2chb - Revision history

OCA at 06:42, 9 August 2023

2023-08-09T06:42:42Z

← Older revision		Revision as of 06:42, 9 August 2023
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	<StructureSection load='2chb' size='340' side='right'caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2chb' size='340' side='right'caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [https://pdbe.org/2chb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [https://www.ebi.ac.uk/pdbsum/2chb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [https://pdbe.org/2chb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [https://www.ebi.ac.uk/pdbsum/2chb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.		[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Bacillo virgola del koch trevisan 1884]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Hol, W G.J~~]]		[[Category: Vibrio cholerae]]
	[[Category: ~~Merritt, E A~~]]		[[Category: Hol WGJ]]
	[[Category: ~~Pentasaccharide]]~~		[[Category: Merritt EA]]
	~~[[Category: Toxin]]~~
	~~[[Category: Toxin-receptor complex~~]]

OCA at 06:55, 1 December 2021

2021-12-01T06:55:47Z

← Older revision		Revision as of 06:55, 1 December 2021
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	<StructureSection load='2chb' size='340' side='right'caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2chb' size='340' side='right'caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [~~http~~://pdbe.org/2chb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2chb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2chb ProSAT]</span></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [https://pdbe.org/2chb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [https://www.ebi.ac.uk/pdbsum/2chb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.		[[https://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 10:53, 26 February 2020

2020-02-26T10:53:43Z

← Older revision		Revision as of 10:53, 26 February 2020
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	==CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE==		==CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE==
	<StructureSection load='2chb' size='340' side='right' caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2chb' size='340' side='right'caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>
Line 20:		Line 20:

	==See Also==		==See Also==
	*[[Cholera toxin\|Cholera toxin]]		*[[Cholera toxin 3D structures\|Cholera toxin 3D structures]]
	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]		*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
	== References ==		== References ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Bacillo virgola del koch trevisan 1884]]		[[Category: Bacillo virgola del koch trevisan 1884]]
			[[Category: Large Structures]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Merritt, E A]]		[[Category: Merritt, E A]]

OCA at 08:12, 23 May 2018

2018-05-23T08:12:30Z

← Older revision		Revision as of 08:12, 23 May 2018
Line 1:		Line 1:

	==CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE==		==CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE==
	<StructureSection load='2chb' size='340' side='right' caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2chb' size='340' side='right' caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>~~</td></tr>~~		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [http://pdbe.org/2chb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [http://www.ebi.ac.uk/pdbsum/2chb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2chb ProSAT]</span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [http://pdbe.org/2chb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [http://www.ebi.ac.uk/pdbsum/2chb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 15:57, 11 September 2015

2015-09-11T15:57:27Z

← Older revision		Revision as of 15:57, 11 September 2015
Line 2:		Line 2:
	<StructureSection load='2chb' size='340' side='right' caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='2chb' size='340' side='right' caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Vibrio_cholerae Vibrio cholerae~~]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>		<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [http://www.ebi.ac.uk/pdbsum/2chb PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [http://pdbe.org/2chb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [http://www.ebi.ac.uk/pdbsum/2chb PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 17:		Line 17:
	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2chb" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
Line 25:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Vibrio cholerae~~]]		[[Category: Bacillo virgola del koch trevisan 1884]]
	[[Category: Hol, W G.J]]		[[Category: Hol, W G.J]]
	[[Category: Merritt, E A]]		[[Category: Merritt, E A]]

OCA at 18:41, 25 December 2014

2014-12-25T18:41:54Z

← Older revision		Revision as of 18:41, 25 December 2014
Line 1:		Line 1:
	[[~~Image~~:~~2chb~~.~~png~~\|~~left~~\|~~200px~~]]		==CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE==
			<StructureSection load='2chb' size='340' side='right' caption='[[2chb]], [[Resolution\|resolution]] 2.00Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CHB FirstGlance]. <br>
			</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
			<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
			<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2chb RCSB], [http://www.ebi.ac.uk/pdbsum/2chb PDBsum]</span></td></tr>
			</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/CHTB_VIBCH CHTB_VIBCH]] The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The wide range of receptor binding affinities reported to result from mutations at residue Gly 33 of the cholera toxin B-pentamer (CTB) has been most puzzling. For instance, introduction of an aspartate at this position abolishes receptor binding, whereas substitution by arginine retains receptor affinity despite the larger side chain. We now report the structure determination and 2.3-A refinement of the CTB mutant Gly 33-->Arg complexed with the GM1 oligosaccharide, as well as the 2.2-A refinement of a Gly 33-->Asp mutant of the closely related Escherichia coli heat-labile enterotoxin B-pentamer (LTB). Two of the five receptor binding sites in the Gly 33-->Arg CTB mutant are occupied by bound GM1 oligosaccharide; two other sites are involved in a reciprocal toxin:toxin interaction; one site is unoccupied. We further report a higher resolution (2.0 A) determination and refinement of the wild-type CTB:GM1 oligosaccharide complex in which all five oligosaccharides are seen to be bound in essentially identical conformations. Saccharide conformation and binding interactions are very similar in both the CTB wild-type and Gly 33-->Arg mutant complexes. The protein conformation observed for the binding-deficient Gly 33-->Asp mutant of LTB does not differ substantially from that seen in the toxin:saccharide complexes. The critical nature of the side chain of residue 33 is apparently due to a limited range of subtle rearrangements available to both the toxin and the saccharide to accommodate receptor binding. The intermolecular interactions seen in the CTB (Gly 33-->Arg) complex with oligosaccharide suggest that the affinity of this mutant for the receptor is close to the self-affinity corresponding to the toxin:toxin binding interaction that has now been observed in crystal structures of three CTB mutants.

