2bc9 - Revision history

OCA at 07:36, 23 August 2023

2023-08-23T07:36:44Z

← Older revision		Revision as of 07:36, 23 August 2023
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	<StructureSection load='2bc9' size='340' side='right'caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2bc9' size='340' side='right'caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID~~-~~GUANYLATE+ESTER'>GNP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></~~td><td class="sblockDat"~~>~~GBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [https://pdbe.org/2bc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [https://www.ebi.ac.uk/pdbsum/2bc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [https://pdbe.org/2bc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [https://www.ebi.ac.uk/pdbsum/2bc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GBP1_HUMAN GBP1_HUMAN]] Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.<ref>PMID:22106366</ref>		[https://www.uniprot.org/uniprot/GBP1_HUMAN GBP1_HUMAN] Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.<ref>PMID:22106366</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ghosh, A]]		[[Category: Ghosh A]]
	[[Category: Herrmann, C]]		[[Category: Herrmann C]]
	[[Category: Praefcke~~, G J.K~~]]		[[Category: Praefcke GJK]]
	[[Category: Renault, L]]		[[Category: Renault L]]
	[[Category: Wittinghofer, A]]		[[Category: Wittinghofer A]]
	~~[[Category: Protein- guanine nucleotide complex]]~~
	~~[[Category: Signaling protein~~]]

OCA at 11:39, 3 February 2021

2021-02-03T11:39:38Z

← Older revision		Revision as of 11:39, 3 February 2021
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	==Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp==		==Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp==
	<StructureSection load='2bc9' size='340' side='right' caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2bc9' size='340' side='right'caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</div></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [~~http~~://pdbe.org/2bc9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bc9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [https://pdbe.org/2bc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [https://www.ebi.ac.uk/pdbsum/2bc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GBP1_HUMAN GBP1_HUMAN]] Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.<ref>PMID:22106366</ref>		[[https://www.uniprot.org/uniprot/GBP1_HUMAN GBP1_HUMAN]] Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.<ref>PMID:22106366</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</div>		</div>
	<div class="pdbe-citations 2bc9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bc9" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Ghosh, A]]		[[Category: Ghosh, A]]
	[[Category: Herrmann, C]]		[[Category: Herrmann, C]]

OCA at 18:44, 24 January 2018

2018-01-24T18:44:18Z

← Older revision		Revision as of 18:44, 24 January 2018
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	==Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp==		==Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp==
	<StructureSection load='2bc9' size='340' side='right' caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2bc9' size='340' side='right' caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://pdbe.org/2bc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://pdbe.org/2bc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bc9 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bc9_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bc9_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2bc9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bc9" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[GTP-binding protein\|GTP-binding protein]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:18, 8 February 2016

2016-02-08T04:18:42Z

← Older revision		Revision as of 04:18, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bc9 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:47, 10 September 2015

2015-09-10T07:47:25Z

← Older revision		Revision as of 07:47, 10 September 2015
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	<StructureSection load='2bc9' size='340' side='right' caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='2bc9' size='340' side='right' caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://pdbe.org/2bc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bc9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Ghosh, A]]		[[Category: Ghosh, A]]
	[[Category: Herrmann, C]]		[[Category: Herrmann, C]]

OCA at 20:33, 24 December 2014

2014-12-24T20:33:53Z

← Older revision		Revision as of 20:33, 24 December 2014
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>
	<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GBP1_HUMAN GBP1_HUMAN]] Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.<ref>PMID:22106366</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghosh, A.]]		[[Category: Ghosh, A]]
	[[Category: Herrmann, C]]		[[Category: Herrmann, C]]
	[[Category: Praefcke, G J.K.]]		[[Category: Praefcke, G J.K]]
	[[Category: Renault, L.]]		[[Category: Renault, L]]
	[[Category: Wittinghofer, A.]]		[[Category: Wittinghofer, A]]
	[[Category: Protein- guanine nucleotide complex]]		[[Category: Protein- guanine nucleotide complex]]
	[[Category: Signaling protein]]		[[Category: Signaling protein]]

