2bd2 - Revision history

OCA at 05:20, 25 September 2024

2024-09-25T05:20:46Z

← Older revision		Revision as of 05:20, 25 September 2024
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	<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat">~~<scene name='pdbligand=ARG:ARGININE'>ARG</scene>,~~ <scene name='pdbligand=CA:CALCIUM+ION'>CA~~</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE~~</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [https://pdbe.org/2bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [https://pdbe.org/2bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>
	</table>		</table>
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bd2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bd2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 08:20, 25 October 2023

2023-10-25T08:20:11Z

← Older revision		Revision as of 08:20, 25 October 2023
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	<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pig Pig~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ARG:ARGININE'>ARG</scene>~~, ~~<scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</~~div~~><~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<~~tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b~~></td><~~td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [https://pdbe.org/2bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [https://pdbe.org/2bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.		[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pancreatic elastase]]~~		[[Category: Sus scrofa]]
	~~[[Category: Pig~~]]		[[Category: Liu B]]
	[[Category: Liu, B]]		[[Category: Schofield CJ]]
	[[Category: Schofield~~, C J~~]]		[[Category: Wilmouth RC]]
	[[Category: Wilmouth~~, R C]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Serine proteinase~~]]

OCA at 09:43, 5 May 2021

2021-05-05T09:43:43Z

← Older revision		Revision as of 09:43, 5 May 2021
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	<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [~~http~~://pdbe.org/2bd2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [https://pdbe.org/2bd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [https://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.		[[https://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 09:15, 24 July 2019

2019-07-24T09:15:01Z

← Older revision		Revision as of 09:15, 24 July 2019
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	==Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0==		==Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0==
	<StructureSection load='2bd2' size='340' side='right' caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2bd2' size='340' side='right'caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bd2_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bd2_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2bd2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bd2" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Elastase 3D structures\|Elastase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Pig]]		[[Category: Pig]]

OCA at 07:25, 18 October 2017

2017-10-18T07:25:39Z

← Older revision		Revision as of 07:25, 18 October 2017
Line 1:		Line 1:

	==Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0==		==Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0==
	<StructureSection load='2bd2' size='340' side='right' caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2bd2' size='340' side='right' caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sus_scrofa Sus scrofa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pig Pig]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://pdbe.org/2bd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://pdbe.org/2bd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bd2 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bd2 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 29:		Line 30:
	</div>		</div>
	<div class="pdbe-citations 2bd2" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bd2" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Elastase\|Elastase]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: ~~Sus scrofa~~]]		[[Category: Pig]]
	[[Category: Liu, B]]		[[Category: Liu, B]]
	[[Category: Schofield, C J]]		[[Category: Schofield, C J]]

OCA at 23:53, 11 September 2015

2015-09-11T23:53:56Z

← Older revision		Revision as of 23:53, 11 September 2015
Line 6:		Line 6:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://pdbe.org/2bd2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~ELA1_PIG ELA1_PIG~~]] Acts upon elastin.		[[http://www.uniprot.org/uniprot/CELA1_PIG CELA1_PIG]] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bd2" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 21:04, 25 December 2014

2014-12-25T21:04:55Z

← Older revision		Revision as of 21:04, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ELA1_PIG ELA1_PIG]] Acts upon elastin.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]
	[[Category: Liu, B.]]		[[Category: Liu, B]]
	[[Category: Schofield, C J.]]		[[Category: Schofield, C J]]
	[[Category: Wilmouth, R C.]]		[[Category: Wilmouth, R C]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]

