2ca5 - Revision history

OCA at 09:23, 9 May 2024

2024-05-09T09:23:46Z

← Older revision		Revision as of 09:23, 9 May 2024
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	<StructureSection load='2ca5' size='340' side='right'caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ca5' size='340' side='right'caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [https://pdbe.org/2ca5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [https://pdbe.org/2ca5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/MXIH_SHIFL MXIH_SHIFL]] Necessary for the secretion of IPA invasins.		[https://www.uniprot.org/uniprot/MXIH_SHIFL MXIH_SHIFL] Necessary for the secretion of IPA invasins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Shigella paradysenteriae weldin 1927]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Blocker~~, A J~~]]		[[Category: Shigella flexneri]]
	[[Category: Cordes~~, F S~~]]		[[Category: Blocker AJ]]
	[[Category: Deane~~, J E~~]]		[[Category: Cordes FS]]
	[[Category: Johnson, S]]		[[Category: Deane JE]]
	[[Category: Kenjale, R]]		[[Category: Johnson S]]
	[[Category: Lea~~, S M~~]]		[[Category: Kenjale R]]
	[[Category: Picking~~, W D~~]]		[[Category: Lea SM]]
	[[Category: Picking~~, W L~~]]		[[Category: Picking WD]]
	[[Category: Roversi, P]]		[[Category: Picking WL]]
	~~[[Category: Mxih]]~~		[[Category: Roversi P]]
	~~[[Category: Needle complex]]~~
	~~[[Category: Protein transport]]~~
	~~[[Category: Transport protein]]~~
	~~[[Category: Type iii secretion system]]~~
	~~[[Category: Virulence~~]]

OCA at 06:51, 1 December 2021

2021-12-01T06:51:41Z

← Older revision		Revision as of 06:51, 1 December 2021
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	<StructureSection load='2ca5' size='340' side='right'caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ca5' size='340' side='right'caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [~~http~~://pdbe.org/2ca5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ca5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [https://pdbe.org/2ca5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/MXIH_SHIFL MXIH_SHIFL]] Necessary for the secretion of IPA invasins.		[[https://www.uniprot.org/uniprot/MXIH_SHIFL MXIH_SHIFL]] Necessary for the secretion of IPA invasins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:09, 26 February 2020

2020-02-26T11:09:10Z

← Older revision		Revision as of 11:09, 26 February 2020
Line 1:		Line 1:

	==MxiH needle protein of Shigella Flexneri (monomeric form, residues 1- 78)==		==MxiH needle protein of Shigella Flexneri (monomeric form, residues 1- 78)==
	<StructureSection load='2ca5' size='340' side='right' caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ca5' size='340' side='right'caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Shigella paradysenteriae weldin 1927]]		[[Category: Shigella paradysenteriae weldin 1927]]
			[[Category: Large Structures]]
	[[Category: Blocker, A J]]		[[Category: Blocker, A J]]
	[[Category: Cordes, F S]]		[[Category: Cordes, F S]]

OCA at 08:38, 23 May 2018

2018-05-23T08:38:44Z

← Older revision		Revision as of 08:38, 23 May 2018
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	==~~MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI~~ (~~MONOMERIC FORM~~, ~~RESIDUES~~ 1-78)==
			==MxiH needle protein of Shigella Flexneri (monomeric form, residues 1- 78)==
	<StructureSection load='2ca5' size='340' side='right' caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ca5' size='340' side='right' caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://pdbe.org/2ca5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://pdbe.org/2ca5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca5 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca5_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca5_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 13:57, 9 February 2016

2016-02-09T13:57:34Z

← Older revision		Revision as of 13:57, 9 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ca5 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:54, 10 September 2015

2015-09-10T22:54:17Z

← Older revision		Revision as of 22:54, 10 September 2015
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	<StructureSection load='2ca5' size='340' side='right' caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='2ca5' size='340' side='right' caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Shigella_flexneri Shigella flexneri~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"shigella_paradysenteriae"_weldin_1927 "shigella paradysenteriae" weldin 1927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://pdbe.org/2ca5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ca5" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Shigella ~~flexneri~~]]		[[Category: Shigella paradysenteriae weldin 1927]]
	[[Category: Blocker, A J]]		[[Category: Blocker, A J]]
	[[Category: Cordes, F S]]		[[Category: Cordes, F S]]

