2b7e - Revision history

OCA at 09:24, 22 May 2024

2024-05-22T09:24:00Z

← Older revision		Revision as of 09:24, 22 May 2024
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	==First FF domain of Prp40 Yeast Protein==		==First FF domain of Prp40 Yeast Protein==
	<StructureSection load='2b7e' size='340' side='right'caption='[[2b7e~~]], [[NMR_Ensembles_of_Models \| 12 NMR models~~]]' scene=''>		<StructureSection load='2b7e' size='340' side='right'caption='[[2b7e]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_18824 Atcc 18824~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7E FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>PRP40 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~4932 ATCC 18824])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [https://pdbe.org/2b7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [https://www.ebi.ac.uk/pdbsum/2b7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [https://pdbe.org/2b7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [https://www.ebi.ac.uk/pdbsum/2b7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref>		[https://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 18824]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gasch, A]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Macias~~, M J~~]]		[[Category: Gasch A]]
	[[Category: Martin-Malpartida, P]]		[[Category: Macias MJ]]
	[[Category: Ramirez-Espain, X]]		[[Category: Martin-Malpartida P]]
	[[Category: Ruiz, L]]		[[Category: Ramirez-Espain X]]
	[[Category: Wiesner, S]]		[[Category: Ruiz L]]
	~~[[Category: Structural protein~~]]		[[Category: Wiesner S]]

OCA at 11:37, 3 February 2021

2021-02-03T11:37:09Z

← Older revision		Revision as of 11:37, 3 February 2021
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	==First FF domain of Prp40 Yeast Protein==		==First FF domain of Prp40 Yeast Protein==
	<StructureSection load='2b7e' size='340' side='right' caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2b7e' size='340' side='right'caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B7E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [~~http~~://pdbe.org/2b7e PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b7e PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7e ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [https://pdbe.org/2b7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [https://www.ebi.ac.uk/pdbsum/2b7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref>		[[https://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	==See Also==		==See Also==
	*[[Pre-mRNA-splicing ~~factor~~\|Pre-mRNA-splicing ~~factor~~]]		*[[Pre-mRNA splicing factors 3D structures\|Pre-mRNA splicing factors 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 18824]]		[[Category: Atcc 18824]]
			[[Category: Large Structures]]
	[[Category: Gasch, A]]		[[Category: Gasch, A]]
	[[Category: Macias, M J]]		[[Category: Macias, M J]]

OCA at 06:40, 16 May 2018

2018-05-16T06:40:56Z

← Older revision		Revision as of 06:40, 16 May 2018
Line 1:		Line 1:

	==First FF domain of Prp40 Yeast Protein==		==First FF domain of Prp40 Yeast Protein==
	<StructureSection load='2b7e' size='340' side='right' caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2b7e' size='340' side='right' caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
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	<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://pdbe.org/2b7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://pdbe.org/2b7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b7e ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7e_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7e_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:13, 7 February 2016

2016-02-07T21:13:51Z

← Older revision		Revision as of 21:13, 7 February 2016
Line 16:		Line 16:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b7e ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:02, 10 September 2015

2015-09-10T05:02:30Z

← Older revision		Revision as of 05:02, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2b7e' size='340' side='right' caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>		<StructureSection load='2b7e' size='340' side='right' caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Saccharomyces_cerevisiae Saccharomyces cerevisiae~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ~~Saccharomyces cerevisiae~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://pdbe.org/2b7e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2b7e" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharomyces cerevisiae~~]]		[[Category: Atcc 18824]]
	[[Category: Gasch, A]]		[[Category: Gasch, A]]
	[[Category: Macias, M J]]		[[Category: Macias, M J]]

OCA at 18:18, 24 December 2014

2014-12-24T18:18:13Z

← Older revision		Revision as of 18:18, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Gasch, A.]]		[[Category: Gasch, A]]
	[[Category: Macias, M J.]]		[[Category: Macias, M J]]
	[[Category: Martin-Malpartida, P.]]		[[Category: Martin-Malpartida, P]]
	[[Category: Ramirez-Espain, X.]]		[[Category: Ramirez-Espain, X]]
	[[Category: Ruiz, L.]]		[[Category: Ruiz, L]]
	[[Category: Wiesner, S.]]		[[Category: Wiesner, S]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

