2bwt - Revision history

OCA at 13:57, 13 December 2023

2023-12-13T13:57:29Z

← Older revision		Revision as of 13:57, 13 December 2023
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	<StructureSection load='2bwt' size='340' side='right'caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2bwt' size='340' side='right'caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [https://pdbe.org/2bwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [https://www.ebi.ac.uk/pdbsum/2bwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [https://pdbe.org/2bwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [https://www.ebi.ac.uk/pdbsum/2bwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwt ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/AMPP_ECOLI AMPP_ECOLI]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]		[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Xaa-Pro aminopeptidase]]~~		[[Category: Graham SC]]
	[[Category: Graham~~, S C~~]]		[[Category: Guss JM]]
	[[Category: Guss~~, J M]]~~
	~~[[Category: Pita-bread enzyme]]~~
	~~[[Category: Aminopeptidase p]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Manganese enzyme]]~~
	~~[[Category: Metalloenzyme]]~~
	~~[[Category: Proline-specific enzyme~~]]

OCA at 07:11, 24 February 2021

2021-02-24T07:11:14Z

← Older revision		Revision as of 07:11, 24 February 2021
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	<StructureSection load='2bwt' size='340' side='right'caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2bwt' size='340' side='right'caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [~~http~~://pdbe.org/2bwt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bwt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [https://pdbe.org/2bwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [https://www.ebi.ac.uk/pdbsum/2bwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:53, 10 May 2019

2019-05-10T11:53:11Z

← Older revision		Revision as of 11:53, 10 May 2019
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	==Asp260Ala Escherichia coli Aminopeptidase P==		==Asp260Ala Escherichia coli Aminopeptidase P==
	<StructureSection load='2bwt' size='340' side='right' caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2bwt' size='340' side='right'caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Aminopeptidase\|Aminopeptidase]]		*[[Aminopeptidase 3D structures\|Aminopeptidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Bacillus coli migula 1895]]		[[Category: Bacillus coli migula 1895]]
			[[Category: Large Structures]]
	[[Category: Xaa-Pro aminopeptidase]]		[[Category: Xaa-Pro aminopeptidase]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]

OCA at 06:36, 16 May 2018

2018-05-16T06:36:57Z

← Older revision		Revision as of 06:36, 16 May 2018
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	==~~ASP260ALA ESCHERICHIA COLI AMINOPEPTIDASE~~ P==
			==Asp260Ala Escherichia coli Aminopeptidase P==
	<StructureSection load='2bwt' size='340' side='right' caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2bwt' size='340' side='right' caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://pdbe.org/2bwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://pdbe.org/2bwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bwt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bwt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bwt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bwt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:41, 12 September 2015

2015-09-12T01:41:21Z

← Older revision		Revision as of 01:41, 12 September 2015
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	<StructureSection load='2bwt' size='340' side='right' caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='2bwt' size='340' side='right' caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Escherichia_coli Escherichia~~ coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://pdbe.org/2bwt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 26:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bwt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 33:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Escherichia~~ coli]]		[[Category: Bacillus coli migula 1895]]
	[[Category: Xaa-Pro aminopeptidase]]		[[Category: Xaa-Pro aminopeptidase]]
	[[Category: Graham, S C]]		[[Category: Graham, S C]]

OCA at 16:46, 15 January 2015

2015-01-15T16:46:36Z

OCA at 05:47, 29 September 2014

2014-09-29T05:47:18Z

← Older revision		Revision as of 05:47, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2bwt~~.~~png~~\|~~left~~\|~~200px~~]]		==ASP260ALA ESCHERICHIA COLI AMINOPEPTIDASE P==
			<StructureSection load='2bwt' size='340' side='right' caption='[[2bwt]], [[Resolution\|resolution]] 2.90Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bw/2bwt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Aminopeptidase P (APPro) is a manganese-dependent enzyme that cleaves the N-terminal amino acid from polypeptides where the second residue is proline. APPro shares a similar fold, substrate specificity, and catalytic mechanism with methionine aminopeptidase and prolidase. To investigate the roles of conserved residues at the active site, seven mutant forms of APPro were characterized kinetically and structurally. Mutation of individual metal ligands selectively abolished binding of either or both Mn(II) atoms at the active site, and none of these metal-ligand mutants had detectable catalytic activity. Mutation of the conserved active site residues His243 and His361 revealed that both are required for catalysis. We propose that His243 stabilizes substrate binding through an interaction with the carbonyl oxygen of the requisite proline residue of a substrate and that His361 stabilizes substrate binding and the gem-diol catalytic intermediate. Sequence, structural, and kinetic analyses reveal that His350, conserved in APPro and prolidase but not in methionine aminopeptidase, forms part of a hydrophobic binding pocket that gives APPro its proline specificity. Further, peptides in which the required proline residue is replaced by N-methylalanine or alanine are cleaved by APPro, but they are extremely poor substrates due to a loss of interactions between the prolidyl ring of the substrate and the hydrophobic proline-binding pocket.

