2bb5 - Revision history

OCA at 07:52, 30 October 2024

2024-10-30T07:52:21Z

← Older revision		Revision as of 07:52, 30 October 2024
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
	~~<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>~~
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [https://pdbe.org/2bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [https://pdbe.org/2bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>
	</table>		</table>
Line 17:		Line 16:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bb5_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bb5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:36, 23 August 2023

2023-08-23T07:36:10Z

← Older revision		Revision as of 07:36, 23 August 2023
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	<StructureSection load='2bb5' size='340' side='right'caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2bb5' size='340' side='right'caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B12:COBALAMIN'>B12</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style~~=~~'overflow: auto; max-height: 3em;'~~>~~[[2bb6\|2bb6]], [[2bbc\|2bbc]]~~<~~/div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~TCN2, TC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [https://pdbe.org/2bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [https://pdbe.org/2bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[https://omim.org/entry/275350 275350]]. This results in various forms of anemia.		[https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[https://omim.org/entry/275350 275350]. This results in various forms of anemia.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.		[https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fedosov~~, S N~~]]		[[Category: Fedosov SN]]
	[[Category: Garau, G]]		[[Category: Garau G]]
	[[Category: Geremia, S]]		[[Category: Geremia S]]
	[[Category: Petersen~~, T E~~]]		[[Category: Petersen TE]]
	[[Category: Randaccio, L]]		[[Category: Randaccio L]]
	[[Category: Wuerges, J]]		[[Category: Wuerges J]]
	~~[[Category: Alpha_6 - alpha_6 barrel]]~~
	~~[[Category: Transport protein~~]]

OCA at 11:39, 3 February 2021

2021-02-03T11:39:06Z

← Older revision		Revision as of 11:39, 3 February 2021
Line 1:		Line 1:

	==Structure of Human Transcobalamin in complex with Cobalamin==		==Structure of Human Transcobalamin in complex with Cobalamin==
	<StructureSection load='2bb5' size='340' side='right' caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2bb5' size='340' side='right'caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bb6\|2bb6]], [[2bbc\|2bbc]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [~~http~~://pdbe.org/2bb5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [https://pdbe.org/2bb5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [https://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[~~http~~://omim.org/entry/275350 275350]]. This results in various forms of anemia.		[[https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[https://omim.org/entry/275350 275350]]. This results in various forms of anemia.
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.		[[https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Fedosov, S N]]		[[Category: Fedosov, S N]]
	[[Category: Garau, G]]		[[Category: Garau, G]]

OCA at 06:49, 16 May 2018

2018-05-16T06:49:26Z

← Older revision		Revision as of 06:49, 16 May 2018
Line 1:		Line 1:

	==Structure of Human Transcobalamin in complex with Cobalamin==		==Structure of Human Transcobalamin in complex with Cobalamin==
	<StructureSection load='2bb5' size='340' side='right' caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2bb5' size='340' side='right' caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://pdbe.org/2bb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://pdbe.org/2bb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bb5 ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bb5_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bb5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 05:24, 10 February 2016

2016-02-10T05:24:05Z

← Older revision		Revision as of 05:24, 10 February 2016
Line 20:		Line 20:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bb5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:47, 11 September 2015

2015-09-11T05:47:53Z

← Older revision		Revision as of 05:47, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2bb5' size='340' side='right' caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>		<StructureSection load='2bb5' size='340' side='right' caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://pdbe.org/2bb5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bb5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Fedosov, S N]]		[[Category: Fedosov, S N]]
	[[Category: Garau, G]]		[[Category: Garau, G]]

OCA at 10:38, 8 January 2015

2015-01-08T10:38:02Z

← Older revision		Revision as of 10:38, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia.		[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia.
Line 35:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fedosov, S N.]]		[[Category: Fedosov, S N]]
	[[Category: Garau, G.]]		[[Category: Garau, G]]
	[[Category: Geremia, S.]]		[[Category: Geremia, S]]
	[[Category: Petersen, T E.]]		[[Category: Petersen, T E]]
	[[Category: Randaccio, L.]]		[[Category: Randaccio, L]]
	[[Category: Wuerges, J.]]		[[Category: Wuerges, J]]
	[[Category: Alpha_6 - alpha_6 barrel]]		[[Category: Alpha_6 - alpha_6 barrel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 01:20, 30 September 2014

