2bce - Revision history

OCA at 07:46, 23 October 2024

2024-10-23T07:46:21Z

← Older revision		Revision as of 07:46, 23 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bce_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bce_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 06:42, 9 August 2023

2023-08-09T06:42:10Z

← Older revision		Revision as of 06:42, 9 August 2023
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	<StructureSection load='2bce' size='340' side='right'caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bce' size='340' side='right'caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Bovin Bovin~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
	</td></tr><tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"~~><span class~~=~~'plainlinks'~~>[~~https://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase~~]~~, with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.~~1.~~13] </span>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [https://pdbe.org/2bce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [https://www.ebi.ac.uk/pdbsum/2bce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bce ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [https://pdbe.org/2bce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [https://www.ebi.ac.uk/pdbsum/2bce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bce ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CEL_BOVIN CEL_BOVIN]] Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.		[https://www.uniprot.org/uniprot/CEL_BOVIN CEL_BOVIN] Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bovin~~]]		[[Category: Bos taurus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Sterol esterase]]~~		[[Category: Chen JC-H]]
	[[Category: Chen~~, J C.~~H]]		[[Category: Ellsworth JL]]
	[[Category: Ellsworth~~, J L~~]]		[[Category: Krucinski J]]
	[[Category: Krucinski, J]]		[[Category: Lange LG]]
	[[Category: Lange~~, L G~~]]		[[Category: Miercke LJW]]
	[[Category: Miercke~~, L J.W~~]]		[[Category: Saenz G]]
	[[Category: Saenz, G]]		[[Category: Spilburg CA]]
	[[Category: Spilburg~~, C A~~]]		[[Category: Starr JR]]
	[[Category: Starr~~, J R~~]]		[[Category: Stroud RM]]
	[[Category: Stroud~~, R M~~]]		[[Category: Wang X]]
	[[Category: Wang, X]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Lipase]]~~
	~~[[Category: Serine esterase~~]]

OCA at 13:37, 13 October 2021

2021-10-13T13:37:20Z

← Older revision		Revision as of 13:37, 13 October 2021
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	<StructureSection load='2bce' size='340' side='right'caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bce' size='340' side='right'caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [~~http~~://pdbe.org/2bce PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bce PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bce ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [https://pdbe.org/2bce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [https://www.ebi.ac.uk/pdbsum/2bce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bce ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CEL_BOVIN CEL_BOVIN]] Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.		[[https://www.uniprot.org/uniprot/CEL_BOVIN CEL_BOVIN]] Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 13:54, 18 December 2019

2019-12-18T13:54:49Z

← Older revision		Revision as of 13:54, 18 December 2019
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	==CHOLESTEROL ESTERASE FROM BOS TAURUS==		==CHOLESTEROL ESTERASE FROM BOS TAURUS==
	<StructureSection load='2bce' size='340' side='right' caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bce' size='340' side='right'caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
	*[[Cholesterol esterase\|Cholesterol esterase]]		*[[Cholesterol esterase 3D structures\|Cholesterol esterase 3D structures]]
	*[[Lipase\|Lipase]]		*[[Lipase 3D Structures\|Lipase 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bovin]]		[[Category: Bovin]]
			[[Category: Large Structures]]
	[[Category: Sterol esterase]]		[[Category: Sterol esterase]]
	[[Category: Chen, J C.H]]		[[Category: Chen, J C.H]]

OCA at 06:43, 14 March 2018

2018-03-14T06:43:30Z

← Older revision		Revision as of 06:43, 14 March 2018
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	==CHOLESTEROL ESTERASE FROM BOS TAURUS==		==CHOLESTEROL ESTERASE FROM BOS TAURUS==
	<StructureSection load='2bce' size='340' side='right' caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bce' size='340' side='right' caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>
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	<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://pdbe.org/2bce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://pdbe.org/2bce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bce ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bce_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bce_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bce ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:40, 11 September 2015

2015-09-11T07:40:15Z

← Older revision		Revision as of 07:40, 11 September 2015
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	<StructureSection load='2bce' size='340' side='right' caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2bce' size='340' side='right' caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Bos_taurus Bos taurus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://pdbe.org/2bce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bce" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bos taurus~~]]		[[Category: Bovin]]
	[[Category: Sterol esterase]]		[[Category: Sterol esterase]]
	[[Category: Chen, J C.H]]		[[Category: Chen, J C.H]]

