2c19 - Revision history

OCA at 09:02, 6 November 2024

2024-11-06T09:02:37Z

← Older revision		Revision as of 09:02, 6 November 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c19_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c19_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:01, 13 December 2023

2023-12-13T14:01:36Z

← Older revision		Revision as of 14:01, 13 December 2023
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	<StructureSection load='2c19' size='340' side='right'caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2c19' size='340' side='right'caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C19 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~, ~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.05Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	~~<tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></~~td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], ~~[[2c15\|2c15]], [[2c18\|2c18]]~~<~~/div></td></tr>~~
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [https://pdbe.org/2c19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [https://www.ebi.ac.uk/pdbsum/2c19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [https://pdbe.org/2c19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [https://www.ebi.ac.uk/pdbsum/2c19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).		[https://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Porphobilinogen synthase~~]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Frankenberg-Dinkel, N]]		[[Category: Frankenberg-Dinkel N]]
	[[Category: Frere, F]]		[[Category: Frere F]]
	[[Category: Gacond, S]]		[[Category: Gacond S]]
	[[Category: Heinz~~, D W~~]]		[[Category: Heinz DW]]
	[[Category: Neier, R]]		[[Category: Neier R]]
	[[Category: Nentwich, M]]		[[Category: Nentwich M]]
	~~[[Category: Cocrystallization]]~~
	~~[[Category: Enzyme mechanism]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Metalloenzyme]]~~
	~~[[Category: Porphyrin biosynthesis~~]]

OCA at 10:32, 17 February 2021

2021-02-17T10:32:58Z

OCA at 11:55, 10 May 2019

2019-05-10T11:55:04Z

← Older revision		Revision as of 11:55, 10 May 2019
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	==5-(4-Carboxy-2-oxo-butylsulfanyl)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa==		==5-(4-Carboxy-2-oxo-butylsulfanyl)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa==
	<StructureSection load='2c19' size='340' side='right' caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2c19' size='340' side='right'caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Frankenberg-Dinkel, N]]		[[Category: Frankenberg-Dinkel, N]]

OCA at 08:34, 23 May 2018

2018-05-23T08:34:57Z

← Older revision		Revision as of 08:34, 23 May 2018
Line 1:		Line 1:
	==5-(4-~~CARBOXY~~-2-~~OXO~~-~~BUTYLSULFANYL~~)-4-~~OXO~~-~~PENTANOIC ACID ACID BOUND TO PORPHOBILINOGEN SYNTHASE FROM PSEUDOMONAS AERUGINOSA~~==
			==5-(4-Carboxy-2-oxo-butylsulfanyl)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa==
	<StructureSection load='2c19' size='340' side='right' caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2c19' size='340' side='right' caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://pdbe.org/2c19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://pdbe.org/2c19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c19_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c19_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:04, 8 February 2016

2016-02-08T03:04:25Z

← Older revision		Revision as of 03:04, 8 February 2016
Line 19:		Line 19:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c19 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:15, 10 September 2015

2015-09-10T07:15:49Z

← Older revision		Revision as of 07:15, 10 September 2015
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	<StructureSection load='2c19' size='340' side='right' caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2c19' size='340' side='right' caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Pseudomonas_aeruginosa Pseudomonas aeruginosa~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://pdbe.org/2c19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2c19" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
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	</StructureSection>		</StructureSection>
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	~~[[Category: Pseudomonas aeruginosa]]~~
	[[Category: Frankenberg-Dinkel, N]]		[[Category: Frankenberg-Dinkel, N]]
	[[Category: Frere, F]]		[[Category: Frere, F]]

OCA at 20:07, 24 December 2014

2014-12-24T20:07:13Z

← Older revision		Revision as of 20:07, 24 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 38:
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]
	[[Category: Frankenberg-Dinkel, N.]]		[[Category: Frankenberg-Dinkel, N]]
	[[Category: Frere, F.]]		[[Category: Frere, F]]
	[[Category: Gacond, S.]]		[[Category: Gacond, S]]
	[[Category: Heinz, D W.]]		[[Category: Heinz, D W]]
	[[Category: Neier, R.]]		[[Category: Neier, R]]
	[[Category: Nentwich, M.]]		[[Category: Nentwich, M]]
	[[Category: Cocrystallization]]		[[Category: Cocrystallization]]
	[[Category: Enzyme mechanism]]		[[Category: Enzyme mechanism]]
	[[Category: Lyase]]		[[Category: Lyase]]
	[[Category: Metalloenzyme]]		[[Category: Metalloenzyme]]
	~~[[Category: Porphobilinogen synthase]]~~
	[[Category: Porphyrin biosynthesis]]		[[Category: Porphyrin biosynthesis]]