	~~{{STRUCTURE_2bwt\| PDB=2bwt \| SCENE= }}~~		Kinetic and crystallographic analysis of mutant Escherichia coli aminopeptidase P: insights into substrate recognition and the mechanism of catalysis.,Graham SC, Lilley PE, Lee M, Schaeffer PM, Kralicek AV, Dixon NE, Guss JM Biochemistry. 2006 Jan 24;45(3):964-75. PMID:16411772<ref>PMID:16411772</ref>

	~~===ASP260ALA ESCHERICHIA COLI AMINOPEPTIDASE P===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16411772}}~~

	~~==About this Structure==~~
	~~[[2bwt]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Escherichia_coli Escherichia coli]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2BWT OCA].~~

	==See Also==		==See Also==
	*[[Aminopeptidase\|Aminopeptidase]]		*[[Aminopeptidase\|Aminopeptidase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016411772<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Xaa-Pro aminopeptidase]]		[[Category: Xaa-Pro aminopeptidase]]

OCA at 22:13, 20 October 2012

2012-10-20T22:13:20Z

← Older revision		Revision as of 22:13, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2bwt]] is a 1 chain structure ~~of [[Aminopeptidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA].		[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA].

	==See Also==		==See Also==

OCA: Protected "2bwt" [edit=sysop:move=sysop]

2012-07-27T15:36:10Z

Protected "2bwt" [edit=sysop:move=sysop]

← Older revision	Revision as of 15:36, 27 July 2012
(No difference)

OCA at 15:36, 27 July 2012

2012-07-27T15:36:09Z

← Older revision		Revision as of 15:36, 27 July 2012
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2bwt.png\|left\|200px]]		[[Image:2bwt.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2bwt", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2bwt\| PDB=2bwt \| SCENE= }}		{{STRUCTURE_2bwt\| PDB=2bwt \| SCENE= }}

	===ASP260ALA ESCHERICHIA COLI AMINOPEPTIDASE P===		===ASP260ALA ESCHERICHIA COLI AMINOPEPTIDASE P===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16411772}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16411772 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16411772}}		{{ABSTRACT_PUBMED_16411772}}

	==About this Structure==		==About this Structure==
	~~2BWT~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA].		[[2bwt]] is a 1 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA].

			==See Also==
			*[[Aminopeptidase\|Aminopeptidase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16411772~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016411772</ref><references group="xtra"/>
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Xaa-Pro aminopeptidase]]		[[Category: Xaa-Pro aminopeptidase]]
Line 34:		Line 25:
	[[Category: Metalloenzyme]]		[[Category: Metalloenzyme]]
	[[Category: Proline-specific enzyme]]		[[Category: Proline-specific enzyme]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 09:21:46 2009''~~

← Older revision		Revision as of 16:46, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bwt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BWT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a16\|1a16]], [[1az9\|1az9]], [[1jaw\|1jaw]], [[1m35\|1m35]], [[1n51\|1n51]], [[1w2m\|1w2m]], [[1w7v\|1w7v]], [[1wbq\|1wbq]], [[2bh3\|2bh3]], [[2bha\|2bha]], [[2bhb\|2bhb]], [[2bhc\|2bhc]], [[2bhd\|2bhd]], [[2bn7\|2bn7]], [[2bws\|2bws]], [[2bwu\|2bwu]], [[2bwv\|2bwv]], [[2bww\|2bww]], [[2bwx\|2bwx]], [[2bwy\|2bwy]], [[1wl9\|1wl9]], [[1wl6\|1wl6]], [[1wlr\|1wlr]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bwt RCSB], [http://www.ebi.ac.uk/pdbsum/2bwt PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 35:
	[[Category: Escherichia coli]]		[[Category: Escherichia coli]]
	[[Category: Xaa-Pro aminopeptidase]]		[[Category: Xaa-Pro aminopeptidase]]
	[[Category: Graham, S C.]]		[[Category: Graham, S C]]
	[[Category: Guss, J M.]]		[[Category: Guss, J M]]
	[[Category: Pita-bread enzyme]]		[[Category: Pita-bread enzyme]]
	[[Category: Aminopeptidase p]]		[[Category: Aminopeptidase p]]