2cdf - Revision history

OCA at 07:49, 23 October 2024

2024-10-23T07:49:01Z

← Older revision		Revision as of 07:49, 23 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 14:13, 13 December 2023

2023-12-13T14:13:43Z

← Older revision		Revision as of 14:13, 13 December 2023
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	<StructureSection load='2cdf' size='340' side='right'caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2cdf' size='340' side='right'caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1b88\|1b88]]~~, [[~~1bwm~~\|~~1bwm~~]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</div></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [https://pdbe.org/2cdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [https://www.ebi.ac.uk/pdbsum/2cdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [https://pdbe.org/2cdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [https://www.ebi.ac.uk/pdbsum/2cdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdf ProSAT]</span></td></tr>
	</table>		</table>
			== Disease ==
			[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] TCR-alpha-beta-positive T-cell deficiency. The disease is caused by variants affecting the gene represented in this entry.
			== Function ==
			[https://www.uniprot.org/uniprot/TRAC_HUMAN TRAC_HUMAN] Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).<ref>PMID:15040585</ref> <ref>PMID:23524462</ref> <ref>PMID:24600447</ref> <ref>PMID:25493333</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human~~]]		[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cerundolo, V]]		[[Category: Cerundolo V]]
	[[Category: Gadola~~, S D~~]]		[[Category: Gadola SD]]
	[[Category: Harlos, K]]		[[Category: Harlos K]]
	[[Category: Jakobsen~~, B K~~]]		[[Category: Jakobsen BK]]
	[[Category: Jones~~, E Y~~]]		[[Category: Jones EY]]
	[[Category: Koch, M]]		[[Category: Koch M]]
	[[Category: Lissin~~, N M~~]]		[[Category: Lissin NM]]
	[[Category: Marles-Wright, J]]		[[Category: Marles-Wright J]]
	[[Category: Matulis, G]]		[[Category: Matulis G]]
	[[Category: Sheperd, D]]		[[Category: Sheperd D]]
	[[Category: Stuart~~, D I~~]]		[[Category: Stuart DI]]
	[[Category: Villiger~~, P M]]~~		[[Category: Villiger PM]]
	~~[[Category: Alpha-galactosylceramide]]~~
	~~[[Category: Cd1d]]~~
	~~[[Category: Cell receptor]]~~
	~~[[Category: Mhc class i]]~~
	~~[[Category: Natural killer t cell]]~~
	~~[[Category: Non-canonical tcr]]~~
	~~[[Category: T cell receptor]]~~
	~~[[Category: Tcr]]~~
	~~[[Category: Tcr 5e~~]]

OCA at 06:53, 1 December 2021

2021-12-01T06:53:27Z

← Older revision		Revision as of 06:53, 1 December 2021
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	<StructureSection load='2cdf' size='340' side='right'caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2cdf' size='340' side='right'caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CDF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [~~http~~://pdbe.org/2cdf PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cdf PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdf ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [https://pdbe.org/2cdf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [https://www.ebi.ac.uk/pdbsum/2cdf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 11:13, 26 February 2020

2020-02-26T11:13:58Z

← Older revision		Revision as of 11:13, 26 February 2020
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	==Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5E)==		==Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5E)==
	<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2cdf' size='340' side='right'caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
			[[Category: Large Structures]]
	[[Category: Cerundolo, V]]		[[Category: Cerundolo, V]]
	[[Category: Gadola, S D]]		[[Category: Gadola, S D]]

OCA at 08:45, 23 May 2018

2018-05-23T08:45:35Z

← Older revision		Revision as of 08:45, 23 May 2018
Line 1:		Line 1:
	==~~STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D~~-~~ALPHA~~-~~GALACTOSYLCERAMIDE~~-~~SPECIFIC~~ T ~~CELL RECEPTORS~~ (TCR 5E)==
			==Structure and binding kinetics of three different human CD1d-alpha- Galactosylceramide-specific T cell receptors (TCR 5E)==
	<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://pdbe.org/2cdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://pdbe.org/2cdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdf ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdf_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdf_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 19:36, 9 February 2016

2016-02-09T19:36:07Z

← Older revision		Revision as of 19:36, 9 February 2016
Line 14:		Line 14:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cdf ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 01:24, 11 September 2015

2015-09-11T01:24:48Z

← Older revision		Revision as of 01:24, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://pdbe.org/2cdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cdf" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Homo sapiens~~]]		[[Category: Human]]
	[[Category: Cerundolo, V]]		[[Category: Cerundolo, V]]
	[[Category: Gadola, S D]]		[[Category: Gadola, S D]]

