2bbc - Revision history

OCA at 07:52, 30 October 2024

2024-10-30T07:52:28Z

← Older revision		Revision as of 07:52, 30 October 2024
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	<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat">~~<scene name='pdbligand=B12:COBALAMIN'>B12</scene>,~~ <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [https://pdbe.org/2bbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [https://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [https://pdbe.org/2bbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [https://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>
	</table>		</table>
Line 15:		Line 15:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 07:36, 23 August 2023

2023-08-23T07:36:20Z

← Older revision		Revision as of 07:36, 23 August 2023
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	<StructureSection load='2bbc' size='340' side='right'caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bbc' size='340' side='right'caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=B12:COBALAMIN'>B12</scene>~~, ~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2bb5\|2bb5]], [[2bb6\|2bb6]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">TCN2, TC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [https://pdbe.org/2bbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [https://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [https://pdbe.org/2bbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [https://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TCO2_BOVIN TCO2_BOVIN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.		[https://www.uniprot.org/uniprot/TCO2_BOVIN TCO2_BOVIN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bovin~~]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Fedosov~~, S N~~]]		[[Category: Fedosov SN]]
	[[Category: Garau, G]]		[[Category: Garau G]]
	[[Category: Geremia, S]]		[[Category: Geremia S]]
	[[Category: Petersen~~, T E~~]]		[[Category: Petersen TE]]
	[[Category: Randaccio, L]]		[[Category: Randaccio L]]
	[[Category: Wuerges, J]]		[[Category: Wuerges J]]
	~~[[Category: Alpha_6 - alpha_6 barrel]]~~
	~~[[Category: Transport protein~~]]

OCA at 13:37, 13 October 2021

2021-10-13T13:37:12Z

← Older revision		Revision as of 13:37, 13 October 2021
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	<StructureSection load='2bbc' size='340' side='right'caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bbc' size='340' side='right'caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bb5\|2bb5]], [[2bb6\|2bb6]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [~~http~~://pdbe.org/2bbc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [https://pdbe.org/2bbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [https://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TCO2_BOVIN TCO2_BOVIN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.		[[https://www.uniprot.org/uniprot/TCO2_BOVIN TCO2_BOVIN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 15:49, 20 November 2019

2019-11-20T15:49:11Z

← Older revision		Revision as of 15:49, 20 November 2019
Line 1:		Line 1:

	==Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form==		==Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form==
	<StructureSection load='2bbc' size='340' side='right' caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bbc' size='340' side='right'caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
Line 15:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
			[[Category: Large Structures]]
	[[Category: Fedosov, S N]]		[[Category: Fedosov, S N]]
	[[Category: Garau, G]]		[[Category: Garau, G]]

OCA at 14:13, 12 October 2017

2017-10-12T14:13:35Z

← Older revision		Revision as of 14:13, 12 October 2017
Line 1:		Line 1:

	==Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form==		==Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form==
	<StructureSection load='2bbc' size='340' side='right' caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bbc' size='340' side='right' caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://pdbe.org/2bbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://pdbe.org/2bbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbc ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 23:33, 7 February 2016

2016-02-07T23:33:55Z

← Older revision		Revision as of 23:33, 7 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 05:52, 10 September 2015

2015-09-10T05:52:40Z

← Older revision		Revision as of 05:52, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bbc' size='340' side='right' caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='2bbc' size='340' side='right' caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 ~~Bos taurus~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://pdbe.org/2bbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bbc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bos taurus~~]]		[[Category: Bovin]]
	[[Category: Fedosov, S N]]		[[Category: Fedosov, S N]]
	[[Category: Garau, G]]		[[Category: Garau, G]]

OCA at 18:58, 24 December 2014

2014-12-24T18:58:59Z

← Older revision		Revision as of 18:58, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TCO2_BOVIN TCO2_BOVIN]] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Fedosov, S N.]]		[[Category: Fedosov, S N]]
	[[Category: Garau, G.]]		[[Category: Garau, G]]
	[[Category: Geremia, S.]]		[[Category: Geremia, S]]
	[[Category: Petersen, T E.]]		[[Category: Petersen, T E]]
	[[Category: Randaccio, L.]]		[[Category: Randaccio, L]]
	[[Category: Wuerges, J.]]		[[Category: Wuerges, J]]
	[[Category: Alpha_6 - alpha_6 barrel]]		[[Category: Alpha_6 - alpha_6 barrel]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

OCA at 03:42, 29 September 2014

2014-09-29T03:42:20Z

← Older revision		Revision as of 03:42, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2bbc~~.~~png~~\|~~left~~\|~~200px~~]]		==Structure of Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form==
			<StructureSection load='2bbc' size='340' side='right' caption='[[2bbc]], [[Resolution\|resolution]] 2.40Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2bbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BBC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bb5\|2bb5]], [[2bb6\|2bb6]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TCN2, TC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bbc RCSB], [http://www.ebi.ac.uk/pdbsum/2bbc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Cobalamin (Cbl, vitamin B(12)) serves for two essential cofactors in mammals. The pathway for its intestinal absorption, plasma transport, and cellular uptake uses cell surface receptors and three Cbl-transporting proteins, haptocorrin, intrinsic factor, and transcobalamin (TC). We present the structure determination of a member of the mammalian Cbl-transporter family. The crystal structures of recombinant human and bovine holo-TCs reveal a two-domain architecture, with an N-terminal alpha(6)-alpha(6) barrel and a smaller C-terminal domain. One Cbl molecule in base-on conformation is buried inside the domain interface. Structural data combined with previous binding assays indicate a domain motion in the first step of Cbl binding. In a second step, the weakly coordinated ligand H(2)O at the upper axial side of added H(2)O-Cbl is displaced by a histidine residue of the alpha(6)-alpha(6) barrel. Analysis of amino acid conservation on TC's surface in orthologous proteins suggests the location of the TC-receptor-recognition site in an extended region on the alpha(6)-alpha(6) barrel. The TC structure allows for the mapping of sites of amino acid variation due to polymorphisms of the human TC gene. Structural information is used to predict the overall fold of haptocorrin and intrinsic factor and permits a rational approach to the design of new Cbl-based bioconjugates for diagnostic or therapeutic drug delivery.

	~~{{STRUCTURE_2bbc\| PDB=2bbc \| SCENE= }}~~		Structural basis for mammalian vitamin B12 transport by transcobalamin.,Wuerges J, Garau G, Geremia S, Fedosov SN, Petersen TE, Randaccio L Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4386-91. Epub 2006 Mar 14. PMID:16537422<ref>PMID:16537422</ref>

	~~===Structure~~ of ~~Cobalamin-complexed Bovine Transcobalamin in trigonal crystal form===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16537422}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2bbc]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BBC OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016537422<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Fedosov, S N.]]		[[Category: Fedosov, S N.]]

OCA: Protected "2bbc" [edit=sysop:move=sysop]

2012-10-24T06:19:54Z

Protected "2bbc" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:19, 24 October 2012
(No difference)