2bpi - Revision history

OCA at 13:51, 13 December 2023

2023-12-13T13:51:54Z

← Older revision		Revision as of 13:51, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2bpi' size='340' side='right'caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2bpi' size='340' side='right'caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Plaf7 Plaf7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPI FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.52Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [https://pdbe.org/2bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [https://www.ebi.ac.uk/pdbsum/2bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [https://pdbe.org/2bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [https://www.ebi.ac.uk/pdbsum/2bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/SODF_PLAF7 SODF_PLAF7]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.		[https://www.uniprot.org/uniprot/SODF_PLAF7 SODF_PLAF7] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Plaf7]]~~		[[Category: Plasmodium falciparum 3D7]]
	~~[[Category: Superoxide dismutase~~]]		[[Category: Boucher IW]]
	[[Category: Boucher~~, I W~~]]		[[Category: Brannigan J]]
	[[Category: Brannigan, J]]		[[Category: Brzozowski M]]
	[[Category: Brzozowski, M]]		[[Category: Wilkinson AJ]]
	[[Category: Wilkinson~~, A J]]~~
	~~[[Category: Dismutase]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Oxidoreductase~~]]

OCA at 10:22, 8 December 2021

2021-12-08T10:22:40Z

← Older revision		Revision as of 10:22, 8 December 2021
Line 3:		Line 3:
	<StructureSection load='2bpi' size='340' side='right'caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2bpi' size='340' side='right'caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [~~http~~://pdbe.org/2bpi PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bpi PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpi ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [https://pdbe.org/2bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [https://www.ebi.ac.uk/pdbsum/2bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/SODF_PLAF7 SODF_PLAF7]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.		[[https://www.uniprot.org/uniprot/SODF_PLAF7 SODF_PLAF7]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:57, 19 February 2020

2020-02-19T07:57:10Z

← Older revision		Revision as of 07:57, 19 February 2020
Line 1:		Line 1:

	==Structure of Iron dependent superoxide dismutase from P. falciparum.==		==Structure of Iron dependent superoxide dismutase from P. falciparum.==
	<StructureSection load='2bpi' size='340' side='right' caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2bpi' size='340' side='right'caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
	*[[Superoxide ~~Dismutase~~\|Superoxide ~~Dismutase~~]]		*[[Superoxide dismutase 3D structures\|Superoxide dismutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Plaf7]]		[[Category: Plaf7]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]

OCA at 06:17, 16 May 2018

2018-05-16T06:17:13Z

← Older revision		Revision as of 06:17, 16 May 2018
Line 1:		Line 1:

	==Structure of Iron dependent superoxide dismutase from P. falciparum.==		==Structure of Iron dependent superoxide dismutase from P. falciparum.==
	<StructureSection load='2bpi' size='340' side='right' caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2bpi' size='340' side='right' caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://pdbe.org/2bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://pdbe.org/2bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpi ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bpi_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bpi_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 02:09, 8 February 2016

2016-02-08T02:09:16Z

← Older revision		Revision as of 02:09, 8 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://pdbe.org/2bpi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bpi ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bpi" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 06:38, 15 April 2015

2015-04-15T06:38:05Z

← Older revision		Revision as of 06:38, 15 April 2015
Line 2:		Line 2:
	<StructureSection load='2bpi' size='340' side='right' caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>		<StructureSection load='2bpi' size='340' side='right' caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plaf7 Plaf7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
Line 34:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Plasmodium falciparum 3d7~~]]		[[Category: Plaf7]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Boucher, I W]]		[[Category: Boucher, I W]]

OCA at 19:47, 24 December 2014

2014-12-24T19:47:51Z

← Older revision		Revision as of 19:47, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/SODF_PLAF7 SODF_PLAF7]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Boucher, I W.]]		[[Category: Boucher, I W]]
	[[Category: Brannigan, J.]]		[[Category: Brannigan, J]]
	[[Category: Brzozowski, M]]		[[Category: Brzozowski, M]]
	[[Category: Wilkinson, A J.]]		[[Category: Wilkinson, A J]]
	[[Category: Dismutase]]		[[Category: Dismutase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 04:07, 3 October 2014

