2cch - Revision history

OCA at 06:09, 1 October 2025

2025-10-01T06:09:43Z

← Older revision		Revision as of 06:09, 1 October 2025
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cch_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cch_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:13, 13 December 2023

2023-12-13T14:13:00Z

← Older revision		Revision as of 14:13, 13 December 2023
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	<StructureSection load='2cch' size='340' side='right'caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cch' size='340' side='right'caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2CCH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CCH FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE-5~~-~~TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~TPO~~:~~PHOSPHOTHREONINE~~'>~~TPO~~</scene><~~/td~~></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td><~~td class~~=~~"sblockDat"><div style~~=~~'overflow~~: ~~auto; max-height: 3em;~~'>[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</~~div~~></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [https://pdbe.org/2cch PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [https://www.ebi.ac.uk/pdbsum/2cch PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cch ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [~~http~~://pdbe.org/2cch PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cch PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cch ProSAT]</span></td></tr>
	</table>		</table>
	~~== Disease ==~~
	[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>
	== Function ==		== Function ==
	[~~[http~~://www.uniprot.org/uniprot/~~CDC6_HUMAN CDC6_HUMAN~~]~~] Involved~~ in the initiation of DNA replication. ~~Also participates~~ in checkpoint ~~controls~~ that ~~ensure~~ DNA ~~replication~~ is ~~completed before~~ mitosis ~~is initiated~~. ~~[[http://www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control~~ of ~~the cell cycle~~ at ~~the~~ G1/S ~~(start)~~ and the ~~G2/M~~ (~~mitosis~~) ~~transitions~~.		[https://www.uniprot.org/uniprot/CDK2_HUMAN CDK2_HUMAN] Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. Phosphorylates CABLES1 (By similarity). Cyclin E/CDK2 prevents oxidative stress-mediated Ras-induced senescence by phosphorylating MYC. Involved in G1-S phase DNA damage checkpoint that prevents cells with damaged DNA from initiating mitosis; regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. Phosphorylation of RB1 disturbs its interaction with E2F1. NPM1 phosphorylation by cyclin E/CDK2 promotes its dissociates from unduplicated centrosomes, thus initiating centrosome duplication. Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. Required for vitamin D-mediated growth inhibition by being itself inactivated. Involved in the nitric oxide- (NO) mediated signaling in a nitrosylation/activation-dependent manner. USP37 is activated by phosphorylation and thus triggers G1-S transition. CTNNB1 phosphorylation regulates insulin internalization.<ref>PMID:10499802</ref> <ref>PMID:11051553</ref> <ref>PMID:10995386</ref> <ref>PMID:10995387</ref> <ref>PMID:10884347</ref> <ref>PMID:11113184</ref> <ref>PMID:15800615</ref> <ref>PMID:18372919</ref> <ref>PMID:20147522</ref> <ref>PMID:20079829</ref> <ref>PMID:20935635</ref> <ref>PMID:20195506</ref> <ref>PMID:19966300</ref> <ref>PMID:21262353</ref> <ref>PMID:21596315</ref> <ref>PMID:21319273</ref> <ref>PMID:17495531</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Brown~~, N R~~]]		[[Category: Brown NR]]
	[[Category: Cheng~~, K Y~~]]		[[Category: Cheng KY]]
	[[Category: Cole~~, P A~~]]		[[Category: Cole PA]]
	[[Category: Johnson~~, L N~~]]		[[Category: Johnson LN]]
	[[Category: Kontogiannis, L]]		[[Category: Kontogiannis L]]
	[[Category: Lowe~~, E D~~]]		[[Category: Lowe ED]]
	[[Category: Noble~~, M E.M~~]]		[[Category: Noble MEM]]
	[[Category: Shen, K]]		[[Category: Shen K]]
	[[Category: Siligardi, G]]		[[Category: Siligardi G]]
	[[Category: Skamnaki, V]]		[[Category: Skamnaki V]]
	~~[[Category: Atp-binding]]~~
	~~[[Category: Cdk2]]~~
	~~[[Category: Cell cycle]]~~
	~~[[Category: Cell division]]~~
	~~[[Category: Cyclin]]~~
	~~[[Category: Mitosis]]~~
	~~[[Category: Nuclear protein]]~~
	~~[[Category: Peptide specificity]]~~
	~~[[Category: Phosphorylation]]~~
	~~[[Category: Polymorphism]]~~
	~~[[Category: Protein kinase]]~~
	~~[[Category: Recruitment]]~~
	~~[[Category: Serine-threonine-protein kinase]]~~
	~~[[Category: Serine/threonine-protein kinase]]~~
	~~[[Category: Transferase~~]]

