2cin - Revision history

OCA at 08:26, 9 April 2025

2025-04-09T08:26:19Z

← Older revision		Revision as of 08:26, 9 April 2025
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cin_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cin_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:26, 22 May 2024

2024-05-22T11:26:50Z

← Older revision		Revision as of 11:26, 22 May 2024
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	<StructureSection load='2cin' size='340' side='right'caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2cin' size='340' side='right'caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Myctu Myctu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIN FirstGlance]. <br>
	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=PLP:PYRIDOXAL~~-~~5-PHOSPHATE'>PLP</scene>~~</td></tr>		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.98Å</td></tr>
	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~><div style='overflow: auto; max-height: 3em;'>[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</div></td></tr>~~		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	~~<tr~~ id~~='activity'><td class~~="~~sblockLbl~~"><~~b>Activity:</b></td><td class~~=~~"sblockDat"><span class~~=~~'plainlinks'>[https~~:~~//en.wikipedia.org/wiki/L~~-~~lysine_6~~-~~transaminase L-lysine 6-transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36]~~ </~~span~~></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [https://pdbe.org/2cin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [https://www.ebi.ac.uk/pdbsum/2cin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cin ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [https://pdbe.org/2cin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [https://www.ebi.ac.uk/pdbsum/2cin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cin ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/LAT_MYCTU LAT_MYCTU]
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: L-lysine 6-transaminase]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Myctu~~]]		[[Category: Mycobacterium tuberculosis H37Rv]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran R]]
	[[Category: Tripathi~~, S M]]~~		[[Category: Tripathi SM]]
	~~[[Category: Aminotransferase]]~~
	~~[[Category: Internal aldimine]]~~
	~~[[Category: Lysine amino transferase]]~~
	~~[[Category: Mycobacterium tuberculosis]]~~
	~~[[Category: Plp]]~~
	~~[[Category: Pyridoxal phosphate]]~~
	~~[[Category: Rv3290c]]~~
	~~[[Category: Transferase~~]]

OCA at 20:35, 20 October 2021

2021-10-20T20:35:33Z

← Older revision		Revision as of 20:35, 20 October 2021
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	<StructureSection load='2cin' size='340' side='right'caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2cin' size='340' side='right'caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</div></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [~~http~~://pdbe.org/2cin PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cin PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cin ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [https://pdbe.org/2cin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [https://www.ebi.ac.uk/pdbsum/2cin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cin ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==

OCA at 19:06, 11 December 2019

2019-12-11T19:06:18Z

← Older revision		Revision as of 19:06, 11 December 2019
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	==Lysine aminotransferase from M. tuberculosis in the internal aldimine form==		==Lysine aminotransferase from M. tuberculosis in the internal aldimine form==
	<StructureSection load='2cin' size='340' side='right' caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2cin' size='340' side='right'caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminotransferase 3D structures\|Aminotransferase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
			[[Category: Large Structures]]
	[[Category: Myctu]]		[[Category: Myctu]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]

OCA at 18:47, 24 January 2018

2018-01-24T18:47:21Z

← Older revision		Revision as of 18:47, 24 January 2018
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	==~~LYSINE AMINOTRANSFERASE FROM~~ M. ~~TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM~~==
			==Lysine aminotransferase from M. tuberculosis in the internal aldimine form==
	<StructureSection load='2cin' size='340' side='right' caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2cin' size='340' side='right' caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
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	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://pdbe.org/2cin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://pdbe.org/2cin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cin ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cin_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cin_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
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	</div>		</div>
	<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>

	~~==See Also==~~
	*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 00:06, 8 February 2016

2016-02-08T00:06:44Z

← Older revision		Revision as of 00:06, 8 February 2016
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cin ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>

			==See Also==
			*[[Aminotransferase\|Aminotransferase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 06:05, 10 September 2015

2015-09-10T06:05:34Z

← Older revision		Revision as of 06:05, 10 September 2015
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	<StructureSection load='2cin' size='340' side='right' caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='2cin' size='340' side='right' caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Mycobacterium_tuberculosis Mycobacterium tuberculosis~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://pdbe.org/2cin PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cin" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: ~~Mycobacterium tuberculosis~~]]		[[Category: Myctu]]
	[[Category: Ramachandran, R]]		[[Category: Ramachandran, R]]
	[[Category: Tripathi, S M]]		[[Category: Tripathi, S M]]
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	[[Category: Internal aldimine]]		[[Category: Internal aldimine]]
	[[Category: Lysine amino transferase]]		[[Category: Lysine amino transferase]]
			[[Category: Mycobacterium tuberculosis]]
	[[Category: Plp]]		[[Category: Plp]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
	[[Category: Rv3290c]]		[[Category: Rv3290c]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 17:28, 15 January 2015

