2b3d - Revision history

OCA at 14:54, 20 September 2023

2023-09-20T14:54:03Z

← Older revision		Revision as of 14:54, 20 September 2023
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [https://pdbe.org/2b3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [https://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [https://pdbe.org/2b3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [https://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>
	</table>		</table>

OCA at 05:48, 31 May 2023

2023-05-31T05:48:08Z

← Older revision		Revision as of 05:48, 31 May 2023
Line 3:		Line 3:
	<StructureSection load='2b3d' size='340' side='right'caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2b3d' size='340' side='right'caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2amj\|2amj]]</div></td></tr>~~
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [https://pdbe.org/2b3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [https://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [https://pdbe.org/2b3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [https://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/MDAB_ECOLI MDAB_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Adams~~, M A~~]]		[[Category: Adams MA]]
	[[Category: Jia, Z]]		[[Category: Jia Z]]
	~~[[Category: Dt-diaphorase]]~~
	~~[[Category: Menadione reductase]]~~
	~~[[Category: Modulator of drug activity b]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Quinone~~]]

OCA at 09:42, 5 May 2021

2021-05-05T09:42:24Z

← Older revision		Revision as of 09:42, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2b3d' size='340' side='right'caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2b3d' size='340' side='right'caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2amj\|2amj]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [~~http~~://pdbe.org/2b3d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [https://pdbe.org/2b3d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [https://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 09:10, 24 July 2019

2019-07-24T09:10:10Z

← Older revision		Revision as of 09:10, 24 July 2019
Line 1:		Line 1:

	==Crystal structure of Modulator of Drug activity B in complex with flavin adenine dinucleotide==		==Crystal structure of Modulator of Drug activity B in complex with flavin adenine dinucleotide==
	<StructureSection load='2b3d' size='340' side='right' caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2b3d' size='340' side='right'caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
Line 12:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3d_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Adams, M A]]		[[Category: Adams, M A]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]

OCA at 13:16, 12 October 2017

2017-10-12T13:16:02Z

← Older revision		Revision as of 13:16, 12 October 2017
Line 1:		Line 1:

	==Crystal structure of Modulator of Drug activity B in complex with flavin adenine dinucleotide==		==Crystal structure of Modulator of Drug activity B in complex with flavin adenine dinucleotide==
	<StructureSection load='2b3d' size='340' side='right' caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2b3d' size='340' side='right' caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://pdbe.org/2b3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://pdbe.org/2b3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3d ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 22:43, 7 February 2016

2016-02-07T22:43:59Z

← Older revision		Revision as of 22:43, 7 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b3d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:33, 10 September 2015

2015-09-10T05:33:44Z

← Older revision		Revision as of 05:33, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2b3d' size='340' side='right' caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2b3d' size='340' side='right' caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://pdbe.org/2b3d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2b3d" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Adams, M A]]		[[Category: Adams, M A]]
	[[Category: Jia, Z]]		[[Category: Jia, Z]]

OCA at 09:12, 8 January 2015

2015-01-08T09:12:29Z

← Older revision		Revision as of 09:12, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 30:
	</StructureSection>		</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Adams, M A.]]		[[Category: Adams, M A]]
	[[Category: Jia, Z.]]		[[Category: Jia, Z]]
	[[Category: Dt-diaphorase]]		[[Category: Dt-diaphorase]]
	[[Category: Menadione reductase]]		[[Category: Menadione reductase]]

OCA at 01:45, 30 September 2014

2014-09-30T01:45:12Z

← Older revision		Revision as of 01:45, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2b3d~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal structure of Modulator of Drug activity B in complex with flavin adenine dinucleotide==
			<StructureSection load='2b3d' size='340' side='right' caption='[[2b3d]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2b3d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B3D FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2amj\|2amj]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b3d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b3d RCSB], [http://www.ebi.ac.uk/pdbsum/2b3d PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3d_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Modulator of drug activity B (MdaB) is a putative member of the DT-diaphorase family of NAD(P)H:oxidoreductases that afford cellular protection against quinonoid compounds. While there have been extensive investigations of mammalian homologues, putative prokaryotic members of this enzyme family have received little attention. The three-dimensional crystal structure of apo-MdaB reported herein exhibits significant structural similarity to a number of flavoproteins, including the mammalian DT-diaphorases. We have shown by mass spectrometry that the endogenously associated cofactor is flavin adenine dinucleotide and we present here the structure of MdaB in complex with this compound. Growth of Escherichia coli carrying null mutations in the genes encoding MdaB or quinol monooxygenase, the gene for which shares the mdaB promoter, were not affected by the presence of menadione. However, over-expression of recombinant quinol monooxygenase conferred a state of resistance against both tetracycline and adriamycin. This work suggests that the redox cycle formed by these proteins protects E. coli from the toxic effects of polyketide compounds rather than the oxidative stress of menadione alone.

	~~{{STRUCTURE_2b3d\| PDB=2b3d \| SCENE= }}~~		Modulator of drug activity B from Escherichia coli: crystal structure of a prokaryotic homologue of DT-diaphorase.,Adams MA, Jia Z J Mol Biol. 2006 Jun 2;359(2):455-65. Epub 2006 Apr 7. PMID:16630630<ref>PMID:16630630</ref>

	~~===Crystal structure of Modulator~~ of ~~Drug activity B in complex with flavin adenine dinucleotide===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16630630}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2b3d]] is a 2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2B3D OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016630630<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Adams, M A.]]		[[Category: Adams, M A.]]

OCA: Protected "2b3d" [edit=sysop:move=sysop]

2013-01-06T10:59:42Z

Protected "2b3d" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:59, 6 January 2013
(No difference)