OCA at 04:37, 29 September 2014

2014-09-29T04:37:54Z

← Older revision		Revision as of 04:37, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2bd2~~.~~png~~\|~~left~~\|~~200px~~]]		==Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0==
			<StructureSection load='2bd2' size='340' side='right' caption='[[2bd2]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BD2 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PHE:PHENYLALANINE'>PHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1hax\|1hax]], [[1hay\|1hay]], [[1haz\|1haz]], [[1qix\|1qix]], [[2bb4\|2bb4]], [[2bd3\|2bd3]], [[2bd4\|2bd4]], [[2bd5\|2bd5]], [[2bd6\|2bd6]], [[2bd7\|2bd7]], [[2bd8\|2bd8]], [[2bd9\|2bd9]], [[2bda\|2bda]], [[2bdb\|2bdb]], [[2bdc\|2bdc]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bd2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bd2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bd2 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bd/2bd2_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Although the subject of many studies, detailed structural information on aspects of the catalytic cycle of serine proteases is lacking. Crystallographic analyses were performed in which an acyl-enzyme complex, formed from elastase and a peptide, was reacted with a series of nucleophilic dipeptides. Multiple analyses led to electron density maps consistent with the formation of a tetrahedral species. In certain cases, apparent peptide bond formation at the active site was observed, and the electron density maps suggested production of a cis-amide rather than a trans-amide. Evidence for a cis-amide configuration was also observed in the noncovalent complex between elastase and an alpha1-antitrypsin-derived tetrapeptide. Although there are caveats on the relevance of the crystallographic data to solution catalysis, the results enable detailed proposals for the pathway of the acylation step to be made. At least in some cases, it is proposed that the alcohol of Ser-195 may preferentially attack the carbonyl of the cis-amide form of the substrate, in a stereoelectronically favored manner, to give a tetrahedral oxyanion intermediate, which undergoes N-inversion and/or C-N bond rotation to enable protonation of the leaving group nitrogen. The mechanistic proposals may have consequences for protease inhibition, in particular for the design of high energy intermediate analogues.

	~~{{STRUCTURE_2bd2\| PDB=2bd2 \| SCENE= }}~~		Structural analyses on intermediates in serine protease catalysis.,Liu B, Schofield CJ, Wilmouth RC J Biol Chem. 2006 Aug 18;281(33):24024-35. Epub 2006 Jun 5. PMID:16754679<ref>PMID:16754679</ref>

	~~===Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16754679}}~~

	~~==About this Structure==~~
	~~[[2bd2]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Sus_scrofa Sus scrofa]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA].~~

	==See Also==		==See Also==
	*[[Elastase\|Elastase]]		*[[Elastase\|Elastase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016754679<~~/~~ref~~><~~ref group="xtra">PMID:009187653</ref><ref group="xtra">PMID:011473259</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]

OCA at 21:38, 20 October 2012

2012-10-20T21:38:16Z

← Older revision		Revision as of 21:38, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2bd2]] is a 2 chain structure ~~of [[Elastase]]~~ with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA].		[[2bd2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BD2 OCA].

	==See Also==		==See Also==

OCA at 13:49, 27 July 2012

2012-07-27T13:49:40Z

← Older revision		Revision as of 13:49, 27 July 2012
Line 1:		Line 1:
	[[Image:2bd2.png\|left\|200px]]		[[Image:2bd2.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2bd2", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2bd2\| PDB=2bd2 \| SCENE= }}		{{STRUCTURE_2bd2\| PDB=2bd2 \| SCENE= }}

	===Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0===		===Porcine pancreatic elastase complexed with beta-casomorphin-7 and Arg-Phe at pH 5.0===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16754679}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16754679 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16754679}}		{{ABSTRACT_PUBMED_16754679}}

Line 22:		Line 11:

	==See Also==		==See Also==
	*[[Elastase]]		*[[Elastase\|Elastase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16754679~~</ref><ref group="xtra">PMID:~~9187653~~</ref><ref group="xtra">PMID:~~11473259~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016754679</ref><ref group="xtra">PMID:009187653</ref><ref group="xtra">PMID:011473259</ref><references group="xtra"/>
	[[Category: Pancreatic elastase]]		[[Category: Pancreatic elastase]]
	[[Category: Sus scrofa]]		[[Category: Sus scrofa]]