OCA at 18:39, 15 January 2015

2015-01-15T18:39:14Z

← Older revision		Revision as of 18:39, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1b88\|1b88]], [[1bwm\|1bwm]], [[1h5b\|1h5b]], [[1hxm\|1hxm]], [[1ktk\|1ktk]], [[1l0y\|1l0y]], [[1nfd\|1nfd]], [[1tvd\|1tvd]], [[2axh\|2axh]], [[2axj\|2axj]], [[2cde\|2cde]], [[2cdg\|2cdg]], [[1ao7\|1ao7]], [[1qrn\|1qrn]], [[1qse\|1qse]], [[1qsf\|1qsf]], [[1bd2\|1bd2]], [[1lp9\|1lp9]], [[1mi5\|1mi5]], [[2bnq\|2bnq]], [[2bnr\|2bnr]], [[2bnu\|2bnu]], [[1kgc\|1kgc]], [[1fo0\|1fo0]], [[1kj2\|1kj2]], [[1nam\|1nam]], [[2ckb\|2ckb]], [[1g6r\|1g6r]], [[1mwa\|1mwa]], [[1kb5\|1kb5]], [[1tcr\|1tcr]], [[1fyt\|1fyt]], [[1j8h\|1j8h]], [[1d9k\|1d9k]], [[1ymm\|1ymm]], [[1ypz\|1ypz]], [[1zt4\|1zt4]], [[1z5l\|1z5l]], [[1zhn\|1zhn]], [[2akr\|2akr]], [[1cd1\|1cd1]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdf RCSB], [http://www.ebi.ac.uk/pdbsum/2cdf PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 29:
	</StructureSection>		</StructureSection>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cerundolo, V.]]		[[Category: Cerundolo, V]]
	[[Category: Gadola, S D.]]		[[Category: Gadola, S D]]
	[[Category: Harlos, K.]]		[[Category: Harlos, K]]
	[[Category: Jakobsen, B K.]]		[[Category: Jakobsen, B K]]
	[[Category: Jones, E Y.]]		[[Category: Jones, E Y]]
	[[Category: Koch, M.]]		[[Category: Koch, M]]
	[[Category: Lissin, N M.]]		[[Category: Lissin, N M]]
	[[Category: Marles-Wright, J.]]		[[Category: Marles-Wright, J]]
	[[Category: Matulis, G.]]		[[Category: Matulis, G]]
	[[Category: Sheperd, D.]]		[[Category: Sheperd, D]]
	[[Category: Stuart, D I.]]		[[Category: Stuart, D I]]
	[[Category: Villiger, P M.]]		[[Category: Villiger, P M]]
	[[Category: Alpha-galactosylceramide]]		[[Category: Alpha-galactosylceramide]]
	[[Category: Cd1d]]		[[Category: Cd1d]]

OCA at 10:08, 3 October 2014

2014-10-03T10:08:31Z

@@ Line 1: / Line 1: @@
-{{STRUCTURE_2cdf|  PDB=2cdf  |  SCENE=  }}
+==STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)==
-===STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)===
+<StructureSection load='2cdf' size='340' side='right' caption='[[2cdf]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-{{ABSTRACT_PUBMED_16520393}}
+== Structural highlights ==
-==About this Structure==
+Structure and binding kinetics of three different human CD1d-alpha-galactosylceramide-specific T cell receptors.,Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, Harlos K, Villiger PM, Stuart DI, Jakobsen BK, Cerundolo V, Jones EY J Exp Med. 2006 Mar 20;203(3):699-710. Epub 2006 Mar 6. PMID:16520393<ref>PMID:16520393</ref>
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<ref group="xtra">PMID:016520393</ref><references group="xtra"/><references/>
+</div>
 [[Category: Homo sapiens]]
 [[Category: Cerundolo, V.]]

OCA at 08:47, 23 April 2014

2014-04-23T08:47:27Z

← Older revision		Revision as of 08:47, 23 April 2014
Line 1:		Line 1:
	~~[[Image:2cdf.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cdf", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cdf\| PDB=2cdf \| SCENE= }}		{{STRUCTURE_2cdf\| PDB=2cdf \| SCENE= }}

	===STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)===		===STRUCTURE AND BINDING KINETICS OF THREE DIFFERENT HUMAN CD1D-ALPHA-GALACTOSYLCERAMIDE-SPECIFIC T CELL RECEPTORS (TCR 5E)===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16520393}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16520393 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16520393}}		{{ABSTRACT_PUBMED_16520393}}

Line 22:		Line 7:

	==Reference==		==Reference==
	<ref group="xtra">PMID:016520393</ref><references group="xtra"/>		<ref group="xtra">PMID:016520393</ref><references group="xtra"/><references/>
	[[Category: Homo sapiens]]		[[Category: Homo sapiens]]
	[[Category: Cerundolo, V.]]		[[Category: Cerundolo, V.]]