2cki - Revision history

OCA at 00:50, 21 November 2024

2024-11-21T00:50:47Z

← Older revision		Revision as of 00:50, 21 November 2024
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [https://pdbe.org/2cki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [https://www.ebi.ac.uk/pdbsum/2cki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [https://pdbe.org/2cki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [https://www.ebi.ac.uk/pdbsum/2cki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>
	</table>		</table>
	~~== Function ==~~
	[https://www.uniprot.org/uniprot/ULIL_METAC ULIL_METAC] Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.<ref>PMID:16627477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2cki_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2cki_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/~~initialview01~~.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>

OCA at 11:27, 22 May 2024

2024-05-22T11:27:02Z

← Older revision		Revision as of 11:27, 22 May 2024
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	<StructureSection load='2cki' size='340' side='right'caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cki' size='340' side='right'caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Metac Metac~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanosarcina_acetivorans_C2A Methanosarcina acetivorans C2A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~VAL~~:~~VALINE~~'>~~VAL~~</scene>, <scene name='pdbligand=ZN:~~ZINC+ION~~'>ZN</scene>~~</td></tr>~~		</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene></td></tr>		<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [https://pdbe.org/2cki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [https://www.ebi.ac.uk/pdbsum/2cki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [https://pdbe.org/2cki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [https://www.ebi.ac.uk/pdbsum/2cki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[https://www.uniprot.org/uniprot/ULIL_METAC ULIL_METAC]] Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.<ref>PMID:16627477</ref>		[https://www.uniprot.org/uniprot/ULIL_METAC ULIL_METAC] Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.<ref>PMID:16627477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: ~~Metac~~]]		[[Category: Methanosarcina acetivorans C2A]]
	[[Category: Baumann, U]]		[[Category: Baumann U]]
	[[Category: Garcia-Castellanos, R]]		[[Category: Garcia-Castellanos R]]
	[[Category: Gomis-Ruth~~, F X~~]]		[[Category: Gomis-Ruth FX]]
	[[Category: Seco, J]]		[[Category: Seco J]]
	[[Category: Tallant, C]]		[[Category: Tallant C]]
	~~[[Category: Hydrolase]]~~
	~~[[Category: Metalloprotease~~]]

OCA at 10:34, 17 February 2021

2021-02-17T10:34:47Z

← Older revision		Revision as of 10:34, 17 February 2021
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	<StructureSection load='2cki' size='340' side='right'caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cki' size='340' side='right'caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Metac Metac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2CKI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Metac Metac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CKI FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [~~http~~://pdbe.org/2cki PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/2cki PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [https://pdbe.org/2cki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [https://www.ebi.ac.uk/pdbsum/2cki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[~~http~~://www.uniprot.org/uniprot/ULIL_METAC ULIL_METAC]] Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.<ref>PMID:16627477</ref>		[[https://www.uniprot.org/uniprot/ULIL_METAC ULIL_METAC]] Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.<ref>PMID:16627477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]

OCA at 12:00, 10 May 2019

2019-05-10T12:00:16Z

← Older revision		Revision as of 12:00, 10 May 2019
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	==Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases.==		==Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases.==
	<StructureSection load='2cki' size='340' side='right' caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cki' size='340' side='right'caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metac Metac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metac Metac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKI FirstGlance]. <br>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
			[[Category: Large Structures]]
	[[Category: Metac]]		[[Category: Metac]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]

OCA at 08:21, 23 May 2018

2018-05-23T08:21:06Z

← Older revision		Revision as of 08:21, 23 May 2018
Line 1:		Line 1:

	==Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases.==		==Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases.==
	<StructureSection load='2cki' size='340' side='right' caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cki' size='340' side='right' caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://pdbe.org/2cki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://pdbe.org/2cki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2cki ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	Check<jmol>		Check<jmol>
	<jmolCheckbox>		<jmolCheckbox>
	<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2cki_consurf.spt"</scriptWhenChecked>		<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2cki_consurf.spt"</scriptWhenChecked>
	<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>		<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>

OCA at 09:34, 8 February 2016

2016-02-08T09:34:10Z

← Older revision		Revision as of 09:34, 8 February 2016
Line 5:		Line 5:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://pdbe.org/2cki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	<text>to colour the structure by Evolutionary Conservation</text>		<text>to colour the structure by Evolutionary Conservation</text>
	</jmolCheckbox>		</jmolCheckbox>
	</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/~~chain_selection~~.php?pdb_ID=~~2ata~~ ConSurf].		</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cki ConSurf].
	<div style="clear:both"></div>		<div style="clear:both"></div>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
			<div class="pdbe-citations 2cki" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:25, 1 April 2015

2015-04-01T07:25:25Z

← Older revision		Revision as of 07:25, 1 April 2015
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	[[Category: Metac]]		[[Category: Metac]]
	[[Category: Baumann, U]]		[[Category: Baumann, U]]
	[[Category: Castellanos, R ~~Garcia-~~]]		[[Category: Garcia-Castellanos, R]]
	[[Category: Ruth, F X~~.Gomis-~~]]		[[Category: Gomis-Ruth, F X]]
	[[Category: Seco, J]]		[[Category: Seco, J]]
	[[Category: Tallant, C]]		[[Category: Tallant, C]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]