OCA at 00:23, 30 September 2014

2014-09-30T00:23:56Z

← Older revision		Revision as of 00:23, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2c19~~.~~png~~\|~~left~~\|~~200px~~]]		==5-(4-CARBOXY-2-OXO-BUTYLSULFANYL)-4-OXO-PENTANOIC ACID ACID BOUND TO PORPHOBILINOGEN SYNTHASE FROM PSEUDOMONAS AERUGINOSA==
			<StructureSection load='2c19' size='340' side='right' caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C19 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [http://www.ebi.ac.uk/pdbsum/2c19 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c1/2c19_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Porphobilinogen synthase catalyzes the first committed step of the tetrapyrrole biosynthesis pathway. In an aldol-like condensation, two molecules of 5-aminolevulinic acid (ALA) form the first pyrrole, porphobilinogen. Newly synthesized analogues of a reaction intermediate of porphobilinogen synthase have been employed in studying the active site and the catalytic mechanism of this early enzyme of tetrapyrrole biosynthesis. This study combines structural and kinetic evaluation of the inhibition potency of these inhibitors. In addition, one of the determined protein structures provides for the first time structural evidence of a magnesium ion in the active site. From these results, we can corroborate an earlier postulated enzymatic mechanism that starts with formation of a C-C bond, linking C3 of the A-side ALA to C4 of the P-side ALA through an aldole addition. The obtained data are discussed with respect to the current literature.

	~~{{STRUCTURE_2c19\| PDB=2c19 \| SCENE= }}~~		Probing the active site of Pseudomonas aeruginosa porphobilinogen synthase using newly developed inhibitors.,Frere F, Nentwich M, Gacond S, Heinz DW, Neier R, Frankenberg-Dinkel N Biochemistry. 2006 Jul 11;45(27):8243-53. PMID:16819823<ref>PMID:16819823</ref>

	~~===5-(4-CARBOXY-2-OXO-BUTYLSULFANYL)-4-OXO-PENTANOIC ACID ACID BOUND TO PORPHOBILINOGEN SYNTHASE FROM PSEUDOMONAS AERUGINOSA===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16819823}}~~

	~~==About this Structure==~~
	~~[[2c19]] is~~ a ~~2 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2C19 OCA].~~

	==See Also==		==See Also==
	*[[Porphobilinogen synthase\|Porphobilinogen synthase]]		*[[Porphobilinogen synthase\|Porphobilinogen synthase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016819823<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Porphobilinogen synthase]]		[[Category: Porphobilinogen synthase]]
	[[Category: Pseudomonas aeruginosa]]		[[Category: Pseudomonas aeruginosa]]

OCA: Protected "2c19" [edit=sysop:move=sysop]

2013-01-06T09:47:13Z

Protected "2c19" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:47, 6 January 2013
(No difference)

← Older revision		Revision as of 10:32, 17 February 2021
Line 3:		Line 3:
	<StructureSection load='2c19' size='340' side='right'caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>		<StructureSection load='2c19' size='340' side='right'caption='[[2c19]], [[Resolution\|resolution]] 2.05Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C19 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1X:(Z)-N~6~-[(4R,5S)-5-(2-CARBOXYETHYL)-4-(CARBOXYMETHYL)DIHYDRO-2H-THIOPYRAN-3(4H)-YLIDENE]-L-LYSINE'>C1X</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b4k\|1b4k]], [[1gzg\|1gzg]], [[1w54\|1w54]], [[1w56\|1w56]], [[1w5m\|1w5m]], [[1w5n\|1w5n]], [[1w5o\|1w5o]], [[1w5p\|1w5p]], [[1w5q\|1w5q]], [[2c13\|2c13]], [[2c14\|2c14]], [[2c15\|2c15]], [[2c18\|2c18]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [~~http~~://pdbe.org/2c19 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c19 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c19 OCA], [https://pdbe.org/2c19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c19 RCSB], [https://www.ebi.ac.uk/pdbsum/2c19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).		[[https://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]