OCA at 05:09, 29 September 2014

2014-09-29T05:09:38Z

← Older revision		Revision as of 05:09, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2bc9~~.~~png~~\|~~left~~\|~~200px~~]]		==Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp==
			<StructureSection load='2bc9' size='340' side='right' caption='[[2bc9]], [[Resolution\|resolution]] 2.80Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BC9 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2b8w\|2b8w]], [[2b92\|2b92]], [[2d4h\|2d4h]], [[1dg3\|1dg3]], [[1f5n\|1f5n]]</td></tr>
			<tr><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GBP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bc9 RCSB], [http://www.ebi.ac.uk/pdbsum/2bc9 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bc9_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Interferons are immunomodulatory cytokines that mediate anti-pathogenic and anti-proliferative effects in cells. Interferon-gamma-inducible human guanylate binding protein 1 (hGBP1) belongs to the family of dynamin-related large GTP-binding proteins, which share biochemical properties not found in other families of GTP-binding proteins such as nucleotide-dependent oligomerization and fast cooperative GTPase activity. hGBP1 has an additional property by which it hydrolyses GTP to GMP in two consecutive cleavage reactions. Here we show that the isolated amino-terminal G domain of hGBP1 retains the main enzymatic properties of the full-length protein and can cleave GDP directly. Crystal structures of the N-terminal G domain trapped at successive steps along the reaction pathway and biochemical data reveal the molecular basis for nucleotide-dependent homodimerization and cleavage of GTP. Similar to effector binding in other GTP-binding proteins, homodimerization is regulated by structural changes in the switch regions. Homodimerization generates a conformation in which an arginine finger and a serine are oriented for efficient catalysis. Positioning of the substrate for the second hydrolysis step is achieved by a change in nucleotide conformation at the ribose that keeps the guanine base interactions intact and positions the beta-phosphates in the gamma-phosphate-binding site.

	~~{{STRUCTURE_2bc9\| PDB=2bc9 \| SCENE= }}~~		How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP.,Ghosh A, Praefcke GJ, Renault L, Wittinghofer A, Herrmann C Nature. 2006 Mar 2;440(7080):101-4. PMID:16511497<ref>PMID:16511497</ref>

	~~===Crystal-structure~~ of the ~~N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16511497}}~~

	~~==About this Structure==~~
	~~[[2bc9]] is a 1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA].~~

	==See Also==		==See Also==
	*[[GTP-binding protein\|GTP-binding protein]]		*[[GTP-binding protein\|GTP-binding protein]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016511497<~~/~~ref~~><~~ref group="xtra">PMID:010970849</ref><ref group="xtra">PMID:010676968</ref><ref group="xtra">PMID:019424291</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghosh, A.]]		[[Category: Ghosh, A.]]

OCA at 08:53, 20 October 2012

2012-10-20T08:53:23Z

← Older revision		Revision as of 08:53, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2bc9]] is a 1 chain structure ~~of [[GTP-binding protein]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA].		[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA].

	==See Also==		==See Also==

OCA at 21:05, 25 July 2012

2012-07-25T21:05:35Z

← Older revision		Revision as of 21:05, 25 July 2012
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	[[Image:2bc9.png\|left\|200px]]		[[Image:2bc9.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2bc9", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2bc9\| PDB=2bc9 \| SCENE= }}		{{STRUCTURE_2bc9\| PDB=2bc9 \| SCENE= }}

	===Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp===		===Crystal-structure of the N-terminal large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with non-hydrolysable GTP analogue GppNHp===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16511497}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16511497 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16511497}}		{{ABSTRACT_PUBMED_16511497}}

	==About this Structure==		==About this Structure==
	[[2bc9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA].		[[2bc9]] is a 1 chain structure of [[GTP-binding protein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BC9 OCA].

			==See Also==
			*[[GTP-binding protein\|GTP-binding protein]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16511497~~</ref><ref group="xtra">PMID:~~10970849~~</ref><ref group="xtra">PMID:~~10676968~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016511497</ref><ref group="xtra">PMID:010970849</ref><ref group="xtra">PMID:010676968</ref><ref group="xtra">PMID:019424291</ref><references group="xtra"/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Ghosh, A.]]		[[Category: Ghosh, A.]]

OCA: Protected "2bc9" [edit=sysop:move=sysop]

2011-03-14T20:18:24Z

Protected "2bc9" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:18, 14 March 2011
(No difference)