2box - Revision history

OCA at 07:47, 23 October 2024

2024-10-23T07:47:05Z

← Older revision		Revision as of 07:47, 23 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2box_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2box_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 13:50, 13 December 2023

2023-12-13T13:50:44Z

← Older revision		Revision as of 13:50, 13 December 2023
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	<StructureSection load='2box' size='340' side='right'caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2box' size='340' side='right'caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bo2\|2bo2]], [[2bou\|2bou]]</div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [https://pdbe.org/2box PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [https://www.ebi.ac.uk/pdbsum/2box PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2box ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [https://pdbe.org/2box PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [https://www.ebi.ac.uk/pdbsum/2box PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2box ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Vibratory urticaria. The disease is caused by variants affecting the gene represented in this entry.
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~EMR2_HUMAN EMR2_HUMAN]~~] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>		[https://www.uniprot.org/uniprot/AGRE2_HUMAN AGRE2_HUMAN] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242).<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref> <ref>PMID:22575658</ref> <ref>PMID:26841242</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Abbott~~, R J.M~~]]		[[Category: Abbott RJM]]
	[[Category: Handford~~, P A~~]]		[[Category: Handford PA]]
	[[Category: Knott, V]]		[[Category: Knott V]]
	[[Category: Lea~~, S M~~]]		[[Category: Lea SM]]
	[[Category: McDonnell~~, J M~~]]		[[Category: McDonnell JM]]
	[[Category: Roversi, P]]		[[Category: Roversi P]]
	[[Category: Spendlove, I]]		[[Category: Spendlove I]]
	[[Category: Teriete, P]]		[[Category: Teriete P]]
	~~[[Category: Calcium-binding]]~~
	~~[[Category: Cd55]]~~
	~~[[Category: Cd97]]~~
	~~[[Category: Cell adhesion]]~~
	~~[[Category: Egf-like domain]]~~
	~~[[Category: G-protein coupled receptor]]~~
	~~[[Category: Immune system~~]]

OCA at 13:15, 24 November 2021

2021-11-24T13:15:04Z

← Older revision		Revision as of 13:15, 24 November 2021
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	<StructureSection load='2box' size='340' side='right'caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2box' size='340' side='right'caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bo2\|2bo2]], [[2bou\|2bou]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [~~http~~://pdbe.org/2box PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2box PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2box ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [https://pdbe.org/2box PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [https://www.ebi.ac.uk/pdbsum/2box PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2box ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>		[[https://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 08:17, 19 February 2020

2020-02-19T08:17:57Z

← Older revision		Revision as of 08:17, 19 February 2020
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	==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium.==		==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium.==
	<StructureSection load='2box' size='340' side='right' caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2box' size='340' side='right'caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Abbott, R J.M]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A]]		[[Category: Handford, P A]]

OCA at 06:49, 16 May 2018

2018-05-16T06:49:41Z

← Older revision		Revision as of 06:49, 16 May 2018
Line 1:		Line 1:
	==EGF ~~DOMAINS~~ 1,2,5 ~~OF HUMAN~~ EMR2, A 7-TM ~~IMMUNE SYSTEM MOLECULE~~, ~~IN COMPLEX WITH STRONTIUM~~.==
			==EGF Domains 1,2,5 of human EMR2, a 7-TM immune system molecule, in complex with strontium.==
	<StructureSection load='2box' size='340' side='right' caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2box' size='340' side='right' caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://pdbe.org/2box PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://pdbe.org/2box PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2box ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2box_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2box_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	[[Category: Knott, V]]		[[Category: Knott, V]]
	[[Category: Lea, S M]]		[[Category: Lea, S M]]
	[[Category: ~~Mcdonnell~~, J M]]		[[Category: McDonnell, J M]]
	[[Category: Roversi, P]]		[[Category: Roversi, P]]
	[[Category: Spendlove, I]]		[[Category: Spendlove, I]]

OCA at 10:17, 9 February 2016

2016-02-09T10:17:55Z

← Older revision		Revision as of 10:17, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2box ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 21:16, 10 September 2015

2015-09-10T21:16:57Z

← Older revision		Revision as of 21:16, 10 September 2015
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	<StructureSection load='2box' size='340' side='right' caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='2box' size='340' side='right' caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://pdbe.org/2box PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2box" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Abbott, R J.M]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A]]		[[Category: Handford, P A]]

