2bxt - Revision history

OCA at 05:07, 17 October 2024

2024-10-17T05:07:54Z

← Older revision		Revision as of 05:07, 17 October 2024
Line 17:		Line 17:
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:24, 22 May 2024

2024-05-22T11:24:30Z

← Older revision		Revision as of 11:24, 22 May 2024
Line 3:		Line 3:
	<StructureSection load='2bxt' size='340' side='right'caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2bxt' size='340' side='right'caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2BXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene~~></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene>, <scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</div></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [https://pdbe.org/2bxt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [https://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [~~http~~://pdbe.org/2bxt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[~~[http~~://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[~~http~~://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[~~http~~://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[~~http~~://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[~~http~~://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>		[https://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[https://omim.org/entry/613679 613679]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[https://omim.org/entry/601367 601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[https://omim.org/entry/188050 188050]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[https://omim.org/entry/614390 614390]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref> [[http://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME]] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.		[https://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 30:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Hirudo medicinalis]]
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	~~[[Category: Thrombin]]~~		[[Category: Bosio S]]
	[[Category: Bosio, S]]		[[Category: Bulat S]]
	[[Category: Bulat, S]]		[[Category: Cerezo-Galvez S]]
	[[Category: Cerezo-Galvez, S]]		[[Category: Feurer A]]
	[[Category: Feurer, A]]		[[Category: Grabowski E]]
	[[Category: Grabowski, E]]		[[Category: Matassa VG]]
	[[Category: Matassa~~, V G~~]]		[[Category: Metz G]]
	[[Category: Metz, G]]		[[Category: Ott I]]
	[[Category: Ott, I]]		[[Category: Papadopoulos MA]]
	[[Category: Papadopoulos~~, M A~~]]		[[Category: Rosenbaum C]]
	[[Category: Rosenbaum, C]]		[[Category: Schamberger J]]
	[[Category: Schamberger, J]]		[[Category: Sekul R]]
	[[Category: Sekul, R]]
	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~
	~~[[Category: Serine proteinase~~]]

OCA at 04:40, 19 November 2020

2020-11-19T04:40:21Z

← Older revision		Revision as of 04:40, 19 November 2020
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>

OCA at 08:03, 1 July 2020

2020-07-01T08:03:45Z

← Older revision		Revision as of 08:03, 1 July 2020
Line 1:		Line 1:

	==Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker==		==Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker==
	<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2bxt' size='340' side='right'caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2BXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 26:		Line 26:

	==See Also==		==See Also==
	*[[Hirudin\|Hirudin]]		*[[Hirudin 3D structures\|Hirudin 3D structures]]
	*[[Thrombin\|Thrombin]]		*[[Thrombin 3D Structures\|Thrombin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 33:		Line 33:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Thrombin]]		[[Category: Thrombin]]
	[[Category: Bosio, S]]		[[Category: Bosio, S]]

OCA at 09:00, 26 September 2018

2018-09-26T09:00:41Z

← Older revision		Revision as of 09:00, 26 September 2018
Line 3:		Line 3:
	<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
Line 18:		Line 18:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
Line 32:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Human]]
	[[Category: Thrombin]]		[[Category: Thrombin]]
	[[Category: Bosio, S]]		[[Category: Bosio, S]]

OCA at 14:28, 22 December 2016

2016-12-22T14:28:46Z

← Older revision		Revision as of 14:28, 22 December 2016
Line 1:		Line 1:
	==~~DESIGN AND DISCOVERY OF NOVEL~~, ~~POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC~~ P1-P2-~~LINKER~~==
			==Design and Discovery of Novel, Potent Thrombin Inhibitors with a Solubilizing Cationic P1-P2-Linker==
	<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure ~~with sequence from [http://en.wikipedia.org/wiki/Human Human]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bxt ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[http://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[http://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[http://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>		[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[http://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[http://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[http://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref>		[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref> [[http://www.uniprot.org/uniprot/HIRV2_HIRME HIRV2_HIRME]] Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Human]]~~
	[[Category: Thrombin]]		[[Category: Thrombin]]
	[[Category: Bosio, S]]		[[Category: Bosio, S]]

OCA at 20:18, 7 February 2016

2016-02-07T20:18:18Z

← Older revision		Revision as of 20:18, 7 February 2016
Line 21:		Line 21:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bxt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>

OCA at 04:40, 10 September 2015

2015-09-10T04:40:35Z

← Older revision		Revision as of 04:40, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://pdbe.org/2bxt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 31:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Thrombin]]		[[Category: Thrombin]]
	[[Category: Bosio, S]]		[[Category: Bosio, S]]

