2cfb - Revision history

OCA at 14:15, 13 December 2023

2023-12-13T14:15:52Z

← Older revision		Revision as of 14:15, 13 December 2023
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	<StructureSection load='2cfb' size='340' side='right'caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cfb' size='340' side='right'caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Pcc_6301 Pcc 6301~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFB FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PLR:(5~~-~~HYDROXY-4~~,~~6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.85Å</td></tr>
	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>[https~~:~~//en.wikipedia.org/wiki/Glutamate~~-1-~~semialdehyde_2~~,1-~~aminomutase Glutamate~~-1-~~semialdehyde 2,1-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8]~~ </~~span~~></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [https://pdbe.org/2cfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [https://www.ebi.ac.uk/pdbsum/2cfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [https://pdbe.org/2cfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [https://www.ebi.ac.uk/pdbsum/2cfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfb ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/GSA_THEVB GSA_THEVB]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Pcc 6301~~]]		[[Category: Synechococcus elongatus]]
	[[Category: Heinz~~, D W~~]]		[[Category: Heinz DW]]
	[[Category: Jahn, D]]		[[Category: Jahn D]]
	[[Category: Moser, J]]		[[Category: Moser J]]
	[[Category: Schubert, W D]]		[[Category: Schubert W-D]]
	[[Category: Schulze~~, J O]]~~		[[Category: Schulze JO]]
	~~[[Category: Aminotransferase]]~~
	~~[[Category: Chlorophyll biosynthesis]]~~
	~~[[Category: Isomerase]]~~
	~~[[Category: Porphyrin biosynthesis]]~~
	~~[[Category: Pyridoxal phosphate dependent]]~~
	~~[[Category: Tetrapyrrole biosynthesis~~]]

OCA at 06:54, 1 December 2021

2021-12-01T06:54:27Z

← Older revision		Revision as of 06:54, 1 December 2021
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	<StructureSection load='2cfb' size='340' side='right'caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cfb' size='340' side='right'caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [~~http~~://pdbe.org/2cfb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cfb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [https://pdbe.org/2cfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [https://www.ebi.ac.uk/pdbsum/2cfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 10:58, 26 February 2020

2020-02-26T10:58:01Z

← Older revision		Revision as of 10:58, 26 February 2020
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	==Glutamate-1-semialdehyde 2,1-Aminomutase from Thermosynechococcus elongatus==		==Glutamate-1-semialdehyde 2,1-Aminomutase from Thermosynechococcus elongatus==
	<StructureSection load='2cfb' size='340' side='right' caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cfb' size='340' side='right'caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>
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	==See Also==		==See Also==
	*[[Aminomutase\|Aminomutase]]		*[[Aminomutase 3D structures\|Aminomutase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
			[[Category: Large Structures]]
	[[Category: Pcc 6301]]		[[Category: Pcc 6301]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]

OCA at 08:20, 23 May 2018

2018-05-23T08:20:23Z

← Older revision		Revision as of 08:20, 23 May 2018
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	==~~GLUTAMATE~~-1-~~SEMIALDEHYDE~~ 2,1-~~AMINOMUTASE FROM THERMOSYNECHOCOCCUS ELONGATUS~~==
			==Glutamate-1-semialdehyde 2,1-Aminomutase from Thermosynechococcus elongatus==
	<StructureSection load='2cfb' size='340' side='right' caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cfb' size='340' side='right' caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://pdbe.org/2cfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://pdbe.org/2cfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfb ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfb_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfb_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 07:46, 8 February 2016

2016-02-08T07:46:36Z

← Older revision		Revision as of 07:46, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfb ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2cfb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cfb" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminomutase\|Aminomutase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:23, 10 September 2015

2015-09-10T09:23:30Z

← Older revision		Revision as of 09:23, 10 September 2015
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	<StructureSection load='2cfb' size='340' side='right' caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>		<StructureSection load='2cfb' size='340' side='right' caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Synechococcus_elongatus Synechococcus elongatus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pcc_6301 Pcc 6301]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://pdbe.org/2cfb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cfb" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: ~~Synechococcus elongatus~~]]		[[Category: Pcc 6301]]
	[[Category: Heinz, D W]]		[[Category: Heinz, D W]]
	[[Category: Jahn, D]]		[[Category: Jahn, D]]

OCA at 17:59, 15 January 2015

2015-01-15T17:59:29Z

← Older revision		Revision as of 17:59, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene></td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 31:		Line 31:
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]
	[[Category: Heinz, D W.]]		[[Category: Heinz, D W]]
	[[Category: Jahn, D.]]		[[Category: Jahn, D]]
	[[Category: Moser, J.]]		[[Category: Moser, J]]
	[[Category: Schubert, W D.]]		[[Category: Schubert, W D]]
	[[Category: Schulze, J O.]]		[[Category: Schulze, J O]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Chlorophyll biosynthesis]]		[[Category: Chlorophyll biosynthesis]]

