2cdq - Revision history

OCA at 09:24, 9 May 2024

2024-05-09T09:24:28Z

← Older revision		Revision as of 09:24, 9 May 2024
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	<StructureSection load='2cdq' size='340' side='right'caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cdq' size='340' side='right'caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Arath Arath~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene~~></td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [https://pdbe.org/2cdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [https://www.ebi.ac.uk/pdbsum/2cdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [https://pdbe.org/2cdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [https://www.ebi.ac.uk/pdbsum/2cdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdq ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/AK1_ARATH AK1_ARATH] Involved in the first step of essential amino acids lysine, threonine, methionine and isoleucine synthesis via the aspartate-family pathway.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arath]]~~		[[Category: Arabidopsis thaliana]]
	~~[[Category: Aspartate kinase~~]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Curien, G]]		[[Category: Curien G]]
	[[Category: Dumas, R]]		[[Category: Dumas R]]
	[[Category: Ferrer~~, J L~~]]		[[Category: Ferrer JL]]
	[[Category: Laurencin, M]]		[[Category: Laurencin M]]
	[[Category: Mas-Droux, C]]		[[Category: Mas-Droux C]]
	[[Category: Robert-Genthon, M]]		[[Category: Robert-Genthon M]]
	~~[[Category: Act domain]]~~
	~~[[Category: Allosteric effector]]~~
	~~[[Category: Allostery]]~~
	~~[[Category: Amino acid biosynthesis]]~~
	~~[[Category: Amino acid metabolism]]~~
	~~[[Category: Lysine]]~~
	~~[[Category: Plant]]~~
	~~[[Category: S-adenosylmethionine]]~~
	~~[[Category: Transferase~~]]

OCA at 06:53, 1 December 2021

2021-12-01T06:53:38Z

← Older revision		Revision as of 06:53, 1 December 2021
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	<StructureSection load='2cdq' size='340' side='right'caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cdq' size='340' side='right'caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [~~http~~://pdbe.org/2cdq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cdq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [https://pdbe.org/2cdq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [https://www.ebi.ac.uk/pdbsum/2cdq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:44, 26 February 2020

2020-02-26T10:44:44Z

← Older revision		Revision as of 10:44, 26 February 2020
Line 1:		Line 1:

	==Crystal structure of Arabidopsis thaliana aspartate kinase complexed with lysine and S- adenosylmethionine==		==Crystal structure of Arabidopsis thaliana aspartate kinase complexed with lysine and S- adenosylmethionine==
	<StructureSection load='2cdq' size='340' side='right' caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cdq' size='340' side='right'caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>
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	[[Category: Arath]]		[[Category: Arath]]
	[[Category: Aspartate kinase]]		[[Category: Aspartate kinase]]
			[[Category: Large Structures]]
	[[Category: Curien, G]]		[[Category: Curien, G]]
	[[Category: Dumas, R]]		[[Category: Dumas, R]]

OCA at 07:59, 23 May 2018

2018-05-23T07:59:07Z

← Older revision		Revision as of 07:59, 23 May 2018
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	==~~CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND~~ S-~~ADENOSYLMETHIONINE~~==
			==Crystal structure of Arabidopsis thaliana aspartate kinase complexed with lysine and S- adenosylmethionine==
	<StructureSection load='2cdq' size='340' side='right' caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cdq' size='340' side='right' caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://pdbe.org/2cdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://pdbe.org/2cdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdq ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdq_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdq_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 21:10, 8 February 2016

2016-02-08T21:10:43Z

← Older revision		Revision as of 21:10, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cdq ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:25, 10 September 2015

2015-09-10T15:25:29Z

← Older revision		Revision as of 15:25, 10 September 2015
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	<StructureSection load='2cdq' size='340' side='right' caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cdq' size='340' side='right' caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Arabidopsis_thaliana Arabidopsis thaliana~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://pdbe.org/2cdq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cdq" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Arabidopsis thaliana~~]]		[[Category: Arath]]
	[[Category: Aspartate kinase]]		[[Category: Aspartate kinase]]
	[[Category: Curien, G]]		[[Category: Curien, G]]

