2cdb - Revision history

OCA at 14:13, 13 December 2023

2023-12-13T14:13:35Z

← Older revision		Revision as of 14:13, 13 December 2023
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	<StructureSection load='2cdb' size='340' side='right'caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cdb' size='340' side='right'caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</div></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [https://pdbe.org/2cdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [https://www.ebi.ac.uk/pdbsum/2cdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [https://pdbe.org/2cdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [https://www.ebi.ac.uk/pdbsum/2cdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/~~GLCDH_SULSF GLCDH_SULSF]~~] Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-galactose, D-xylose and L-arabinose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor. Physiologically, seems to be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.<ref>PMID:12824170</ref> <ref>PMID:3827812</ref>		[https://www.uniprot.org/uniprot/GLCDH_SACSO GLCDH_SACSO] Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-galactose, D-xylose and L-arabinose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor. Physiologically, seems to be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.<ref>PMID:12824170</ref> <ref>PMID:3827812</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 35091]]~~
	~~[[Category: Glucose 1-dehydrogenase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Danson~~, M J~~]]		[[Category: Saccharolobus solfataricus]]
	[[Category: Hough~~, D W~~]]		[[Category: Danson MJ]]
	[[Category: Lamble~~, H J~~]]		[[Category: Hough DW]]
	[[Category: Milburn~~, C C~~]]		[[Category: Lamble HJ]]
	[[Category: Taylor~~, G L~~]]		[[Category: Milburn CC]]
	[[Category: Theodossis, A]]		[[Category: Taylor GL]]
	~~[[Category: Mdr family]]~~		[[Category: Theodossis A]]
	~~[[Category: Oxidoreductase]]~~
	~~[[Category: Reductase~~]]

OCA at 06:53, 1 December 2021

2021-12-01T06:53:26Z

← Older revision		Revision as of 06:53, 1 December 2021
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	<StructureSection load='2cdb' size='340' side='right'caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cdb' size='340' side='right'caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~'saccharolobus_solfataricus' 'saccharolobus solfataricus'~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [~~http~~://pdbe.org/2cdb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cdb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [https://pdbe.org/2cdb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [https://www.ebi.ac.uk/pdbsum/2cdb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/GLCDH_SULSF GLCDH_SULSF]] Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-galactose, D-xylose and L-arabinose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor. Physiologically, seems to be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.<ref>PMID:12824170</ref> <ref>PMID:3827812</ref>		[[https://www.uniprot.org/uniprot/GLCDH_SULSF GLCDH_SULSF]] Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-galactose, D-xylose and L-arabinose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor. Physiologically, seems to be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.<ref>PMID:12824170</ref> <ref>PMID:3827812</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Saccharolobus solfataricus~~]]		[[Category: Atcc 35091]]
	[[Category: Glucose 1-dehydrogenase]]		[[Category: Glucose 1-dehydrogenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:01, 26 February 2020

2020-02-26T11:01:40Z

← Older revision		Revision as of 11:01, 26 February 2020
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	==Sulfolobus solfataricus Glucose Dehydrogenase 1 in complex with NADP and glucose==		==Sulfolobus solfataricus Glucose Dehydrogenase 1 in complex with NADP and glucose==
	<StructureSection load='2cdb' size='340' side='right' caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cdb' size='340' side='right'caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>
Line 36:		Line 36:
	[[Category: Saccharolobus solfataricus]]		[[Category: Saccharolobus solfataricus]]
	[[Category: Glucose 1-dehydrogenase]]		[[Category: Glucose 1-dehydrogenase]]
			[[Category: Large Structures]]
	[[Category: Danson, M J]]		[[Category: Danson, M J]]
	[[Category: Hough, D W]]		[[Category: Hough, D W]]

OCA at 08:27, 23 May 2018

2018-05-23T08:27:12Z

← Older revision		Revision as of 08:27, 23 May 2018
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	==~~SULFOLOBUS SOLFATARICUS GLUCOSE DEHYDROGENASE~~ 1 ~~IN COMPLEX WITH~~ NADP ~~AND GLUCOSE~~==
			==Sulfolobus solfataricus Glucose Dehydrogenase 1 in complex with NADP and glucose==
	<StructureSection load='2cdb' size='340' side='right' caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cdb' size='340' side='right' caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Atcc_35091 Atcc 35091~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/'saccharolobus_solfataricus' 'saccharolobus solfataricus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [http://pdbe.org/2cdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [http://www.ebi.ac.uk/pdbsum/2cdb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [http://pdbe.org/2cdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [http://www.ebi.ac.uk/pdbsum/2cdb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Atcc 35091~~]]		[[Category: Saccharolobus solfataricus]]
	[[Category: Glucose 1-dehydrogenase]]		[[Category: Glucose 1-dehydrogenase]]
	[[Category: Danson, M J]]		[[Category: Danson, M J]]

OCA at 22:26, 9 February 2016

2016-02-09T22:26:15Z

← Older revision		Revision as of 22:26, 9 February 2016
Line 18:		Line 18:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cdb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 02:38, 11 September 2015