2015-01-15T17:28:43Z

← Older revision		Revision as of 17:28, 15 January 2015
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>
	<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum]</span></td></tr>
	<table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 32:		Line 32:
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]
	[[Category: Ramachandran, R.]]		[[Category: Ramachandran, R]]
	[[Category: Tripathi, S M.]]		[[Category: Tripathi, S M]]
	[[Category: Aminotransferase]]		[[Category: Aminotransferase]]
	[[Category: Internal aldimine]]		[[Category: Internal aldimine]]
	[[Category: Lysine amino transferase]]		[[Category: Lysine amino transferase]]
	~~[[Category: Mycobacterium tuberculosis]]~~
	[[Category: Plp]]		[[Category: Plp]]
	[[Category: Pyridoxal phosphate]]		[[Category: Pyridoxal phosphate]]
	[[Category: Rv3290c]]		[[Category: Rv3290c]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 02:22, 30 September 2014

2014-09-30T02:22:25Z

← Older revision		Revision as of 02:22, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2cin~~.~~png~~\|~~left~~\|~~200px~~]]		==LYSINE AMINOTRANSFERASE FROM M. TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM==
			<StructureSection load='2cin' size='340' side='right' caption='[[2cin]], [[Resolution\|resolution]] 1.98Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cin]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CIN FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[2cjd\|2cjd]], [[2cjg\|2cjg]], [[2cjh\|2cjh]]</td></tr>
			<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/L-lysine_6-transaminase L-lysine 6-transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.36 2.6.1.36] </span></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cin OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cin RCSB], [http://www.ebi.ac.uk/pdbsum/2cin PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ci/2cin_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			Lysine epsilon-aminotransferase (LAT) is a PLP-dependent enzyme that is highly up-regulated in nutrient-starved tuberculosis models. It catalyzes an overall reaction involving the transfer of the epsilon-amino group of L-lysine to alpha-ketoglutarate to yield L-glutamate and alpha-aminoadipate-delta-semialdehyde. We have cloned and characterized the enzyme from Mycobacterium tuberculosisH37Rv. We report here the crystal structures of the enzyme, the first from any source, in the unliganded form, external aldimine with L-lysine, with bound PMP and with its C5 substrate alpha-ketoglutarate. In addition to interaction details in the active site, the structures reveal a Glu243 "switch" through which the enzyme changes substrate specificities. The unique substrate L-lysine is recognized specifically when Glu243 maintains a salt-bridge with Arg422. On the other hand, the binding of the common C5 substrates L-glutamate and alpha-ketoglutarate is enabled when Glu243 switches away and unshields Arg422. The structures reported here, sequence conservation and earlier mutational studies suggest that the "glutamate switch" is an elegant solution devised by a subgroup of fold type I aminotransferases for recognition of structurally diverse substrates in the same binding site and provides for reaction specificity.

	~~{{STRUCTURE_2cin\| PDB=2cin \| SCENE= }}~~		Direct evidence for a glutamate switch necessary for substrate recognition: crystal structures of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv.,Mani Tripathi S, Ramachandran R J Mol Biol. 2006 Oct 6;362(5):877-86. Epub 2006 Aug 11. PMID:16950391<ref>PMID:16950391</ref>

	~~===LYSINE AMINOTRANSFERASE FROM M. TUBERCULOSIS IN THE INTERNAL ALDIMINE FORM===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16950391}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cin]] is~~ a ~~1 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CIN OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016950391<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: L-lysine 6-transaminase]]		[[Category: L-lysine 6-transaminase]]
	[[Category: Mycobacterium tuberculosis]]		[[Category: Mycobacterium tuberculosis]]

OCA: Protected "2cin" [edit=sysop:move=sysop]

2013-01-06T11:35:13Z

Protected "2cin" [edit=sysop:move=sysop]

← Older revision	Revision as of 11:35, 6 January 2013
(No difference)