2bth - Revision history

OCA at 05:33, 15 May 2024

2024-05-15T05:33:55Z

← Older revision		Revision as of 05:33, 15 May 2024
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	==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==		==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==
	<StructureSection load='2bth' size='340' side='right'caption='[[2bth~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>		<StructureSection load='2bth' size='340' side='right'caption='[[2bth]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</div></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [https://pdbe.org/2bth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [https://www.ebi.ac.uk/pdbsum/2bth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [https://pdbe.org/2bth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [https://www.ebi.ac.uk/pdbsum/2bth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bth ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/ODO2_ECOLI ODO2_ECOLI] The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895]]~~		[[Category: Escherichia coli]]
	~~[[Category: Dihydrolipoyllysine-residue succinyltransferase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Allen~~, M D~~]]		[[Category: Allen MD]]
	[[Category: Ferguson, N]]		[[Category: Ferguson N]]
	~~[[Category: Acyltransferase]]~~
	~~[[Category: Lipoyl]]~~
	~~[[Category: Transferase~~]]

OCA at 13:39, 13 October 2021

2021-10-13T13:39:42Z

← Older revision		Revision as of 13:39, 13 October 2021
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	<StructureSection load='2bth' size='340' side='right'caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bth' size='340' side='right'caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [~~http~~://pdbe.org/2bth PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bth PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bth ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [https://pdbe.org/2bth PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [https://www.ebi.ac.uk/pdbsum/2bth PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bth ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:24, 11 December 2019

2019-12-11T19:24:43Z

← Older revision		Revision as of 19:24, 11 December 2019
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	==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==		==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==
	<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bth' size='340' side='right'caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2bth" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bth" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[2-oxoglutarate dehydrogenase 3D structures\|2-oxoglutarate dehydrogenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydrolipoyllysine-residue succinyltransferase]]		[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
			[[Category: Large Structures]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Ferguson, N]]		[[Category: Ferguson, N]]

OCA at 18:45, 24 January 2018

2018-01-24T18:45:10Z

← Older revision		Revision as of 18:45, 24 January 2018
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	<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2bth_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2bth_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2bth" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2bth" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[2-Oxoglutarate Dehydrogenase\|2-Oxoglutarate Dehydrogenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydrolipoyllysine-residue succinyltransferase]]		[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]

OCA at 06:28, 19 April 2017

2017-04-19T06:28:58Z

← Older revision		Revision as of 06:28, 19 April 2017
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	==~~PERIPHERAL~~-~~SUBUNIT BINDING DOMAINS FROM MESOPHILIC~~, ~~THERMOPHILIC~~, ~~AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST~~, ~~APPARENTLY TWO~~-~~STATE TRANSITIONS~~==
			==Peripheral-subunit binding domains from mesophilic, thermophilic, and hyperthermophilic bacteria fold by ultrafast, apparently two-state transitions==
	<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]~~. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://pdbe.org/2bth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://pdbe.org/2bth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bth ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bth ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacillus coli migula 1895]]~~
	[[Category: Dihydrolipoyllysine-residue succinyltransferase]]		[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
	[[Category: Allen, M D]]		[[Category: Allen, M D]]

OCA at 09:15, 11 September 2015

2015-09-11T09:15:45Z

← Older revision		Revision as of 09:15, 11 September 2015
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	<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://pdbe.org/2bth PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bth" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Bacillus coli migula 1895]]
	[[Category: Dihydrolipoyllysine-residue succinyltransferase]]		[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
	~~[[Category: Escherichia coli]]~~
	[[Category: Allen, M D]]		[[Category: Allen, M D]]
	[[Category: Ferguson, N]]		[[Category: Ferguson, N]]

OCA at 09:22, 8 January 2015

2015-01-08T09:22:37Z

← Older revision		Revision as of 09:22, 8 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Dihydrolipoyllysine-residue succinyltransferase]]		[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Allen, M D.]]		[[Category: Allen, M D]]
	[[Category: Ferguson, N.]]		[[Category: Ferguson, N]]
	[[Category: Acyltransferase]]		[[Category: Acyltransferase]]
	[[Category: Lipoyl]]		[[Category: Lipoyl]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 05:43, 29 September 2014