OCA at 04:55, 19 November 2020

2020-11-19T04:55:13Z

← Older revision		Revision as of 04:55, 19 November 2020
Line 1:		Line 1:

	==The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue==		==The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue==
	<StructureSection load='2cch' size='340' side='right' caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cch' size='340' side='right'caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CCH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2CCH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://pdbe.org/2cch PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cch ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://pdbe.org/2cch PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cch ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	==See Also==		==See Also==
	*[[Cyclin\|Cyclin]]		*[[Cyclin 3D structures\|Cyclin 3D structures]]
	*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]		*[[Cyclin-dependent kinase 3D structures\|Cyclin-dependent kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 41:		Line 41:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Brown, N R]]		[[Category: Brown, N R]]
	[[Category: Cheng, K Y]]		[[Category: Cheng, K Y]]

OCA at 08:47, 23 May 2018

2018-05-23T08:47:41Z

← Older revision		Revision as of 08:47, 23 May 2018
Line 1:		Line 1:
	==~~THE CRYSTAL STRUCTURE OF~~ CDK2 ~~CYCLIN~~ A ~~IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM~~ CDC ~~MODIFIED WITH A GAMMA~~-~~LINKED~~ ATP ~~ANALOGUE~~==
			==The crystal structure of CDK2 cyclin A in complex with a substrate peptide derived from CDC modified with a gamma-linked ATP analogue==
	<StructureSection load='2cch' size='340' side='right' caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cch' size='340' side='right' caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://pdbe.org/2cch PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://pdbe.org/2cch PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cch ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 16:		Line 17:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cch_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cch_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cch ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 33:		Line 34:

	==See Also==		==See Also==
	*[[Cell division protein kinase\|Cell division protein kinase]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
			*[[Cyclin-dependent kinase\|Cyclin-dependent kinase]]
	== References ==		== References ==
	<references/>		<references/>
Line 59:		Line 60:
	[[Category: Peptide specificity]]		[[Category: Peptide specificity]]
	[[Category: Phosphorylation]]		[[Category: Phosphorylation]]
			[[Category: Polymorphism]]
	[[Category: Protein kinase]]		[[Category: Protein kinase]]
	[[Category: Recruitment]]		[[Category: Recruitment]]

OCA at 08:08, 11 September 2015

2015-09-11T08:08:55Z

← Older revision		Revision as of 08:08, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cch' size='340' side='right' caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cch' size='340' side='right' caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://pdbe.org/2cch PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 30:		Line 30:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cch" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Cell division protein kinase 2\|Cell division protein kinase 2]]		*[[Cell division protein kinase\|Cell division protein kinase]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
	== References ==		== References ==
Line 38:		Line 39:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Brown, N R]]		[[Category: Brown, N R]]
	[[Category: Cheng, K Y]]		[[Category: Cheng, K Y]]

OCA at 17:18, 15 January 2015

2015-01-15T17:18:36Z

← Older revision		Revision as of 17:18, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCH FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCH FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum]</span></td></tr>
	<table>		</table>
	== Disease ==		== Disease ==
	[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>		[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>
Line 39:		Line 39:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brown, N R.]]		[[Category: Brown, N R]]
	[[Category: Cheng, K Y.]]		[[Category: Cheng, K Y]]
	[[Category: Cole, P A.]]		[[Category: Cole, P A]]
	[[Category: Johnson, L N.]]		[[Category: Johnson, L N]]
	[[Category: Kontogiannis, L.]]		[[Category: Kontogiannis, L]]
	[[Category: Lowe, E D.]]		[[Category: Lowe, E D]]
	[[Category: Noble, M E.M.]]		[[Category: Noble, M E.M]]
	[[Category: Shen, K.]]		[[Category: Shen, K]]
	[[Category: Siligardi, G.]]		[[Category: Siligardi, G]]
	[[Category: Skamnaki, V.]]		[[Category: Skamnaki, V]]
	[[Category: Atp-binding]]		[[Category: Atp-binding]]
	[[Category: Cdk2]]		[[Category: Cdk2]]