OCA at 13:22, 25 December 2014

2014-12-25T13:22:07Z

← Older revision		Revision as of 13:22, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>		</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CEL_BOVIN CEL_BOVIN]] Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Sterol esterase]]		[[Category: Sterol esterase]]
	[[Category: Chen, J C.H.]]		[[Category: Chen, J C.H]]
	[[Category: Ellsworth, J L.]]		[[Category: Ellsworth, J L]]
	[[Category: Krucinski, J.]]		[[Category: Krucinski, J]]
	[[Category: Lange, L G.]]		[[Category: Lange, L G]]
	[[Category: Miercke, L J.W.]]		[[Category: Miercke, L J.W]]
	[[Category: Saenz, G.]]		[[Category: Saenz, G]]
	[[Category: Spilburg, C A.]]		[[Category: Spilburg, C A]]
	[[Category: Starr, J R.]]		[[Category: Starr, J R]]
	[[Category: Stroud, R M.]]		[[Category: Stroud, R M]]
	[[Category: Wang, X.]]		[[Category: Wang, X]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Lipase]]		[[Category: Lipase]]
	[[Category: Serine esterase]]		[[Category: Serine esterase]]

OCA at 04:35, 29 September 2014

2014-09-29T04:35:23Z

← Older revision		Revision as of 04:35, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2bce~~.~~png~~\|~~left~~\|~~200px~~]]		==CHOLESTEROL ESTERASE FROM BOS TAURUS==
			<StructureSection load='2bce' size='340' side='right' caption='[[2bce]], [[Resolution\|resolution]] 1.60Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BCE FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_esterase Sterol esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.13 3.1.1.13] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bce OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bce RCSB], [http://www.ebi.ac.uk/pdbsum/2bce PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bc/2bce_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The structure of pancreatic cholesterol esterase, an enzyme that hydrolyzes a wide variety of dietary lipids, mediates the absorption of cholesterol esters, and is dependent on bile salts for optimal activity, is determined to 1.6 A resolution. A full-length construct, mutated to eliminate two N-linked glycosylation sites (N187Q/N361Q), was expressed in HEK 293 cells. Enzymatic activity assays show that the purified, recombinant, mutant enzyme has activity identical to that of the native, glycosylated enzyme purified from bovine pancreas. The mutant enzyme is monomeric and exhibits improved homogeneity which aided in the growth of well-diffracting crystals. Crystals of the mutant enzyme grew in space group C2, with the following cell dimensions: a = 100.42 A, b = 54.25 A, c = 106.34 A, and beta = 104.12 degrees, with a monomer in the asymmetric unit. The high-resolution crystal structure of bovine pancreatic cholesterol esterase (Rcryst = 21.1%; Rfree = 25.0% to 1.6 A resolution) shows an alpha-beta hydrolase fold with an unusual active site environment around the catalytic triad. The hydrophobic C terminus of the protein is lodged in the active site, diverting the oxyanion hole away from the productive binding site and the catalytic Ser194. The amphipathic, helical lid found in other triglyceride lipases is truncated in the structure of cholesterol esterase and therefore is not a salient feature of activation of this lipase. These two structural features, along with the bile salt-dependent activity of the enzyme, implicate a new mode of lipase activation.

	~~{{STRUCTURE_2bce\| PDB=2bce \| SCENE= }}~~		Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation.,Chen JC, Miercke LJ, Krucinski J, Starr JR, Saenz G, Wang X, Spilburg CA, Lange LG, Ellsworth JL, Stroud RM Biochemistry. 1998 Apr 14;37(15):5107-17. PMID:9548741<ref>PMID:9548741</ref>

	~~===CHOLESTEROL ESTERASE FROM BOS TAURUS===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9548741}}~~

	~~==About this Structure==~~
	~~[[2bce]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Bos_taurus Bos taurus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2BCE OCA].~~

	==See Also==		==See Also==
			*[[Cholesterol esterase\|Cholesterol esterase]]
	*[[Lipase\|Lipase]]		*[[Lipase\|Lipase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:009548741<~~/~~ref~~><~~ref group="xtra">PMID:011933065</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Sterol esterase]]		[[Category: Sterol esterase]]

OCA at 17:11, 20 October 2012

2012-10-20T17:11:00Z

← Older revision		Revision as of 17:11, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2bce]] is a 1 chain structure ~~of [[Lipase]]~~ with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA].		[[2bce]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BCE OCA].

	==See Also==		==See Also==

OCA at 00:04, 27 July 2012

2012-07-27T00:04:37Z

← Older revision		Revision as of 00:04, 27 July 2012
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	[[Image:2bce.png\|left\|200px]]		[[Image:2bce.png\|left\|200px]]

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	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2bce\| PDB=2bce \| SCENE= }}		{{STRUCTURE_2bce\| PDB=2bce \| SCENE= }}

	===CHOLESTEROL ESTERASE FROM BOS TAURUS===		===CHOLESTEROL ESTERASE FROM BOS TAURUS===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9548741}}, adds the Publication Abstract to the page~~
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	==See Also==		==See Also==
	*[[Lipase]]		*[[Lipase\|Lipase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~9548741~~</ref><references group="xtra"/>		<ref group="xtra">PMID:009548741</ref><ref group="xtra">PMID:011933065</ref><references group="xtra"/>
	[[Category: Bos taurus]]		[[Category: Bos taurus]]
	[[Category: Sterol esterase]]		[[Category: Sterol esterase]]