2cef - Revision history

OCA at 09:03, 6 November 2024

2024-11-06T09:03:29Z

← Older revision		Revision as of 09:03, 6 November 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEF FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [https://pdbe.org/2cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [https://www.ebi.ac.uk/pdbsum/2cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [https://pdbe.org/2cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [https://www.ebi.ac.uk/pdbsum/2cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>
	</table>		</table>

OCA at 20:51, 12 April 2023

2023-04-12T20:51:15Z

← Older revision		Revision as of 20:51, 12 April 2023
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	==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity.==		==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity.==
	<StructureSection load='2cef' size='340' side='right'caption='[[2cef~~]], [[NMR_Ensembles_of_Models \| 10 NMR models~~]]' scene=''>		<StructureSection load='2cef' size='340' side='right'caption='[[2cef]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEF FirstGlance]. <br>
	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~></td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [https://pdbe.org/2cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [https://www.ebi.ac.uk/pdbsum/2cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [https://pdbe.org/2cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [https://www.ebi.ac.uk/pdbsum/2cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>		[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Agrawal, S]]		[[Category: Agrawal S]]
	[[Category: Craft~~, J W~~]]		[[Category: Craft JW]]
	[[Category: Legge~~, G B~~]]		[[Category: Legge GB]]
	[[Category: Ruf, W]]		[[Category: Ruf W]]
	[[Category: Sen, M]]		[[Category: Sen M]]
	~~[[Category: Blood clotting]]~~
	~~[[Category: Blood coagulation protein]]~~
	~~[[Category: Coagulation protein]]~~
	~~[[Category: Lipoprotein]]~~
	~~[[Category: Palmitate]]~~
	~~[[Category: Pin1]]~~
	~~[[Category: Transmembrane]]~~
	~~[[Category: Ww domain~~]]

OCA at 10:30, 7 July 2021

2021-07-07T10:30:24Z

← Older revision		Revision as of 10:30, 7 July 2021
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	<StructureSection load='2cef' size='340' side='right'caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2cef' size='340' side='right'caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CEF FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</div></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [~~http~~://pdbe.org/2cef PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cef PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [https://pdbe.org/2cef PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [https://www.ebi.ac.uk/pdbsum/2cef PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>		[[https://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:45, 2 October 2019

2019-10-02T10:45:37Z

← Older revision		Revision as of 10:45, 2 October 2019
Line 1:		Line 1:

	==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity.==		==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity.==
	<StructureSection load='2cef' size='340' side='right' caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2cef' size='340' side='right'caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CEF FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Agrawal, S]]		[[Category: Agrawal, S]]
	[[Category: Craft, J W]]		[[Category: Craft, J W]]

OCA at 07:20, 17 January 2018

2018-01-17T07:20:59Z

← Older revision		Revision as of 07:20, 17 January 2018
Line 1:		Line 1:
	==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity==
			==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity.==
	<StructureSection load='2cef' size='340' side='right' caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>		<StructureSection load='2cef' size='340' side='right' caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://pdbe.org/2cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://pdbe.org/2cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cef ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:45, 11 September 2015

2015-09-11T15:45:51Z

← Older revision		Revision as of 15:45, 11 September 2015
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	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://pdbe.org/2cef PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cef" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 18:34, 25 December 2014

2014-12-25T18:34:38Z

← Older revision		Revision as of 18:34, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CEF FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CEF FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/TF_HUMAN TF_HUMAN]] Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.<ref>PMID:12652293</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 19:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Agrawal, S.]]		[[Category: Agrawal, S]]
	[[Category: Craft, J W.]]		[[Category: Craft, J W]]
	[[Category: Legge, G B.]]		[[Category: Legge, G B]]
	[[Category: Ruf, W.]]		[[Category: Ruf, W]]
	[[Category: Sen, M.]]		[[Category: Sen, M]]
	[[Category: Blood clotting]]		[[Category: Blood clotting]]
	[[Category: Blood coagulation protein]]		[[Category: Blood coagulation protein]]