OCA at 17:33, 15 January 2015

2015-01-15T17:33:59Z

← Older revision		Revision as of 17:33, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[http://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[http://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[http://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>		[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[http://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[http://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[http://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>
Line 33:		Line 33:
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Thrombin]]		[[Category: Thrombin]]
	[[Category: Bosio, S.]]		[[Category: Bosio, S]]
	[[Category: Bulat, S.]]		[[Category: Bulat, S]]
	[[Category: Cerezo-Galvez, S.]]		[[Category: Cerezo-Galvez, S]]
	[[Category: Feurer, A.]]		[[Category: Feurer, A]]
	[[Category: Grabowski, E.]]		[[Category: Grabowski, E]]
	[[Category: Matassa, V G.]]		[[Category: Matassa, V G]]
	[[Category: Metz, G.]]		[[Category: Metz, G]]
	[[Category: Ott, I.]]		[[Category: Ott, I]]
	[[Category: Papadopoulos, M A.]]		[[Category: Papadopoulos, M A]]
	[[Category: Rosenbaum, C.]]		[[Category: Rosenbaum, C]]
	[[Category: Schamberger, J.]]		[[Category: Schamberger, J]]
	[[Category: Sekul, R.]]		[[Category: Sekul, R]]
	[[Category: Hydrolase-hydrolase inhibitor complex]]		[[Category: Hydrolase-hydrolase inhibitor complex]]
	[[Category: Serine proteinase]]		[[Category: Serine proteinase]]