2015-09-11T02:38:23Z

← Older revision		Revision as of 02:38, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cdb' size='340' side='right' caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='2cdb' size='340' side='right' caption='[[2cdb]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Sulfolobus_solfataricus Sulfolobus solfataricus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35091 Atcc 35091]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [http://www.ebi.ac.uk/pdbsum/2cdb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [http://pdbe.org/2cdb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [http://www.ebi.ac.uk/pdbsum/2cdb PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/GLCDH_SULSF GLCDH_SULSF]] Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Displays broad substrate specificity since it is able to catalyze the oxidation of a number of alternative aldose sugars, such as D-galactose, D-xylose and L-arabinose, to the corresponding glyconate. Can utilize both NAD(+) and NADP(+) as electron acceptor. Physiologically, seems to be involved in the degradation of both glucose and galactose through a non-phosphorylative variant of the Entner-Doudoroff pathway.<ref>PMID:12824170</ref> <ref>PMID:3827812</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 26:		Line 28:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cdb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Atcc 35091]]
	[[Category: Glucose 1-dehydrogenase]]		[[Category: Glucose 1-dehydrogenase]]
	~~[[Category: Sulfolobus solfataricus]]~~
	[[Category: Danson, M J]]		[[Category: Danson, M J]]
	[[Category: Hough, D W]]		[[Category: Hough, D W]]

OCA at 18:10, 15 January 2015

2015-01-15T18:10:53Z

← Older revision		Revision as of 18:10, 15 January 2015
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cd9\|2cd9]], [[2cda\|2cda]], [[2cdc\|2cdc]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucose_1-dehydrogenase Glucose 1-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.47 1.1.1.47] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [http://www.ebi.ac.uk/pdbsum/2cdb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdb RCSB], [http://www.ebi.ac.uk/pdbsum/2cdb PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: Glucose 1-dehydrogenase]]		[[Category: Glucose 1-dehydrogenase]]
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]
	[[Category: Danson, M J.]]		[[Category: Danson, M J]]
	[[Category: Hough, D W.]]		[[Category: Hough, D W]]
	[[Category: Lamble, H J.]]		[[Category: Lamble, H J]]
	[[Category: Milburn, C C.]]		[[Category: Milburn, C C]]
	[[Category: Taylor, G L.]]		[[Category: Taylor, G L]]
	[[Category: Theodossis, A.]]		[[Category: Theodossis, A]]
	[[Category: Mdr family]]		[[Category: Mdr family]]
	[[Category: Oxidoreductase]]		[[Category: Oxidoreductase]]
	[[Category: Reductase]]		[[Category: Reductase]]

OCA at 10:50, 3 October 2014

2014-10-03T10:50:49Z

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2cdb|  PDB=2cdb  |  SCENE=  }}
+==SULFOLOBUS SOLFATARICUS GLUCOSE DEHYDROGENASE 1 IN COMPLEX WITH NADP AND GLUCOSE==
-===SULFOLOBUS SOLFATARICUS GLUCOSE DEHYDROGENASE 1 IN COMPLEX WITH NADP AND GLUCOSE===
+<StructureSection load='2cdb' size='340' side='right' caption='[[2cdb]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-{{ABSTRACT_PUBMED_16556607}}
+== Structural highlights ==
-==About this Structure==
+The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.,Milburn CC, Lamble HJ, Theodossis A, Bull SD, Hough DW, Danson MJ, Taylor GL J Biol Chem. 2006 May 26;281(21):14796-804. Epub 2006 Mar 23. PMID:16556607<ref>PMID:16556607</ref>
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:016556607</ref><references group="xtra"/><references/>
+</div>
 [[Category: Glucose 1-dehydrogenase]]
 [[Category: Sulfolobus solfataricus]]

OCA at 08:16, 23 April 2014

2014-04-23T08:16:48Z

← Older revision		Revision as of 08:16, 23 April 2014
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	~~[[Image:2cdb.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cdb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cdb\| PDB=2cdb \| SCENE= }}		{{STRUCTURE_2cdb\| PDB=2cdb \| SCENE= }}

	===SULFOLOBUS SOLFATARICUS GLUCOSE DEHYDROGENASE 1 IN COMPLEX WITH NADP AND GLUCOSE===		===SULFOLOBUS SOLFATARICUS GLUCOSE DEHYDROGENASE 1 IN COMPLEX WITH NADP AND GLUCOSE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16556607}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16556607 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16556607}}		{{ABSTRACT_PUBMED_16556607}}

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	==Reference==		==Reference==
	<ref group="xtra">PMID:016556607</ref><references group="xtra"/>		<ref group="xtra">PMID:016556607</ref><references group="xtra"/><references/>
	[[Category: Glucose 1-dehydrogenase]]		[[Category: Glucose 1-dehydrogenase]]
	[[Category: Sulfolobus solfataricus]]		[[Category: Sulfolobus solfataricus]]

OCA: Protected "2cdb" [edit=sysop:move=sysop]

2011-08-24T06:03:55Z

Protected "2cdb" [edit=sysop:move=sysop]

← Older revision	Revision as of 06:03, 24 August 2011
(No difference)