2cjs - Revision history

OCA at 09:26, 9 May 2024

2024-05-09T09:26:23Z

← Older revision		Revision as of 09:26, 9 May 2024
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	<StructureSection load='2cjs' size='340' side='right'caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2cjs' size='340' side='right'caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=2CJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]~~</td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [~~http~~://pdbe.org/2cjs PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [https://pdbe.org/2cjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [https://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>
	</table>		</table>
			== Function ==
			[https://www.uniprot.org/uniprot/UN13A_RAT UN13A_RAT] Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion.<ref>PMID:9697857</ref> <ref>PMID:11343654</ref> <ref>PMID:11792326</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	~~[[Category: Buffalo rat]]~~
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dai, H]]		[[Category: Rattus norvegicus]]
	[[Category: Dulubova, I]]		[[Category: Dai H]]
	[[Category: Lu, J]]		[[Category: Dulubova I]]
	[[Category: Machius, M]]		[[Category: Lu J]]
	[[Category: Rizo, J]]		[[Category: Machius M]]
	[[Category: Sudhof~~, T C~~]]		[[Category: Rizo J]]
	[[Category: Tomchick~~, D R]]~~		[[Category: Sudhof TC]]
	~~[[Category: C2 domain]]~~		[[Category: Tomchick DR]]
	~~[[Category: Exocytosis]]~~
	~~[[Category: Metal-binding]]~~
	~~[[Category: Munc13]]~~
	~~[[Category: Neurotransmitter release]]~~
	~~[[Category: Neurotransmitter transport]]~~
	~~[[Category: Phorbol-ester binding]]~~
	~~[[Category: Protein- protein interaction]]~~
	~~[[Category: Rim]]~~
	~~[[Category: Synapse]]~~
	~~[[Category: Synaptosome]]~~
	~~[[Category: Transport]]~~
	~~[[Category: Zinc finger~~]]

OCA at 07:53, 4 November 2020

2020-11-04T07:53:35Z

← Older revision		Revision as of 07:53, 4 November 2020
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	==Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules==		==Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules==
	<StructureSection load='2cjs' size='340' side='right' caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2cjs' size='340' side='right'caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://pdbe.org/2cjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://pdbe.org/2cjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>
	</table>		</table>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
			[[Category: Large Structures]]
	[[Category: Dai, H]]		[[Category: Dai, H]]
	[[Category: Dulubova, I]]		[[Category: Dulubova, I]]

OCA at 08:15, 23 May 2018

2018-05-23T08:15:46Z

← Older revision		Revision as of 08:15, 23 May 2018
Line 1:		Line 1:

	==Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules==		==Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules==
	<StructureSection load='2cjs' size='340' side='right' caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2cjs' size='340' side='right' caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://pdbe.org/2cjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://pdbe.org/2cjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cjs ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	~~[[http://www.uniprot.org/uniprot/RIMS2_RAT RIMS2_RAT]] Rab effector involved in exocytosis. May act as scaffold protein.~~
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjs_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjs_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 14:54, 9 February 2016

2016-02-09T14:54:52Z

← Older revision		Revision as of 14:54, 9 February 2016
Line 17:		Line 17:
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cjs ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:20, 10 September 2015

2015-09-10T23:20:33Z

← Older revision		Revision as of 23:20, 10 September 2015
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	<StructureSection load='2cjs' size='340' side='right' caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='2cjs' size='340' side='right' caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rattus_norvegicus Rattus norvegicus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://pdbe.org/2cjs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cjs" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Rattus norvegicus~~]]		[[Category: Buffalo rat]]
	[[Category: Dai, H]]		[[Category: Dai, H]]
	[[Category: Dulubova, I]]		[[Category: Dulubova, I]]

OCA at 07:31, 25 December 2014

2014-12-25T07:31:46Z

← Older revision		Revision as of 07:31, 25 December 2014
Line 3:		Line 3:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJS FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/RIMS2_RAT RIMS2_RAT]] Rab effector involved in exocytosis. May act as scaffold protein.
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Dai, H.]]		[[Category: Dai, H]]
	[[Category: Dulubova, I.]]		[[Category: Dulubova, I]]
	[[Category: Lu, J.]]		[[Category: Lu, J]]
	[[Category: Machius, M.]]		[[Category: Machius, M]]
	[[Category: Rizo, J.]]		[[Category: Rizo, J]]
	[[Category: Sudhof, T C.]]		[[Category: Sudhof, T C]]
	[[Category: Tomchick, D R.]]		[[Category: Tomchick, D R]]
	[[Category: C2 domain]]		[[Category: C2 domain]]
	[[Category: Exocytosis]]		[[Category: Exocytosis]]

OCA at 00:57, 30 September 2014

2014-09-30T00:57:24Z

← Older revision		Revision as of 00:57, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2cjs~~.~~png~~\|~~left~~\|~~200px~~]]		==Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules==
			<StructureSection load='2cjs' size='340' side='right' caption='[[2cjs]], [[Resolution\|resolution]] 1.78Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CJS FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1y8f\|1y8f]], [[2a20\|2a20]], [[2bwq\|2bwq]], [[2cjt\|2cjt]]</td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cjs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cjs RCSB], [http://www.ebi.ac.uk/pdbsum/2cjs PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cj/2cjs_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			C(2) domains are well characterized as Ca(2+)/phospholipid-binding modules, but little is known about how they mediate protein-protein interactions. In neurons, a Munc13-1 C(2)A-domain/RIM zinc-finger domain (ZF) heterodimer couples synaptic vesicle priming to presynaptic plasticity. We now show that the Munc13-1 C(2)A domain homodimerizes, and that homodimerization competes with Munc13-1/RIM heterodimerization. X-ray diffraction studies guided by nuclear magnetic resonance (NMR) experiments reveal the crystal structures of the Munc13-1 C(2)A-domain homodimer and the Munc13-1 C(2)A-domain/RIM ZF heterodimer at 1.44 A and 1.78 A resolution, respectively. The C(2)A domain adopts a beta-sandwich structure with a four-stranded concave side that mediates homodimerization, leading to the formation of an eight-stranded beta-barrel. In contrast, heterodimerization involves the bottom tip of the C(2)A-domain beta-sandwich and a C-terminal alpha-helical extension, which wrap around the RIM ZF domain. Our results describe the structural basis for a Munc13-1 homodimer-Munc13-1/RIM heterodimer switch that may be crucial for vesicle priming and presynaptic plasticity, uncovering at the same time an unexpected versatility of C(2) domains as protein-protein interaction modules, and illustrating the power of combining NMR spectroscopy and X-ray crystallography to study protein complexes.