OCA at 08:21, 14 January 2015

2015-01-14T08:21:36Z

← Older revision		Revision as of 08:21, 14 January 2015
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	==~~STRUCTURE OF ULILYSIN~~, ~~A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES~~.==		==Structure of Ulilysin, a member of the pappalysin family of metzincin metalloendopeptidases.==
	<StructureSection load='2cki' size='340' side='right' caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='2cki' size='340' side='right' caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Methanosarcina_acetivorans Methanosarcina acetivorans~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKI FirstGlance]. <br>		<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Metac Metac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKI FirstGlance]. <br>
	</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
	<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum]</span></td></tr>
	<table>		</table>
			== Function ==
			[[http://www.uniprot.org/uniprot/ULIL_METAC ULIL_METAC]] Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile bond.<ref>PMID:16627477</ref>
	== Evolutionary Conservation ==		== Evolutionary Conservation ==
	[[Image:Consurf_key_small.gif\|200px\|right]]		[[Image:Consurf_key_small.gif\|200px\|right]]
Line 29:		Line 31:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: ~~Methanosarcina acetivorans~~]]		[[Category: Metac]]
	[[Category: Baumann, U.]]		[[Category: Baumann, U]]
	[[Category: ~~Garcia-~~Castellanos, R.]]		[[Category: Castellanos, R Garcia-]]
	[[Category: ~~Gomis-~~Ruth, F X.]]		[[Category: Ruth, F X.Gomis-]]
	[[Category: Seco, J.]]		[[Category: Seco, J]]
	[[Category: Tallant, C.]]		[[Category: Tallant, C]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]
	[[Category: Metalloprotease]]		[[Category: Metalloprotease]]

OCA at 00:10, 30 September 2014

2014-09-30T00:10:10Z

← Older revision		Revision as of 00:10, 30 September 2014
Line 1:		Line 1:
	[[Image:~~2cki~~.~~png~~\|~~left~~\|~~200px~~]]		==STRUCTURE OF ULILYSIN, A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES.==
			<StructureSection load='2cki' size='340' side='right' caption='[[2cki]], [[Resolution\|resolution]] 1.70Å' scene=''>
			== Structural highlights ==
			<table><tr><td colspan='2'>[[2cki]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2CKI FirstGlance]. <br>
			</td></tr><tr><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=VAL:VALINE'>VAL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
			<tr><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
			<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cki OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2cki RCSB], [http://www.ebi.ac.uk/pdbsum/2cki PDBsum]</span></td></tr>
			<table>
			== Evolutionary Conservation ==
			[[Image:Consurf_key_small.gif\|200px\|right]]
			Check<jmol>
			<jmolCheckbox>
			<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ck/2cki_consurf.spt"</scriptWhenChecked>
			<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
			<text>to colour the structure by Evolutionary Conservation</text>
			</jmolCheckbox>
			</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary\|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
			<div style="clear:both"></div>
			<div style="background-color:#fffaf0;">
			== Publication Abstract from PubMed ==
			The metzincin clan encompasses several families of zinc-dependent metalloproteases with proven function both in physiology and pathology. They act either as broad spectrum protein degraders or as sheddases, operating through limited proteolysis. Among the structurally uncharacterized metzincin families are the pappalysins, of which the most thoroughly studied member is human pregnancy-associated plasma protein A (PAPP-A), a heavily glycosylated 170-kDa multidomain protein specifically cleaving insulin-like growth factor (IGF)-binding proteins (IGFBPs). Proulilysin is a 38-kDa archaeal protein that shares sequence similarity with PAPP-A but encompasses only the pro-domain and the catalytic domain. It undergoes calcium-mediated autolytic activation, and the mature protein adopts a three-dimensional structure with two subdomains separated by an active site cleft containing the catalytic zinc ion. This structure is reminiscent of human members of the adamalysin/ADAMs (a disintegrin and a metalloprotease) family of metzincins. A bound dipeptide yields information on the substrate specificity of ulilysin, which specifically hydrolyzes IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Accordingly, ulilysin has higher proteolytic efficiency and a broader substrate specificity than human PAPP-A. The structure of ulilysin represents a prototype for the catalytic domain of pappalysins.

	~~{{STRUCTURE_2cki\| PDB=2cki \| SCENE= }}~~		Molecular analysis of ulilysin, the structural prototype of a new family of metzincin metalloproteases.,Tallant C, Garcia-Castellanos R, Seco J, Baumann U, Gomis-Ruth FX J Biol Chem. 2006 Jun 30;281(26):17920-8. Epub 2006 Apr 20. PMID:16627477<ref>PMID:16627477</ref>

	~~===STRUCTURE OF ULILYSIN~~, ~~A MEMBER OF THE PAPPALYSIN FAMILY OF METZINCIN METALLOENDOPEPTIDASES.===~~		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
			</div>
	~~{{ABSTRACT_PUBMED_16627477}}~~		== References ==
			<references/>
	~~==About this Structure==~~		__TOC__
	~~[[2cki]] is~~ a ~~2 chain structure with sequence from [http://en~~.~~wikipedia~~.~~org/wiki/Methanosarcina_acetivorans Methanosarcina acetivorans]~~. ~~Full crystallographic information is available from [http:~~/~~/oca.weizmann.ac.il/oca-bin/ocashort?id=2CKI OCA].~~		</StructureSection>

	==~~Reference~~==
	<~~ref group="xtra">PMID:016627477<~~/~~ref~~><~~references group="xtra"~~/>
	[[Category: Methanosarcina acetivorans]]		[[Category: Methanosarcina acetivorans]]
	[[Category: Baumann, U.]]		[[Category: Baumann, U.]]

OCA: Protected "2cki" [edit=sysop:move=sysop]

2013-01-06T09:35:50Z

Protected "2cki" [edit=sysop:move=sysop]

← Older revision	Revision as of 09:35, 6 January 2013
(No difference)