2014-09-30T01:20:44Z

← Older revision		Revision as of 01:20, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2bb5\| PDB=2bb5 \| SCENE= }}~~		==Structure of Human Transcobalamin in complex with Cobalamin==
	===Structure of Human Transcobalamin in complex with Cobalamin===		<StructureSection load='2bb5' size='340' side='right' caption='[[2bb5]], [[Resolution\|resolution]] 3.20Å' scene=''>
	~~{{ABSTRACT_PUBMED_16537422}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2bb5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BB5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BB5 FirstGlance]. <br>
	==Disease==		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb6\|2bb6]], [[2bbc\|2bbc]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bb5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bb5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bb5 RCSB], [http://www.ebi.ac.uk/pdbsum/2bb5 PDBsum]</span></td></tr>
			<table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia.		[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia.
			== Function ==
	==Function==
	[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.		[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bb5_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Cobalamin (Cbl, vitamin B(12)) serves for two essential cofactors in mammals. The pathway for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors and three Cbl-transporting proteins, haptocorrin, intrinsic factor, and transcobalamin (TC). We present the structure determination of a member of the mammalian Cbl-transporter family. The crystal structures of recombinant human and bovine holo-TCs reveal a two-domain architecture, with an N-terminal alpha(6)-alpha(6) barrel and a smaller C-terminal domain. One Cbl molecule in base-on conformation is buried inside the domain interface. Structural data combined with previous binding assays indicate a domain motion in the first step of Cbl binding. In a second step, the weakly coordinated ligand H(2)O at the upper axial side of added H(2)O-Cbl is displaced by a histidine residue of the alpha(6)-alpha(6) barrel. Analysis of amino acid conservation on TC's surface in orthologous proteins suggests the location of the TC-receptor-recognition site in an extended region on the alpha(6)-alpha(6) barrel. The TC structure allows for the mapping of sites of amino acid variation due to polymorphisms of the human TC gene. Structural information is used to predict the overall fold of haptocorrin and intrinsic factor and permits a rational approach to the design of new Cbl-based bioconjugates for diagnostic or therapeutic drug delivery.

	~~==About this Structure==~~		Structural basis for mammalian vitamin B12 transport by transcobalamin.,Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422<ref>PMID:16537422</ref>
	~~[[2bb5]] is a 2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http~~:~~//oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2BB5 OCA].~~

	==~~Reference~~==		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~<ref group="xtra">PMID:016537422</ref>~~<references ~~group="xtra"~~/><~~references~~/>		</div>
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fedosov, S N.]]		[[Category: Fedosov, S N.]]

OCA at 00:44, 25 March 2013

2013-03-25T00:44:21Z

← Older revision		Revision as of 00:44, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2bb5.png\|left\|200px]]~~

	{{STRUCTURE_2bb5\| PDB=2bb5 \| SCENE= }}		{{STRUCTURE_2bb5\| PDB=2bb5 \| SCENE= }}
			===Structure of Human Transcobalamin in complex with Cobalamin===
			{{ABSTRACT_PUBMED_16537422}}

	===~~Structure~~ of ~~Human Transcobalamin~~ in ~~complex with Cobalamin===~~		==Disease==
			[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[http://omim.org/entry/275350 275350]]. This results in various forms of anemia.

	~~{{ABSTRACT_PUBMED_16537422}}~~		==Function==
			[[http://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.

	==About this Structure==		==About this Structure==
Line 11:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:016537422</ref><references group="xtra"/>		<ref group="xtra">PMID:016537422</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Fedosov, S N.]]		[[Category: Fedosov, S N.]]

OCA: Protected "2bb5" [edit=sysop:move=sysop]

2012-10-24T06:27:57Z

Protected "2bb5" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:27, 24 October 2012
(No difference)