2ca8 - Revision history

OCA at 14:11, 13 December 2023

2023-12-13T14:11:12Z

← Older revision		Revision as of 14:11, 13 December 2023
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	<StructureSection load='2ca8' size='340' side='right'caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2ca8' size='340' side='right'caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Blood_fluke Blood fluke~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>~~, ~~<scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.49Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height: 3em;~~'>~~[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]~~</~~div~~><~~/td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks~~'>~~[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [https://pdbe.org/2ca8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [https://pdbe.org/2ca8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.		[https://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Blood fluke]]~~
	~~[[Category: Glutathione transferase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Angelucci, F]]		[[Category: Schistosoma haematobium]]
	[[Category: Baiocco, P]]		[[Category: Angelucci F]]
	[[Category: Bellelli, A]]		[[Category: Baiocco P]]
	[[Category: Brunori, M]]		[[Category: Bellelli A]]
	[[Category: Gourlay~~, L J~~]]		[[Category: Brunori M]]
	[[Category: Miele~~, A E]]~~		[[Category: Gourlay LJ]]
	~~[[Category: Detoxification]]~~		[[Category: Miele AE]]
	~~[[Category: Glutathione]]~~
	~~[[Category: Prostaglandin d2 synthase]]~~
	~~[[Category: Sigma class gst]]~~
	~~[[Category: Transferase~~]]

OCA at 06:51, 1 December 2021

2021-12-01T06:51:42Z

← Older revision		Revision as of 06:51, 1 December 2021
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	<StructureSection load='2ca8' size='340' side='right'caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2ca8' size='340' side='right'caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [~~http~~://pdbe.org/2ca8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ca8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [https://pdbe.org/2ca8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ca8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.		[[https://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:03, 26 February 2020

2020-02-26T11:03:49Z

← Older revision		Revision as of 11:03, 26 February 2020
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	==Structure of Sh28GST in complex with GSH at pH 6.0==		==Structure of Sh28GST in complex with GSH at pH 6.0==
	<StructureSection load='2ca8' size='340' side='right' caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2ca8' size='340' side='right'caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
	*[[Glutathione S-transferase\|Glutathione S-transferase]]		*[[Glutathione S-transferase 3D structures\|Glutathione S-transferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Blood fluke]]		[[Category: Blood fluke]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
			[[Category: Large Structures]]
	[[Category: Angelucci, F]]		[[Category: Angelucci, F]]
	[[Category: Baiocco, P]]		[[Category: Baiocco, P]]

OCA at 08:30, 23 May 2018

2018-05-23T08:30:22Z

← Older revision		Revision as of 08:30, 23 May 2018
Line 1:		Line 1:

	==Structure of Sh28GST in complex with GSH at pH 6.0==		==Structure of Sh28GST in complex with GSH at pH 6.0==
	<StructureSection load='2ca8' size='340' side='right' caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2ca8' size='340' side='right' caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://pdbe.org/2ca8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://pdbe.org/2ca8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ca8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ca8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 08:38, 11 September 2015

2015-09-11T08:38:32Z

← Older revision		Revision as of 08:38, 11 September 2015
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	<StructureSection load='2ca8' size='340' side='right' caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>		<StructureSection load='2ca8' size='340' side='right' caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Schistosoma_haematobium Schistosoma haematobium~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Blood_fluke Blood fluke]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://pdbe.org/2ca8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ca8" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Blood fluke]]
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	~~[[Category: Schistosoma haematobium]]~~
	[[Category: Angelucci, F]]		[[Category: Angelucci, F]]
	[[Category: Baiocco, P]]		[[Category: Baiocco, P]]

OCA at 13:58, 25 December 2014

2014-12-25T13:58:44Z

← Older revision		Revision as of 13:58, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 35:		Line 37:
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Schistosoma haematobium]]		[[Category: Schistosoma haematobium]]
	[[Category: Angelucci, F.]]		[[Category: Angelucci, F]]
	[[Category: Baiocco, P.]]		[[Category: Baiocco, P]]
	[[Category: Bellelli, A.]]		[[Category: Bellelli, A]]
	[[Category: Brunori, M.]]		[[Category: Brunori, M]]
	[[Category: Gourlay, L J.]]		[[Category: Gourlay, L J]]
	[[Category: Miele, A E.]]		[[Category: Miele, A E]]
	[[Category: Detoxification]]		[[Category: Detoxification]]
	[[Category: Glutathione]]		[[Category: Glutathione]]