	~~{{STRUCTURE_2cjs\| PDB=2cjs \| SCENE= }}~~		Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch.,Lu J, Machius M, Dulubova I, Dai H, Sudhof TC, Tomchick DR, Rizo J PLoS Biol. 2006 Jul;4(7):e192. PMID:16732694<ref>PMID:16732694</ref>

	~~===Structural Basis for~~ a ~~Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16732694}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cjs]] is a 3 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Rattus_norvegicus Rattus norvegicus]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016732694<~~/~~ref><ref group="xtra">PMID:016052212</ref~~><~~references group="xtra"~~/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Dai, H.]]		[[Category: Dai, H.]]

OCA at 12:45, 30 January 2013

2013-01-30T12:45:33Z

← Older revision		Revision as of 12:45, 30 January 2013
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	[[Image:2cjs.png\|left\|200px]]		[[Image:2cjs.png\|left\|200px]]

	~~<!--~~
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	{{STRUCTURE_2cjs\| PDB=2cjs \| SCENE= }}		{{STRUCTURE_2cjs\| PDB=2cjs \| SCENE= }}

	===~~STRUCTURAL BASIS FOR A MUNC13~~-1 ~~DIMERIC~~ - ~~MUNC13~~-1 - RIM ~~HETERODIMER SWITCH~~: C2-~~DOMAINS AS VERSATILE PROTEIN~~-~~PROTEIN INTERACTION MODULES~~===		===Structural Basis for a Munc13-1 Homodimer - Munc13-1 - RIM Heterodimer Switch: C2-domains as Versatile Protein-Protein Interaction Modules===


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	~~The line below this paragraph, {{ABSTRACT_PUBMED_16732694}}, adds the Publication Abstract to the page~~
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	~~-->~~
	{{ABSTRACT_PUBMED_16732694}}		{{ABSTRACT_PUBMED_16732694}}

OCA: Protected "2cjs" [edit=sysop:move=sysop]

2011-08-24T05:38:13Z

Protected "2cjs" [edit=sysop:move=sysop]

← Older revision	Revision as of 05:38, 24 August 2011
(No difference)

OCA at 05:38, 24 August 2011

2011-08-24T05:38:12Z

← Older revision		Revision as of 05:38, 24 August 2011
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	~~{{Seed}}~~
	[[Image:2cjs.png\|left\|200px]]		[[Image:2cjs.png\|left\|200px]]

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	{{STRUCTURE_2cjs\| PDB=2cjs \| SCENE= }}		{{STRUCTURE_2cjs\| PDB=2cjs \| SCENE= }}

	===STRUCTURAL BASIS FOR A MUNC13-1 ~~HOMODIMER~~- MUNC13-1- RIM HETERODIMER SWITCH: C2-DOMAINS AS VERSATILE PROTEIN-PROTEIN INTERACTION MODULES===		===STRUCTURAL BASIS FOR A MUNC13-1 DIMERIC - MUNC13-1 - RIM HETERODIMER SWITCH: C2-DOMAINS AS VERSATILE PROTEIN-PROTEIN INTERACTION MODULES===


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	==About this Structure==		==About this Structure==
	~~2CJS~~ is a 3 ~~chains~~ structure ~~of sequences~~ from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA].		[[2cjs]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CJS OCA].

	==Reference==		==Reference==
	<ref group="xtra">PMID:~~16732694~~</ref><references group="xtra"/>		<ref group="xtra">PMID:016732694</ref><ref group="xtra">PMID:016052212</ref><references group="xtra"/>
	[[Category: Rattus norvegicus]]		[[Category: Rattus norvegicus]]
	[[Category: Dai, H.]]		[[Category: Dai, H.]]
Line 32:		Line 31:
	[[Category: Sudhof, T C.]]		[[Category: Sudhof, T C.]]
	[[Category: Tomchick, D R.]]		[[Category: Tomchick, D R.]]
	~~[[Category: Alternative splicing]]~~
	[[Category: C2 domain]]		[[Category: C2 domain]]
	~~[[Category: Coiled coil]]~~
	[[Category: Exocytosis]]		[[Category: Exocytosis]]
	[[Category: Metal-binding]]		[[Category: Metal-binding]]
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	[[Category: Neurotransmitter transport]]		[[Category: Neurotransmitter transport]]
	[[Category: Phorbol-ester binding]]		[[Category: Phorbol-ester binding]]
	[[Category: Protein-protein interaction]]		[[Category: Protein- protein interaction]]
	[[Category: Rim]]		[[Category: Rim]]
	[[Category: Synapse]]		[[Category: Synapse]]
	[[Category: Synaptosome]]		[[Category: Synaptosome]]
	[[Category: Transport]]		[[Category: Transport]]
	~~[[Category: Zinc]]~~
	[[Category: Zinc finger]]		[[Category: Zinc finger]]

	~~''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 10:38:20 2009''~~