2ch8 - Revision history

OCA at 05:08, 17 October 2024

2024-10-17T05:08:51Z

← Older revision		Revision as of 05:08, 17 October 2024
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:26, 22 May 2024

2024-05-22T11:26:45Z

← Older revision		Revision as of 11:26, 22 May 2024
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	<StructureSection load='2ch8' size='340' side='right'caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2ch8' size='340' side='right'caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Ebvg Ebvg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~"><~~scene name~~='~~pdbligand~~=PT:~~PLATINUM+(II)+ION'~~>PT</~~scene~~>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.3Å</td></tr>
			<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [https://pdbe.org/2ch8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [https://pdbe.org/2ch8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/BARF1_EBVB9 BARF1_EBVB9]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>		[https://www.uniprot.org/uniprot/BARF1_EBVB9 BARF1_EBVB9] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Ebvg~~]]		[[Category: Human gammaherpesvirus 4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Burmeister~~, W P~~]]		[[Category: Burmeister WP]]
	[[Category: Ooka, T]]		[[Category: Ooka T]]
	[[Category: Ruggiero, F]]		[[Category: Ruggiero F]]
	[[Category: Tarbouriech, N]]		[[Category: Tarbouriech N]]
	[[Category: DeTurenne-Tessier, M]]		[[Category: DeTurenne-Tessier M]]
	~~[[Category: Barf1]]~~
	~~[[Category: Early protein]]~~
	~~[[Category: Immunoglobulin domain]]~~
	~~[[Category: Oncogene]]~~
	~~[[Category: Viral protein~~]]

OCA at 06:55, 1 December 2021

2021-12-01T06:55:39Z

← Older revision		Revision as of 06:55, 1 December 2021
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	<StructureSection load='2ch8' size='340' side='right'caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2ch8' size='340' side='right'caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=~~MAN~~:~~ALPHA-D-MANNOSE~~'>~~MAN~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL~~-D-~~GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=PT:~~PLATINUM+(II)+ION~~'>PT</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [~~http~~://pdbe.org/2ch8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2ch8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [https://pdbe.org/2ch8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [https://www.ebi.ac.uk/pdbsum/2ch8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/BARF1_EBVB9 BARF1_EBVB9]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>		[[https://www.uniprot.org/uniprot/BARF1_EBVB9 BARF1_EBVB9]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 10:52, 26 February 2020

2020-02-26T10:52:39Z

← Older revision		Revision as of 10:52, 26 February 2020
Line 1:		Line 1:

	==Structure of the Epstein-Barr Virus Oncogene BARF1==		==Structure of the Epstein-Barr Virus Oncogene BARF1==
	<StructureSection load='2ch8' size='340' side='right' caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2ch8' size='340' side='right'caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
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	</StructureSection>		</StructureSection>
	[[Category: Ebvg]]		[[Category: Ebvg]]
			[[Category: Large Structures]]
	[[Category: Burmeister, W P]]		[[Category: Burmeister, W P]]
	[[Category: Ooka, T]]		[[Category: Ooka, T]]

OCA at 08:10, 23 May 2018

2018-05-23T08:10:51Z

← Older revision		Revision as of 08:10, 23 May 2018
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	==~~STRUCTURE OF THE EPSTEIN~~-~~BARR VIRUS ONCOGENE~~ BARF1==
			==Structure of the Epstein-Barr Virus Oncogene BARF1==
	<StructureSection load='2ch8' size='340' side='right' caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2ch8' size='340' side='right' caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PT:~~PLATINUM+(II)+ION~~'>PT</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://pdbe.org/2ch8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://pdbe.org/2ch8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ch8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch8_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch8_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ch8 ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	[[Category: Ebvg]]		[[Category: Ebvg]]
	[[Category: Burmeister, W P]]		[[Category: Burmeister, W P]]
	~~[[Category: Deturenne-Tessier, M]]~~
	[[Category: Ooka, T]]		[[Category: Ooka, T]]
	[[Category: Ruggiero, F]]		[[Category: Ruggiero, F]]
	[[Category: Tarbouriech, N]]		[[Category: Tarbouriech, N]]
			[[Category: DeTurenne-Tessier, M]]
	[[Category: Barf1]]		[[Category: Barf1]]
	[[Category: Early protein]]		[[Category: Early protein]]

OCA at 16:41, 11 September 2015

2015-09-11T16:41:31Z

← Older revision		Revision as of 16:41, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2ch8' size='340' side='right' caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>		<StructureSection load='2ch8' size='340' side='right' caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Human_herpesvirus_4 Human herpesvirus 4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ebvg Ebvg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://pdbe.org/2ch8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/~~BRF1_EBV BRF1_EBV~~]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>		[[http://www.uniprot.org/uniprot/BARF1_EBVB9 BARF1_EBVB9]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2ch8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Human herpesvirus 4~~]]		[[Category: Ebvg]]
	[[Category: Burmeister, W P]]		[[Category: Burmeister, W P]]
	[[Category: Deturenne-Tessier, M]]		[[Category: Deturenne-Tessier, M]]

OCA at 19:08, 25 December 2014

2014-12-25T19:08:31Z

← Older revision		Revision as of 19:08, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>		<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/BRF1_EBV BRF1_EBV]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	</StructureSection>		</StructureSection>
	[[Category: Human herpesvirus 4]]		[[Category: Human herpesvirus 4]]
	[[Category: Burmeister, W P.]]		[[Category: Burmeister, W P]]
	[[Category: Deturenne-Tessier, M.]]		[[Category: Deturenne-Tessier, M]]
	[[Category: Ooka, T.]]		[[Category: Ooka, T]]
	[[Category: Ruggiero, F.]]		[[Category: Ruggiero, F]]
	[[Category: Tarbouriech, N.]]		[[Category: Tarbouriech, N]]
	[[Category: Barf1]]		[[Category: Barf1]]
	[[Category: Early protein]]		[[Category: Early protein]]

