2cdt - Revision history

OCA at 14:14, 13 December 2023

2023-12-13T14:14:18Z

← Older revision		Revision as of 14:14, 13 December 2023
Line 3:		Line 3:
	<StructureSection load='2cdt' size='340' side='right'caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='2cdt' size='340' side='right'caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Chick Chick~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~<div style='overflow: auto; max~~-~~height: 3em;'>[[1aey\|1aey]]~~, [[~~1aj3~~\|~~1aj3~~]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</div></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.54Å</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [https://pdbe.org/2cdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [https://www.ebi.ac.uk/pdbsum/2cdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [https://pdbe.org/2cdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [https://www.ebi.ac.uk/pdbsum/2cdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdt ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/SPTN1_CHICK SPTN1_CHICK] Morphologically, spectrin-like proteins appear to be related to spectrin, showing a flexible rod-like structure. They can bind actin but seem to differ in their calmodulin-binding activity. In nonerythroid tissues, spectrins, in association with some other proteins, may play an important role in membrane organization.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 28:		Line 30:

	==See Also==		==See Also==
	*[[Spectrin\|Spectrin]]		*[[Spectrin 3D structures\|Spectrin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Chick~~]]		[[Category: Gallus gallus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Camara-Artigas, A]]		[[Category: Camara-Artigas A]]
	[[Category: Casares, S]]		[[Category: Casares S]]
	[[Category: Conejero-Lara, F]]		[[Category: Conejero-Lara F]]
	[[Category: Lopez-Mayorga, O]]		[[Category: Lopez-Mayorga O]]
	[[Category: Vega~~, M C]]~~		[[Category: Vega MC]]
	~~[[Category: Actin-binding]]~~
	~~[[Category: Calmodulin-binding]]~~
	~~[[Category: Cytoskeleton]]~~
	~~[[Category: Sh3-domain]]~~
	~~[[Category: Structural protein~~]]

OCA at 06:53, 1 December 2021

2021-12-01T06:53:43Z

← Older revision		Revision as of 06:53, 1 December 2021
Line 3:		Line 3:
	<StructureSection load='2cdt' size='340' side='right'caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='2cdt' size='340' side='right'caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [~~http~~://pdbe.org/2cdt PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cdt PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdt ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [https://pdbe.org/2cdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [https://www.ebi.ac.uk/pdbsum/2cdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:45, 26 February 2020

2020-02-26T10:45:28Z

← Older revision		Revision as of 10:45, 26 February 2020
Line 1:		Line 1:

	==alpha-SPECTRIN SH3 DOMAIN A56S MUTANT==		==alpha-SPECTRIN SH3 DOMAIN A56S MUTANT==
	<StructureSection load='2cdt' size='340' side='right' caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='2cdt' size='340' side='right'caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
Line 34:		Line 34:
	</StructureSection>		</StructureSection>
	[[Category: Chick]]		[[Category: Chick]]
			[[Category: Large Structures]]
	[[Category: Camara-Artigas, A]]		[[Category: Camara-Artigas, A]]
	[[Category: Casares, S]]		[[Category: Casares, S]]

OCA at 08:00, 23 May 2018

2018-05-23T08:00:00Z

← Older revision		Revision as of 08:00, 23 May 2018
Line 1:		Line 1:
	==~~ALPHA~~-SPECTRIN SH3 DOMAIN A56S MUTANT==
			==alpha-SPECTRIN SH3 DOMAIN A56S MUTANT==
	<StructureSection load='2cdt' size='340' side='right' caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='2cdt' size='340' side='right' caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://pdbe.org/2cdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://pdbe.org/2cdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cdt ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 10:		Line 11:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdt_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdt_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cdt ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:36, 11 September 2015

2015-09-11T23:36:29Z

← Older revision		Revision as of 23:36, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2cdt' size='340' side='right' caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>		<StructureSection load='2cdt' size='340' side='right' caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Gallus_gallus Gallus gallus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://pdbe.org/2cdt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
Line 24:		Line 24:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cdt" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 32:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Gallus gallus~~]]		[[Category: Chick]]
	[[Category: Camara-Artigas, A]]		[[Category: Camara-Artigas, A]]
	[[Category: Casares, S]]		[[Category: Casares, S]]

OCA at 16:07, 15 January 2015

2015-01-15T16:07:50Z

← Older revision		Revision as of 16:07, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A]]
	[[Category: Casares, S.]]		[[Category: Casares, S]]
	[[Category: Conejero-Lara, F.]]		[[Category: Conejero-Lara, F]]
	[[Category: Lopez-Mayorga, O.]]		[[Category: Lopez-Mayorga, O]]
	[[Category: Vega, M C.]]		[[Category: Vega, M C]]
	[[Category: Actin-binding]]		[[Category: Actin-binding]]
	[[Category: Calmodulin-binding]]		[[Category: Calmodulin-binding]]