2014-09-29T05:43:49Z

← Older revision		Revision as of 05:43, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2bth~~.~~png~~\|~~left~~\|~~200px~~]]		==PERIPHERAL-SUBUNIT BINDING DOMAINS FROM MESOPHILIC, THERMOPHILIC, AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST, APPARENTLY TWO-STATE TRANSITIONS==
			<StructureSection load='2bth' size='340' side='right' caption='[[2bth]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BTH FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bal\|1bal]], [[1bbl\|1bbl]], [[1c4t\|1c4t]], [[1e2o\|1e2o]], [[1pmr\|1pmr]], [[1scz\|1scz]], [[2btg\|2btg]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_succinyltransferase Dihydrolipoyllysine-residue succinyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.61 2.3.1.61] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bth RCSB], [http://www.ebi.ac.uk/pdbsum/2bth PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bt/2bth_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			We have determined the solution structures, equilibrium properties and ultra-fast folding kinetics for three bacterial homologues of the peripheral subunit-binding domain (PSBD) family. The mesophilic homologue, BBL, was less stable than the thermophilic and hyper-thermophilic variants (E3BD and POB, respectively). The broad unfolding transitions of each PSBD, when probed by different techniques, were essentially superimposable, consistent with co-operative denaturation. Temperature-jump and continuous-flow fluorescence methods were used to measure the folding kinetics for E3BD, POB and BBL. E3BD folded fairly rapidly at 298K (folding half-time approximately 25 micros) and BBL and POB folded even faster (folding half-times approximately 3-5 micros). The variations in equilibrium and kinetic behaviour observed for the PSBD family resembles that of the homeodomain family, where the folding pattern changes from apparent two-state transitions to multi-state kinetics as the denatured state becomes more structured. The faster folding of POB may be a consequence of its higher propensity to form helical structure in the region corresponding to the folding nucleus of E3BD. The ultra-fast folding of BBL appears to be a consequence of residual structure in the denatured ensemble, as with engrailed homeodomain. We discuss issues concerning "one-state", downhill folding, and find no evidence for, and strong evidence against, it occurring in these PSBDs. The shorter construct used previously for BBL was destabilized significantly and the stability further perturbed by the introduction of fluorescent probes. Thermal titrations for 11 side-chains scattered around the protein, when probed by (13)C-NMR experiments, could be fit globally to a common co-operative transition.

	~~{{STRUCTURE_2bth\| PDB=2bth \| SCENE= }}~~		Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family.,Ferguson N, Sharpe TD, Schartau PJ, Sato S, Allen MD, Johnson CM, Rutherford TJ, Fersht AR J Mol Biol. 2005 Oct 21;353(2):427-46. PMID:16168437<ref>PMID:16168437</ref>

	~~===PERIPHERAL-SUBUNIT BINDING DOMAINS FROM MESOPHILIC~~, ~~THERMOPHILIC, AND HYPERTHERMOPHILIC BACTERIA FOLD BY ULTRAFAST, APPARENTLY TWO-STATE TRANSITIONS===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16168437}}~~

	~~==About this Structure==~~
	~~[[2bth]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full experimental information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2BTH OCA].~~

	==See Also==		==See Also==
	*[[2-Oxoglutarate Dehydrogenase\|2-Oxoglutarate Dehydrogenase]]		*[[2-Oxoglutarate Dehydrogenase\|2-Oxoglutarate Dehydrogenase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016168437<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Dihydrolipoyllysine-residue succinyltransferase]]		[[Category: Dihydrolipoyllysine-residue succinyltransferase]]
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]

OCA at 17:46, 20 October 2012

2012-10-20T17:46:14Z

← Older revision		Revision as of 17:46, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2bth]] is a 1 chain structure ~~of [[2-Oxoglutarate Dehydrogenase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA].		[[2bth]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BTH OCA].

	==See Also==		==See Also==

OCA: Protected "2bth" [edit=sysop:move=sysop]

2012-07-27T01:56:21Z

Protected "2bth" [edit=sysop:move=sysop]

← Older revision	Revision as of 01:56, 27 July 2012
(No difference)