OCA at 01:12, 30 September 2014

2014-09-30T01:12:32Z

← Older revision		Revision as of 01:12, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2b7e~~.~~png~~\|~~left~~\|~~200px~~]]		==First FF domain of Prp40 Yeast Protein==
			<StructureSection load='2b7e' size='340' side='right' caption='[[2b7e]], [[NMR_Ensembles_of_Models \| 12 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B7E FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PRP40 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b7e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b7e RCSB], [http://www.ebi.ac.uk/pdbsum/2b7e PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b7/2b7e_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The yeast splicing factor Prp40 (pre-mRNA processing protein 40) consists of a pair of WW domains followed by several FF domains. The region comprising the FF domains has been shown to associate with the 5' end of U1 small nuclear RNA and to interact directly with two proteins, the Clf1 (Crooked neck-like factor 1) and the phosphorylated repeats of the C-terminal domain of RNA polymerase II (CTD-RNAPII). In this work we reported the solution structure of the first FF domain of Prp40 and the identification of a novel ligand-binding site in FF domains. By using chemical shift assays, we found a binding site for the N-terminal crooked neck tetratricopeptide repeat of Clf1 that is distinct and structurally separate from the previously identified CTD-RNAPII binding pocket of the FBP11 (formin-binding protein 11) FF1 domain. No interaction, however, was observed between the Prp40 FF1 domain and three different peptides derived from the CTD-RNAPII protein. Indeed, the equivalent CTD-RNAPII-binding site in the Prp40 FF1 domain is predominantly negatively charged and thus unfavorable for an interaction with phosphorylated peptide sequences. Sequence alignments and phylogenetic tree reconstructions using the FF domains of three functionally related proteins, Prp40, FBP11, and CA150, revealed that Prp40 and FBP11 are not orthologous proteins and supported the different ligand specificities shown by their respective FF1 domains. Our results also revealed that not all FF domains in Prp40 are functionally equivalent. We proposed that at least two different interaction surfaces exist in FF domains that have evolved to recognize distinct binding motifs.

	~~{{STRUCTURE_2b7e\| PDB=2b7e \| SCENE= }}~~		The structure of Prp40 FF1 domain and its interaction with the crn-TPR1 motif of Clf1 gives a new insight into the binding mode of FF domains.,Gasch A, Wiesner S, Martin-Malpartida P, Ramirez-Espain X, Ruiz L, Macias MJ J Biol Chem. 2006 Jan 6;281(1):356-64. Epub 2005 Oct 27. PMID:16253993<ref>PMID:16253993</ref>

	~~===First FF domain~~ of ~~Prp40 Yeast Protein===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_16253993}}~~		==See Also==
			*[[Pre-mRNA-splicing factor\|Pre-mRNA-splicing factor]]
	==~~About this Structure~~==		== References ==
	[[~~2b7e~~]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:016253993<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Gasch, A.]]		[[Category: Gasch, A.]]

OCA: Protected "2b7e" [edit=sysop:move=sysop]

2013-01-06T10:28:09Z

Protected "2b7e" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:28, 6 January 2013
(No difference)

OCA at 10:28, 6 January 2013

2013-01-06T10:28:07Z

← Older revision		Revision as of 10:28, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2b7e.png\|left\|200px]]		[[Image:2b7e.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2b7e", creates the "Structure Box" on the page.~~
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	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2b7e\| PDB=2b7e \| SCENE= }}		{{STRUCTURE_2b7e\| PDB=2b7e \| SCENE= }}

	===First FF domain of Prp40 Yeast Protein===		===First FF domain of Prp40 Yeast Protein===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16253993}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_16253993}}		{{ABSTRACT_PUBMED_16253993}}

	==About this Structure==		==About this Structure==
	~~2B7E~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA].		[[2b7e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16253993~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016253993</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Gasch, A.]]		[[Category: Gasch, A.]]
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	[[Category: Wiesner, S.]]		[[Category: Wiesner, S.]]
	[[Category: Structural protein]]		[[Category: Structural protein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:33:33 2009''~~

OCA at 14:33, 16 February 2009

2009-02-16T14:33:35Z

← Older revision		Revision as of 14:33, 16 February 2009
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	==About this Structure==		==About this Structure==
	2B7E is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA].		2B7E is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B7E OCA].

	==Reference==		==Reference==
	The structure of Prp40 FF1 domain and its interaction with the crn-TPR1 motif of Clf1 gives a new insight into the binding mode of FF domains., Gasch A, Wiesner S, Martin-Malpartida P, Ramirez-Espain X, Ruiz L, Macias MJ, J Biol Chem. 2006 Jan 6;281(1):356-64. Epub 2005 Oct 27. PMID:~~[http:~~//~~www.ncbi.nlm.nih.gov/pubmed/16253993 16253993]~~		<ref group="xtra">PMID:16253993</ref><references group="xtra"/>
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	~~[[Category: Single protein]]~~
	[[Category: Gasch, A.]]		[[Category: Gasch, A.]]
	[[Category: Macias, M J.]]		[[Category: Macias, M J.]]
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	[[Category: Structural protein]]		[[Category: Structural protein]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun Jul 27 19~~:45:~~58 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:33:33 2009''