2cd7 - Revision history

OCA at 14:13, 13 December 2023

2023-12-13T14:13:25Z

← Older revision		Revision as of 14:13, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2cd7' size='340' side='right'caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cd7' size='340' side='right'caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus~~ aureus~~" (rosenbach 1884) zopf 1885~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks~~'>~~[https://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [https://pdbe.org/2cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [https://pdbe.org/2cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ARSC_STAAU ARSC_STAAU]] Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.[HAMAP-Rule:MF_01624]		[https://www.uniprot.org/uniprot/ARSC_STAAU ARSC_STAAU] Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.[HAMAP-Rule:MF_01624]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 38:		Line 37:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Belle, K Van~~]]		[[Category: Staphylococcus aureus]]
	[[Category: Brosens, E]]		[[Category: Brosens E]]
	[[Category: Buts, L]]		[[Category: Buts L]]
	[[Category: Loris, R]]		[[Category: Loris R]]
	[[Category: Messens, J]]		[[Category: Messens J]]
	[[Category: Roos, G]]		[[Category: Roos G]]
	[[Category: ~~Wyns, L~~]]		[[Category: Van Belle K]]
	[[Category: ~~Arsenical resistance]]~~		[[Category: Wyns L]]
	~~[[Category: Detoxification]]~~
	~~[[Category: Hydrolase]]~~
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Ptpase i fold]]~~
	~~[[Category: Redox-active center~~]]

OCA at 09:46, 5 May 2021

2021-05-05T09:46:36Z

← Older revision		Revision as of 09:46, 5 May 2021
Line 3:		Line 3:
	<StructureSection load='2cd7' size='340' side='right'caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cd7' size='340' side='right'caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [~~http~~://pdbe.org/2cd7 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cd7 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd7 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [https://pdbe.org/2cd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ARSC_STAAU ARSC_STAAU]] Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.[HAMAP-Rule:MF_01624]		[[https://www.uniprot.org/uniprot/ARSC_STAAU ARSC_STAAU]] Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.[HAMAP-Rule:MF_01624]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 07:15, 24 July 2019

2019-07-24T07:15:05Z

← Older revision		Revision as of 07:15, 24 July 2019
Line 1:		Line 1:

	==Staphylococcus aureus pI258 arsenate reductase (ArsC) H62Q mutant==		==Staphylococcus aureus pI258 arsenate reductase (ArsC) H62Q mutant==
	<StructureSection load='2cd7' size='340' side='right' caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cd7' size='340' side='right'caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>
Line 32:		Line 32:

	==See Also==		==See Also==
	*[[Arsenate reductase\|Arsenate reductase]]		*[[Arsenate reductase 3D structures\|Arsenate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Belle, K Van]]		[[Category: Belle, K Van]]
	[[Category: Brosens, E]]		[[Category: Brosens, E]]

OCA at 08:00, 23 May 2018

2018-05-23T08:00:45Z

← Older revision		Revision as of 08:00, 23 May 2018
Line 1:		Line 1:
	==~~STAPHYLOCOCCUS AUREUS PI258 ARSENATE REDUCTASE~~ (~~ARSC~~) H62Q ~~MUTANT~~==
			==Staphylococcus aureus pI258 arsenate reductase (ArsC) H62Q mutant==
	<StructureSection load='2cd7' size='340' side='right' caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cd7' size='340' side='right' caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 6:		Line 7:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://pdbe.org/2cd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://pdbe.org/2cd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cd7 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 14:		Line 15:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cd7_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cd7_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 16:18, 9 February 2016

2016-02-09T16:18:20Z

← Older revision		Revision as of 16:18, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cd7 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:57, 10 September 2015

2015-09-10T23:57:17Z

← Older revision		Revision as of 23:57, 10 September 2015
Line 2:		Line 2:
	<StructureSection load='2cd7' size='340' side='right' caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cd7' size='340' side='right' caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Staphylococcus_aureus Staphylococcus~~ aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://pdbe.org/2cd7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 28:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cd7" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 35:		Line 36:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Staphylococcus aureus]]~~
	[[Category: Belle, K Van]]		[[Category: Belle, K Van]]
	[[Category: Brosens, E]]		[[Category: Brosens, E]]

OCA at 08:01, 25 December 2014

2014-12-25T08:01:33Z

← Older revision		Revision as of 08:01, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ARSC_STAAU ARSC_STAAU]] Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.[HAMAP-Rule:MF_01624]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 34:		Line 36:
	</StructureSection>		</StructureSection>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Belle, K Van.]]		[[Category: Belle, K Van]]
	[[Category: Brosens, E.]]		[[Category: Brosens, E]]
	[[Category: Buts, L.]]		[[Category: Buts, L]]
	[[Category: Loris, R.]]		[[Category: Loris, R]]
	[[Category: Messens, J.]]		[[Category: Messens, J]]
	[[Category: Roos, G.]]		[[Category: Roos, G]]
	[[Category: Wyns, L.]]		[[Category: Wyns, L]]
	[[Category: Arsenical resistance]]		[[Category: Arsenical resistance]]
	[[Category: Detoxification]]		[[Category: Detoxification]]