OCA at 00:36, 30 September 2014

2014-09-30T00:36:44Z

← Older revision		Revision as of 00:36, 30 September 2014
Line 1:		Line 1:
	~~{{STRUCTURE_2cch\| PDB=2cch \| SCENE= }}~~		==THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE==
	===THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE===		<StructureSection load='2cch' size='340' side='right' caption='[[2cch]], [[Resolution\|resolution]] 1.70Å' scene=''>
	~~{{ABSTRACT_PUBMED_16707497}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CCH FirstGlance]. <br>
	==Disease==		</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
	[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>		<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aq1\|1aq1]], [[1b38\|1b38]], [[1b39\|1b39]], [[1buh\|1buh]], [[1ckp\|1ckp]], [[1di8\|1di8]], [[1dm2\|1dm2]], [[1e1v\|1e1v]], [[1e1x\|1e1x]], [[1e9h\|1e9h]], [[1f5q\|1f5q]], [[1fin\|1fin]], [[1fq1\|1fq1]], [[1fvt\|1fvt]], [[1fvv\|1fvv]], [[1g5s\|1g5s]], [[1gih\|1gih]], [[1gii\|1gii]], [[1gij\|1gij]], [[1gy3\|1gy3]], [[1gz8\|1gz8]], [[1h00\|1h00]], [[1h01\|1h01]], [[1h07\|1h07]], [[1h08\|1h08]], [[1h0v\|1h0v]], [[1h0w\|1h0w]], [[1h1p\|1h1p]], [[1h1q\|1h1q]], [[1h1r\|1h1r]], [[1h1s\|1h1s]], [[1h24\|1h24]], [[1h25\|1h25]], [[1h26\|1h26]], [[1h27\|1h27]], [[1h28\|1h28]], [[1hck\|1hck]], [[1hcl\|1hcl]], [[1jst\|1jst]], [[1jsu\|1jsu]], [[1jsv\|1jsv]], [[1jvp\|1jvp]], [[1ke5\|1ke5]], [[1ke6\|1ke6]], [[1ke7\|1ke7]], [[1ke8\|1ke8]], [[1ke9\|1ke9]], [[1ogu\|1ogu]], [[1oi9\|1oi9]], [[1oiq\|1oiq]], [[1oir\|1oir]], [[1oit\|1oit]], [[1oiu\|1oiu]], [[1oiy\|1oiy]], [[1oku\|1oku]], [[1okv\|1okv]], [[1okw\|1okw]], [[1ol1\|1ol1]], [[1ol2\|1ol2]], [[1p2a\|1p2a]], [[1p5e\|1p5e]], [[1pf8\|1pf8]], [[1pkd\|1pkd]], [[1pw2\|1pw2]], [[1pxi\|1pxi]], [[1pxj\|1pxj]], [[1pxk\|1pxk]], [[1pxl\|1pxl]], [[1pxm\|1pxm]], [[1pxn\|1pxn]], [[1pxo\|1pxo]], [[1pxp\|1pxp]], [[1pye\|1pye]], [[1qmz\|1qmz]], [[1r78\|1r78]], [[1urc\|1urc]], [[1urw\|1urw]], [[1v1k\|1v1k]], [[1vyw\|1vyw]], [[1vyz\|1vyz]], [[1w0x\|1w0x]], [[1w8c\|1w8c]], [[1w98\|1w98]], [[1wcc\|1wcc]], [[1y8y\|1y8y]], [[1y91\|1y91]], [[2b52\|2b52]], [[2b53\|2b53]], [[2b54\|2b54]], [[2b55\|2b55]], [[2bhe\|2bhe]], [[2bhh\|2bhh]], [[2bkz\|2bkz]], [[2bpm\|2bpm]], [[2btr\|2btr]], [[2bts\|2bts]], [[2c4g\|2c4g]], [[2c5n\|2c5n]], [[2c5o\|2c5o]], [[2c5p\|2c5p]], [[2c5t\|2c5t]], [[2c5v\|2c5v]], [[2c5x\|2c5x]], [[2c5y\|2c5y]], [[2c68\|2c68]], [[2c69\|2c69]], [[2c6i\|2c6i]], [[2c6k\|2c6k]], [[2c6l\|2c6l]], [[2c6m\|2c6m]], [[2c6o\|2c6o]], [[2c6t\|2c6t]], [[2exm\|2exm]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cch FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cch OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cch RCSB], [http://www.ebi.ac.uk/pdbsum/2cch PDBsum]</span></td></tr>
			<table>
			== Disease ==
			[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>
			== Function ==
			[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. [[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cc/2cch_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Phospho-CDK2/cyclin A, a kinase that is active in cell cycle S phase, contains an RXL substrate recognition site that is over 40 A from the catalytic site. The role of this recruitment site, which enhances substrate affinity and catalytic efficiency, has been investigated using peptides derived from the natural substrates, namely CDC6 and p107, and a bispeptide inhibitor in which the gamma-phosphate of ATP is covalently attached by a linker to the CDC6 substrate peptide. X-ray studies with a 30-residue CDC6 peptide in complex with pCDK2/cyclin A showed binding of a dodecamer peptide at the recruitment site and a heptapeptide at the catalytic site, but no density for the linking 11 residues. Kinetic studies established that the CDC6 peptide had an 18-fold lower Km compared with heptapeptide substrate and that this effect required the recruitment peptide to be covalently linked to the substrate peptide. X-ray studies with the CDC6 bispeptide showed binding of the dodecamer at the recruitment site and the modified ATP in two alternative conformations at the catalytic site. The CDC6 bispeptide was a potent inhibitor competitive with both ATP and peptide substrate of pCDK2/cyclin A activity against a heptapeptide substrate (Ki = 0.83 nm) but less effective against RXL-containing substrates. We discuss how localization at the recruitment site (KD 0.4 microm) leads to increased catalytic efficiency and the design of a potent inhibitor. The notion of a flexible linker between the sites, which must have more than a minimal number of residues, provides an explanation for recognition and discrimination against different substrates.

