2ccc - Revision history

OCA at 14:12, 13 December 2023

2023-12-13T14:12:54Z

← Older revision		Revision as of 14:12, 13 December 2023
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	<StructureSection load='2ccc' size='340' side='right'caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ccc' size='340' side='right'caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Hals3 Hals3~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Halobacterium_salinarum_R1 Halobacterium salinarum R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [https://pdbe.org/2ccc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [https://www.ebi.ac.uk/pdbsum/2ccc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [https://pdbe.org/2ccc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [https://www.ebi.ac.uk/pdbsum/2ccc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccc ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/DODEC_HALS3 DODEC_HALS3] May function as storage protein that sequesters riboflavin and related compounds, thereby protecting the cell against undesirable reactions mediated by the free flavins. Binds and sequesters riboflavin, lumiflavin and lumichrome. Can also bind FAD and FMN (in vitro), but has low affinity for FAD and even lower affinity for FMN. Protects bound flavins against light damage; Trp-36 rapidly quenches the flavin excited state. Promotes the conversion of bound riboflavin to lumichrome.<ref>PMID:12679016</ref> <ref>PMID:16460756</ref> <ref>PMID:17027852</ref> <ref>PMID:19224924</ref> <ref>PMID:20408700</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Hals3~~]]		[[Category: Halobacterium salinarum R1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Grininger, M]]		[[Category: Grininger M]]
	[[Category: Oesterhelt, D]]		[[Category: Oesterhelt D]]
	[[Category: Zeth, K]]		[[Category: Zeth K]]
	~~[[Category: Flavoprotein~~]]

OCA at 06:52, 1 December 2021

2021-12-01T06:52:51Z

← Older revision		Revision as of 06:52, 1 December 2021
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	<StructureSection load='2ccc' size='340' side='right'caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ccc' size='340' side='right'caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [~~http~~://pdbe.org/2ccc PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ccc PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [https://pdbe.org/2ccc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [https://www.ebi.ac.uk/pdbsum/2ccc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:00, 26 February 2020

2020-02-26T11:00:18Z

← Older revision		Revision as of 11:00, 26 February 2020
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	==Complexes of Dodecin with Flavin and Flavin-like Ligands==		==Complexes of Dodecin with Flavin and Flavin-like Ligands==
	<StructureSection load='2ccc' size='340' side='right' caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ccc' size='340' side='right'caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Hals3]]		[[Category: Hals3]]
			[[Category: Large Structures]]
	[[Category: Grininger, M]]		[[Category: Grininger, M]]
	[[Category: Oesterhelt, D]]		[[Category: Oesterhelt, D]]
	[[Category: Zeth, K]]		[[Category: Zeth, K]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]

OCA at 08:24, 23 May 2018

2018-05-23T08:24:27Z

← Older revision		Revision as of 08:24, 23 May 2018
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	==~~COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN~~-~~LIKE LIGANDS~~==
			==Complexes of Dodecin with Flavin and Flavin-like Ligands==
	<StructureSection load='2ccc' size='340' side='right' caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ccc' size='340' side='right' caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://pdbe.org/2ccc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://pdbe.org/2ccc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ccc ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2ccc_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2ccc_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 00:57, 8 February 2016

2016-02-08T00:57:16Z

← Older revision		Revision as of 00:57, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ccc ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:23, 10 September 2015

2015-09-10T06:23:38Z

← Older revision		Revision as of 06:23, 10 September 2015
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	<StructureSection load='2ccc' size='340' side='right' caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2ccc' size='340' side='right' caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Halobacterium_salinarum Halobacterium salinarum~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Hals3 Hals3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://pdbe.org/2ccc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ccc" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Halobacterium salinarum~~]]		[[Category: Hals3]]
	[[Category: Grininger, M]]		[[Category: Grininger, M]]
	[[Category: Oesterhelt, D]]		[[Category: Oesterhelt, D]]
	[[Category: Zeth, K]]		[[Category: Zeth, K]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]

OCA at 18:05, 15 January 2015

2015-01-15T18:05:59Z

← Older revision		Revision as of 18:05, 15 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Halobacterium salinarum]]		[[Category: Halobacterium salinarum]]
	[[Category: Grininger, M.]]		[[Category: Grininger, M]]
	[[Category: Oesterhelt, D.]]		[[Category: Oesterhelt, D]]
	[[Category: Zeth, K.]]		[[Category: Zeth, K]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]

