2cfe - Revision history

OCA at 14:15, 13 December 2023

2023-12-13T14:15:54Z

← Older revision		Revision as of 14:15, 13 December 2023
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	<StructureSection load='2cfe' size='340' side='right'caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cfe' size='340' side='right'caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Atcc_96803 Atcc 96803~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.5Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [https://pdbe.org/2cfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [https://www.ebi.ac.uk/pdbsum/2cfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [https://pdbe.org/2cfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [https://www.ebi.ac.uk/pdbsum/2cfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/O93970_MALSM O93970_MALSM]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]		[https://www.uniprot.org/uniprot/O93970_MALSM O93970_MALSM] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Atcc 96803]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Crameri, R]]		[[Category: Malassezia sympodialis]]
	[[Category: Fluckiger, S]]		[[Category: Crameri R]]
	[[Category: Glaser~~, A G~~]]		[[Category: Fluckiger S]]
	[[Category: Limacher, A]]		[[Category: Glaser AG]]
	[[Category: Scapozza, L]]		[[Category: Limacher A]]
	[[Category: Scheynius, A]]		[[Category: Scapozza L]]
	~~[[Category: Allergen]]~~		[[Category: Scheynius A]]
	~~[[Category: Autoreactivity]]~~
	~~[[Category: Cyclophilin]]~~
	~~[[Category: Epitope]]~~
	~~[[Category: Fungi]]~~
	~~[[Category: Ige]]~~
	~~[[Category: Immune system]]~~
	~~[[Category: Malassezia sympodiali~~]]

OCA at 14:35, 29 December 2021

2021-12-29T14:35:04Z

← Older revision		Revision as of 14:35, 29 December 2021
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	<StructureSection load='2cfe' size='340' side='right'caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cfe' size='340' side='right'caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [~~http~~://pdbe.org/2cfe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cfe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfe ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [https://pdbe.org/2cfe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [https://www.ebi.ac.uk/pdbsum/2cfe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/O93970_MALSM O93970_MALSM]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]		[[https://www.uniprot.org/uniprot/O93970_MALSM O93970_MALSM]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 11:03, 27 March 2020

2020-03-27T11:03:01Z

← Older revision		Revision as of 11:03, 27 March 2020
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	==The 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family==		==The 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family==
	<StructureSection load='2cfe' size='340' side='right' caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cfe' size='340' side='right'caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
Line 30:		Line 30:

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin 3D structures\|Cyclophilin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 96803]]		[[Category: Atcc 96803]]
			[[Category: Large Structures]]
	[[Category: Crameri, R]]		[[Category: Crameri, R]]
	[[Category: Fluckiger, S]]		[[Category: Fluckiger, S]]

OCA at 08:31, 23 May 2018

2018-05-23T08:31:37Z

← Older revision		Revision as of 08:31, 23 May 2018
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	==~~THE~~ 1.5 A ~~CRYSTAL STRUCTURE OF THE MALASSEZIA SYMPODIALIS MALA S~~ 6 ~~ALLERGEN~~, ~~A MEMBER OF THE CYCLOPHILIN PAN~~-~~ALLERGEN FAMILY~~==
			==The 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family==
	<StructureSection load='2cfe' size='340' side='right' caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cfe' size='340' side='right' caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://pdbe.org/2cfe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://pdbe.org/2cfe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfe ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 12:		Line 13:
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfe_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfe_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfe ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:27, 11 September 2015

2015-09-11T15:27:01Z

← Older revision		Revision as of 15:27, 11 September 2015
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	<StructureSection load='2cfe' size='340' side='right' caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>		<StructureSection load='2cfe' size='340' side='right' caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Malassezia_sympodialis Malassezia sympodialis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_96803 Atcc 96803]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://pdbe.org/2cfe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum]</span></td></tr>
	</table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/O93970_MALSM O93970_MALSM]] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 24:		Line 26:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cfe" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 31:		Line 34:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Malassezia sympodialis~~]]		[[Category: Atcc 96803]]
	[[Category: Crameri, R]]		[[Category: Crameri, R]]
	[[Category: Fluckiger, S]]		[[Category: Fluckiger, S]]

OCA at 16:51, 15 January 2015

2015-01-15T16:51:51Z

← Older revision		Revision as of 16:51, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	</StructureSection>		</StructureSection>
	[[Category: Malassezia sympodialis]]		[[Category: Malassezia sympodialis]]
	[[Category: Crameri, R.]]		[[Category: Crameri, R]]
	[[Category: Fluckiger, S.]]		[[Category: Fluckiger, S]]
	[[Category: Glaser, A G.]]		[[Category: Glaser, A G]]
	[[Category: Limacher, A.]]		[[Category: Limacher, A]]
	[[Category: Scapozza, L.]]		[[Category: Scapozza, L]]
	[[Category: Scheynius, A.]]		[[Category: Scheynius, A]]
	[[Category: Allergen]]		[[Category: Allergen]]
	[[Category: Autoreactivity]]		[[Category: Autoreactivity]]