OCA at 04:26, 29 September 2014

2014-09-29T04:26:19Z

← Older revision		Revision as of 04:26, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2cdt~~.~~png~~\|~~left~~\|~~200px~~]]		==ALPHA-SPECTRIN SH3 DOMAIN A56S MUTANT==
			<StructureSection load='2cdt' size='340' side='right' caption='[[2cdt]], [[Resolution\|resolution]] 2.54Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CDT FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1aey\|1aey]], [[1aj3\|1aj3]], [[1bk2\|1bk2]], [[1cun\|1cun]], [[1e6g\|1e6g]], [[1e6h\|1e6h]], [[1e7o\|1e7o]], [[1g2b\|1g2b]], [[1h8k\|1h8k]], [[1hd3\|1hd3]], [[1m8m\|1m8m]], [[1neg\|1neg]], [[1pwt\|1pwt]], [[1qkw\|1qkw]], [[1qkx\|1qkx]], [[1shg\|1shg]], [[1tuc\|1tuc]], [[1tud\|1tud]], [[1u06\|1u06]], [[1u4q\|1u4q]], [[1u5p\|1u5p]], [[1uue\|1uue]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cdt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cdt RCSB], [http://www.ebi.ac.uk/pdbsum/2cdt PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/2cdt_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Site-directed mutagenesis has been used to produce local stability changes at two regions of the binding site surface of the alpha-spectrin SH3 domain (Spc-SH3) differing in their intrinsic stability. Mutations were made at residue 56, located at the solvent-exposed side of the short 3(10) helix, and at residue 21 in the tip of the flexible RT-loop. NMR chemical-shift analysis and X-ray crystallography indicated negligible changes produced by the mutations in the native structure limited to subtle rearrangements near the mutated residue and at flexible loops. Additionally, mutations do not alter importantly the SH3 binding site structure, although produce significant changes in its affinity for a proline-rich decapeptide. The changes in global stability measured by differential scanning calorimetry are consistent the local energy changes predicted by theoretical models, with the most significant effects observed for the Ala-Gly mutations. Propagation of the local stability changes throughout the domain structure has been studied at a per-residue level of resolution by NMR-detected amide hydrogen-deuterium exchange (HX). Stability propagation is remarkably efficient in this small domain, apparently due to its intrinsically low stability. Nevertheless, the HX-core of the domain is not fully cooperative, indicating the existence of co-operative subunits within the core, which is markedly polarized. An equilibrium phi-analysis of the changes in the apparent Gibbs energies of HX per residue produced by the mutations has allowed us to characterize structurally the conformational states leading to HX. Some of these states resemble notably the folding transition state of the Spc-SH3 domain, suggesting a great potential of this approach to explore the folding energy landscape of proteins. An energy perturbation propagates more effectively from a flexible region to the core than in the opposite direction, because the former affects a broader region of the energy landscape than the latter. This might be of importance in understanding the special thermodynamic signature of the SH3-peptide interaction and the relevance of the dual character of SH3 binding sites.

	~~{{STRUCTURE_2cdt\| PDB=2cdt \| SCENE= }}~~		Cooperative propagation of local stability changes from low-stability and high-stability regions in a SH3 domain.,Casares S, Lopez-Mayorga O, Vega MC, Camara-Artigas A, Conejero-Lara F Proteins. 2007 May 15;67(3):531-47. PMID:17330285<ref>PMID:17330285</ref>

	~~===ALPHA-SPECTRIN SH3 DOMAIN A56S MUTANT===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_17330285}}~~

	~~==About this Structure==~~
	~~[[2cdt]] is~~ a ~~1 chain structure with sequence from [http://en.wikipedia~~.~~org/wiki/Gallus_gallus Gallus gallus]~~. ~~Full crystallographic information is available from [http://oca~~.~~weizmann.ac.il/oca-bin~~/~~ocashort?id=2CDT OCA].~~

	==See Also==		==See Also==
	*[[Spectrin\|Spectrin]]		*[[Spectrin\|Spectrin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:017330285<~~/~~ref~~><~~ref group="xtra">PMID:001279434</ref><references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A.]]

OCA at 21:31, 20 October 2012

2012-10-20T21:31:13Z

← Older revision		Revision as of 21:31, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2cdt]] is a 1 chain structure ~~of [[Spectrin]]~~ with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA].		[[2cdt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDT OCA].

	==See Also==		==See Also==

OCA at 13:29, 27 July 2012

2012-07-27T13:29:45Z

← Older revision		Revision as of 13:29, 27 July 2012
Line 1:		Line 1:
	[[Image:2cdt.png\|left\|200px]]		[[Image:2cdt.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cdt", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cdt\| PDB=2cdt \| SCENE= }}		{{STRUCTURE_2cdt\| PDB=2cdt \| SCENE= }}

	===ALPHA-SPECTRIN SH3 DOMAIN A56S MUTANT===		===ALPHA-SPECTRIN SH3 DOMAIN A56S MUTANT===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_17330285}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 17330285 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_17330285}}		{{ABSTRACT_PUBMED_17330285}}

Line 22:		Line 11:

	==See Also==		==See Also==
	*[[Spectrin]]		*[[Spectrin\|Spectrin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~17330285~~</ref><ref group="xtra">PMID:~~1279434~~</ref><references group="xtra"/>		<ref group="xtra">PMID:017330285</ref><ref group="xtra">PMID:001279434</ref><references group="xtra"/>
	[[Category: Gallus gallus]]		[[Category: Gallus gallus]]
	[[Category: Camara-Artigas, A.]]		[[Category: Camara-Artigas, A.]]

OCA: Protected "2cdt" [edit=sysop:move=sysop]

2010-12-26T23:35:35Z

Protected "2cdt" [edit=sysop:move=sysop]

← Older revision	Revision as of 23:35, 26 December 2010
(No difference)