OCA at 02:43, 30 September 2014

2014-09-30T02:43:25Z

← Older revision		Revision as of 02:43, 30 September 2014
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	[[Image:~~2ccc~~.~~png~~\|~~left~~\|~~200px~~]]		==COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS==
			<StructureSection load='2ccc' size='340' side='right' caption='[[2ccc]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCC FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LFN:LUMIFLAVIN'>LFN</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1mog\|1mog]], [[2cc6\|2cc6]], [[2cc7\|2cc7]], [[2cc8\|2cc8]], [[2cc9\|2cc9]], [[2ccb\|2ccb]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ccc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ccc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ccc RCSB], [http://www.ebi.ac.uk/pdbsum/2ccc PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2ccc_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Dodecin is a small dodecameric flavoprotein from Halobacterium salinarum that contains two flavins stacked between two tryptophan residues to form an aromatic tetrade. The functional properties of heterologously expressed dodecin were investigated by fluorescence spectroscopy, which allowed the determination of dissociation constants for a number of protein-ligand complexes. The values obtained were in the nanomolar to micromolar range and correlate positively with the ligand size. These data were supplemented by X-ray crystal structures of the apododecin and holocomplexes with lumichrome, lumiflavin, riboflavin and FMN at resolutions between 1.55 to 1.95 A to unravel a gating mechanism as the structural basis for the preferential binding of the small ligands lumichrome and lumiflavin. The detailed analysis of the dodecin manifold for preferential binding of lumichrome and lumiflavin provides insight on a subatom level into a protein's strategy to gain selectivity for low molecular mass compounds by steric restrictions rather than specific interactions. Investigations on the ligand composition of a wild-type dodecin crystal (1.32 A resolution) support conclusions of functional and structural investigations on heterologously expressed dodecin, and strongly suggest that lumichrome, a molecule associated with the flavin metabolism, is a ligand of dodecin in vivo. Studies on mutant protein and a Halorhodospira halophila homologue spread the idea of a lumichrome binding system as a possible "waste"-trapping device, widely distributed in prokaryotes.

	~~{{STRUCTURE_2ccc\| PDB=2ccc \| SCENE= }}~~		Dodecins: a family of lumichrome binding proteins.,Grininger M, Zeth K, Oesterhelt D J Mol Biol. 2006 Mar 31;357(3):842-57. Epub 2006 Jan 18. PMID:16460756<ref>PMID:16460756</ref>

	~~===COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16460756}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2ccc]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Halobacterium_salinarum Halobacterium salinarum]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016460756<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Halobacterium salinarum]]		[[Category: Halobacterium salinarum]]
	[[Category: Grininger, M.]]		[[Category: Grininger, M.]]

OCA: Protected "2ccc" [edit=sysop:move=sysop]

2013-01-06T11:55:28Z

Protected "2ccc" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:55, 6 January 2013
(No difference)

OCA at 11:55, 6 January 2013

2013-01-06T11:55:25Z

← Older revision		Revision as of 11:55, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2ccc.png\|left\|200px]]		[[Image:2ccc.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ccc", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ccc\| PDB=2ccc \| SCENE= }}		{{STRUCTURE_2ccc\| PDB=2ccc \| SCENE= }}

	===COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS===		===COMPLEXES OF DODECIN WITH FLAVIN AND FLAVIN-LIKE LIGANDS===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16460756}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16460756 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16460756}}		{{ABSTRACT_PUBMED_16460756}}

	==About this Structure==		==About this Structure==
	~~2CCC~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA].		[[2ccc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Halobacterium_salinarum Halobacterium salinarum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCC OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16460756~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016460756</ref><references group="xtra"/>
	[[Category: Halobacterium salinarum]]		[[Category: Halobacterium salinarum]]
	[[Category: Grininger, M.]]		[[Category: Grininger, M.]]
Line 29:		Line 17:
	[[Category: Zeth, K.]]		[[Category: Zeth, K.]]
	[[Category: Flavoprotein]]		[[Category: Flavoprotein]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:38:49 2009''~~