2bxe - Revision history

OCA at 00:49, 21 November 2024

2024-11-21T00:49:24Z

← Older revision		Revision as of 00:49, 21 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxe_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 13:57, 13 December 2023

2023-12-13T13:57:53Z

← Older revision		Revision as of 13:57, 13 December 2023
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	<StructureSection load='2bxe' size='340' side='right'caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2bxe' size='340' side='right'caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BXE FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=1FL:5~~-(2,~~4-DIFLUOROPHENYL)-~~2~~-HYDROXY-BENZOIC+ACID'>1FL</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.95Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [https://pdbe.org/2bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [https://www.ebi.ac.uk/pdbsum/2bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [https://pdbe.org/2bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [https://www.ebi.ac.uk/pdbsum/2bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxe ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>		[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>		[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Bhattacharya~~, A A~~]]		[[Category: Bhattacharya AA]]
	[[Category: Curry, S]]		[[Category: Curry S]]
	[[Category: Ghuman, J]]		[[Category: Ghuman J]]
	[[Category: Petitpas, I]]		[[Category: Petitpas I]]
	[[Category: Zunszain~~, P A]]~~		[[Category: Zunszain PA]]
	~~[[Category: Carrier protein]]~~
	~~[[Category: Drug-binding]]~~
	~~[[Category: Lipid-binding]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Transport protein~~]]

OCA at 13:19, 24 November 2021

2021-11-24T13:19:52Z

OCA at 07:59, 19 February 2020

2020-02-19T07:59:33Z

← Older revision		Revision as of 07:59, 19 February 2020
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	==Human serum albumin complexed with diflunisal==		==Human serum albumin complexed with diflunisal==
	<StructureSection load='2bxe' size='340' side='right' caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2bxe' size='340' side='right'caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Albumin\|Albumin]]		*[[Albumin 3D structures\|Albumin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Bhattacharya, A A]]		[[Category: Bhattacharya, A A]]
	[[Category: Curry, S]]		[[Category: Curry, S]]

OCA at 06:20, 16 May 2018

2018-05-16T06:20:47Z

← Older revision		Revision as of 06:20, 16 May 2018
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	==Human serum albumin complexed with diflunisal==		==Human serum albumin complexed with diflunisal==
	<StructureSection load='2bxe' size='340' side='right' caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2bxe' size='340' side='right' caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://pdbe.org/2bxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://pdbe.org/2bxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxe ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxe_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:36, 9 February 2016

2016-02-09T16:36:26Z

← Older revision		Revision as of 16:36, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bxe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:07, 11 September 2015

2015-09-11T00:07:35Z

← Older revision		Revision as of 00:07, 11 September 2015
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	<StructureSection load='2bxe' size='340' side='right' caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2bxe' size='340' side='right' caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://pdbe.org/2bxe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2bxe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Bhattacharya, A A]]		[[Category: Bhattacharya, A A]]
	[[Category: Curry, S]]		[[Category: Curry, S]]

OCA at 16:21, 15 January 2015

2015-01-15T16:21:04Z

← Older revision		Revision as of 16:21, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>		[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
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	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bhattacharya, A A.]]		[[Category: Bhattacharya, A A]]
	[[Category: Curry, S.]]		[[Category: Curry, S]]
	[[Category: Ghuman, J.]]		[[Category: Ghuman, J]]
	[[Category: Petitpas, I.]]		[[Category: Petitpas, I]]
	[[Category: Zunszain, P A.]]		[[Category: Zunszain, P A]]
	[[Category: Carrier protein]]		[[Category: Carrier protein]]
	[[Category: Drug-binding]]		[[Category: Drug-binding]]

OCA at 04:09, 3 October 2014

2014-10-03T04:09:43Z

← Older revision		Revision as of 04:09, 3 October 2014
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	~~{{STRUCTURE_2bxe\| PDB~~=2bxe \| ~~SCENE~~= }}		==Human serum albumin complexed with diflunisal==
	===~~Human serum albumin complexed~~ with ~~diflunisal~~===		<StructureSection load='2bxe' size='340' side='right' caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>
	~~{{ABSTRACT_PUBMED_16169013}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXE FirstGlance]. <br>
	==Disease==		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [http://www.ebi.ac.uk/pdbsum/2bxe PDBsum]</span></td></tr>
			<table>
			== Disease ==
	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>		[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxe_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Human serum albumin (HSA) is an abundant plasma protein that binds a remarkably wide range of drugs, thereby restricting their free, active concentrations. The problem of overcoming the binding affinity of lead compounds for HSA represents a major challenge in drug development. Crystallographic analysis of 17 different complexes of HSA with a wide variety of drugs and small-molecule toxins reveals the precise architecture of the two primary drug-binding sites on the protein, identifying residues that are key determinants of binding specificity and illuminating the capacity of both pockets for flexible accommodation. Numerous secondary binding sites for drugs distributed across the protein have also been identified. The binding of fatty acids, the primary physiological ligand for the protein, is shown to alter the polarity and increase the volume of drug site 1. These results clarify the interpretation of accumulated drug binding data and provide a valuable template for design efforts to modulate the interaction with HSA.