OCA at 00:47, 30 September 2014

2014-09-30T00:47:08Z

← Older revision		Revision as of 00:47, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2bxt\| PDB=2bxt \| SCENE= }}~~		==DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER==
	===DESIGN AND DISCOVERY OF NOVEL, POTENT THROMBIN INHIBITORS WITH A SOLUBILIZING CATIONIC P1-P2-LINKER===		<StructureSection load='2bxt' size='340' side='right' caption='[[2bxt]], [[Resolution\|resolution]] 1.83Å' scene=''>
			== Structural highlights ==
	==Disease==		<table><tr><td colspan='2'>[[2bxt]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BXT FirstGlance]. <br>
	[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[http://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref><ref>PMID:6405779</ref><ref>PMID:3771562</ref><ref>PMID:3567158</ref><ref>PMID:3801671</ref><ref>PMID:3242619</ref><ref>PMID:2719946</ref><ref>PMID:1354985</ref><ref>PMID:1421398</ref><ref>PMID:1349838</ref><ref>PMID:7865694</ref><ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[http://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[http://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C2D:6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL'>C2D</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
	==Function==		<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1a2c\|1a2c]], [[1a3b\|1a3b]], [[1a3e\|1a3e]], [[1a46\|1a46]], [[1a4w\|1a4w]], [[1a5g\|1a5g]], [[1a61\|1a61]], [[1abi\|1abi]], [[1abj\|1abj]], [[1ad8\|1ad8]], [[1ae8\|1ae8]], [[1afe\|1afe]], [[1aht\|1aht]], [[1ai8\|1ai8]], [[1aix\|1aix]], [[1awf\|1awf]], [[1awh\|1awh]], [[1ay6\|1ay6]], [[1b5g\|1b5g]], [[1b7x\|1b7x]], [[1ba8\|1ba8]], [[1bb0\|1bb0]], [[1bcu\|1bcu]], [[1bhx\|1bhx]], [[1bmm\|1bmm]], [[1bmn\|1bmn]], [[1bth\|1bth]], [[1c1u\|1c1u]], [[1c1v\|1c1v]], [[1c1w\|1c1w]], [[1c4u\|1c4u]], [[1c4v\|1c4v]], [[1c4y\|1c4y]], [[1c5l\|1c5l]], [[1c5n\|1c5n]], [[1c5o\|1c5o]], [[1ca8\|1ca8]], [[1d3d\|1d3d]], [[1d3p\|1d3p]], [[1d3q\|1d3q]], [[1d3t\|1d3t]], [[1d4p\|1d4p]], [[1d6w\|1d6w]], [[1d9i\|1d9i]], [[1de7\|1de7]], [[1dit\|1dit]], [[1dm4\|1dm4]], [[1doj\|1doj]], [[1dwb\|1dwb]], [[1dwc\|1dwc]], [[1dwd\|1dwd]], [[1dwe\|1dwe]], [[1dx5\|1dx5]], [[1e0f\|1e0f]], [[1eb1\|1eb1]], [[1eoj\|1eoj]], [[1eol\|1eol]], [[1fpc\|1fpc]], [[1fph\|1fph]], [[1g30\|1g30]], [[1g32\|1g32]], [[1g37\|1g37]], [[1ghv\|1ghv]], [[1ghw\|1ghw]], [[1ghx\|1ghx]], [[1ghy\|1ghy]], [[1gj4\|1gj4]], [[1gj5\|1gj5]], [[1h8d\|1h8d]], [[1h8i\|1h8i]], [[1hag\|1hag]], [[1hah\|1hah]], [[1hai\|1hai]], [[1hao\|1hao]], [[1hap\|1hap]], [[1hbt\|1hbt]], [[1hdt\|1hdt]], [[1hgt\|1hgt]], [[1hlt\|1hlt]], [[1hut\|1hut]], [[1hxe\|1hxe]], [[1hxf\|1hxf]], [[1ihs\|1ihs]], [[1iht\|1iht]], [[1jmo\|1jmo]], [[1jou\|1jou]], [[1jwt\|1jwt]], [[1k21\|1k21]], [[1k22\|1k22]], [[1kts\|1kts]], [[1ktt\|1ktt]], [[1lhc\|1lhc]], [[1lhd\|1lhd]], [[1lhe\|1lhe]], [[1lhf\|1lhf]], [[1lhg\|1lhg]], [[1mh0\|1mh0]], [[1mu6\|1mu6]], [[1mu8\|1mu8]], [[1mue\|1mue]], [[1nm6\|1nm6]], [[1no9\|1no9]], [[1nrn\|1nrn]], [[1nro\|1nro]], [[1nrp\|1nrp]], [[1nrq\|1nrq]], [[1nrr\|1nrr]], [[1nrs\|1nrs]], [[1nt1\|1nt1]], [[1nu7\|1nu7]], [[1nu9\|1nu9]], [[1ny2\|1ny2]], [[1nzq\|1nzq]], [[1o0d\|1o0d]], [[1o2g\|1o2g]], [[1o5g\|1o5g]], [[1ook\|1ook]], [[1oyt\|1oyt]], [[1p8v\|1p8v]], [[1ppb\|1ppb]], [[1qbv\|1qbv]], [[1qhr\|1qhr]], [[1qj1\|1qj1]], [[1qj6\|1qj6]], [[1qj7\|1qj7]], [[1qur\|1qur]], [[1qvh\|1qvh]], [[1rd3\|1rd3]], [[1riw\|1riw]], [[1sb1\|1sb1]], [[1sfq\|1sfq]], [[1sg8\|1sg8]], [[1sgi\|1sgi]], [[1shh\|1shh]], [[1sl3\|1sl3]], [[1sr5\|1sr5]], [[1t4u\|1t4u]], [[1t4v\|1t4v]], [[1ta2\|1ta2]], [[1ta6\|1ta6]], [[1tb6\|1tb6]], [[1tbz\|1tbz]], [[1thp\|1thp]], [[1thr\|1thr]], [[1ths\|1ths]], [[1tmb\|1tmb]], [[1tmt\|1tmt]], [[1tmu\|1tmu]], [[1tom\|1tom]], [[1tq0\|1tq0]], [[1tq7\|1tq7]], [[1twx\|1twx]], [[1uma\|1uma]], [[1uvs\|1uvs]], [[1vr1\|1vr1]], [[1vzq\|1vzq]], [[1w7g\|1w7g]], [[1way\|1way]], [[1wbg\|1wbg]], [[1xm1\|1xm1]], [[1xmn\|1xmn]], [[1zrb\|1zrb]], [[2a0q\|2a0q]], [[2bvr\|2bvr]], [[2bvs\|2bvs]], [[2bvx\|2bvx]], [[2bxu\|2bxu]], [[2hgt\|2hgt]], [[2hnt\|2hnt]], [[2hpp\|2hpp]], [[2hpq\|2hpq]], [[2thf\|2thf]], [[3hat\|3hat]], [[3htc\|3htc]], [[4htc\|4htc]], [[4thn\|4thn]], [[5gds\|5gds]], [[7kme\|7kme]], [[8kme\|8kme]]</td></tr>
	[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref>		<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thrombin Thrombin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.5 3.4.21.5] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bxt RCSB], [http://www.ebi.ac.uk/pdbsum/2bxt PDBsum]</span></td></tr>
	==~~About this Structure~~==		<table>
	[[~~2bxt~~]] ~~is a 3 chain~~ structure ~~with sequence from~~ [http://en.~~wikipedia~~.~~org/wiki~~/~~Homo_sapiens Homo sapiens~~]. ~~Full crystallographic information is~~ available from [http://~~oca~~.~~weizmann~~.ac.il/~~oca-bin~~/~~ocashort~~?id=~~2BXT OCA~~].		== Disease ==
			[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Defects in F2 are the cause of factor II deficiency (FA2D) [MIM:[http://omim.org/entry/613679 613679]]. It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels.<ref>PMID:14962227</ref> <ref>PMID:6405779</ref> <ref>PMID:3771562</ref> <ref>PMID:3567158</ref> <ref>PMID:3801671</ref> <ref>PMID:3242619</ref> <ref>PMID:2719946</ref> <ref>PMID:1354985</ref> <ref>PMID:1421398</ref> <ref>PMID:1349838</ref> <ref>PMID:7865694</ref> <ref>PMID:7792730</ref> Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:[http://omim.org/entry/601367 601367]]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.<ref>PMID:15534175</ref> Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1) [MIM:[http://omim.org/entry/188050 188050]]. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2) [MIM:[http://omim.org/entry/614390 614390]]. A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.<ref>PMID:11506076</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/THRB_HUMAN THRB_HUMAN]] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.<ref>PMID:2856554</ref>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bx/2bxt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>

	==See Also==		==See Also==
	*[[Hirudin\|Hirudin]]		*[[Hirudin\|Hirudin]]
	*[[Thrombin\|Thrombin]]		*[[Thrombin\|Thrombin]]
			== References ==
	==~~Reference~~==		<references/>
	<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Thrombin]]		[[Category: Thrombin]]