	~~==Function==~~		The role of the phospho-CDK2/cyclin A recruitment site in substrate recognition.,Cheng KY, Noble ME, Skamnaki V, Brown NR, Lowe ED, Kontogiannis L, Shen K, Cole PA, Siligardi G, Johnson LN J Biol Chem. 2006 Aug 11;281(32):23167-79. Epub 2006 May 17. PMID:16707497<ref>PMID:16707497</ref>
	~~[[http://www.uniprot.org~~/~~uniprot/CDC6_HUMAN CDC6_HUMAN]] Involved~~ in ~~the initiation of DNA replication~~. ~~Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated~~. ~~[[http~~:~~//www~~.~~uniprot~~.~~org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1~~/~~S (start) and the G2/M (mitosis) transitions.~~

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2cch]] is~~ a ~~6 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Homo_sapiens Homo sapiens]~~. ~~Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA].~~		</div>

	==See Also==		==See Also==
	*[[Cell ~~Division Protein Kinase~~ 2\|Cell ~~Division Protein Kinase~~ 2]]		*[[Cell division protein kinase 2\|Cell division protein kinase 2]]
	*[[Cyclin\|Cyclin]]		*[[Cyclin\|Cyclin]]
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:016707497</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brown, N R.]]		[[Category: Brown, N R.]]

OCA at 04:08, 25 March 2013

2013-03-25T04:08:47Z

← Older revision		Revision as of 04:08, 25 March 2013
Line 1:		Line 1:
	~~[[Image:2cch.png\|left\|200px]]~~

	{{STRUCTURE_2cch\| PDB=2cch \| SCENE= }}		{{STRUCTURE_2cch\| PDB=2cch \| SCENE= }}
			===THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA-LINKED ATP ANALOGUE===
			{{ABSTRACT_PUBMED_16707497}}

	===~~THE CRYSTAL STRUCTURE OF CDK2 CYCLIN A IN COMPLEX WITH A SUBSTRATE PEPTIDE DERIVED FROM CDC MODIFIED WITH A GAMMA~~-~~LINKED ATP ANALOGUE===~~		==Disease==
			[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Defects in CDC6 are the cause of Meier-Gorlin syndrome type 5 (MGORS5) [MIM:[http://omim.org/entry/613805 613805]]. MGORS5 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.<ref>PMID:21358632</ref>

	~~{{ABSTRACT_PUBMED_16707497}}~~		==Function==
			[[http://www.uniprot.org/uniprot/CDC6_HUMAN CDC6_HUMAN]] Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. [[http://www.uniprot.org/uniprot/CCNA2_HUMAN CCNA2_HUMAN]] Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.

	==About this Structure==		==About this Structure==
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	==Reference==		==Reference==
	<ref group="xtra">PMID:016707497</ref><references group="xtra"/>		<ref group="xtra">PMID:016707497</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Brown, N R.]]		[[Category: Brown, N R.]]

OCA at 17:21, 20 October 2012

2012-10-20T17:21:12Z

← Older revision		Revision as of 17:21, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2cch]] is a 6 chain structure ~~of [[Cell Division Protein Kinase 2]] and [[Cyclin]]~~ with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA].		[[2cch]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CCH OCA].

	==See Also==		==See Also==

OCA: Protected "2cch" [edit=sysop:move=sysop]

2012-07-27T00:38:33Z

Protected "2cch" [edit=sysop:move=sysop]

← Older revision	Revision as of 00:38, 27 July 2012
(No difference)