2c3f - Revision history

OCA at 09:21, 9 May 2024

2024-05-09T09:21:28Z

← Older revision		Revision as of 09:21, 9 May 2024
Line 3:		Line 3:
	<StructureSection load='2c3f' size='340' side='right'caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2c3f' size='340' side='right'caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C3F FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks~~'>~~[https://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [https://pdbe.org/2c3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [https://www.ebi.ac.uk/pdbsum/2c3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c3f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [https://pdbe.org/2c3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [https://www.ebi.ac.uk/pdbsum/2c3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c3f ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/Q9A0M7_STRP1 Q9A0M7_STRP1]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Micrococcus scarlatinae klein 1884]]~~
	~~[[Category: Hyaluronate lyase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Black~~, G W~~]]		[[Category: Streptococcus pyogenes]]
	[[Category: Charnock~~, S J~~]]		[[Category: Black GW]]
	[[Category: Davies~~, G J~~]]		[[Category: Charnock SJ]]
	[[Category: Dodson~~, E J~~]]		[[Category: Davies GJ]]
	[[Category: Linsay, A M]]		[[Category: Dodson EJ]]
	[[Category: Smith~~, N L~~]]		[[Category: Linsay A-M]]
	[[Category: Taylor~~, E J~~]]		[[Category: Smith NL]]
	[[Category: Turkenburg~~, J P]]~~		[[Category: Taylor EJ]]
	~~[[Category: Hyaluronan lyase]]~~		[[Category: Turkenburg JP]]
	~~[[Category: Hyaluronidase]]~~
	~~[[Category: Lyase]]~~
	~~[[Category: Phage tail fibre]]~~
	~~[[Category: Scarlet fever]]~~
	~~[[Category: Triple-stranded beta- helix~~]]

OCA at 06:47, 1 December 2021

2021-12-01T06:47:25Z

← Older revision		Revision as of 06:47, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2c3f' size='340' side='right'caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2c3f' size='340' side='right'caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C3F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [~~http~~://pdbe.org/2c3f PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c3f PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c3f ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [https://pdbe.org/2c3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [https://www.ebi.ac.uk/pdbsum/2c3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c3f ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:08, 26 February 2020

2020-02-26T11:08:25Z

← Older revision		Revision as of 11:08, 26 February 2020
Line 1:		Line 1:

	==The structure of a group A streptococcal phage-encoded tail-fibre showing hyaluronan lyase activity.==		==The structure of a group A streptococcal phage-encoded tail-fibre showing hyaluronan lyase activity.==
	<StructureSection load='2c3f' size='340' side='right' caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2c3f' size='340' side='right'caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>
Line 29:		Line 29:

	==See Also==		==See Also==
	*[[Hyaluronidase\|Hyaluronidase]]		*[[Hyaluronidase 3D structures\|Hyaluronidase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 36:		Line 36:
	[[Category: Micrococcus scarlatinae klein 1884]]		[[Category: Micrococcus scarlatinae klein 1884]]
	[[Category: Hyaluronate lyase]]		[[Category: Hyaluronate lyase]]
			[[Category: Large Structures]]
	[[Category: Black, G W]]		[[Category: Black, G W]]
	[[Category: Charnock, S J]]		[[Category: Charnock, S J]]

OCA at 08:37, 23 May 2018

2018-05-23T08:37:42Z

← Older revision		Revision as of 08:37, 23 May 2018
Line 1:		Line 1:
	==~~THE STRUCTURE OF~~ A ~~GROUP A STREPTOCOCCAL PHAGE~~-~~ENCODED TAIL~~-~~FIBRE SHOWING HYALURONAN LYASE ACTIVITY~~.==
			==The structure of a group A streptococcal phage-encoded tail-fibre showing hyaluronan lyase activity.==
	<StructureSection load='2c3f' size='340' side='right' caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2c3f' size='340' side='right' caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://pdbe.org/2c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://pdbe.org/2c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c3f ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 11:		Line 12:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/2c3f_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/2c3f_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 03:11, 8 February 2016

2016-02-08T03:11:40Z

← Older revision		Revision as of 03:11, 8 February 2016
Line 15:		Line 15:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c3f ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:19, 10 September 2015

2015-09-10T07:19:00Z

← Older revision		Revision as of 07:19, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2c3f' size='340' side='right' caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='2c3f' size='340' side='right' caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Streptococcus_pyogenes Streptococcus pyogenes~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_scarlatinae"_klein_1884 "micrococcus scarlatinae" klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://pdbe.org/2c3f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 25:		Line 25:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2c3f" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 32:		Line 33:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Micrococcus scarlatinae klein 1884]]
	[[Category: Hyaluronate lyase]]		[[Category: Hyaluronate lyase]]
	~~[[Category: Streptococcus pyogenes]]~~
	[[Category: Black, G W]]		[[Category: Black, G W]]
	[[Category: Charnock, S J]]		[[Category: Charnock, S J]]