OCA at 02:40, 30 September 2014

2014-09-30T02:40:02Z

← Older revision		Revision as of 02:40, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2cfb~~.~~png~~\|~~left~~\|~~200px~~]]		==GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE FROM THERMOSYNECHOCOCCUS ELONGATUS==
			<StructureSection load='2cfb' size='340' side='right' caption='[[2cfb]], [[Resolution\|resolution]] 2.85Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFB FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLR:(5-HYDROXY-4,6-DIMETHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>PLR</scene><br>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutamate-1-semialdehyde_2,1-aminomutase Glutamate-1-semialdehyde 2,1-aminomutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.8 5.4.3.8] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfb RCSB], [http://www.ebi.ac.uk/pdbsum/2cfb PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfb_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Glutamate-1-semialdehyde 2,1-aminomutase (GSAM) is the second enzyme in the C(5) pathway of tetrapyrrole biosynthesis found in most bacteria, in archaea and in plants. It catalyzes the transamination of glutamate-1-semialdehyde to 5-aminolevulinic acid (ALA) in a pyridoxal 5'-phosphate (PLP)-dependent manner. We present the crystal structure of GSAM from the thermophilic cyanobacterium Thermosynechococcus elongatus (GSAM(Tel)) in its PLP-bound form at 2.85A resolution. GSAM(Tel) is a symmetric homodimer, whereas GSAM from Synechococcus (GSAM(Syn)) has been described as asymmetric. The symmetry of GSAM(Tel) thus challenges the previously proposed negative cooperativity between monomers of this enzyme. Furthermore, GSAM(Tel) reveals an extensive flexible region at the interface of the proposed complex of GSAM with glutamyl-tRNA reductase (GluTR), the preceding enzyme in tetrapyrrole biosynthesis. Compared to GSAM(Syn), the monomers of GSAM(Tel) are rotated away from each other along the dimerization interface by 10 degrees . The associated flexibility of GSAM may be essential for complex formation with GluTR to occur. Unexpectedly, we find that GSAM is structurally related to 5-aminolevulinate synthase (ALAS), the ALA-producing enzyme in the Shemin pathway of alpha-proteobacteria and non-plant eukaryotes. This structural relationship applies also to the corresponding subfamilies of PLP-dependent enzymes. We thus propose that the CoA-subfamily (including ALAS) and the aminotransferase subfamily II (including GSAM) are evolutionarily closely related and that ALAS may thus have evolved from GSAM.

	~~{{STRUCTURE_2cfb\| PDB=2cfb \| SCENE= }}~~		Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis.,Schulze JO, Schubert WD, Moser J, Jahn D, Heinz DW J Mol Biol. 2006 May 19;358(5):1212-20. Epub 2006 Mar 10. PMID:16564539<ref>PMID:16564539</ref>

	~~===GLUTAMATE-1-SEMIALDEHYDE 2~~,~~1-AMINOMUTASE FROM THERMOSYNECHOCOCCUS ELONGATUS===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16564539}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cfb]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Synechococcus_elongatus Synechococcus elongatus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016564539<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]

OCA: Protected "2cfb" [edit=sysop:move=sysop]

2013-01-06T11:52:39Z

Protected "2cfb" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:52, 6 January 2013
(No difference)

OCA at 11:52, 6 January 2013

2013-01-06T11:52:37Z

← Older revision		Revision as of 11:52, 6 January 2013
Line 1:		Line 1:
	~~{{Seed}}~~
	[[Image:2cfb.png\|left\|200px]]		[[Image:2cfb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cfb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cfb\| PDB=2cfb \| SCENE= }}		{{STRUCTURE_2cfb\| PDB=2cfb \| SCENE= }}

	===GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE FROM THERMOSYNECHOCOCCUS ELONGATUS===		===GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE FROM THERMOSYNECHOCOCCUS ELONGATUS===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16564539}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16564539 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16564539}}		{{ABSTRACT_PUBMED_16564539}}

	==About this Structure==		==About this Structure==
	~~2CFB~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA].		[[2cfb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFB OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16564539~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016564539</ref><references group="xtra"/>
	[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]		[[Category: Glutamate-1-semialdehyde 2,1-aminomutase]]
	[[Category: Synechococcus elongatus]]		[[Category: Synechococcus elongatus]]
Line 37:		Line 25:
	[[Category: Pyridoxal phosphate dependent]]		[[Category: Pyridoxal phosphate dependent]]
	[[Category: Tetrapyrrole biosynthesis]]		[[Category: Tetrapyrrole biosynthesis]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 20:18:25 2009''~~