OCA at 04:20, 3 October 2014

2014-10-03T04:20:00Z

← Older revision		Revision as of 04:20, 3 October 2014
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	~~{{STRUCTURE_2ca8\| PDB=2ca8 \| SCENE= }}~~		==Structure of Sh28GST in complex with GSH at pH 6.0==
	===Structure of Sh28GST in complex with GSH at pH 6.0===		<StructureSection load='2ca8' size='340' side='right' caption='[[2ca8]], [[Resolution\|resolution]] 2.49Å' scene=''>
	~~{{ABSTRACT_PUBMED_16777141}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CA8 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2c80\|2c80]], [[2c8u\|2c8u]], [[2cai\|2cai]], [[2caq\|2caq]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ca8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ca8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ca8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ca8 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ca/2ca8_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			During turnover, the catalytic tyrosine residue (Tyr10) of the sigma class Schistosoma haematobium wild-type glutathione-S-transferase is expected to switch alternately in and out of the reduced glutathione-binding site (G-site). The Tyrout10 conformer forms a pi-cation interaction with the guanidinium group of Arg21. As in other similar glutathione-S-transferases, the catalytic Tyr has a low pKa of 7.2. In order to investigate the catalytic role of Tyr10, and the structural and functional roles of Arg21, we carried out structural studies on two Arg21 mutants (R21L and R21Q) and a Tyr10 mutant, Y10F. Our crystallographic data for the two Arg21 mutants indicate that only the Tyrout10 conformation is populated, thereby excluding a role of Arg21 in the stabilisation of the out conformation. However, Arg21 was confirmed to be catalytically important and essential for the low pKa of Tyr10. Upon comparison with structural data generated for reduced glutathione-bound and inhibitor-bound wild-type enzymes, it was observed that the orientations of Tyr10 and Arg35 are concerted and that, upon ligand binding, minor rearrangements occur within conserved residues in the active site loop. These rearrangements are coupled to quaternary rigid-body movements at the dimer interface and alterations in the localisation and structural order of the C-terminal domain.

	~~==Function==~~		Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography.,Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2. PMID:16777141<ref>PMID:16777141</ref>
	~~[[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation~~ of ~~reduced~~ glutathione ~~to a wide number of exogenous~~ and ~~endogenous hydrophobic electrophiles~~. ~~GST isoenzymes appear to play a central role in the parasite detoxification system~~. ~~Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut~~.

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2ca8]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Schistosoma_haematobium Schistosoma haematobium]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].~~		</div>

	==See Also==		==See Also==
	*[[Glutathione S-transferase\|Glutathione S-transferase]]		*[[Glutathione S-transferase\|Glutathione S-transferase]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:016777141</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Schistosoma haematobium]]		[[Category: Schistosoma haematobium]]

OCA at 19:22, 17 April 2013

2013-04-17T19:22:56Z

← Older revision		Revision as of 19:22, 17 April 2013
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	~~[[Image:2ca8.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ca8", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ca8\| PDB=2ca8 \| SCENE= }}		{{STRUCTURE_2ca8\| PDB=2ca8 \| SCENE= }}
			===Structure of Sh28GST in complex with GSH at pH 6.0===
			{{ABSTRACT_PUBMED_16777141}}

	==~~=Stucture of Sh28GST in complex with GSH at pH 6.0=~~==		==Function==
			[[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.

	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16777141}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov), where 16777141 is~~ the ~~PubMed ID number~~.
	~~-->~~
	~~{{ABSTRACT_PUBMED_16777141}}~~

	==About this Structure==		==About this Structure==
	[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].		[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].

			==See Also==
			*[[Glutathione S-transferase\|Glutathione S-transferase]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:016777141</ref><references group="xtra"/>		<ref group="xtra">PMID:016777141</ref><references group="xtra"/><references/>
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Schistosoma haematobium]]		[[Category: Schistosoma haematobium]]

OCA: Protected "2ca8" [edit=sysop:move=sysop]

2012-02-29T07:31:57Z

Protected "2ca8" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:31, 29 February 2012
(No difference)

OCA at 07:31, 29 February 2012

2012-02-29T07:31:56Z

← Older revision		Revision as of 07:31, 29 February 2012
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	~~{{Seed}}~~
	[[Image:2ca8.png\|left\|200px]]		[[Image:2ca8.png\|left\|200px]]

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	{{STRUCTURE_2ca8\| PDB=2ca8 \| SCENE= }}		{{STRUCTURE_2ca8\| PDB=2ca8 \| SCENE= }}

	===~~STRUCTURE OF SH28GST IN COMPLEX WITH~~ GSH ~~AT PH~~ 6.0===		===Stucture of Sh28GST in complex with GSH at pH 6.0===


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	==About this Structure==		==About this Structure==
	~~2CA8~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].		[[2ca8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CA8 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16777141~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016777141</ref><references group="xtra"/>
	[[Category: Glutathione transferase]]		[[Category: Glutathione transferase]]
	[[Category: Schistosoma haematobium]]		[[Category: Schistosoma haematobium]]
Line 37:		Line 36:
	[[Category: Sigma class gst]]		[[Category: Sigma class gst]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 18:04:32 2009''~~