OCA at 06:00, 29 September 2014

2014-09-29T06:00:32Z

← Older revision		Revision as of 06:00, 29 September 2014
Line 1:		Line 1:
	[[~~Image~~:~~2cef~~.~~png~~\|~~left~~\|~~200px~~]]		==Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity==
			<StructureSection load='2cef' size='340' side='right' caption='[[2cef]], [[NMR_Ensembles_of_Models \| 10 NMR models]]' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cef]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CEF FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1ahw\|1ahw]], [[1boy\|1boy]], [[1dan\|1dan]], [[1fak\|1fak]], [[1j9c\|1j9c]], [[1jps\|1jps]], [[1nl8\|1nl8]], [[1o5d\|1o5d]], [[1tfh\|1tfh]], [[1uj3\|1uj3]], [[1w0y\|1w0y]], [[1w2k\|1w2k]], [[1wqv\|1wqv]], [[1wss\|1wss]], [[1wtg\|1wtg]], [[1wun\|1wun]], [[1wv7\|1wv7]], [[1z6j\|1z6j]], [[2c4f\|2c4f]], [[2ceh\|2ceh]], [[2cez\|2cez]], [[2cfj\|2cfj]], [[2hft\|2hft]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cef FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cef OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cef RCSB], [http://www.ebi.ac.uk/pdbsum/2cef PDBsum]</span></td></tr>
			<table>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Tissue Factor (TF) is well known for its role during the activation of the coagulation pathway, but it is also critical for tumor biology and inflammation through protease activated receptor (PAR) 2 signaling. This signaling function is modulated by the successive phosphorylation of residues Ser253 and Ser258 within the TF cytoplasmic region (TFCR). This paper reports how we used NMR and spectroscopic methods to investigate the structural propensities of the unphosphorylated and phosphorylated forms of the TFCR. When unphosphorylated, the TFCR forms a local hydrophobic collapse around Trp254 and an electropositive patch from the membrane proximal basic block (Arg246-Lys247) to the conserved PKCalpha consensus residue Lys255. Phosphorylation of Ser253 alters the charge characteristics of this membrane proximal region, thereby strengthening the interaction between residue Ala248 and the Trp254 aromatic group. Phosphorylation of the Ser258-Pro259 motif destabilizes a turn at the C-terminus to form an extended polyproline helical motif. Our data suggests that by changing both its charge and local structural propensity, covalent modifications of the TFCR can potentially regulate its association with the cellular membrane and its signaling partners.

	~~{{STRUCTURE_2cef\| PDB=2cef \| SCENE= }}~~		Spectroscopic Characterization of Successive Phosphorylation of the Tissue Factor Cytoplasmic Region.,Sen M, Herzik M, Craft JW, Creath AL, Agrawal S, Ruf W, Legge GB Open Spectrosc J. 2009 Jan 1;3:58-64. PMID:20076769<ref>PMID:20076769</ref>

	~~===Phosphorylation~~ of the ~~Cytoplasmic Tail~~ of ~~Tissue Factor and its Role in Modulating Structure and Binding Affinity===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_20076769}}~~		== References ==
			<references/>
	==~~About this Structure~~==		__TOC__
	~~[[2cef]] is a 1 chain structure. Full experimental information is available from [http:~~//~~oca.weizmann.ac.il/oca-bin/ocashort?id=2CEF OCA].~~		</StructureSection>
	[[Category: Agrawal, S.]]		[[Category: Agrawal, S.]]
	[[Category: Craft, J W.]]		[[Category: Craft, J W.]]

OCA at 09:48, 5 December 2012

2012-12-05T09:48:12Z

← Older revision		Revision as of 09:48, 5 December 2012
Line 3:		Line 3:
	{{STRUCTURE_2cef\| PDB=2cef \| SCENE= }}		{{STRUCTURE_2cef\| PDB=2cef \| SCENE= }}

	===~~PHOSPHORYLATION OF THE CYTOPLASMIC TAIL OF TISSUE FACTOR AND ITS ROLE IN MODULATING STRUCTURE AND BINDING AFFINITY~~===		===Phosphorylation of the Cytoplasmic Tail of Tissue Factor and its Role in Modulating Structure and Binding Affinity===

			{{ABSTRACT_PUBMED_20076769}}

	==About this Structure==		==About this Structure==
Line 13:		Line 14:
	[[Category: Ruf, W.]]		[[Category: Ruf, W.]]
	[[Category: Sen, M.]]		[[Category: Sen, M.]]
			[[Category: Blood clotting]]
	[[Category: Blood coagulation protein]]		[[Category: Blood coagulation protein]]
	[[Category: Coagulation protein]]		[[Category: Coagulation protein]]
Line 18:		Line 20:
	[[Category: Palmitate]]		[[Category: Palmitate]]
	[[Category: Pin1]]		[[Category: Pin1]]
	~~[[Category: Tissue factor]]~~
	[[Category: Transmembrane]]		[[Category: Transmembrane]]
	~~[[Category: Unphosphorylated]]~~
	[[Category: Ww domain]]		[[Category: Ww domain]]

OCA: Protected "2cef" [edit=sysop:move=sysop]

2012-10-24T07:58:47Z

Protected "2cef" [edit=sysop:move=sysop]

← Older revision	Revision as of 07:58, 24 October 2012
(No difference)