OCA at 01:34, 30 September 2014

2014-09-30T01:34:09Z

← Older revision		Revision as of 01:34, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2cd7~~.~~png~~\|~~left~~\|~~200px~~]]		==STAPHYLOCOCCUS AUREUS PI258 ARSENATE REDUCTASE (ARSC) H62Q MUTANT==
			<StructureSection load='2cd7' size='340' side='right' caption='[[2cd7]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CD7 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1jf8\|1jf8]], [[1jfv\|1jfv]], [[1ljl\|1ljl]], [[1lju\|1lju]], [[1lk0\|1lk0]], [[1rxe\|1rxe]], [[1rxi\|1rxi]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Arsenate_reductase_(glutaredoxin) Arsenate reductase (glutaredoxin)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.20.4.1 1.20.4.1] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cd7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cd7 RCSB], [http://www.ebi.ac.uk/pdbsum/2cd7 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cd7_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			In the thioredoxin (Trx)-coupled arsenate reductase family, arsenate reductase from Staphylococcus aureus plasmid pI258 (Sa_ArsC) and from Bacillus subtilis (Bs_ArsC) are structurally related detoxification enzymes. Catalysis of the reduction of arsenate to arsenite involves a P-loop (Cys10Thr11Gly12Asn13Ser14Cys15Arg16) structural motif and a disulphide cascade between three conserved cysteine residues (Cys10, Cys82 and Cys89). For its activity, Sa_ArsC benefits from the binding of tetrahedral oxyanions in the P-loop active site and from the binding of potassium in a specific cation-binding site. In contrast, the steady-state kinetic parameters of Bs_ArsC are not affected by sulphate or potassium. The commonly occurring mutation of a histidine (H62), located about 6 A from the potassium-binding site in Sa_ArsC, to a glutamine uncouples the kinetic dependency on potassium. In addition, the binding affinity for potassium is affected by the presence of a lysine (K33) or an aspartic acid (D33) in combination with two negative charges (D30 and E31) on the surface of Trx-coupled arsenate reductases. In the P-loop of the Trx-coupled arsenate reductase family, the peptide bond between Gly12 and Asn13 can adopt two distinct conformations. The unique geometry of the P-loop with Asn13 in beta conformation, which is not observed in structurally related LMW PTPases, is stabilized by tetrahedral oxyanions and decreases the pK(a) value of Cys10 and Cys82. Tetrahedral oxyanions stabilize the P-loop in its catalytically most active form, which might explain the observed increase in k(cat) value for Sa_ArsC. Therefore, a subtle interplay of potassium and sulphate dictates the kinetics of Trx-coupled arsenate reductases.

	~~{{STRUCTURE_2cd7\| PDB=2cd7 \| SCENE= }}~~		Interplay between ion binding and catalysis in the thioredoxin-coupled arsenate reductase family.,Roos G, Buts L, Van Belle K, Brosens E, Geerlings P, Loris R, Wyns L, Messens J J Mol Biol. 2006 Jul 21;360(4):826-38. Epub 2006 Jun 6. PMID:16797027<ref>PMID:16797027</ref>

	~~===STAPHYLOCOCCUS AUREUS PI258 ARSENATE REDUCTASE (ARSC) H62Q MUTANT===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>

	~~{{ABSTRACT_PUBMED_16797027}}~~		==See Also==
			*[[Arsenate reductase\|Arsenate reductase]]
	==~~About this Structure~~==		== References ==
	[[~~2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus~~]~~. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA~~].		<references/>
			__TOC__
	==~~Reference~~==		</StructureSection>
	<~~ref group="xtra">PMID:016797027<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Belle, K Van.]]		[[Category: Belle, K Van.]]

OCA: Protected "2cd7" [edit=sysop:move=sysop]

2013-01-06T10:48:26Z

Protected "2cd7" [edit=sysop:move=sysop]

← Older revision	Revision as of 10:48, 6 January 2013
(No difference)

OCA at 10:48, 6 January 2013

2013-01-06T10:48:24Z

← Older revision		Revision as of 10:48, 6 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2cd7.png\|left\|200px]]		[[Image:2cd7.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cd7", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cd7\| PDB=2cd7 \| SCENE= }}		{{STRUCTURE_2cd7\| PDB=2cd7 \| SCENE= }}

	===STAPHYLOCOCCUS AUREUS PI258 ARSENATE REDUCTASE (ARSC) H62Q MUTANT===		===STAPHYLOCOCCUS AUREUS PI258 ARSENATE REDUCTASE (ARSC) H62Q MUTANT===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16797027}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16797027 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16797027}}		{{ABSTRACT_PUBMED_16797027}}

	==About this Structure==		==About this Structure==
	~~2CD7~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA].		[[2cd7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CD7 OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16797027~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016797027</ref><references group="xtra"/>
	[[Category: Staphylococcus aureus]]		[[Category: Staphylococcus aureus]]
	[[Category: Belle, K Van.]]		[[Category: Belle, K Van.]]
Line 38:		Line 26:
	[[Category: Ptpase i fold]]		[[Category: Ptpase i fold]]
	[[Category: Redox-active center]]		[[Category: Redox-active center]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 11:07:32 2009''~~