OCA at 07:14, 25 December 2014

2014-12-25T07:14:22Z

← Older revision		Revision as of 07:14, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/MXIH_SHIFL MXIH_SHIFL]] Necessary for the secretion of IPA invasins.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Shigella flexneri]]		[[Category: Shigella flexneri]]
	[[Category: Blocker, A J.]]		[[Category: Blocker, A J]]
	[[Category: Cordes, F S.]]		[[Category: Cordes, F S]]
	[[Category: Deane, J E.]]		[[Category: Deane, J E]]
	[[Category: Johnson, S.]]		[[Category: Johnson, S]]
	[[Category: Kenjale, R.]]		[[Category: Kenjale, R]]
	[[Category: Lea, S M.]]		[[Category: Lea, S M]]
	[[Category: Picking, W D.]]		[[Category: Picking, W D]]
	[[Category: Picking, W L.]]		[[Category: Picking, W L]]
	[[Category: Roversi, P.]]		[[Category: Roversi, P]]
	[[Category: Mxih]]		[[Category: Mxih]]
	[[Category: Needle complex]]		[[Category: Needle complex]]

OCA at 00:28, 30 September 2014

2014-09-30T00:28:29Z

← Older revision		Revision as of 00:28, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2ca5~~.~~png~~\|~~left~~\|~~200px~~]]		==MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI (MONOMERIC FORM, RESIDUES 1-78)==
			<StructureSection load='2ca5' size='340' side='right' caption='[[2ca5]], [[Resolution\|resolution]] 2.10Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ca5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA5 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca5 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca5 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca5_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Type III secretion systems are essential virulence determinants for many Gram-negative bacterial pathogens. The type III secretion system consists of cytoplasmic, transmembrane, and extracellular domains. The extracellular domain is a hollow needle protruding above the bacterial surface and is held within a basal body that traverses both bacterial membranes. Effector proteins are translocated, via this external needle, directly into host cells, where they subvert normal cell functions to aid infection. Physical contact with host cells initiates secretion and leads to formation of a pore, thought to be contiguous with the needle channel, in the host-cell membrane. Here, we report the crystal structure of the Shigella flexneri needle subunit MxiH and a complete model for the needle assembly built into our three-dimensional EM reconstruction. The model, combined with mutagenesis data, reveals that signaling of host-cell contact is relayed through the needle via intersubunit contacts and suggests a mode of binding for a tip complex.

	~~{{STRUCTURE_2ca5\| PDB=2ca5 \| SCENE= }}~~		Molecular model of a type III secretion system needle: Implications for host-cell sensing.,Deane JE, Roversi P, Cordes FS, Johnson S, Kenjale R, Daniell S, Booy F, Picking WD, Picking WL, Blocker AJ, Lea SM Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12529-33. Epub 2006 Aug 3. PMID:16888041<ref>PMID:16888041</ref>

	~~===MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI (MONOMERIC FORM~~, ~~RESIDUES 1-78)===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16888041}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ca5]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Shigella_flexneri Shigella flexneri]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CA5 OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016888041<~~/~~ref~~><~~ref group="xtra">PMID:016511329</ref><ref group="xtra">PMID:020543831</ref><references group="xtra"~~/>
	[[Category: Shigella flexneri]]		[[Category: Shigella flexneri]]
	[[Category: Blocker, A J.]]		[[Category: Blocker, A J.]]

OCA at 12:27, 23 January 2013

2013-01-23T12:27:20Z

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	[[Image:2ca5.png\|left\|200px]]		[[Image:2ca5.png\|left\|200px]]

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	{{STRUCTURE_2ca5\| PDB=2ca5 \| SCENE= }}		{{STRUCTURE_2ca5\| PDB=2ca5 \| SCENE= }}

	===MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI (MONOMERIC FORM, RESIDUES 1-78)===		===MXIH NEEDLE PROTEIN OF SHIGELLA FLEXNERI (MONOMERIC FORM, RESIDUES 1-78)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16888041}}, adds the Publication Abstract to the page~~
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	{{ABSTRACT_PUBMED_16888041}}		{{ABSTRACT_PUBMED_16888041}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16888041~~</ref><ref group="xtra">PMID:~~16511329~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016888041</ref><ref group="xtra">PMID:016511329</ref><ref group="xtra">PMID:020543831</ref><references group="xtra"/>
	[[Category: Shigella flexneri]]		[[Category: Shigella flexneri]]
	[[Category: Blocker, A J.]]		[[Category: Blocker, A J.]]

OCA: Protected "2ca5" [edit=sysop:move=sysop]

2011-03-14T19:10:54Z

Protected "2ca5" [edit=sysop:move=sysop]

← Older revision	Revision as of 19:10, 14 March 2011
(No difference)