OCA at 17:02, 15 January 2015

2015-01-15T17:02:59Z

← Older revision		Revision as of 17:02, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 34:
	[[Category: Hyaluronate lyase]]		[[Category: Hyaluronate lyase]]
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes]]
	[[Category: Black, G W.]]		[[Category: Black, G W]]
	[[Category: Charnock, S J.]]		[[Category: Charnock, S J]]
	[[Category: Davies, G J.]]		[[Category: Davies, G J]]
	[[Category: Dodson, E J.]]		[[Category: Dodson, E J]]
	[[Category: Linsay, A M.]]		[[Category: Linsay, A M]]
	[[Category: Smith, N L.]]		[[Category: Smith, N L]]
	[[Category: Taylor, E J.]]		[[Category: Taylor, E J]]
	[[Category: Turkenburg, J P.]]		[[Category: Turkenburg, J P]]
	[[Category: Hyaluronan lyase]]		[[Category: Hyaluronan lyase]]
	[[Category: Hyaluronidase]]		[[Category: Hyaluronidase]]

OCA at 04:48, 29 September 2014

2014-09-29T04:48:54Z

← Older revision		Revision as of 04:48, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2c3f~~.~~png~~\|~~left~~\|~~200px~~]]		==THE STRUCTURE OF A GROUP A STREPTOCOCCAL PHAGE-ENCODED TAIL-FIBRE SHOWING HYALURONAN LYASE ACTIVITY.==
			<StructureSection load='2c3f' size='340' side='right' caption='[[2c3f]], [[Resolution\|resolution]] 1.81Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C3F FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Hyaluronate_lyase Hyaluronate lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.2.1 4.2.2.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c3f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c3f RCSB], [http://www.ebi.ac.uk/pdbsum/2c3f PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c3/2c3f_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Streptococcus pyogenes (group A Streptococcus) causes severe invasive infections including scarlet fever, pharyngitis (streptococcal sore throat), skin infections, necrotizing fasciitis (flesh-eating disease), septicemia, erysipelas, cellulitis, acute rheumatic fever, and toxic shock. The conversion from nonpathogenic to toxigenic strains of S. pyogenes is frequently mediated by bacteriophage infection. One of the key bacteriophage-encoded virulence factors is a putative "hyaluronidase," HylP1, a phage tail-fiber protein responsible for the digestion of the S. pyogenes hyaluronan capsule during phage infection. Here we demonstrate that HylP1 is a hyaluronate lyase. The 3D structure, at 1.8-angstroms resolution, reveals an unusual triple-stranded beta-helical structure and provides insight into the structural basis for phage tail assembly and the role of phage tail proteins in virulence. Unlike the triple-stranded beta-helix assemblies of the bacteriophage T4 injection machinery and the tailspike endosialidase of the Escherichia coli K1 bacteriophage K1F, HylP1 possesses three copies of the active center on the triple-helical fiber itself without the need for an accessory catalytic domain. The triple-stranded beta-helix is not simply a structural scaffold, as previously envisaged; it is harnessed to provide a 200-angstroms-long substrate-binding groove for the optimal reduction in hyaluronan viscosity to aid phage penetration of the capsule.

	~~{{STRUCTURE_2c3f\| PDB=2c3f \| SCENE= }}~~		Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded beta-helix.,Smith NL, Taylor EJ, Lindsay AM, Charnock SJ, Turkenburg JP, Dodson EJ, Davies GJ, Black GW Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17652-7. Epub 2005 Nov 28. PMID:16314578<ref>PMID:16314578</ref>

	~~===THE STRUCTURE OF A GROUP A STREPTOCOCCAL PHAGE-ENCODED TAIL-FIBRE SHOWING HYALURONAN LYASE ACTIVITY.===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16314578}}~~

	~~==About this Structure==~~
	~~[[2c3f]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA].~~

	==See Also==		==See Also==
	*[[Hyaluronidase\|Hyaluronidase]]		*[[Hyaluronidase\|Hyaluronidase]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016314578<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Hyaluronate lyase]]		[[Category: Hyaluronate lyase]]
	[[Category: Streptococcus pyogenes]]		[[Category: Streptococcus pyogenes]]

OCA at 08:42, 20 October 2012

2012-10-20T08:42:49Z

← Older revision		Revision as of 08:42, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2c3f]] is a 1 chain structure ~~of [[Hyaluronidase]]~~ with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA].		[[2c3f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C3F OCA].

	==See Also==		==See Also==

OCA: Protected "2c3f" [edit=sysop:move=sysop]

2012-07-25T20:31:47Z

Protected "2c3f" [edit=sysop:move=sysop]

← Older revision	Revision as of 20:31, 25 July 2012
(No difference)