OCA at 17:25, 15 January 2015

2015-01-15T17:25:47Z

← Older revision		Revision as of 17:25, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Aspartate kinase]]		[[Category: Aspartate kinase]]
	[[Category: Curien, G.]]		[[Category: Curien, G]]
	[[Category: Dumas, R.]]		[[Category: Dumas, R]]
	[[Category: Ferrer, J L.]]		[[Category: Ferrer, J L]]
	[[Category: Laurencin, M.]]		[[Category: Laurencin, M]]
	[[Category: Mas-Droux, C.]]		[[Category: Mas-Droux, C]]
	[[Category: Robert-Genthon, M.]]		[[Category: Robert-Genthon, M]]
	[[Category: Act domain]]		[[Category: Act domain]]
	[[Category: Allosteric effector]]		[[Category: Allosteric effector]]
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	[[Category: Amino acid biosynthesis]]		[[Category: Amino acid biosynthesis]]
	[[Category: Amino acid metabolism]]		[[Category: Amino acid metabolism]]
	~~[[Category: Aspartate kinase]]~~
	[[Category: Lysine]]		[[Category: Lysine]]
	[[Category: Plant]]		[[Category: Plant]]
	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 02:20, 30 September 2014

2014-09-30T02:20:58Z

← Older revision		Revision as of 02:20, 30 September 2014
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	[[Image:~~2cdq~~.~~png~~\|~~left~~\|~~200px~~]]		==CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE==
			<StructureSection load='2cdq' size='340' side='right' caption='[[2cdq]], [[Resolution\|resolution]] 2.85Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDQ FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LYS:LYSINE'>LYS</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate_kinase Aspartate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.4 2.7.2.4] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdq RCSB], [http://www.ebi.ac.uk/pdbsum/2cdq PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdq_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Asp kinase catalyzes the first step of the Asp-derived essential amino acid pathway in plants and microorganisms. Depending on the source organism, this enzyme contains up to four regulatory ACT domains and exhibits several isoforms under the control of a great variety of allosteric effectors. We report here the dimeric structure of a Lys and S-adenosylmethionine-sensitive Asp kinase isoform from Arabidopsis thaliana in complex with its two inhibitors. This work reveals the structure of an Asp kinase and an enzyme containing two ACT domains cocrystallized with its effectors. Only one ACT domain (ACT1) is implicated in effector binding. A loop involved in the binding of Lys and S-adenosylmethionine provides an explanation for the synergistic inhibition by these effectors. The presence of S-adenosylmethionine in the regulatory domain indicates that ACT domains are also able to bind nucleotides. The organization of ACT domains in the present structure is different from that observed in Thr deaminase and in the regulatory subunit of acetohydroxyacid synthase III.

	~~{{STRUCTURE_2cdq\| PDB=2cdq \| SCENE= }}~~		A novel organization of ACT domains in allosteric enzymes revealed by the crystal structure of Arabidopsis aspartate kinase.,Mas-Droux C, Curien G, Robert-Genthon M, Laurencin M, Ferrer JL, Dumas R Plant Cell. 2006 Jul;18(7):1681-92. Epub 2006 May 26. PMID:16731588<ref>PMID:16731588</ref>

	~~===CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16731588}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cdq]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016731588<~~/~~ref><ref group="xtra">PMID:016601125</ref~~><~~references group="xtra"~~/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Aspartate kinase]]		[[Category: Aspartate kinase]]

OCA: Protected "2cdq" [edit=sysop:move=sysop]

2013-01-06T11:33:46Z

Protected "2cdq" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:33, 6 January 2013
(No difference)

OCA at 11:33, 6 January 2013

2013-01-06T11:33:44Z

← Older revision		Revision as of 11:33, 6 January 2013
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	~~{{Seed}}~~
	[[Image:2cdq.png\|left\|200px]]		[[Image:2cdq.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cdq", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
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	{{STRUCTURE_2cdq\| PDB=2cdq \| SCENE= }}		{{STRUCTURE_2cdq\| PDB=2cdq \| SCENE= }}

	===CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE===		===CRYSTAL STRUCTURE OF ARABIDOPSIS THALIANA ASPARTATE KINASE COMPLEXED WITH LYSINE AND S-ADENOSYLMETHIONINE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16731588}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16731588 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16731588}}		{{ABSTRACT_PUBMED_16731588}}

	==About this Structure==		==About this Structure==
	~~2CDQ~~ is a 2 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA].		[[2cdq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDQ OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16731588~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016731588</ref><ref group="xtra">PMID:016601125</ref><references group="xtra"/>
	[[Category: Arabidopsis thaliana]]		[[Category: Arabidopsis thaliana]]
	[[Category: Aspartate kinase]]		[[Category: Aspartate kinase]]
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	[[Category: S-adenosylmethionine]]		[[Category: S-adenosylmethionine]]
	[[Category: Transferase]]		[[Category: Transferase]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 03:29:13 2009''~~