2014-10-03T04:07:01Z

← Older revision		Revision as of 04:07, 3 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2bpi~~\| ~~PDB~~=2bpi \| ~~SCENE~~= }}		==Structure of Iron dependent superoxide dismutase from P. falciparum.==
	===~~Structure~~ of ~~Iron dependent~~ superoxide dismutase from P. falciparum.~~===~~		<StructureSection load='2bpi' size='340' side='right' caption='[[2bpi]], [[Resolution\|resolution]] 2.52Å' scene=''>
	~~{{ABSTRACT_PUBMED_17020617}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BPI FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bpi RCSB], [http://www.ebi.ac.uk/pdbsum/2bpi PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bpi_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			BACKGROUND: Superoxide dismutases (SODs) are important enzymes in defence against oxidative stress. In Plasmodium falciparum, they may be expected to have special significance since part of the parasite life cycle is spent in red blood cells where the formation of reactive oxygen species is likely to be promoted by the products of haemoglobin breakdown. Thus, inhibitors of P. falciparum SODs have potential as anti-malarial compounds. As a step towards their development we have determined the crystal structure of the parasite's cytosolic iron superoxide dismutase. RESULTS: The cytosolic iron superoxide dismutase from P. falciparum (PfFeSOD) has been overexpressed in E. coli in a catalytically active form. Its crystal structure has been solved by molecular replacement and refined against data extending to 2.5 A resolution. The structure reveals a two-domain organisation and an iron centre in which the metal is coordinated by three histidines, an aspartate and a solvent molecule. Consistent with ultracentrifugation analysis the enzyme is a dimer in which a hydrogen bonding lattice links the two active centres. CONCLUSION: The tertiary structure of PfFeSOD is very similar to those of a number of other iron-and manganese-dependent superoxide dismutases, moreover the active site residues are conserved suggesting a common mechanism of action. Comparison of the dimer interfaces of PfFeSOD with the human manganese-dependent superoxide dismutase reveals a number of differences, which may underpin the design of parasite-selective superoxide dismutase inhibitors.

	~~==Function==~~		The crystal structure of superoxide dismutase from Plasmodium falciparum.,Boucher IW, Brzozowski AM, Brannigan JA, Schnick C, Smith DJ, Kyes SA, Wilkinson AJ BMC Struct Biol. 2006 Oct 4;6:20. PMID:17020617<ref>PMID:17020617</ref>
	~~[[http~~:~~//www~~.~~uniprot.org~~/~~uniprot/SODF_PLAF7 SODF_PLAF7]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2bpi]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA].~~		</div>

	==See Also==		==See Also==
	*[[Superoxide Dismutase\|Superoxide Dismutase]]		*[[Superoxide Dismutase\|Superoxide Dismutase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:017020617</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Plasmodium falciparum 3d7]]		[[Category: Plasmodium falciparum 3d7]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]

OCA at 10:29, 24 April 2013

2013-04-24T10:29:29Z

← Older revision		Revision as of 10:29, 24 April 2013
Line 1:		Line 1:
	~~[[Image:2bpi.png\|left\|200px]]~~

	{{STRUCTURE_2bpi\| PDB=2bpi \| SCENE= }}		{{STRUCTURE_2bpi\| PDB=2bpi \| SCENE= }}
			===Structure of Iron dependent superoxide dismutase from P. falciparum.===
			{{ABSTRACT_PUBMED_17020617}}

	===~~STUCTURE OF IRON DEPENDENT SUPEROXIDE DISMUTASE FROM P~~. ~~FALCIPARUM~~.~~===~~		==Function==
			[[http://www.uniprot.org/uniprot/SODF_PLAF7 SODF_PLAF7]] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
	~~{{ABSTRACT_PUBMED_17020617}}~~

	==About this Structure==		==About this Structure==
	[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Plasmodium_falciparum~~ Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA].		[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA].

	==See Also==		==See Also==
Line 14:		Line 13:

	==Reference==		==Reference==
	<ref group="xtra">PMID:017020617</ref><references group="xtra"/>		<ref group="xtra">PMID:017020617</ref><references group="xtra"/><references/>
	[[Category: Plasmodium falciparum]]		[[Category: Plasmodium falciparum 3d7]]
	[[Category: Superoxide dismutase]]		[[Category: Superoxide dismutase]]
	[[Category: Boucher, I W.]]		[[Category: Boucher, I W.]]
	[[Category: Brannigan, J A.]]		[[Category: Brannigan, J.]]
	[[Category: Brzozowski, A M.]]		[[Category: Brzozowski, M]]
	[[Category: Wilkinson, A J.]]		[[Category: Wilkinson, A J.]]
	[[Category: Dismutase]]		[[Category: Dismutase]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]

OCA at 08:32, 20 October 2012

2012-10-20T08:32:55Z

← Older revision		Revision as of 08:32, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2bpi]] is a 2 chain structure ~~of [[Superoxide Dismutase]]~~ with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA].		[[2bpi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPI OCA].

	==See Also==		==See Also==