2b8a - Revision history

OCA at 09:24, 22 May 2024

2024-05-22T09:24:09Z

← Older revision		Revision as of 09:24, 22 May 2024
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	==High Resolution Structure of the HDGF PWWP Domain==		==High Resolution Structure of the HDGF PWWP Domain==
	<StructureSection load='2b8a' size='340' side='right'caption='[[2b8a~~]], [[NMR_Ensembles_of_Models \| 26 NMR models~~]]' scene=''>		<StructureSection load='2b8a' size='340' side='right'caption='[[2b8a]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B8A FirstGlance]. <br>
	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>Hdgf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~10116 Buffalo rat])~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [https://pdbe.org/2b8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [https://www.ebi.ac.uk/pdbsum/2b8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [https://pdbe.org/2b8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [https://www.ebi.ac.uk/pdbsum/2b8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HDGF_RAT HDGF_RAT]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).		[https://www.uniprot.org/uniprot/HDGF_RAT HDGF_RAT] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Borloz, M]]		[[Category: Rattus norvegicus]]
	[[Category: Bushweller~~, J H~~]]		[[Category: Borloz M]]
	[[Category: Cierpicki, T]]		[[Category: Bushweller JH]]
	[[Category: Everett, A]]		[[Category: Cierpicki T]]
	[[Category: Grembecka, J]]		[[Category: Everett A]]
	[[Category: Lukasik~~, S M]]~~		[[Category: Grembecka J]]
	~~[[Category: Hdgf]]~~		[[Category: Lukasik SM]]
	~~[[Category: Hormone-growth factor complex]]~~
	~~[[Category: Pwwp~~]]

OCA at 11:37, 3 February 2021

2021-02-03T11:37:42Z

← Older revision		Revision as of 11:37, 3 February 2021
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	==High Resolution Structure of the HDGF PWWP Domain==		==High Resolution Structure of the HDGF PWWP Domain==
	<StructureSection load='2b8a' size='340' side='right' caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>		<StructureSection load='2b8a' size='340' side='right'caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2B8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B8A FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [~~http~~://pdbe.org/2b8a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2b8a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8a ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [https://pdbe.org/2b8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [https://www.ebi.ac.uk/pdbsum/2b8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HDGF_RAT HDGF_RAT]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).		[[https://www.uniprot.org/uniprot/HDGF_RAT HDGF_RAT]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Borloz, M]]		[[Category: Borloz, M]]
	[[Category: Bushweller, J H]]		[[Category: Bushweller, J H]]

OCA at 06:46, 16 May 2018

2018-05-16T06:46:08Z

← Older revision		Revision as of 06:46, 16 May 2018
Line 1:		Line 1:

	==High Resolution Structure of the HDGF PWWP Domain==		==High Resolution Structure of the HDGF PWWP Domain==
	<StructureSection load='2b8a' size='340' side='right' caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>		<StructureSection load='2b8a' size='340' side='right' caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://pdbe.org/2b8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://pdbe.org/2b8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2b8a ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/2b8a_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/2b8a_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b8a ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:16, 11 September 2015

2015-09-11T13:16:00Z

← Older revision		Revision as of 13:16, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2b8a' size='340' side='right' caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>		<StructureSection load='2b8a' size='340' side='right' caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>
	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 ~~Rattus norvegicus~~])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://pdbe.org/2b8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2b8a" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Rattus norvegicus~~]]		[[Category: Buffalo rat]]
	[[Category: Borloz, M]]		[[Category: Borloz, M]]
	[[Category: Bushweller, J H]]		[[Category: Bushweller, J H]]

OCA at 16:56, 25 December 2014

2014-12-25T16:56:10Z

← Older revision		Revision as of 16:56, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>		<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>		</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HDGF_RAT HDGF_RAT]] Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Borloz, M.]]		[[Category: Borloz, M]]
	[[Category: Bushweller, J H.]]		[[Category: Bushweller, J H]]
	[[Category: Cierpicki, T.]]		[[Category: Cierpicki, T]]
	[[Category: Everett, A.]]		[[Category: Everett, A]]
	[[Category: Grembecka, J.]]		[[Category: Grembecka, J]]
	[[Category: Lukasik, S M.]]		[[Category: Lukasik, S M]]
	[[Category: Hdgf]]		[[Category: Hdgf]]
	[[Category: Hormone-growth factor complex]]		[[Category: Hormone-growth factor complex]]
	[[Category: Pwwp]]		[[Category: Pwwp]]

OCA at 02:57, 30 September 2014

2014-09-30T02:57:00Z

← Older revision		Revision as of 02:57, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2b8a~~.~~png~~\|~~left~~\|~~200px~~]]		==High Resolution Structure of the HDGF PWWP Domain==
			<StructureSection load='2b8a' size='340' side='right' caption='[[2b8a]], [[NMR_Ensembles_of_Models \| 26 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2B8A FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Hdgf ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2b8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b8a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2b8a RCSB], [http://www.ebi.ac.uk/pdbsum/2b8a PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/2b8a_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Hepatoma Derived Growth Factor (HDGF) is an endogenous nuclear-targeted mitogen that is linked with human disease. HDGF is a member of the weakly conserved PWWP domain family. This 70-amino acid motif, originally identified from the WHSC1 gene, has been found in more than 60 eukaryotic proteins. In addition to the PWWP domain, many proteins in this class contain known chromatin remodeling domains, suggesting a role for HDGF in chromatin remodeling. We have determined the NMR structure of the HDGF PWWP domain to high resolution using a combination of NOEs, J-couplings, and dipolar couplings. Comparison of this structure to a previously determined structure of the HDGF PWWP domain shows a significant difference in the C-terminal region. Comparison to structures of other PWWP domains shows a high degree of similarity to the PWWP domain structures from Dnmt3b and mHRP. The results of selected and amplified binding assay and NMR titrations with DNA suggest that the HDGF PWWP domain may function as a nonspecific DNA-binding domain. Based on the NMR titrations, we propose a model of the interaction of the PWWP domain with DNA.

