRUCTURE_2b2a\| PDB=2b2a \| SCENE= }}~~		Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase.,Jacobs SA, Podell ER, Cech TR Nat Struct Mol Biol. 2006 Mar;13(3):218-25. Epub 2006 Feb 5. PMID:16462747<ref>PMID:16462747</ref>

	~~===Crystal Structure of the TEN domain~~ of the ~~Telomerase Reverse Transcriptase===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16462747}}~~

	~~==About this Structure==~~
	~~[[2b2a]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA].~~

	==See Also==		==See Also==
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	*[[Telomerase\|Telomerase]]		*[[Telomerase\|Telomerase]]
	*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]		*[[Telomerase Reverse Transcriptase\|Telomerase Reverse Transcriptase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016462747<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: RNA-directed DNA polymerase]]		[[Category: RNA-directed DNA polymerase]]
	[[Category: Tetrahymena thermophila]]		[[Category: Tetrahymena thermophila]]

OCA at 15:31, 20 October 2012

2012-10-20T15:31:43Z

← Older revision		Revision as of 15:31, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2b2a]] is a 3 chain structure ~~of [[Reverse transcriptase]], [[Telomerase]] and [[Telomerase Reverse Transcriptase]]~~ with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA].		[[2b2a]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B2A OCA].

	==See Also==		==See Also==

OCA at 18:39, 26 July 2012

2012-07-26T18:39:41Z

← Older revision		Revision as of 18:39, 26 July 2012
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	[[Image:2b2a.png\|left\|200px]]		[[Image:2b2a.png\|left\|200px]]

	~~<!--~~
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	{{STRUCTURE_2b2a\| PDB=2b2a \| SCENE= }}		{{STRUCTURE_2b2a\| PDB=2b2a \| SCENE= }}

	===Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase===		===Crystal Structure of the TEN domain of the Telomerase Reverse Transcriptase===


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OCA: Protected "2b2a" [edit=sysop:move=sysop]

2012-06-06T13:45:14Z

Protected "2b2a" [edit=sysop:move=sysop]

← Older revision	Revision as of 13:45, 6 June 2012
(No difference)