OCA at 05:50, 29 September 2014

2014-09-29T05:50:04Z

← Older revision		Revision as of 05:50, 29 September 2014
Line 1:		Line 1:
	[[Image:~~2cfe~~.~~png~~\|~~left~~\|~~200px~~]]		==THE 1.5 A CRYSTAL STRUCTURE OF THE MALASSEZIA SYMPODIALIS MALA S 6 ALLERGEN, A MEMBER OF THE CYCLOPHILIN PAN-ALLERGEN FAMILY==
			<StructureSection load='2cfe' size='340' side='right' caption='[[2cfe]], [[Resolution\|resolution]] 1.50Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CFE FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRO:PROLINE'>PRO</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cfe RCSB], [http://www.ebi.ac.uk/pdbsum/2cfe PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfe_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Cyclophilins constitute a family of proteins involved in many essential cellular functions. They have also been identified as a panallergen family able to elicit IgE-mediated hypersensitivity reactions. Moreover, it has been shown that human cyclophilins are recognized by serum IgE from patients sensitized to environmental cyclophilins. IgE-mediated autoreactivity to self-antigens that have similarity to environmental allergens is often observed in atopic disorders. Therefore comparison of the crystal structure of human proteins with similarity to allergens should allow the identification of structural similarities to rationally explain autoreactivity. A new cyclophilin from Aspergillus fumigatus (Asp f 27) has been cloned, expressed and showed to exhibit cross-reactivity in vitro and in vivo. The three-dimensional structure of cyclophilin from the yeast Malassezia sympodialis (Mala s 6) has been determined at 1.5 A (1 A=0.1 nm) by X-ray diffraction. Crystals belong to space group P4(1)2(1)2 with unit cell dimensions of a=b=71.99 A and c=106.18 A. The structure was solved by molecular replacement using the structure of human cyclophilin A as the search model. The refined structure includes all 162 amino acids of Mala s 6, an active-site-bound Ala-Pro dipeptide and 173 water molecules, with a crystallographic R- and free R-factor of 14.3% and 14.9% respectively. The overall structure consists of an eight-stranded antiparallel beta-barrel and two alpha-helices covering the top and bottom of the barrel, typical for cyclophilins. We identified conserved solvent-exposed residues in the fungal and human structures that are potentially involved in the IgE-mediated cross-reactivity.

	~~{{STRUCTURE_2cfe\| PDB=2cfe \| SCENE= }}~~		Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family.,Glaser AG, Limacher A, Fluckiger S, Scheynius A, Scapozza L, Crameri R Biochem J. 2006 May 15;396(1):41-9. PMID:16483252<ref>PMID:16483252</ref>

	~~===THE 1.5 A CRYSTAL STRUCTURE OF THE MALASSEZIA SYMPODIALIS MALA S 6 ALLERGEN~~, ~~A MEMBER OF THE CYCLOPHILIN PAN-ALLERGEN FAMILY===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16483252}}~~

	~~==About this Structure==~~
	~~[[2cfe]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Malassezia_sympodialis Malassezia sympodialis]~~. ~~Full crystallographic information is available from [http://oca.weizmann.ac.il~~/~~oca-bin/ocashort?id=2CFE OCA].~~

	==See Also==		==See Also==
	*[[Cyclophilin\|Cyclophilin]]		*[[Cyclophilin\|Cyclophilin]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:016483252<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Malassezia sympodialis]]		[[Category: Malassezia sympodialis]]
	[[Category: Crameri, R.]]		[[Category: Crameri, R.]]

OCA at 19:56, 20 October 2012

2012-10-20T19:56:23Z

← Older revision		Revision as of 19:56, 20 October 2012
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	==About this Structure==		==About this Structure==
	[[2cfe]] is a 1 chain structure ~~of [[Cyclophilin]]~~ with sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA].		[[2cfe]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA].

	==See Also==		==See Also==

OCA: Protected "2cfe" [edit=sysop:move=sysop]

2012-07-27T08:56:46Z

Protected "2cfe" [edit=sysop:move=sysop]

← Older revision	Revision as of 08:56, 27 July 2012
(No difference)

OCA at 08:56, 27 July 2012

2012-07-27T08:56:45Z

← Older revision		Revision as of 08:56, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2cfe.png\|left\|200px]]		[[Image:2cfe.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2cfe", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2cfe\| PDB=2cfe \| SCENE= }}		{{STRUCTURE_2cfe\| PDB=2cfe \| SCENE= }}

	===THE 1.5 A CRYSTAL STRUCTURE OF THE MALASSEZIA SYMPODIALIS MALA S 6 ALLERGEN, A MEMBER OF THE CYCLOPHILIN PAN-ALLERGEN FAMILY===		===THE 1.5 A CRYSTAL STRUCTURE OF THE MALASSEZIA SYMPODIALIS MALA S 6 ALLERGEN, A MEMBER OF THE CYCLOPHILIN PAN-ALLERGEN FAMILY===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16483252}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 16483252 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_16483252}}		{{ABSTRACT_PUBMED_16483252}}

	==About this Structure==		==About this Structure==
	~~2CFE~~ is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA].		[[2cfe]] is a 1 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Malassezia_sympodialis Malassezia sympodialis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFE OCA].

			==See Also==
			*[[Cyclophilin\|Cyclophilin]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16483252~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016483252</ref><references group="xtra"/>
	[[Category: Malassezia sympodialis]]		[[Category: Malassezia sympodialis]]
	[[Category: Crameri, R.]]		[[Category: Crameri, R.]]
Line 39:		Line 30:
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Malassezia sympodiali]]		[[Category: Malassezia sympodiali]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 02:10:54 2009''~~