2c8d - Revision history

OCA at 14:08, 13 December 2023

2023-12-13T14:08:55Z

← Older revision		Revision as of 14:08, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2c8d' size='340' side='right'caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2c8d' size='340' side='right'caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8D FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</~~div~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [https://pdbe.org/2c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [https://www.ebi.ac.uk/pdbsum/2c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [https://pdbe.org/2c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [https://www.ebi.ac.uk/pdbsum/2c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~ARC3_CBDP ARC3_CBDP~~]~~] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.~~		[https://www.uniprot.org/uniprot/Q7M0L1_CLOBO Q7M0L1_CLOBO]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 36:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Bacillus botulinus van ermengem 1896~~]]		[[Category: Clostridium botulinum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Boquet, P]]		[[Category: Boquet P]]
	[[Category: Flatau, G]]		[[Category: Flatau G]]
	[[Category: Menetrey, J]]		[[Category: Menetrey J]]
	[[Category: Menez, A]]		[[Category: Menez A]]
	[[Category: Stura~~, E A]]~~		[[Category: Stura EA]]
	~~[[Category: Artt motif]]~~
	~~[[Category: Bacterial toxin]]~~
	~~[[Category: C3 exoenzyme]]~~
	~~[[Category: Glycosyltransferase]]~~
	~~[[Category: Transferase~~]]

OCA at 06:50, 1 December 2021

2021-12-01T06:50:14Z

← Older revision		Revision as of 06:50, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2c8d' size='340' side='right'caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2c8d' size='340' side='right'caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2C8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C8D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [~~http~~://pdbe.org/2c8d PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2c8d PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8d ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [https://pdbe.org/2c8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [https://www.ebi.ac.uk/pdbsum/2c8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.		[[https://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:00, 26 February 2020

2020-02-26T11:00:55Z

← Older revision		Revision as of 11:00, 26 February 2020
Line 1:		Line 1:

	==Structure of the ARTT motif Q212A mutant C3bot1 Exoenzyme (Free state, crystal form I)==		==Structure of the ARTT motif Q212A mutant C3bot1 Exoenzyme (Free state, crystal form I)==
	<StructureSection load='2c8d' size='340' side='right' caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2c8d' size='340' side='right'caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>
Line 31:		Line 31:

	==See Also==		==See Also==
	*[[Exoenzyme\|Exoenzyme]]		*[[Exoenzyme 3D structures\|Exoenzyme 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 37:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus botulinus van ermengem 1896]]		[[Category: Bacillus botulinus van ermengem 1896]]
			[[Category: Large Structures]]
	[[Category: Boquet, P]]		[[Category: Boquet, P]]
	[[Category: Flatau, G]]		[[Category: Flatau, G]]

OCA at 08:25, 23 May 2018

2018-05-23T08:25:42Z

← Older revision		Revision as of 08:25, 23 May 2018
Line 1:		Line 1:
	==~~STRUCTURE OF THE~~ ARTT ~~MOTIF~~ Q212A ~~MUTANT C3BOT1 EXOENZYME~~ (~~FREE STATE~~, ~~CRYSTAL FORM~~ I)==
			==Structure of the ARTT motif Q212A mutant C3bot1 Exoenzyme (Free state, crystal form I)==
	<StructureSection load='2c8d' size='340' side='right' caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2c8d' size='340' side='right' caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 5:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://pdbe.org/2c8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://pdbe.org/2c8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c8d ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 13:		Line 14:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8d_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8d_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c8d ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:58, 11 September 2015

2015-09-11T23:58:50Z

← Older revision		Revision as of 23:58, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2c8d' size='340' side='right' caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='2c8d' size='340' side='right' caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Clostridium_botulinum Clostridium botulinum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://pdbe.org/2c8d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 27:		Line 27:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2c8d" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 34:		Line 35:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Clostridium botulinum~~]]		[[Category: Bacillus botulinus van ermengem 1896]]
	[[Category: Boquet, P]]		[[Category: Boquet, P]]
	[[Category: Flatau, G]]		[[Category: Flatau, G]]

OCA at 21:07, 25 December 2014

2014-12-25T21:07:54Z

← Older revision		Revision as of 21:07, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>		<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 33:		Line 35:
	</StructureSection>		</StructureSection>
	[[Category: Clostridium botulinum]]		[[Category: Clostridium botulinum]]
	[[Category: Boquet, P.]]		[[Category: Boquet, P]]
	[[Category: Flatau, G.]]		[[Category: Flatau, G]]
	[[Category: Menetrey, J.]]		[[Category: Menetrey, J]]
	[[Category: Menez, A.]]		[[Category: Menez, A]]
	[[Category: Stura, E A.]]		[[Category: Stura, E A]]
	[[Category: Artt motif]]		[[Category: Artt motif]]
	[[Category: Bacterial toxin]]		[[Category: Bacterial toxin]]