OCA at 06:12, 25 December 2014

2014-12-25T06:12:55Z

← Older revision		Revision as of 06:12, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>		<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 30:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abbott, R J.M.]]		[[Category: Abbott, R J.M]]
	[[Category: Handford, P A.]]		[[Category: Handford, P A]]
	[[Category: Knott, V.]]		[[Category: Knott, V]]
	[[Category: Lea, S M.]]		[[Category: Lea, S M]]
	[[Category: Mcdonnell, J M.]]		[[Category: Mcdonnell, J M]]
	[[Category: Roversi, P.]]		[[Category: Roversi, P]]
	[[Category: Spendlove, I.]]		[[Category: Spendlove, I]]
	[[Category: Teriete, P~~.]]~~		[[Category: Teriete, P]]
	~~[[Category: 7tm~~]]
	[[Category: Calcium-binding]]		[[Category: Calcium-binding]]
	[[Category: Cd55]]		[[Category: Cd55]]

OCA at 04:26, 3 October 2014

2014-10-03T04:26:12Z

← Older revision		Revision as of 04:26, 3 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2box\| PDB=2box \| SCENE= }}~~		==EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH STRONTIUM.==
	===EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH STRONTIUM.===		<StructureSection load='2box' size='340' side='right' caption='[[2box]], [[Resolution\|resolution]] 2.50Å' scene=''>
	~~{{ABSTRACT_PUBMED_17449467}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2box]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BOX FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bo2\|2bo2]], [[2bou\|2bou]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2box FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2box OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2box RCSB], [http://www.ebi.ac.uk/pdbsum/2box PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2box_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			CD97, the archetypal member of the EGF-TM7 protein family, is constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells following activation. The key isoform of CD97 expressed on leukocytes binds the complement regulatory protein CD55 (also termed decay-accelerating factor). CD97 has been shown recently to mediate co-stimulation of T cells via CD55. Here, we demonstrate that blocking the interaction between CD55 on monocytes and CD97 on T cells leads to inhibition of proliferation and interferon-gamma secretion. This implies that bidirectional interactions between CD97 and CD55 are involved in T cell regulation. Structural studies presented here reveal the molecular basis for this activity. We have solved the structure of EMR2, a very close homolog of CD97, using x-ray crystallography. NMR-based chemical shift mapping of the EMR2-CD55 interaction has allowed us to generate a model for the CD97-CD55 complex. The structure of the complex reveals that the T cell and complement regulatory activities of CD55 occur on opposite faces of the molecule. This suggests that CD55 might simultaneously regulate both the innate and adaptive immune responses, and we have shown that CD55 can still regulate complement when bound to CD97.

	~~==Function==~~		Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55.,Abbott RJ, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, McDonnell JM, Handford PA, Lea SM J Biol Chem. 2007 Jul 27;282(30):22023-32. Epub 2007 Apr 20. PMID:17449467<ref>PMID:17449467</ref>
	~~[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety~~ of ~~glycosaminoglycan chains and promotes~~ cell ~~attachment~~. ~~Promotes granulocyte chemotaxis~~, ~~degranulation and adhesion. In macrophages~~, ~~promotes the release of inflammatory cytokines~~, ~~including IL8 and TNF~~.~~<ref>PMID~~:~~12829604</ref> <ref>~~PMID:~~17928360</ref>~~ <ref>PMID:~~22310662~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2box]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann~~.~~ac.il~~/~~oca-bin/ocashort?id=2BOX OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:017449467</ref><ref group="xtra">PMID:015103144</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Abbott, R J.M.]]		[[Category: Abbott, R J.M.]]

OCA at 02:34, 4 April 2013

2013-04-04T02:34:34Z

@@ Line 1: / Line 1: @@
 {{STRUCTURE_2box|  PDB=2box  |  SCENE=  }}
 ===EGF DOMAINS 1,2,5 OF HUMAN EMR2, A 7-TM IMMUNE SYSTEM MOLECULE, IN COMPLEX WITH STRONTIUM.===
+==Function==
-<!--
+[[http://www.uniprot.org/uniprot/EMR2_HUMAN EMR2_HUMAN]] Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF.<ref>PMID:12829604</ref> <ref>PMID:17928360</ref> <ref>PMID:22310662</ref>
 ==About this Structure==
@@ Line 22: / Line 10: @@
 ==Reference==
-<ref group="xtra">PMID:017449467</ref><ref group="xtra">PMID:015103144</ref><references group="xtra"/>
+<ref group="xtra">PMID:017449467</ref><ref group="xtra">PMID:015103144</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Abbott, R J.M.]]
@@ Line 32: / Line 20: @@
 [[Category: Spendlove, I.]]
 [[Category: Teriete, P.]]