OCA at 08:26, 3 October 2014

2014-10-03T08:26:12Z

← Older revision		Revision as of 08:26, 3 October 2014
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	~~{{STRUCTURE_2ch8\| PDB=2ch8 \| SCENE= }}~~		==STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1==
	===STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1===		<StructureSection load='2ch8' size='340' side='right' caption='[[2ch8]], [[Resolution\|resolution]] 2.30Å' scene=''>
	~~{{ABSTRACT_PUBMED_16647084}}~~		== Structural highlights ==
			<table><tr><td colspan='2'>[[2ch8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_4 Human herpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CH8 FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ch8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ch8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ch8 RCSB], [http://www.ebi.ac.uk/pdbsum/2ch8 PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2ch8_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The Epstein-Barr virus is a human gamma-herpesvirus that persistently infects more than 90% of the human population. It is associated with numerous epithelial cancers, principally undifferentiated nasopharyngeal carcinoma and gastric carcinoma. The BARF1 gene is expressed in a high proportion of these cancers. An oncogenic, mitogenic and immortalizing activity of the BARF1 protein has been shown. We solved the structure of the secreted BARF1 glycoprotein expressed in a human cell line by X-ray crystallography at a resolution of 2.3A. The BARF1 protein consists of two immunoglobulin (Ig)-like domains. The N-terminal domain belongs to the subfamily of variable domains whereas the C-terminal one is related to a constant Ig-domain. BARF1 shows an unusual hexamerisation involving two principal contacts, one between the C-terminal domains and one between the N-terminal domains. The C-terminal contact with an uncommonly large contact surface extends the beta-sandwich of the Ig-domain through the second molecule. The N-terminal contact involves Ig-domains with an unusual relative orientation but with a more classical contact surface with a size in the range of dimer interactions of Ig-domains. The structure of BARF1 is most closely related to CD80 or B7-1, a co-stimulatory molecule present on antigen presenting cells, from which BARF1 must have been derived during evolution. Still, domain orientation and oligomerization differ between BARF1 and CD80. It had been shown that BARF1 binds to hCSF-1, the human colony-stimulating factor 1, but this interaction has to be principally different from the one between CSF-1 and CSF-1 receptor.

	~~==Function==~~		Structure of the Epstein-Barr virus oncogene BARF1.,Tarbouriech N, Ruggiero F, de Turenne-Tessier M, Ooka T, Burmeister WP J Mol Biol. 2006 Jun 9;359(3):667-78. Epub 2006 Apr 18. PMID:16647084<ref>PMID:16647084</ref>
	~~[[http://www~~.~~uniprot.org/uniprot/BRF1_EBV BRF1_EBV]] Plays diverse functions in immunomodulation and oncogenicity~~, ~~maybe by acting as a functional receptor for human CSF1~~. ~~May inhibit interferon secretion from mononuclear cells~~. ~~Exhibits oncogenic activity in vitro~~.~~<ref>~~PMID:~~15064715</ref> <ref>PMID:15778977</ref>~~ <ref>PMID:~~16054293~~</ref>

	~~==About this Structure==~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	~~[[2ch8]] is~~ a ~~4 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Human_herpesvirus_4 Human herpesvirus 4]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CH8 OCA].~~		</div>
			== References ==
	==~~Reference~~==		<references/>
	~~<ref group="xtra">PMID:016647084</ref>~~<references ~~group="xtra"~~/><~~references~~/>		__TOC__
			</StructureSection>
	[[Category: Human herpesvirus 4]]		[[Category: Human herpesvirus 4]]
	[[Category: Burmeister, W P.]]		[[Category: Burmeister, W P.]]

OCA at 08:36, 23 April 2014

2014-04-23T08:36:28Z

← Older revision		Revision as of 08:36, 23 April 2014
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	~~[[Image:2ch8.png\|left\|200px]]~~

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2ch8", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2ch8\| PDB=2ch8 \| SCENE= }}		{{STRUCTURE_2ch8\| PDB=2ch8 \| SCENE= }}

	===STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1===		===STRUCTURE OF THE EPSTEIN-BARR VIRUS ONCOGENE BARF1===
			{{ABSTRACT_PUBMED_16647084}}

			==Function==
	~~<!--~~		[[http://www.uniprot.org/uniprot/BRF1_EBV BRF1_EBV]] Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro.<ref>PMID:15064715</ref> <ref>PMID:15778977</ref> <ref>PMID:16054293</ref>
	~~The line below this paragraph, {{ABSTRACT_PUBMED_16647084}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at~~ http://www.~~pubmed~~.~~gov)~~, ~~where 16647084 is the PubMed ID number~~.
	-->
	~~{{ABSTRACT_PUBMED_16647084}}~~

	==About this Structure==		==About this Structure==
Line 22:		Line 10:

	==Reference==		==Reference==
	<ref group="xtra">PMID:016647084</ref><references group="xtra"/>		<ref group="xtra">PMID:016647084</ref><references group="xtra"/><references/>
	[[Category: Human herpesvirus 4]]		[[Category: Human herpesvirus 4]]
	[[Category: Burmeister, W P.]]		[[Category: Burmeister, W P.]]

OCA: Protected "2ch8" [edit=sysop:move=sysop]

2011-08-24T05:26:08Z

Protected "2ch8" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:26, 24 August 2011
(No difference)