	~~{{STRUCTURE_2b8a\| PDB=2b8a \| SCENE= }}~~		High resolution structure of the HDGF PWWP domain: a potential DNA binding domain.,Lukasik SM, Cierpicki T, Borloz M, Grembecka J, Everett A, Bushweller JH Protein Sci. 2006 Feb;15(2):314-23. Epub 2005 Dec 29. PMID:16384999<ref>PMID:16384999</ref>

	~~===High Resolution Structure~~ of the ~~HDGF PWWP Domain===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16384999}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2b8a]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full experimental information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016384999<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Borloz, M.]]		[[Category: Borloz, M.]]

OCA: Protected "2b8a" [edit=sysop:move=sysop]

2013-01-06T12:07:14Z

Protected "2b8a" [edit=sysop:move=sysop]

← Older revision	Revision as of 12:07, 6 January 2013
(No difference)

OCA at 12:07, 6 January 2013

2013-01-06T12:07:12Z

← Older revision		Revision as of 12:07, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2b8a.png\|left\|200px]]		[[Image:2b8a.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2b8a", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2b8a\| PDB=2b8a \| SCENE= }}		{{STRUCTURE_2b8a\| PDB=2b8a \| SCENE= }}

	===High Resolution Structure of the HDGF PWWP Domain===		===High Resolution Structure of the HDGF PWWP Domain===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16384999}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16384999 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16384999}}		{{ABSTRACT_PUBMED_16384999}}

	==About this Structure==		==About this Structure==
	~~2B8A~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].		[[2b8a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16384999~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016384999</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Borloz, M.]]		[[Category: Borloz, M.]]
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	[[Category: Lukasik, S M.]]		[[Category: Lukasik, S M.]]
	[[Category: Hdgf]]		[[Category: Hdgf]]
			[[Category: Hormone-growth factor complex]]
	[[Category: Pwwp]]		[[Category: Pwwp]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:27:30 2009''~~

OCA at 20:27, 17 February 2009

2009-02-17T20:27:32Z

← Older revision		Revision as of 20:27, 17 February 2009
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	==About this Structure==		==About this Structure==
	2B8A is a ~~[[Single protein]]~~ structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].		2B8A is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].

	==Reference==		==Reference==
	High resolution structure of the HDGF PWWP domain: a potential DNA binding domain., Lukasik SM, Cierpicki T, Borloz M, Grembecka J, Everett A, Bushweller JH, Protein Sci. 2006 Feb;15(2):314-23. Epub 2005 Dec 29. PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~16384999 16384999]~~		<ref group="xtra">PMID:16384999</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	~~[[Category: Single protein]]~~
	[[Category: Borloz, M.]]		[[Category: Borloz, M.]]
	[[Category: Bushweller, J H.]]		[[Category: Bushweller, J H.]]
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	[[Category: Pwwp]]		[[Category: Pwwp]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue ~~Jul 29 06~~:40:~~15 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 22:27:30 2009''

OCA at 03:40, 29 July 2008

2008-07-29T03:40:21Z

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	{{STRUCTURE_2b8a\| PDB=2b8a \| SCENE= }}		{{STRUCTURE_2b8a\| PDB=2b8a \| SCENE= }}

	~~'''~~High Resolution Structure of the HDGF PWWP Domain~~'''~~		===High Resolution Structure of the HDGF PWWP Domain===


	~~==Overview==~~		<!--
	~~Hepatoma Derived Growth Factor (HDGF) is an endogenous nuclear~~-~~targeted mitogen that is linked with human disease. HDGF is a member of the weakly conserved PWWP domain family. This 70~~-~~amino acid motif, originally identified from the WHSC1 gene, has been found in more than 60 eukaryotic proteins. In addition to the PWWP domain, many proteins in~~ this class contain known chromatin remodeling domains, suggesting a role for HDGF in chromatin remodeling. We have determined the NMR structure of the HDGF PWWP domain to high resolution using a combination of NOEs, ~~J-couplings~~, ~~and dipolar couplings. Comparison of this structure to a previously determined structure of the HDGF PWWP domain shows a significant difference in~~ the ~~C-terminal region. Comparison to structures of other PWWP domains shows a high degree of similarity~~ to the ~~PWWP domain structures from Dnmt3b and mHRP~~. ~~The results of selected and amplified binding assay and NMR titrations with DNA suggest that the HDGF PWWP domain may function as a nonspecific DNA-binding domain~~. ~~Based on the NMR titrations~~, ~~we propose a model of~~ the ~~interaction of the PWWP domain with DNA~~.		The line below this paragraph, {{ABSTRACT_PUBMED_16384999}}, adds the Publication Abstract to the page
			(as it appears on PubMed at http://www.pubmed.gov), where 16384999 is the PubMed ID number.
			-->
			{{ABSTRACT_PUBMED_16384999}}

	==About this Structure==		==About this Structure==
	2B8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].		2B8A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B8A OCA].

	==Reference==		==Reference==
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	[[Category: Hdgf]]		[[Category: Hdgf]]
	[[Category: Pwwp]]		[[Category: Pwwp]]
	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 19~~:58:34 2008''
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