	~~{{STRUCTURE_2chb\| PDB=2chb \| SCENE= }}~~		Structural studies of receptor binding by cholera toxin mutants.,Merritt EA, Sarfaty S, Jobling MG, Chang T, Holmes RK, Hirst TR, Hol WG Protein Sci. 1997 Jul;6(7):1516-28. PMID:9232653<ref>PMID:9232653</ref>

	~~===CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_9232653}}~~

	~~==About this Structure==~~
	~~[[2chb]] is~~ a ~~5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes~~ the ~~now removed PDB entry [http://oca~~.~~weizmann~~.ac.~~il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http:/~~/~~oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].~~

	==See Also==		==See Also==
	*[[Cholera toxin\|Cholera toxin]]		*[[Cholera toxin\|Cholera toxin]]
	*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]		*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]
			== References ==
	==~~Reference~~==		<references/>
	<~~ref group="xtra">PMID:009232653<~~/~~ref~~><~~references group="xtra"~~/>		__TOC__
			</StructureSection>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J]]
	[[Category: Merritt, E A.]]		[[Category: Merritt, E A]]
	[[Category: Pentasaccharide]]		[[Category: Pentasaccharide]]
	[[Category: Toxin]]		[[Category: Toxin]]
	[[Category: Toxin-receptor complex]]		[[Category: Toxin-receptor complex]]

OCA at 20:07, 20 October 2012

2012-10-20T20:07:06Z

← Older revision		Revision as of 20:07, 20 October 2012
Line 8:		Line 8:

	==About this Structure==		==About this Structure==
	[[2chb]] is a 5 chain structure ~~of [[Cholera toxin]] and [[User:David Solfiell/sandbox 1]]~~ with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].		[[2chb]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].

	==See Also==		==See Also==

OCA: Protected "2chb" [edit=sysop:move=sysop]

2012-07-27T09:27:56Z

Protected "2chb" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:27, 27 July 2012
(No difference)

OCA at 09:27, 27 July 2012

2012-07-27T09:27:54Z

← Older revision		Revision as of 09:27, 27 July 2012
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	~~{{Seed}}~~
	[[Image:2chb.png\|left\|200px]]		[[Image:2chb.png\|left\|200px]]

	~~<!--~~
	~~The line below this paragraph, containing "STRUCTURE_2chb", creates the "Structure Box" on the page.~~
	~~You may change the PDB parameter (which sets the PDB file loaded into the applet)~~
	~~or the SCENE parameter (which sets the initial scene displayed when the page is loaded),~~
	~~or leave the SCENE parameter empty for the default display.~~
	~~-->~~
	{{STRUCTURE_2chb\| PDB=2chb \| SCENE= }}		{{STRUCTURE_2chb\| PDB=2chb \| SCENE= }}

	===CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE===		===CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE===


	~~<!--~~
	~~The line below this paragraph, {{ABSTRACT_PUBMED_9232653}}, adds the Publication Abstract to the page~~
	~~(as it appears on PubMed at http://www.pubmed.gov), where 9232653 is the PubMed ID number.~~
	~~-->~~
	{{ABSTRACT_PUBMED_9232653}}		{{ABSTRACT_PUBMED_9232653}}

	==About this Structure==		==About this Structure==
	~~2CHB~~ is a 5 ~~chains~~ structure of ~~sequences~~ from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].		[[2chb]] is a 5 chain structure of [[Cholera toxin]] and [[User:David Solfiell/sandbox 1]] with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].

			==See Also==
			*[[Cholera toxin\|Cholera toxin]]
			*[[User:David Solfiell/sandbox 1\|User:David Solfiell/sandbox 1]]

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~9232653~~</ref><references group="xtra"/>		<ref group="xtra">PMID:009232653</ref><references group="xtra"/>
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]
	[[Category: Merritt, E A.]]		[[Category: Merritt, E A.]]
	[[Category: Pentasaccharide]]		[[Category: Pentasaccharide]]
	[[Category: Toxin~~/receptor complex~~]]		[[Category: Toxin]]
			[[Category: Toxin-receptor complex]]
	~~''Page seeded by~~ [~~http~~:~~//oca.weizmann.ac.il/oca OCA~~ ] ~~on Wed Jul 29 15:52:52 2009''~~

OCA at 12:52, 29 July 2009

2009-07-29T12:52:54Z

← Older revision		Revision as of 12:52, 29 July 2009
Line 20:		Line 20:

	==About this Structure==		==About this Structure==
	2CHB is a ~~[[Single protein]]~~ structure of ~~sequence~~ from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].		2CHB is a 5 chains structure of sequences from [http://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1chb 1chb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHB OCA].

	==Reference==		==Reference==
	~~Structural studies of receptor binding by cholera toxin mutants., Merritt EA, Sarfaty S, Jobling MG, Chang T, Holmes RK, Hirst TR, Hol WG, Protein Sci. 1997 Jul;6(7):1516-28.~~ PMID:~~[http://www.ncbi.nlm.nih.gov~~/~~pubmed~~/~~9232653 9232653]~~		<ref group="xtra">PMID:9232653</ref><references group="xtra"/>
	~~[[Category: Single protein]]~~
	[[Category: Vibrio cholerae]]		[[Category: Vibrio cholerae]]
	[[Category: Hol, W G.J.]]		[[Category: Hol, W G.J.]]
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	[[Category: Toxin/receptor complex]]		[[Category: Toxin/receptor complex]]

	''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Tue~~ Jul 29 09:30:~~08 2008~~''		''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 29 15:52:52 2009''