	~~==Function==~~		Structural basis of the drug-binding specificity of human serum albumin.,Ghuman J, Zunszain PA, Petitpas I, Bhattacharya AA, Otagiri M, Curry S J Mol Biol. 2005 Oct 14;353(1):38-52. PMID:16169013<ref>PMID:16169013</ref>
	~~[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin,~~ the ~~main protein~~ of ~~plasma~~, ~~has a good binding capacity for water~~, ~~Ca(2+)~~, ~~Na(+), K(+)~~, ~~fatty acids~~, ~~hormones~~, ~~bilirubin and drugs~~. ~~Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc~~.<ref>PMID:~~19021548~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2bxe]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA].~~		</div>

	==See Also==		==See Also==
	*[[Albumin\|Albumin]]		*[[Albumin\|Albumin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:016169013</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Bhattacharya, A A.]]		[[Category: Bhattacharya, A A.]]

OCA at 19:13, 7 August 2013

2013-08-07T19:13:32Z

← Older revision		Revision as of 19:13, 7 August 2013
Line 1:		Line 1:
	{{STRUCTURE_2bxe\| PDB=2bxe \| SCENE= }}		{{STRUCTURE_2bxe\| PDB=2bxe \| SCENE= }}
	===~~HUMAN SERUM ALBUMIN COMPLEXED WITH DIFLUNISAL~~===		===Human serum albumin complexed with diflunisal===
	{{ABSTRACT_PUBMED_16169013}}		{{ABSTRACT_PUBMED_16169013}}

	==Disease==		==Disease==
	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref><ref>PMID:7852505</ref><ref>PMID:9329347</ref><ref>PMID:9589637</ref>		[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[http://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>

	==Function==		==Function==
	[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>		[[http://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>

	==About this Structure==		==About this Structure==
Line 23:		Line 23:
	[[Category: Petitpas, I.]]		[[Category: Petitpas, I.]]
	[[Category: Zunszain, P A.]]		[[Category: Zunszain, P A.]]
	~~[[Category: Albumin]]~~
	[[Category: Carrier protein]]		[[Category: Carrier protein]]
	~~[[Category: Diflunisal]]~~
	[[Category: Drug-binding]]		[[Category: Drug-binding]]
	[[Category: Lipid-binding]]		[[Category: Lipid-binding]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
	[[Category: Transport protein]]		[[Category: Transport protein]]

← Older revision		Revision as of 13:19, 24 November 2021
Line 3:		Line 3:
	<StructureSection load='2bxe' size='340' side='right'caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>		<StructureSection load='2bxe' size='340' side='right'caption='[[2bxe]], [[Resolution\|resolution]] 2.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BXE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BXE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1FL:5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC+ACID'>1FL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2bx8\|2bx8]], [[2bxa\|2bxa]], [[2bxb\|2bxb]], [[2bxc\|2bxc]], [[2bxd\|2bxd]], [[2bxf\|2bxf]], [[2bxg\|2bxg]], [[2bxh\|2bxh]], [[2bxi\|2bxi]], [[2bxk\|2bxk]], [[2bxl\|2bxl]], [[2bxm\|2bxm]], [[2bxn\|2bxn]], [[2bxo\|2bxo]], [[2bxp\|2bxp]], [[2bxq\|2bxq]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [~~http~~://pdbe.org/2bxe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bxe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxe OCA], [https://pdbe.org/2bxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bxe RCSB], [https://www.ebi.ac.uk/pdbsum/2bxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxe ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[~~http~~://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>		[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Defects in ALB are a cause of familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:[https://omim.org/entry/103600 103600]]. FDH is a form of euthyroid hyperthyroxinemia that is due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia in Caucasian population.<ref>PMID:8048949</ref> <ref>PMID:7852505</ref> <ref>PMID:9329347</ref> <ref>PMID:9589637</ref>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>		[[https://www.uniprot.org/uniprot/ALBU_HUMAN ALBU_HUMAN]] Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.<ref>PMID:19021548</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]