OCA at 04:17, 3 October 2014

2014-10-03T04:17:38Z

← Older revision		Revision as of 04:17, 3 October 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2c8d\| PDB=2c8d \| SCENE= }}~~		==STRUCTURE OF THE ARTT MOTIF Q212A MUTANT C3BOT1 EXOENZYME (FREE STATE, CRYSTAL FORM I)==
	===STRUCTURE OF THE ARTT MOTIF Q212A MUTANT C3BOT1 EXOENZYME (FREE STATE, CRYSTAL FORM I)===		<StructureSection load='2c8d' size='340' side='right' caption='[[2c8d]], [[Resolution\|resolution]] 2.20Å' scene=''>
	~~{{ABSTRACT_PUBMED_18369192}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C8D FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1g24\|1g24]], [[1gze\|1gze]], [[1gzf\|1gzf]], [[1uzi\|1uzi]], [[2a78\|2a78]], [[2a9k\|2a9k]], [[2bov\|2bov]], [[2c89\|2c89]], [[2c8a\|2c8a]], [[2c8b\|2c8b]], [[2c8c\|2c8c]], [[2c8e\|2c8e]], [[2c8f\|2c8f]], [[2c8g\|2c8g]], [[2c8h\|2c8h]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c8d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c8d RCSB], [http://www.ebi.ac.uk/pdbsum/2c8d PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c8/2c8d_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			C3-like exoenzymes are ADP-ribosyltransferases that specifically modify some Rho GTPase proteins, leading to their sequestration in the cytoplasm, and thus inhibiting their regulatory activity on the actin cytoskeleton. This modification process goes through three sequential steps involving NAD-hydrolysis, Rho recognition, and binding, leading to Rho ADP-ribosylation. Independently, three distinct residues within the ARTT loop of the C3 exoenzymes are critical for each of these steps. Supporting the critical role of the ARTT loop, we have shown previously that it adopts a distinct conformation upon NAD binding. Here, we present seven wild-type and ARTT loop-mutant structures of C3 exoenzyme of Clostridium botulinum free and bound to its true substrate, NAD, and to its NAD-hydrolysis product, nicotinamide. Altogether, these structures expand our understanding of the conformational diversity of the C3 exoenzyme, mainly within the ARTT loop.

	~~==Function==~~		Structural basis for the NAD-hydrolysis mechanism and the ARTT-loop plasticity of C3 exoenzymes.,Menetrey J, Flatau G, Boquet P, Menez A, Stura EA Protein Sci. 2008 May;17(5):878-86. Epub 2008 Mar 27. PMID:18369192<ref>PMID:18369192</ref>
	~~[[http~~:~~//www~~.~~uniprot~~.~~org~~/~~uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2c8d]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Clostridium_botulinum Clostridium botulinum]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA].~~		</div>

	==~~Reference~~==		==See Also==
	~~<ref group~~=~~"xtra">PMID:018369192</ref><ref group~~=~~"xtra">PMID:012029083</ref>~~<references ~~group="xtra"~~/><~~references~~/>		*[[Exoenzyme\|Exoenzyme]]
			== References ==
			<references/>
			__TOC__
			</StructureSection>
	[[Category: Clostridium botulinum]]		[[Category: Clostridium botulinum]]
	[[Category: Boquet, P.]]		[[Category: Boquet, P.]]

OCA at 23:04, 10 April 2013

2013-04-10T23:04:23Z

← Older revision		Revision as of 23:04, 10 April 2013
Line 1:		Line 1:
	~~[[Image:2c8d.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2c8d", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2c8d\| PDB=2c8d \| SCENE= }}		{{STRUCTURE_2c8d\| PDB=2c8d \| SCENE= }}

	===STRUCTURE OF THE ARTT MOTIF Q212A MUTANT C3BOT1 EXOENZYME (FREE STATE, CRYSTAL FORM I)===		===STRUCTURE OF THE ARTT MOTIF Q212A MUTANT C3BOT1 EXOENZYME (FREE STATE, CRYSTAL FORM I)===
			{{ABSTRACT_PUBMED_18369192}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/ARC3_CBDP ARC3_CBDP]] ADP-ribosylates eukaryotic Rho and Rac proteins on an asparagine residue.
	~~The line below this paragraph, {{ABSTRACT_PUBMED_18369192}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 18369192 is the PubMed ID number~~.
	~~-->~~
	~~{{ABSTRACT_PUBMED_18369192}}~~

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
	<ref group="xtra">PMID:018369192</ref><ref group="xtra">PMID:012029083</ref><references group="xtra"/>		<ref group="xtra">PMID:018369192</ref><ref group="xtra">PMID:012029083</ref><references group="xtra"/><references/>
	[[Category: Clostridium botulinum]]		[[Category: Clostridium botulinum]]
	[[Category: Boquet, P.]]		[[Category: Boquet, P.]]
Line 29:		Line 17:
	[[Category: Menez, A.]]		[[Category: Menez, A.]]
	[[Category: Stura, E A.]]		[[Category: Stura, E A.]]
			[[Category: Artt motif]]
			[[Category: Bacterial toxin]]
			[[Category: C3 exoenzyme]]
			[[Category: Glycosyltransferase]]
			[[Category: Transferase]]

OCA: Protected "2c8d" [edit=sysop:move=sysop]

2011-06-08T04:28:08Z

Protected "2c8d" [edit=sysop:move=sysop]

← Older revision	Revision as of 04:28, 8 June 2011
(No difference)

OCA at 04:28, 8 June 2011

2011-06-08T04:28:06Z

@@ Line 1: / Line 1: @@
 [[Image:2c8d.png|left|200px]]
@@ Line 12: / Line 11: @@
 ===STRUCTURE OF THE ARTT MOTIF Q212A MUTANT C3BOT1 EXOENZYME (FREE STATE, CRYSTAL FORM I)===
 ==About this Structure==
-C8D is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA].
+[[2c8d]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C8D OCA].
 [[Category: Clostridium botulinum]]
 [[Category: Boquet, P.]]
@@ Line 21: / Line 29: @@
 [[Category: Menez, A.]]
 [[Category: Stura, E A.]]